Pratima Nangia-Makker, Ph.D.
Assistant Professor

Education:

Ph. D. from Jawaharlal Nehru University, Delhi, India

Research Interests:
Role of carbohydrate-binding proteins in tumor metastasis and angiogenesis

Publications:

1. Nangia-Makker, P., Ochieng, J., Christman, J. and Raz, A. (1993) Regulation of the expression of galactoside-binding lectin during human monocytic differentiation. Cancer Res. 53: 5033-5037.6. [Medline]

2. Ochieng, J., Fridman, R.G., Nangia-Makker, P., Liotta, L.A., Stetler-Stevenson, W. and Raz, A. (1994) Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9. Biochemistry, 33: 14109-14114. [Medline]

3. Nangia-Makker, P.,Thompson, E., Hogan, C., Ochieng, J., Raz, A. (1995) Induction of tumorigenicity by galectin-3 in a non-tumorigenic human breast carcinoma cell line. Int. J. Oncol. 7: 1079-1087.

4. Akahani, S.,Nangia-Makker, P., Inohara, H., Kim, H-R., Raz, A.(1997) Galectin-3: a novel anti-apoptotic molecule with a functional BH1(NWGR) domain of Bcl-2 family. Cancer Res. 57(23) 5272-5276 [Medline]

5. Warfield, P.R., Nangia-Makker, P., Raz, A., Ochieng, J. (1997) The interaction of a breast epithelial cell line and its galectin-3 transfected subclone with extracellular matrix proteins. Invasion and Metastasis. 17: 101-112 [Medline]

6. Akahani, S., Inohara, H., Nangia-Makker, P., and Raz, A. Galectin-3 in tumor metastasis. In: Trends in Glycosciene and Glycotechnology. Hirabayashi, J. (Ed.) Vol.9, pp 69-75, 1997. [Medline]

7. Nangia-Makker, P., Sarvis, R., Visscher, D., Bailey-Penrod, J., Raz, A., and Sarkar, F. (1998) Galectin-3 and L1 retrotransposons in human breast carcinomas. Breast Cancer Res. Treat. 49 (2) 171-183 [Medline]

8. Shekhar, P.V.M., Nangia-Makker, P., Wolman, S.R., Tait, L., Heppner, G., and Visscher, D.W.(1998) Direct action of estrogen on sequence of progression of human preneoplastic breast disease. American J. Pathol.152(5)1129-1132

9. Bresalier, R.S., Mazurek, N., Sternberg, L.R., Byrd, J.C., Yunker, C.K.,
Nangia-Makker, P., and Raz, A. (1998) Expression of the beta-galactoside-binding protein galectin-3 correlates with the metastatic potential of human colon cancer cells. Gastroenterology, 115(2) 287-296. [Medline]

10. Gong, H.C., Honjo, Y. Nangia-Makker,P., Hogan, V., Mazurak, N., Bresalier, R., and Raz, A. (1999) The amino terminus of galectin-3 governs cellular compartmentalization and function. Cancer Res., 59(24): 6239- 45. [Medline]

11. Nangia-Makker, P., Honjo, Y., Sarvis, R., Akahani, S., Hogan, V., Pienta, K.J., and Raz, A. (2000) Galectin-3 induces Endothelail cell morphogenesis and angiogenesis. Am. J. Pathol. 156(3): 899-909. [Medline]

12. Nangia-Makker, P., Akahani, S., Bresalier, R., Raz, A. Role of galectin-3 in tumor metastasis. In: Lectins and Pathology , M.Caron, A-P Seve, (eds.), Harwood Academic Publishers, pp 67-77, 2000.

13. Nangia-Makker, P., Baccarini, S., and Raz, A. Carbohydrate-recognition and angiogenesis. In: Cancer and Metastasis Reviews. 19:51-57, 2000 [Medline]

14. Nangia-Makker, P.,Baccarini, S., Raz, A. Carbohydrate-binding protein galectin-3: its role in metastasis, angiogenesis and apoptosis. In: Research Trends: current Topics in Biomedical Research. U.Ramachandran (ed) Vol 3, pp 229-236, 2000.

15. Visscher, D.W, Nangia-Makker, P., Heppner, G., P.V.M. Shekhar. Tamoxifen suppresses histologic progression to atypia and DCIS of MCF 10AT xenografts., a model of early human breast cancer. Breast Cancer Res. Treat. 65: 41-47, 2001. [Medline]

16. Honjo, Y., Nangia-Makker, P., Inohara, H., Raz, A. Down regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells. Clin. Cancer Res. 7(3):661- 668,2001. [Medline]

17. Nangia-Makker, P., Honjo, Y., and Raz, A. Galectin-3 binding and metastasis. In: Methods in Molecular Medicine: Metastasis Research Protocols. Vol 11: Analysis of cell behavior in vitro and in vivo S. Brooks and U. Schumacher (eds.) Humana Press Inc. pp 149-158, 2001.

18. Nangia-Makker, P., Conklin, J., Hogan, V., Raz, A. Carbohydrate-binding proteins in cancer and their ligands as therapeutic agents. Trends in Molecular Medicine, Vol 8(4), April 2002 pp 187-192 9 (2002) [Medline]


19. Nangia-Makker, P., Honjo, Y., Hogan, V., Baccarini, S., Raz, A. Inhibition of human cancer growth and metastasis by oral intake of modified citrus pectin. J. Natl. Cancer Inst.

20. Baccarini,S., Nangia-Makker, P. and Raz, A. The 90K/Mac2-binding protein in human diseases. In: Recent Research development in cancer: Vol1, S.G. Pandala, ed., Transworld Research Network, publishers, (In Press)