HYEONG-REH CHOI KIM, Ph.D.
Professor of Pathology

Education:
Northwestern University, Ph.D., 1989
Department of Biochemistry, Molecular Biology and Cell Biology

Faculty Appointments:
Assistant Professor, Wayne State University, School of Medicine, 1993 - 1998
Associate Professor, Wayne State University, School of Medicine, 1998 - 2003
Professor, Wayne State University, School of Medicine, 2003-present

Major Research Interests:
Growth-factor signaling and apoptotic cell death pathway

Representative Publications since 1994:
1. Kim, H.-R. C., Upadhyay, S., Korsmeyer, S. and Deuel, T. F. PDGF B and PDGF A homodimers transform murine fibroblasts depending on the genetic background of the cell. J. Biol. Chem. 269: 30604-30608, 1994 [Medline]

2. Kim, H.-R. C., Upadhyay S., Li, G., Palmer, K. and Deuel, T. F. Platelet-derived growth factor (PDGF) induces apoptosis in growth arrest murine fibroblasts. Proc. Natl. Acad. Sci. 92: 9500-9504, 1995

3. Upadhyay, S., Li, G., Liu, H., Chen, Y.Q., Sarkar, F. H. and Kim, H.-R. C. Bcl-2 suppresses expression of p21WAF1/CIP1 in breast epithelial cells. Cancer Research 55: 4520-4524, 1995
[Medline]

4. Kim, H.E., Han, S.J., Kasza, T., Han, R., Choi, H-S, Palmer, K.C. and Kim, H.-R. C. Platelet-derived growth factor (PDGF) signaling mediates radiation-induced apoptosis in human prostate cancer cells with loss of p53 function. Int. J. Radiation Oncology Biol. Phys. 39: 731-736, 1997 [Medline]

5. Akahani S., Nangia-Makker N., Inohara, H., Kim, H.-R. C. and Raz, A. Galectin-3: A novel anti-apoptotic molecule with a functional BH1 (NWGR) domain of bcl-2 family. Cancer Research 57: 5272-5276, 1997[Medline]

6. Kuo, T. H., Kim, H.-R. C., Zhu, L., Yu, Y., Lin, H.-M. And Tsang, W. Modulation of endoplasmic reticulum calcium pump by bcl-2. Oncogene 17: 1903-1910, 1998

7. Kim, H.-R. C., Luo Y, Gangyong Li and Kessel, D. Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection . Cancer Research 59: 3429-3432, 1999[Medline]

8. Kim, H.-R. C., Lin, H.-M., Biliran, H. and Raz A. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Research 59: 4148-4154, 1999 [Medline]

9. Li, G., R. Fridman and Kim, H.-R. C. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. Cancer Research 59: 6267-6275, 1999

10. Moon, A., Kim, M.-S., Kim, T. G., Kim, S. H., Kim, H. E., Chen, Y. Q. and Kim, H.-R. C. H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: A role for MMP-2 in the H-ras induced invasive phenotype. Int. J. Cancer 85: 176-181, 2000 [Medline]

11. Yu, J., Deuel, T. F. and Kim, H.-R. C. Platelet-derived growth factor (PDGF) receptor-a activates JNK-1 and antagonizes PDGF receptor-b-induced phenotypic transformation. J. Biol. Chem. 275: 19076-19082, 2000 [Medline]

12. Yoshimura, F. K., Wang, T., Yu, F., Kim, H.-R. C. and Turner, J.R. Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes. J. Virology 74: 8119-8126, 2000

13. Kim, H.E., Krug, M. A., Han, I., Ensley, J., Yu, G., Forman, J. D. and Kim, H.-R. C. Neutron radiation enhances cis-platinum cytotoxicity independent of apoptosis in human head and neck carcinoma cells. Clinical Cancer Research 6: 4142-4147, 2000 [Medline]

14. Lin, H-M., Moon, B-K., Yu, F. and Kim, H.-R. C. Galectin-3 mediates genistein-induced G2/M arrest and inhibits apoptosis. Carcinogenesis 21: 1941-1945, 2000 [Medline]

15. Lin, H-M., Lee, Y. J., Li, G., Pestell, R. G., and Kim, H.-R. C. Bcl-2 induces cyclin D1 promoter activity in human breast epithelial cells independent of cell anchorage. Cell Death & Differentiation 8: 44-50, 2001

16. Sun, S-Y., Yue, P., Zhou, J-Y., Wang, Y., Kim, H.-R. C., Lotan, L. and We, G. S. Regulation of TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by bcl-2. Biochem. Biophys. Res. Comm., 280: 788-797, 2001

17. Yu, J., Moon, A. and Kim, H.-R. C. Both platelet-derived growth factor receptor (PDGFR)-a and PDGFR-b induce murine fibroblast cell migration. Biochem. Biophys. Res. Comm., 282: 697-700, 2001[Medline]

18. Chen, G-C, Guan, L-S, Yu, J-H, Li, G-C, Kim, H-R C., and Wang, Z-Y. Rb associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1. Biochem. Biophys. Res. Comm., 284: 507-514, 2001[Medline]

19. Lee, Y. J., Lee, K. H., Kim, H.-R. C., Jessup, J. M., Seol, D. W., Kim, T. H., Billiar, T. R. and Song, Y. K. Sodium nitroprusside enhances TRAIL-induced apoptosis via mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. Oncogene 20: 1476-1485, 2001[Medline]

20. Moon, B.-K., Lee, Y. J., Battle, P., Jessup, J. M., Raz, A. and Kim, H.-R. C. Galectin-3 inhibits nitric oxide induced cell death in human breast carcinoma cells: Implication of galectin-3 function during metastasis. Am. J. Pathology 159: 1055-1060, 2001 [Medline]

21. Yoshii, T., Honjo, Y., Inohara, H., Kim, H.-R. C. and Raz, A. Galectin-3 phosphorylation modulates its biological functions: Anti-apoptosis and cell cycle arrest. J. Biol. Chem. 277: 6852-6857, 2002 [Medline]

22. Yu, F., Finley, R. L. Jr., Raz, A. and Kim, H.-R. C. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria: A role for synexin in galectin-3 translocation. J. Biol. Chem. 277: 15819-15827, 2002 [Medline]

23. Lin, H-M., Pestell, R. G., Raz, A. and Kim, H.-R. C. Galectin-3 enhances cyclin D1 promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. Oncogene 21: 8001-8010, 2002

24. Kang, H-J., Soh, Y., Kim, M-S, Lee, E-J, Surh,Y-J, Kim, H.-R. C. and Moon, A. Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. Int. J. Cancer 103: 475-482, 2003

25. Yu, J., Ustach, C. and Kim, H.-R. C. Platelet-derived growth factor signaling and human cancer. Journal of Biochemistry and Molecular Biology 36: 49-59, 2003

26. Lee, Y.J., Song, Y.K., Song, J.J., Siervo-Sassi, R.R., Kim, H.-R. C., Li L., Spitz, D.R., Lokshin, A., and Kim, J.H.. Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. Exp. Cell Res. 288: 21-34, 2003

27. Liu, X-W, Bernardo, M.M., Fridman, R. and Kim, H.-R. C. Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) Protects Human Breast Epithelial Cells against Intrinsic Apoptotic Cell Death via the FAK/PI 3-kinase and MAPK Signaling Pathway Independent of Matrix Metalloproteinase Inhibition. J. Biol. Chem., 2003 M3:02999 In press

28. Kim, M-S., Lee, E-J., Kim, H.-R. C. and Moon, A. p38 kinase is a key signaling molecule for H-ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Research, 2003 CAN-03-0713 In press

e-mail: hrckim@med.wayne.edu