Untitled Document

Michael Andrew Tainsky. P.h.D.
Professor, Department of Pathology, Karmanos Cancer Institute,
Institute for Chemical Toxicology,
Center for Molecular Medicine and Genetics,
Wayne State University School Of Medicine

Post-Graduate Training:
Postgraduate Training:
Roche Institute of Molecular Biology, Nutley, NJ,
Dr. Herbert Weissbach 9/76/-11/77

Academic Appointments:
6/98-present, Professor and Director, Program in Molecular Biology and Cancer Genetics,
Karmanos Cancer Institute, Wayne State University, Detroit MI
www.karmanos.org/~tainskym/

9/96-6/98, Professor, Department of Tumor Biology,
U.T. M. D. Anderson Cancer Center, Houston, TX.

9/90-8/96, Associate Professor, Department of Tumor Biology,
U.T. M. D. Anderson Cancer Center, Houston, TX.

6/85-8/90, Assistant Professor, Department of Tumor Biology,
U. T. M. D. Anderson Cancer Center, Houston, TX.

10/81-6/85, Senior Staff Fellow, Laboratory of Molecular Oncology, DCE, NCI,
Frederick, MD

11/77-10/81, Scientist II, NCI-Frederick Cancer Research Facility,
Frederick, MD

9/76-10/77, Research Fellow, Roche Institute of Molecular Biology,
Nutley, NJ

9/74-6/75, Teaching Assistant in Biochemistry, Cornell University,
Department of Biochemistry Molecular and Cellular Biology

Major Interests:
The understanding of basic mechanisms of molecular and cellular biology that are altered as cells progress to
become neoplastic.

Recent Publications:

1. Leach, S. D., Berger, D.H. Davidson, B.S. Curley, S.A. and Tainsky, M.A., Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells. Pancreas 16:491-498, 1998

2. Kraus, E., Strong L.C., and Tainsky, M.A.pZ402, an improved SV40 based shuttle vector containing a T-antigen mutant unable to interact with wild-type p53, Gene. 211: 229-234, 1998

3. Deyo, J., Chiao P.J., and Tainsky, M.A., drp, a novel protein expressed at high cell density but not during growth arrest, DNA and Cell. Biol. 17:437-447, 1998.

4. Gollahon, L.S., Kraus, E., Wu, T.A. Yim, S.O. Strong, L.C., Shay, J.W., Tainsky, M.A. Telomerase Activity During Spontaneous Immortalization of Li- Fraumeni Syndrome Skin Fibroblasts, Oncogene. 17: 709-717, 1998.

4. Bhattacharya, A, Doerksen, L.F. Pratt, D.R. Buettner, R. and Michael A. Tainsky, N-ras Oncogene Inhibition of HOX A4 Gene Promoter Induction by Retinoic Acid is Mediated through an RARE, submitted to Nucl. Acids Res.

6. Huang, S.,Jean, D.,Luca, M.,Tainsky, M.A., and Bar-Eli, M. Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J. 17:4358-69, 1998.

7. Bauer, R., M. McGuffin, E., Mattox, W. and Tainsky, M.A., Cloning and characterization of the Drosophila homologue of the AP-2 transcription factor, Oncogene, 17: 1911-1922, 1998.

8. Jean, D.,Gershenwald, J.E.,Huang, S., Luca, M., Hudson, M,J., Tainsky, M.A., and Bar-Eli,M. Loss of AP-2 results in upregulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells. J.Biol.Chem., 273:16501-16508, 1998.

9. Kannan, P. and Tainsky, M.A., The Coactivator PC4 Suppresses ras-Induced Transformation by Restoring AP-2 Transcriptional Activity, Mol. Cell. Biol. 19:899-908, 1999

10. Kannan, P, Yu, Y., , Wankhade, S and Tainsky, M.A. Poly ADP-Ribose Polymerase is a Coactivator for AP-2-mediated Transcriptional Activation, Nucl. Acids Res., 27:866-874, 1999.

11. Wankhade, S., Yu, Y., Weinberg,, J., Tainsky, M.A., and Kannan, P. Characterization of the activation domains of AP-2 family transcription factors. J. Biol. Chem. 275(38):29701-8, 2000.

12. Roh, H.J., Shin, D.M., Lee, J.S., Ro, J.Y., Tainsky, M.A., Hong, W.K., and Hittleman, W.N. Visualization of the timing of gene amplification during multistep head and neck tumorigenesis. Cancer Research . 60:6496-6502, 2000.

13. Caruso JA, Rieners JJ, Emond J, Schultz T, Tainsky, M.A, Alaoui-Jamali M, and Batist G. Genetic alteration of chromosomes 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo. Mutat Res. 473(1):85-99, 2001.

14. Jim Barnholtz-Sloan, Michael A. tainsky, Judith Abrams, Richard K. Severson, Faisal Quereshi, Suzzanne M. Jaques, Nancy Levin, Ann G. Schwartz. Ethnic Differences in survival among women with ovarian carcinoma, Cancer. 94(6):1886-1893, 2002.