William Crossland, Ph.D

Education:
B.A. Trinity College (Hartford, CT), Psychology 1967
M.A. University of Illinois (Urbana, IL), Psychology 1970
Ph.D. University of Illinois (Urbana, IL), Psychology 1972

Training:
POST DOCTORAL: Washington University School of Medicine (St. Louis, MO) Developmental Neurobiology, 1972-1975

Professional and Faculty Appointments:
1980 - present : Associate Professor, Department of Anatomy & Cell Biology, Wayne State University School of Medicine, Detroit, MI
1975-1980: Assistant Professor, Department of Anatomy & Cell Biology, Wayne State University School of Medicine, Detroit, MI

Major Research Interests:
The formation and maintenance of neuronal connections in the visual system

Current Research:
Our lab is interested in what keeps neurons alive in the visual system of developing animals. During normal embryonic development, at least half of the neurons in the body, including the visual system, die. If injured neurons die, the neurons to which they are connected may also atrophy and die. The long term goal of this research is to learn what factors prevent the loss of undamaged neurons during development, and conversely, what factors lead to their death. This trophic relationship is most dramatic in embryonic and neonatal animals, and therefore we study the visual pathways in embryonic and hatchling chicks. The chick visual system is advantageous because of its accessibility and because of the large amount of data available on its development in general, and cell death, in particular.

Recent papers:

1. Crossland, W.J., Hu, X-J., and Rafols, J. A. (1994) A morphological study of the rostral interstitial nucleus of the medial longitudinal fasciculus in the monkey by Nissl, Golgi and computer reconstruction methods. J. Comp. Neurol. 347: 47-63. Medline

2. Quintero, R.A., Crossland, W.J., and Cotton, D.B. (1994) Effect of endoscopic white light on the developing visual pathways: A histologic, histochemical and behavioral study. Amer. J. Obstet. Gynec. 171: 1142-1148. Medline

3. Fujii, J.T, Lucaj, Z., Peduzzi, J.D. and Crossland, W.J. (1995) Development of parvalbumin immunoreactivity in the chick Edinger Westphal nucleus. J. Comp. Neurol. 360:612-620. Medline

4. Yao, R., Crossland, W. and Maisel, H (1996) Electron microscopic detection of glycoconjugates in the chicken lens. Exp. Eye Res. 63:705-711. Medline

5. Li, H. , George, V.K., Crossland, W. J., Anderson, G.F. and Dhabuwala, C.B. (1997) Characterization of cocaine binding sites in the rat testes. J. Urology 158: 962-965. Medline

6. Bonnett, M.L., Quintero, R.A., Carreño, C. and Crossland, W.J. (1997) The effect of endoscopic white light on the developing rat retina. Fetal Diagnosis & Therapy 12:76-80. Medline

7. Church, M.W., Crossland, W.J., Holmes, P.A., Overbeck, G.W. and Tilak, J.P. (1998) Effects of prenatal cocaine on hearing, vision, growth and behavior. Ann. New York Acad. Sci., 846:12-28 Medline

8. Zhao, Z, Kulkarni, J.S., Wakade, T.D., Wakade, A.R., and Crossland, W.J. (1999) 2-deoxyadenosine causes cell death in chick sympathetic ganglia and brain. Cell Tissue Res. 296: 281-291. Medline

9. Sun, H., Crossland, W.J.(2000) Quantitative assessment of localization and colocalization of glutamate, aspartate, glycine and GABA immunoreactivity in the chick retina. Anatomical Record, 260:158-179. Medline

About the Department /Graduate Studies /ResearchFaculty /Body Bequest /Vision Core Grant /Medical School Home Page /WayneStateHomePage

Return

1.	Crossland, W.J., Hu, X-J., and Rafols, J. A. (1994) A morphological study of the rostral interstitial nucleus of the medial longitudinal fasciculus in the monkey by Nissl, Golgi and computer reconstruction methods. J. Comp. Neurol. 347: 47-63. Medline
2.	Quintero, R.A., Crossland, W.J., and Cotton, D.B. (1994) Effect of endoscopic white light on the developing visual pathways: A histologic, histochemical and behavioral study. Amer. J. Obstet. Gynec. 171: 1142-1148. Medline
3.	Fujii, J.T, Lucaj, Z., Peduzzi, J.D. and Crossland, W.J. (1995) Development of parvalbumin immunoreactivity in the chick Edinger Westphal nucleus. J. Comp. Neurol. 360:612-620. Medline
4.	Yao, R., Crossland, W. and Maisel, H (1996) Electron microscopic detection of glycoconjugates in the chicken lens. Exp. Eye Res. 63:705-711. Medline
5.	Li, H. , George, V.K., Crossland, W. J., Anderson, G.F. and Dhabuwala, C.B. (1997) Characterization of cocaine binding sites in the rat testes. J. Urology 158: 962-965. Medline
6.	Bonnett, M.L., Quintero, R.A., Carreño, C. and Crossland, W.J. (1997) The effect of endoscopic white light on the developing rat retina. Fetal Diagnosis & Therapy 12:76-80. Medline
7.	Church, M.W., Crossland, W.J., Holmes, P.A., Overbeck, G.W. and Tilak, J.P. (1998) Effects of prenatal cocaine on hearing, vision, growth and behavior. Ann. New York Acad. Sci., 846:12-28 Medline
8.	Zhao, Z, Kulkarni, J.S., Wakade, T.D., Wakade, A.R., and Crossland, W.J. (1999) 2-deoxyadenosine causes cell death in chick sympathetic ganglia and brain. Cell Tissue Res. 296: 281-291. Medline
9.	Sun, H., Crossland, W.J.(2000) Quantitative assessment of localization and colocalization of glutamate, aspartate, glycine and GABA immunoreactivity in the chick retina. Anatomical Record, 260:158-179. Medline