Harry Goshgarian, Ph.D

e-mail- hgoshgar@med.wayne.edu
Laboratory Home Page

Education:
B.S., 1971 in Zoology, University of Massachusetts, Amherst, MA
M.S., 1973 in Anatomy, University of Michigan, Ann Arbor, MI
Ph.D., 1975 in Anatomy, University of Michigan, Ann Arbor, MI

Training:
Postdoctoral Fellow, Section on Neuronal Development and Regeneration, NINCDS/LNC, National Institutes of Health, Bethesda, Maryland, September 1, 1975 to July 31, 1977.

Research Sabbatical, Department of Neurology Aachen University School of Medicine, Aachen, Germany, May 31, 1993 to September 2, 1993.

Professional and Faculty Appointments:
August 1, 1977 August 31, 1981, Assistant Professor of Anatomy/Cell Biology, Wayne State University
September 1, 1981 August 31, 1990, Associate Professor of Anatomy/Cell Biology, Wayne State University
October 11, 1984 Present, Associate in Orthopedic Surgery, Wayne State University
September 1, 1990 Present, Professor of Anatomy/Cell Biology, Wayne State University
June 1, 2000- Present, Associate in Internal Medicine, Wayne State University

Major Research Interests:
The underlying mechanisms associated with motor recovery following injury/disease of the central nervous system, especially the spinal cord.

Current Research:
One of the life-threatening consequences of cervical spinal cord injury in man is respiratory insufficiency due to the paralysis of the diaphragm and other respiratory muscles. Victims of this type of spinal cord injury require mechanical ventilators to breathe. For over 20 years, my laboratory has been focused on understanding the underlying mechanisms for the unmasking of a latent respiratory motor pathway which restores function to regions of the diaphragm paralyzed by cervical spinal injury in mammalian animal models. In the past the lab has conducted correlative quantitative ultrastructural, immunocytochemical, electrophysiological and biochemical studies to identify the conditions which govern the unmasking of this pathway. Based on this information, we have recently employed pharmacological techniques to manipulate the pathway in order to improve respiratory capability after cervical spinal cord injury. We have shown that these approaches work, not only in our laboratory animal studies, but also in our human clinical trials which are currently underway. Future studies will involve the pharmacological/physiological/molecular characterization of the receptors involved in the recovery process. No other laboratory in the world is approaching the problem of achieving recovery after spinal cord injury from this perspective.

Recent papers:

1. Goshgarian, H.G. The Crossed Phrenic Phenomenon: A Model of Plasticity in the Respiratory Pathways Following Spinal Cord Injury. J. Appl. Physiol. 94:795-810, 2003. Review. Medline

2. Zimmer MB, Goshgarian HG. Spontaneous crossed phrenic activity in the neonatal respiratory network. Exp Neurol. 194(2):530-40, 2005. Medline

3. Minor KH, Akison LK, Goshgarian HG, Seeds NW. Spinal cord injury-induced plasticity in the mouse--the crossed phrenic phenomenon. Exp Neurol. 200(2):486-95, 2006. Medline

4. Zimmer MB, Goshgarian HG. Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. J Spinal Cord Med. 29(2):147-55, 2006. Medline

5. Tzelepis GE, Bascom AT, Safwan Badr M, Goshgarian HG. Effects of theophylline on pulmonary function in patients with traumatic tetraplegia. J Spinal Cord Med. 29(3):227-33. 2006. Medline

6. Zimmer MB, Goshgarian HG. GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury. Exp Neurol. 203(2):493-501, 2007. Medline

7. Zimmer MB, Goshgarian HG. Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms. Exp Neurol. 206(1):137-45, 2007. Medline

8. Zimmer MB, Nantwi K, Goshgarian HG. Effect of spinal cord injury on the neural regulation of respiratory function. Exp Neurol. 2007. Medline

9. Zimmer MB, Nantwi K, Gashgarian HG. Effect of spinal cord injury on the respiratory system: basic research and current clinical treatment options. J Spinal Cord Med. 30(4):319-30, 2007. Review. Medline

10. Alilain WJ, Gashgarian HG. MK-801 upregulates NR2A protein levels and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats. J Spinal Cord Med. 30(4):346-54, 2007. Medline

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1.	Goshgarian, H.G. The Crossed Phrenic Phenomenon: A Model of Plasticity in the Respiratory Pathways Following Spinal Cord Injury. J. Appl. Physiol. 94:795-810, 2003. Review. Medline
2.	Zimmer MB, Goshgarian HG. Spontaneous crossed phrenic activity in the neonatal respiratory network. Exp Neurol. 194(2):530-40, 2005. Medline
3.	Minor KH, Akison LK, Goshgarian HG, Seeds NW. Spinal cord injury-induced plasticity in the mouse--the crossed phrenic phenomenon. Exp Neurol. 200(2):486-95, 2006. Medline
4.	Zimmer MB, Goshgarian HG. Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. J Spinal Cord Med. 29(2):147-55, 2006. Medline
5.	Tzelepis GE, Bascom AT, Safwan Badr M, Goshgarian HG. Effects of theophylline on pulmonary function in patients with traumatic tetraplegia. J Spinal Cord Med. 29(3):227-33. 2006. Medline
6.	Zimmer MB, Goshgarian HG. GABA, not glycine, mediates inhibition of latent respiratory motor pathways after spinal cord injury. Exp Neurol. 203(2):493-501, 2007. Medline
7.	Zimmer MB, Goshgarian HG. Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms. Exp Neurol. 206(1):137-45, 2007. Medline
8.	Zimmer MB, Nantwi K, Goshgarian HG. Effect of spinal cord injury on the neural regulation of respiratory function. Exp Neurol. 2007. Medline
9.	Zimmer MB, Nantwi K, Gashgarian HG. Effect of spinal cord injury on the respiratory system: basic research and current clinical treatment options. J Spinal Cord Med. 30(4):319-30, 2007. Review. Medline
10.	Alilain WJ, Gashgarian HG. MK-801 upregulates NR2A protein levels and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats. J Spinal Cord Med. 30(4):346-54, 2007. Medline