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Dr. Goshgarian's Abbreviated Curriculum Vitae

Harry G. Goshgarian - Department of Anatomy/Cell Biology
Wayne State University School of Medicine
9304 Scott Hall
540 E. Canfield Avenue
Detroit, MI 48201
P.(313) 577-1045

PERSONAL DATA:
Born in Worcester, Massachusetts, August 24, 1948

EDUCATION:
* University of Massachusetts, Amherst, MA; B.S. 1971, Major: Zoology
* University of Michigan, Ann Arbor, MI; M.S. 1973, Major: Anatomy
* University of Michigan, Ann Arbor, MI; Ph.D. 1975, Major: Anatomy

TRAINING:
* Postdoctoral Fellow, Section on Neuronal Development and Regeneration, NINCDS/LNC, National Institutes of Health, Bethesda, Maryland, September 1, 1975 to July 31, 1977.

* Research Sabbatical, Department of Neurology, Aachen University School of Medicine, Aachen, Federal Republic of Germany, May 31, 1993 - Sept. 2, 1993.

FACULTY APPOINTMENTS:

August 1, 1977 - August 31, 1981
Assistant Professor of Anatomy, W.S.U.

September 1, 1981 - August 31, 1990
Associate Professor of Anatomy, W.S.U.

October 11, 1984-Present
Associate in Orthopedic Surgery, W.S.U.

September 1, 1990 - Present
Professor of Anatomy/Cell Biology, W.S.U.

PUBLICATIONS: Click on the Medline links below to view publications.


    1. Carlson, B.M., Civileto, S.E., Goshgarian, H.G.  1974, Nerve interactions and regenerative processes occurring in newt limbs fused end-to-end. Devel. Biol., 37: 248-262. Medline


    2. Goshgarian, H.G. , 1976, The regeneration of brachial nerves of contralateral origin into denervated fused newt forelimbs. J. Exp. Zool., 197: 347-356. Medline


    3. Goshgarian, H.G.  1977, A rapid Silver impregnation of central and peripheral nerve fibers in paraffin and frozen sections. Exp, Neurol., 57: 296-301. Medline


    4. Goshgarian, H.G. , Guth, L. 1977, Demonstration of functionally ineffective synapses in the guinea pig spinal cord. Exp. Neurol. (Nov.), 57(2): 613-622. Medline


    5. Zalewski, A.A., Cresswell, G.F., Goshgarian, H.G. , and Oh, T.H. 1977, The nude mouse: An in vivo model for demonstrating cross-species trophic nerve function. Exp. Neurol., 54: 397-402. Medline


    6. Zalewski, A.A., Goshgarian, H.G. , and Silvers, W.K. 1978, The fate of neurons and neurilemmal cells in allografts of ganglia in the spinal cord of normal and immunologically tolerant rats. Exp., Neurol., 59: 322-330. Medline


    7. Goshgarian, H.G.  1979, The interaction of nerves of opposite regenerating polarity in fused newt forelimbs. J. Exp. Zool., 209: 297-308.Medline


    8. Goshgarian, H.G.  1979, Developmental plasticity in the respiratory pathway of the adult rat. Exp. Neurol., 66: 547-555. Medline


    9. Goshgarian, H.G.  1981, The role of cervical afferent nerve fiber inhibition of the crossed phrenic phenomenon. Exp. Neurol., 72: 211-225. Medline


    10. Goshgarian, H.G.  1981, Functional recovery of the paralyzed diaphragm after spinal cord injury in rats. Paraplegia News, April: 24-27. Medline


    11. Goshgarian, H.G.  and Rafols, J.A. 1981, The phrenic nucleus of the albino rat: A correlative HRP and Golgi study. J. Comp. Neurol., 201: 441-456.Medline


    12. Goshgarian, H.G. , Koistinen, J. and Schmidt, E. 1983, Cell death and changes in the retrograde transport of horseradish peroxidase in rubrospinal neurons following spinal cord hemisection in the adult rat. J. Comp. Neurol., 214: 251-257. Medline


    13. Goshgarian, H.G.  and Rafols, J.A. 1984, The ultrastructure and synaptic architecture of phrenic motorneurons in the spinal cord of the adult rat. J. Neurocytol., 13: 85-109. Medline


    14. Rafols, J.A. and Goshgarian, H.G.  1985, Spinal tanycytes in the adult rat: A correlative Golgi-gold toning study. Anat. Rec. 211: 75-86. Medline


    15. Goshgarian, H.G.  and Roubal, P.J. 1986, Origin and distribution of phrenic primary afferent nerve fibers in the spinal cord in the adult rat. Exp. Neurol. 92: 624-638. Medline


    16. Goshgarian, H.G. , Moran, M.F., and Prcevski, P. 1986, The effect of cervical spinal cord hemisection and hemidiaphragm paralysis on arterial blood gases, pH, and respiratory rate in the adult rat. Exp. Neurol., 93: 440-445. Medline


    17. Furicchia, J.V., and Goshgarian, H.G.  1987, Dendritic organization of phrenic motor neurons in the adult rat. Exp. Neurol., 96: 621-634. Medline


    18. DeVries, K. and Goshgarian, H.G.  1989, Spinal cord localization and characterization of the neurons which give rise to the accessory phrenic nerve in the adult rat. Exp. Neurol., 104(1): 88-90. Medline


    19. Goshgarian, H.G. , Yu, X-J., and Rafols, J.A. 1989, Neuronal and glial changes in the rat phrenic nucleus occurring within hours after spinal cord injury. J. Comp. Neurol., 284(4): 519-533.Medline


    20. Cass, S.P., Davidson, P., and Goshgarian, H.G.  1990, Survival of the vestibular nerve following labyrinthectomy in the cat. Otolaryngol.-Head and Neck Surg. 101(4): 459-465. Medline


    21. Goshgarian, H.G.  and Yu, X.-J. 1990, Chronic hypoxia causes morphological alterations in astroglia in the phrenic nucleus of young adult rats. Exp. Neurol. 107: 170-177. Medline


    22. Cass, S.P. and Goshgarian, H.G.  1990, Increased glial fibrillary acidic protein immunoreactivity in astrocytes within the lateral vestibular nucleus of the cat following labyrinthectomy and vestibular neurectomy. Ann. Otol. Rhinol. Laryngol. 99: 221-227. Medline


    23. Highland, T.R., Ottoni, L., Lamont, R.L. and Goshgarian, H.G.  1990, The contribution of the dorsal and ventral roots of the tibial nerve in the propagation of the spinal somatosensory evoked potential in cats. Spine 15: 560-566. Medline


    24. Lighthall, J.W., Goshgarian, H.G.  and Pinderski, C.R. 1990, Characterization of axonal injury produced by controlled cortical impact. J. Neurotrauma 7(2): 65-76. Medline


    25. Ellenberger, H.H., Feldman, J.L., and Goshgarian, H.G.  1990, Ventral respiratory group projections to phrenic motoneurons: Electron microscopic evidence for monosynaptic connections. J. Comp. Neurol. 302: 707-714. Medline


    26. O'Hara, T.E. Jr., and Goshgarian, H.G.  1991, Quantitative assessment of phrenic nerve functional recovery mediated by the crossed phrenic reflex at various time intervals after spinal cord injury. Exp. Neurol. 111: 244-250. Medline


    27. Goshgarian, H.G. , Ellenberger, H.H., and Feldman, J.L. 1991. Decussation of bulbospinal respiratory axons at the level of the phrenic nuclei in adult rats: A possible substrate for the crossed phrenic phenomenon. Exp. Neurol. 111: 135-139. Medline


    28. Cass, S.P. and Goshgarian, H.G.  1991. Vestibular compensation after labyrinthectomy and vestibular neurectomy in cats. Otolaryngol. -Head and Neck Surg. 104(1): 14-19. Medline


    29. Moreno, D.E., Yu, X.-J., and Goshgarian, H.G.  1992. Identification of the axon pathways which mediate functional recovery of a paralyzed hemidiaphragm following spinal cord hemisection in the adult rat. Exp. Neurol. 116: 219-228. Medline


    30. Goshgarian, H.G. , Ellenberger, H.H., and Feldman, J.L. 1993. Bulbospinal respiratory neurons are a source of double synapses in the phrenic nucleus following cervical spinal cord hemisection in adult rats. Brain Res. 600: 169-173. Medline


    31. Sperry, M.A. and Goshgarian, H.G.  1993. Ultrastructural changes in the rat phrenic nucleus developing within 2 hours after cervical spinal cord hemisection. Exp. Neurol 120: 233-244. Medline


    32. Yu, X.-J. and Goshgarian, H.G.  1993. Aging enhances synaptic efficacy in a latent motor pathway following spinal cord hemisection in adult rats. Exp. Neurol. 121: 231-238. Medline


    33. Liou, W. W. and Goshgarian, H.G.  1994, Quantitative assessment of the effect of chronic phrenicotomy on the induction of the crossed phrenic phenomenon. Exp. Neurol. 127: 145-153. Medline


    34. Liou, W. W. and Goshgarian, H.G.  1996, The superimposed effects of chronic phrenicotomy and cervical spinal cord hemisection on the glial cytoarchitecture in the rat phrenic nucleus. J. Spinal Cord Med. 19(2): 58-70. Medline


    35. Tai, Q. and Goshgarian, H.G.  1996. Ultrastructural quantitative analysis of glutamatergic and GABAergic synaptic terminals in the phrenic nucleus after spinal cord injury. J. Comp., Neurol. 372:343-355. Medline


    36. Castro-Moure, F. and Goshgarian, H.G.  1996. Reversible cervical hemispinalization of the rat spinal cord by a cooling device. Exp. Neurol. 141:102-112. Medline


    37. Nantwi, K.W., El-Bohy, A., and Goshgarian, H.G.  1996. Actions of systemic theophylline on hemidiaphragmatic recovery in rats following cervical spinal cord hemisection. Exp. Neurol. 140:53-59. Medline


    38. Liou, W.W. and Goshgarian, H.G.  1997. The superimposed effects of chronic phrenicotomy and cervical spinal cord hemisection on synaptic cytoarchitecture in the rat phrenic nucleus. Exp. Neurol. 145:258-267. Medline


    39. Castro-Moure, F., Kupsky, W., and Goshgarian, H.G.  1997. Pathophysiological classification of human spinal cord ischemia. J. Spinal Cord Med. 20(1):74-87. Medline


    40. Gould, D.J. and Goshgarian, H.G.  1997. Glial changes in the phrenic nucleus following superimposed cervical spinal cord hemisection and peripheral chronic phrenicotomy injuries in adult rats. Exp. Neurol. 148:1-9. Medline


    41. Hadley, S.D. and Goshgarian, H.G.  1997, Altered immunoreactivity for glial fibrillary acidic protein in astrocytes within 1 hour after cervical spinal cord injury. Exp. Neurol. 146(2):380-387. Medline


    42. Tai, Q., Palazzolo, K.L., and Goshgarian, H.G.  1997, Synaptic Plasticity of 5-hydroxytryptamine immunoreactive terminals in the phrenic nucleus following spinal cord injury: A quantitative electron microscopic analysis. J. Comp. Neurol. 386(4):613-624. Medline


    43. Castro-Moure, F. and Goshgarian, H.G.  1997, Morphological plasticity induced in the phrenic nucleus following cervical cold block of descending respiratory drive. Exp. Neurol. 147(2):299-310. Medline


    44. Tai, Q., Palazzolo, K.L., Mautes, A., Nacimiento, W., Kuhtz-Buschbeck, J.P., Nacimiento, A.C., Goshgarian, H.G.  1997, Ultrastructural characteristics of glutamatergic and GABAergic terminals in cat lamina IX before and after spinal cord injury. J. Spinal Cord. Med. 20(3):311-318. Medline


    45. Cheng, H.-W., Rafols, J.A., Goshgarian, H.G. , Anavi, Y., Tong, J., and McNeill, T.H. 1997, Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation: A Golgi Study. Exp. Neurol. 147(2):287-298. Medline


    46. Castro-Moure, F. and Goshgarian, H.G.  1997, Chronic hypoxia does not induce synaptic plasticity in the phrenic nucleus. Exp. Neurol. 148:293-298. Medline


    47. Nantwi, K.D. and Goshgarian, H.G.  1998, Theophylline-induced recovery in a hemidiaphragm paralyzed by hemisection in rats: contribution of adenosine receptors. Neuropharmacol. 37:113-121. Medline


    48. El-Bohy, A., Schrimsher, G.W., Reier, P.J. and Goshgarian, H.G.  1998, Quantitative assessment of respiratory function following contusion injury of the cervical spinal cord. Exp. Neurol. 150:143-152. Medline


    49. Nantwi, K.D. and Goshgarian, H.G.  1998, Effects of systemic theophylline on chronic recovery of hemidiaphragmatic function following cervical spinal cord injury in adult rats. Brain Res. 789:126-129. Medline


    50. El-Bohy, A.A. and Goshgarian, H.G.  1998, The use of single phrenic axon recordings to assess diaphragm recovery after cervical spinal cord injury. Exp. Neurol. 156(1):172-179. Medline


    51. Zhou, S.-Y., and Goshgarian, H.G. , 1998, Effects of serotonin on crossed phrenic nerve activity in cervical hemispinalized rats.  Soc. for Neurosci. 24(2):1730. Medline


    52. Gould, D.J. and Goshgarian, H.G.  1999, The effects of mitotic inhibition on the spinal cord response to the superimposed injuries of spinal cord hemisection and peripheral axotomy. Exp. Neurol. 158(2):394-402. Medline


    53. Nantwi, K.D. El-Bohy, A. Schrimsher, G.W. Reier, P.J. and Goshgarian, H.G.  1999, Spontaneous functional recovery in a paralyzed hemidiaphragm following upper cervical spinal cord injury in rats. Neuralrehab. and Neural Repair 13(4):255-234.

    54. Nantwi, K.D. and Goshgarian, H.G.  1999, Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats. Exp Neurol. 2001 Mar;168(1):123-34. Medline

    55. Hadley, S.D., Walker, P.D., and Goshgarian, H.G. 1999, Effects of serotonin inhibition on neuronal and astrocyte plasticity in the phrenic nucleus four hours following C2 spinal cord hemisection. Exp Neurol. 1999 Dec;160(2):433-45. Medline

    56. Hadley, S.D., Walker, P.D., and Goshgarian, H.G. 1999, Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon four hours following C2 spinal cord hemisection. Exp Neurol. 1999 Dec;160(2):479-88. Medline

    57. Zhou, S.-Y and Goshgarian, H.G. 2000, 5-Hydroxytryptophan-induced respiratory recovery after cervical spinal cord hemisection in rats. J Appl Physiol. 2000 Oct;89(4):1528-36
      58. Medline

    58. Phillis, J.W. and Goshgarian H.G. 2001, Adenosine and Neurotrauma: Theraputic Perspectives.Neurol Res. 2001 Mar-Apr;23(2-3):183-9. Medline


    59. Nantwi, K.D., Basura, G. and Goshgarian, H.G. , 2001, Long term theophylline-induced functional recovery and alterations in adenosine A1 receptor mRNA expression in C2 hemisected adult rats.  Ninth International Symposium on Neural Regeneration and Repair.  J. Rehab. Res. and Dev. 38(6):S40-41.
      60. Medline

    60. Basura, G.J., Zhou, S, -Y.,Walker, P.D., and Goshgarian, H.G. 2001, Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic montoneurons following acute spinal cord hemisection. Exp. Neurol. 169(2):255-263.
      61. Medline

    61. Zhou, S, -Y., Castro-Moure F. and Goshgarian H.G. 2001, Activation of a latent respiratory motor pathway following cervical spinal cord hemisection by stimulation of neurons in the medullary chemoreceptor area of the rat.Exp Neurol. 2001 Sep;171(1):176-84. Medline

    62. Zhou, S, -Y., Basura, G.J., and Goshgarian H.G. 2001, Seroronin 2 receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats. J Appl Physiol. 2001 Dec;91(6):2665-73. Medline


    63. Nantwi, K.D. and Goshgarian H.G. 2002, Actions of specific adenosine receptor A1 and A2 agonists and antagonists in recovery of phrenic motor output following upper cervical spinal cord injury in adult rats. Clin Exp Pharmacol Physiol. 2002 Oct;29(10):915-23. Medline


    64. Basura, G.J., Nantwi, K.D. and Goshgarian H.G. 2002, Theophyline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation. Brain Res. 956(1):1-13.
      65. Medline

    65. Nantwi, K.D., Basura, G.J.and Goshgarian H.G. 2003, Effects of long-term theophyline exposure on recovery of respiratory function and expression od adenosine A, mRNA in cervical spinal cord hmisected in adult rats. Exp. Neurol. 182 (1):232-239.
      66. Medline

    66. Goshgarian, H.G.   2003, The Crossed Phrenic Phenomenon: A Model of Plasticity in the Respiratory Pathways Following Spinal Cord Injury.  J. Appl. Physiol. 94:795-810.Medline


    67. Nantwi, K.D., Basura, G.J.and Goshgarian H.G. 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function four months after C2 hemisection. J. Spinal Cord Med. (in press)


      68.   PUBLICATIONS (Book Chapters):

      Goshgarian, H.G.  and Rafols, J.A. 1989, Rapid neuronal and glial changes in the phrenic nucleus following spinal cord injury: A possible morphological basis for the unmasking of functionally ineffective synapses. In: V. Kiortsis, S. Koussoulakos, and H. Wallace (eds.), Recent Trends in Regeneration Research NATO ASI series, Plenum, New York, 263-273.

      Goshgarian, H.G.  1990, Possible morphological and physiological correlates to the unmasking of a latent motor pathway after spinal cord injury. In: F.J. Seil (ed.), Advances in Neural Regeneration Research Neurology and Neurobiology Series, Volume 60, Wiley-Liss, Inc., New York, 34

      Goshgarian, H.G.         2002, The Anatomy and Function of the Spinal Cord.  In: V. Lin (ed.), Spinal Cord Medicine, Principles and Practice.  Demos Publishing Company, New York, 15-34.


       
       




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