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Education
and Training:
Niagara University, B.S., 1965
Syracuse University, Masters program, 1965-67
State University of New York, Upstate Medical College, Ph. D., 1973
N.l.H. Postdoctoral fellow, University of Pennsylvania, 1973-76
Visiting Scientist, Molecular Biology, American Red Cross, 1993
Faculty
Appointments:
Research Assistant Professor in Pathology, New York Medical College, 1976-78
Assistant Professor of Pathology, WSU, 1978-83
Adjunct Associate Professor, Madonna University, 1989-present
Associate Professor of Pathology, WSU, 1984-present
Major Interests:
Vascular cell biology, endothelial and smooth muscle cell culture models, angiogenesis, tumor cell - endothelial interactions
Representative Publications:
1. Diglio, CA, Grammas, P, Giacomelli, F and Wiener, J. Angiogenesis in rat aorta ring cultures. Lab. Invest., 60:523-31, 1989.
2. Mooradian, DL and Diglio,CA. Production of a transforming growth factor-beta-like growth factore by RSV-transformed rat cerebral microvascular endothelial cells. Tumor Biol., 12:171 -83, 1991.
3. Chua, BHL, Krebs, CJ, Chua,CC,and Diglio,CA. Endothelin stimulates protein systhesis in smooth muscle cells. Am. Jr. Physiol., 262:E412-16, 1992.
4. Diglio,CA, Liu, W, Grammas,P, Giacomelli,F,and Wiener,J. Isolation and characterization of cerebral resistance vessel endothelium in culture. Tissue and Cell, 25:833-46, 1993.
5. Kantak, SS, Diglio, CA, and Onoda, JM. Low doses radiation-induced endothelial cell retraction. Int. J. Radiation Biology, 64, 319-328, 1993.
6. Tang, DG, Diglio,CA, and Honn,KV. Activation of microvascular endothelium by eicosanoid 12(S)HETE leads to enhanced tumor cell adhesion via upregulation of surface expression of alpha v/beta 3 integrin: a post-transcriptional PKC - and cytoskeleton -dependent process. Cancer Res. 54:565-574., 1994.
7. Grammas, P, Diglio, CA, Giacomelli, F, and Wiener, J. Growth properties and receptor expression in vascular smooth muscle cells from hypertensive rats. Clin. Exp. Hypertension 16, 207-228, 1994.
8. Tang, DG, Renaud,C, Stojakonic,S, Diglio, CA, Porter, A, and Honn, KV. 12(S)HETE is a mitogenic factor for microvascular endothelial cells:Its potential role in angiogenesis. Biochem. Biophys. Res. Com. 211, 462-468,1995.
9. Tang, DG, Diglio,CA,
and Honn, KV. Tyrosine phosphorylation of a 30 kD protein precedes beta 3 integrin
mediated microvascular endothelial cell spreading and motility on extracellular
matrix proteins. Pathol. Oncol. Res. 2, 29-36, 1996.