Kaladhar B. Reddy, Ph.D.
Associate Professor of Pathology
Breast Cancer Program

Education:
Osmania University, Hyderabad, India, 1978, B.Sc.
Osmania University, Hyderabad, India, 1980, M.Sc.
Osmania University, Hyderabad, India, 1984, Ph.D.

Postdoctoral Training:
Postdoctoral Fellow, Department of Pathology, University of Medicine and Dentistry of New Jersey, Newark,, NJ, USA, 1987-1988

Postdoctoral Fellow, Department of Medicine/ Oncology, The University of Texas Health Science Center at San Antonio, TX, USA, 1988-1990

Professional and Faculty Appointments:
Associate Professor, Dept. of Pathology, Wayne State University, Detroit MI, 1998 - Present.

Member, Karmanos Cancer Institute.

Assistant Professor, Dept. of Pathology, School of Medicine, Wayne State University, Detroit, MI, 1993- 1998

Instructor, Dept. of Medicine/ Oncology, The University of Texas Health Science Center at San Antonio, TX 1990-1993

Member, The Institute for Cancer Research and Care, San Antonio, TX 1991- 1993

Research Interests:
Growth factor and hormone mediated signaling, Tumor Biology, Breast Cancer

Selected Publications:
1. Kondapaka SB and Reddy KB: Tyrosine Kinase inhibitor as novel signal transduction and antiproliferative agent: Prostate Cancer. Mol Cell Endocrinol 117: 53-58, 1996.

2. Gulli FP, Palmer CK, Yong QC, Reddy KB: Eppidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity. Cell Growth Differ. 7 (2): 173- 178, 1996.

3. Kondapaka BS, Fridman R, Reddy KB: Epidermal growth factor and Amphiregulin upregulate metalloproteinase-9 (MMP-9) in human breast cancer cells. Int. J. Cancer.70: 722-726, 1997.

4. Visscher DW, Sarkar FH, Kasunic TC and Reddy KB: Clinicopathologic analysis of Amphiregulin and Heregulin immunostaining in Breast Neoplasia. Breast Cancer Res Treat. U.S: 75-80, 1997.

5. Vissher DW, Sarkar FH, Kusinic TC, Reddy KB: Phospholipase C-g immunostaining in human breast carcinoma-Clinical significance and correlations with protease and growth factor receptor species. The Breast Journal. 3: 350-356, 1997.

6. Tureaud J, Sarkar FH, Kulkarni S, Jaszewski R, Reddy KB, Majumdar PN: Increased expression of EGF receptor in the gastric mucosa of aged rats. Am J Physiology. G.I. 273 (36), G389-G398, 1997.

7. Reddy KB, Krueger JS, Kondapaka BS, Diglio C: MAP kinase regulates the expression of MMP-9 in breast epithelial cells. Int. J Cancer. 82: 268-273, 1999.

8. Reddy KB, Keshamouni VG, Yong QC,: The level of tyrosine kinase activity regulates the expression of p21/WAF1 in cancer cells. Int J Oncology. 15: 301-306, 1999.

9. Wall NR, Mohammad RM, Reddy KB, Al-Katib AM. Bryostatin 1 induces the ubiquitination and proteasome degradation of Bcl-2 in the human early pre-B acute lymphoblastic leukemia cell line, reh. Int J Mol Med 5(2): 165-171, 2000.

10. Krueger JS, Keshamouni VG, Atanaskova N, Reddy KB: Temporal and Quantitative regulation of MAP kinase activation modulates cell motility and invasion. Oncogene 20(31): 4209-4218, 2001.

11. Reddy KB, McGowen R, Schuger L, Visscher D, Sheng S: Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model. Oncogene 20, 6538-6543, 2001.

12. Atanaskova N, Keshamouni VG. Krueger JS, Schwartz JA Miller F, and Reddy KB: MAP Kinase/Estrogen Recepetors cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene 21:4000-4008, 2002.

13. Keshamouni VG, Mattingly RR and Reddy KB: Mechanism of 17-beta-Estradiol-Induced Erk 1/2 Activation in Breast Cancer Cells; A Role for HER2 and PKC-delta. J Biol Chem 277:22558-22565, 2002.

E-mail: kreddy@med.wayne.edu
Office: (313) 577-6191
Lab: (313) 577-6228