Education and Training:

Ph.D., Graduate Student/Research Assistant: 8/94-1/2000 Pharmacology/Toxicology Graduate Program
Washington State University, Pullman, WA
Cumulative GPA: 3.9

Bachelor of Science, Biology: 6/92
University of Washington, Seattle, WA
Cumulative GPA: 3.5

Faculty Appointments:

Assistant Professor, Department of Pathology, Wayne State University, 10/04-present.

Major Interests:

As part of the Center for Integrative Metabolic and Endocrine Research (CIMER) at Wayne State
University, my research is focused on defining the molecular mechanisms by which nutrient signals
modify metabolism in liver cells and growth in pancreatic ß-cells. The goal of the research is to define signaling pathways in which to target for the treatment of diabetes.

Representative Publications:

1. J Kato-Weinstein, M K Lingohr, B D Thrall, and R J Bull. Effects of Dichloroacetate on Glycogen
Metabolism in B6C3F1 Mice. Toxicology. 130/2-3, 141-154, 1998.

2. L M Dickson, M K Lingohr, J F McCuaig, S R Hugl, L Snow, B B Kahn, M G Myers, Jr. and C J Rhodes.
Differential Activation of Protein Kinase B and p70(S6)K by Glucose and Insulin-like Growth Factor 1 in
Pancreatic beta-cells (INS-1). J. Biol. Chem. 2001 Jun 15;276(24):21110-20.

3. B Wicksteed, T P Herbert, C Alarcon, M K Lingohr, L G Moss, and C J Rhodes. Cooperativity Between the
Preproinsulin mRNA Untranslated Regions is Necessary for Glucose-stimulated Translation. J. Biol. Chem.
2001 Jun 22;276(25):22553-8.

4. M K Lingohr, B D Thrall, and R J Bull. Effects of Dichloroacetate (DCA) on Serum Insulin Levels and
Insulin-controlled Signaling Proteins in Livers of Male B6C3F1 Mice. Toxicol. Sci. 2001 January 59(1):178-
84.

5. M K Lingohr, L M Dickson, J F McCuaig, S R Hugl, D R Twardzik, and C J Rhodes. Activation of IRS-2-
mediated Signal Transduction by IGF-1, but not TGF-a or EGF, Augments Pancreatic ß-Cell Proliferation.
Diabetes. 2002 April. 51:966-976.

6. R J Bull, G A Orner, R S Cheng, L Stillwell, A J Stauber, L B Sasser, M K Lingohr, and B D Thrall. The
Contribution of Dichloroacetate and Trichloroacetate to Liver Tumor Induction in Mice by Trichloroethylene.
Toxicol. Appl. Pharmacol. 2002 July 1;182(1):55-65.

7. M K Lingohr, R J Bull, J Kato-Weinstein and B D Thrall. Dichloroacetate Stimulates Glycogen
Accumulation in Primary Hepatocytes Through an Insulin-independent Mechanism. Toxicol. Sci. 2002 August
68(2):508-15.

8. M K Lingohr, R Buettner and C J Rhodes. Pancreatic ß-cell Mitogenesis and Survival Signal Transduction
Pathways in the Pathogenesis of Obesity Linked Type-2 Diabetes. Trends Mol. Med. 2002 Aug 8(8):375-84.

9. C E Wrede, L M Dickson, M K Lingohr, I Briaud and C J Rhodes. Protein Kinase B/Akt Prevents Fatty
Acid-induced Apoptosis in Pancreatic ß-cells (INS-1). J. Biol. Chem. 2002 Dec 20;277(51):49676-84.

10. I Briaud, M K Lingohr, L M Dickson, C E Wrede, and C J Rhodes. Differential Activation Mechanisms of
Erk-1/2 and p70(S6K) by Glucose in Pancreatic ß-cells. Diabetes. 2003 Apr 52(4):974-83.

11. C W Wrede, L M Dickson, M K Lingohr, I Briaud, and C J Rhodes. Modulation of Fatty Acid and Phorbol
Ester-mediated Interference of Mitogenic Signaling via Novel Protein Kinase C Isoforms in Pancreatic Beta-cells (INS-1). JME. 2003 June(3):271-86.

12. M K Lingohr, L M Dickson, C E Wrede, J F McCuaig, M G Myers and C J Rhodes. IRS-3 Inhibits IRS-2-
mediated Signal Transduction in Pancreatic ß-cells (INS-1) Leading to Increased Apoptosis and Decreased
Mitogenesis. Molec. Cell. Endocrinol. 2003 June 204(1-2):85-99.

13. B Wicksteed, C Alarcon, I Briaud, L M Dickson, M K Lingohr, and C J Rhodes. Glucose-induced
Translational Control of Proinsulin Biosynthesis is Proportional to Preproinsulin mRNA Levels in Islet ß-cells,
but not Regulated via a Positive Feedback of Insulin Secretion. J. Biol. Chem. 2003 October 278(43):42080-90.

14. M K Lingohr, L M Dickson, I Briaud, C E Wrede, J F McCuaig, and C J Rhodes. Decreasing IRS-2
Expression Levels in Pancreatic ß-cells (INS-1) Promotes Apoptosis, which can be Compensated for by
Introduction of IRS-4 Expression. Molec. Cell. Endocrinol. 2003 November 209(1-2):17-31.

15. I Briaud, L M Dickson, M K Lingohr, J F McCuaig, J C Lawrence, C J Rhodes. IRS-2 Proteasomal
Degradation Mediated by a mTOR-induced Negative Feedback Downregulates PKB-mediated Signaling
Pathway in ß-cells. J. Biol. Chem. 2005 January 21;280(3):2282-93.