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Professor of Pathology
Education:
Ph.D., Wayne State University, 1977
Dr Honn's laboratory research is focused on two major areas as they relate to tumor progression and metastasis. The first area involves the examination of the role played by Bioactive Lipids in processes such as cancer cell motility and invasion, regulation of the cell cycle and apoptosis, angiogenesis and cell signaling. The regulation of enzymes responsible for bioactive lipid synthesis, such as lipoxygenases, cyclooxygenases and thromboxane synthesis is being examined at the genetic and cellular level. In addition translational research on these enzymes is attempting to link their expression in patient tissues with disease progression and response to chemo and radiation therapy. A drug development program has identified a candidate lipoxygenase inhibitor which is being readied for clinical trial. The second area of research focuses on adhesion receptors, in particular integrins, and their role in metastasis. This research has identified novel truncated forms of integrin receptors which may have antagonistic function relative to the parent integrin. This research is also conducted at the basic and translational level. Dr Honn·s laboratory research employs a multidisciplinary approach utilizing molecular, biochemical and cell biology methodologies.
Selected Publications:
Nie, D., Hillman, G. G., Geddes, T., Tang, K., Pierson, C., Grignon, D. J., and Honn, K. V. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. Cancer Res., 58, 4047-51, 1998. [Medline]
Trikha, M., Cai, Y., Grignon, D., and Honn, K. V. Identification of a novel truncated aIIb integrin. Cancer Res., 58, 4771-5, 1998. [Meldine]
Tang, K., Finley, R. L. Jr, Nie, D., and Honn, K. V. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry, 39, 3185-91, 2000.
Nie, D., Tang, K., Diglio, C., and Honn, K. V. Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase. Blood, 95, 2304-11, 2000. [Medline]
Szekeres, C. K., Tang, K., Trikha, M., and Honn, K. V. Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells. J. Biol. Chem., 275, 38831-41, 2000. [Medline]
Raso, E., Tovari, J., Toth, K., Paku, S., Trikha, M., Honn, K. V., and Timar, J. Ectopic aIIbb3 integrin signaling involves 12-lipoxygenase- and PKC-mediated serine phosphorylation events in melanoma cells. Thromb. Haemost., 85, 1037-42, 2001. [Medline]
Pidgeon, G. P., Mustapha, K., Meram, A., and Honn, K. V. Mechanisms controlling cell cycle arrest and induction of apoptosis follwoing 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res. May 1;62(9):2721-7, 2002. [Medline]
Trikha, M., Timar, J., Zacharek, A., Nemeth, J. A., Cai, Y.,
Dome, B., Somlai, B., Raso, E., Ladanyi, A., and Honn, K. V. Role of aIIbb3
integrin in human melanoma growth, survival and metastasis. Int J Cancer 2002
(in press).