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Avraham
Raz, Ph.D.
Professor, Pathology, Radiation Oncology, and Oncology
Education and Training:
B.Sc., Biology, Ben-Gurion
University of the Negev, Beer Sheva, 1970
M.Sc., Physiology, Ben-Gurion University of the Negev, Beer Sheva, 1972
Ph.D., Membrane Biology, The Hebrew University of Jerusalem, Weizmann Institute
of Science, Israel, 1978
Faculty Appointments:
Associate Professor, Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel, 1986-1988
Professor, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI, 1988 - present
Faculty, Graduate Program in Cancer Biology, Wayne State University, School of Medicine, Detroit, MI, 1989 - present
Professor, Department of
Pathology, Wayne State University, School of Medicine, Detroit, MI, 1992- present
Professor, Oncology, WSU- School of Medicine. Detroit 1997-Present
Major Interests:
Cancer Metastasis
Research Area:
Cellular Interaction and Motility
Representative Publications:
1. Pienta, K.J., Naik, H., Akhtar, A., Yamazaki, K., Replogle, T., Lehr, J., Donat, T., Tait, L., Hogan, V. and Raz, A. (1995) Inhibition of a spontaneous rat prostate cancer metastasis by oral adminstration of modified citrus pectin, J. Natl. Cancer Inst., 87:348-353.
2. Schoeppner, H.L., Raz,
A., Ho, S.B., Bresalier, R.S. (1995) Expression of an endogenous galactose-binding
lectin correlates with neoplastic progression in the colon. Cancer 75:2818-2826.
3. Huang, B., Xie, Y., and Raz, A. (1995) Identification of an upstream
region that controls the transcription of the human autocrine motility factor
receptor. BBRC 212:727-742.
4. Inohara, H. and Raz, A. (1995) Functional evidence that cell surface
galectin-3 mediates homotypic cell adhesion. Cancer Research. 55:3267-3271.
5. Silletti, S., Yao, J., Pienta, K.J., Raz, A. (1995) Loss of cell-contact regulation and altered responses to autocrine motility factor correlate with increased malignancy in prostate cancer cells. Int. J. Cancer 63:100-105.
6. Nangia-Makker, P., Thompson, E., Ochieng, J., Raz, A. (1995) Induction of tumorigenicity by galectin-3 in a non-tumorigenic human breast carcinoma cell line. Int. J. Oncology 7:1079 1087.
7. Wang, L., Inohara, H., Pienta, K.J. and Raz, A. (1995) Galectin-3 is a nuclear matrix protein which binds RNA. Biochem. Biophys. Res. Comm. 217:292-303.
8. Korman, H.J., Peabody, J.O., Pienta, K. J., Farah, R., Cerny, J.C. and Raz, A. (1996) Autocrine Motility Factor Receptor as a Novel Urine Marker for Transitional Cell Carcinoma of the Bladder. J. Urology 55:347-349.
9. Silletti, S., Paku, S.
and Raz, A. (1996) Tumor Autocrine Motility Factor Responses are Mediated
Through Cell Contact and Focal Adhesion Rearrangement in the Absence of New
Tyrosine Phosphorylation in Metastatic Cells. Am J. Path 148:1649-1660.
10. Silletti, S., & Raz, A. (1996) Regulation of autocrine motility
fact receptor expression in tumor cell locomotion and metastasis. In: Attempts
to Understand Metastasis Formation (Current Topics in Microbiology and Immunology).
U Gunthert, PM, Schlag, and W. birchmeier, eds., Spinger-Verlag, Berlin. Volume
II, Chapter 7, pp. 137-169.
11. Timar, J., Trikha, M., Szerkeres, K., Bazaz, R., Tovari, J., Silletti, S., Raz, A., and Honn, K.V. (1996) Autocrine motility factor signals integrin-mediated metastatic melanoma cell adhesion and invasion. Cancer Research 56:1902-1908.
12. Watanabe, H., Takehana, K., Date, M., Shinozaki, T. and Raz, A. (1996) Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide. Cancer Res. 56:2960 -2963.
13. Niinaka, Y., Oida, S-I, Ishisaki, A., Takeda, K., Iimura, T., Maruoka, Y., Momose, F., Negishi, A., Ichijo, H., Amahasa, T., Sasaki, S., Watanabe, H. and Raz, A. (1996) Autocrine motility factor and its receptor expressions in human oral squamous cell carcinoma (SCC) cells. Int. J. Oncol. 9:433-436.
14. Yelian, F., Liu, A., Todt, J., Lei, J., Qureshi, F., Jacques, S, Deppe, G. and Raz, A. (1996) Expression and function of autocrine motility factor receptor in human choriocarcinoma, Gynecologic Oncology, 62:159-165.
15. Inohara, H., Akahanki, S., Koths, K. and Raz, A. (1996) Interactions between galectin-3 and Mac-2 binding protein mediate cell-cell adhesion. Cancer Res. 56:4530 - 4534.
16. Breasalier, R.S., Byrd, J.C., Wang, L. and Raz, A. (1996) Colon cancer mucin: A new ligand for the ß-galactoside binding protein galectin-3. Cancer Res. 56:4354 -4357.
17. Timar, J., Raso, E., Fazakas, Z.S., Sillietti, S., Raz, A. and Honn, K.V. (1996) Multiple use of a signal transduction pathway in tumor cell invasion. Anti-Cancer Res. 16:3299-3306.
18. Gervasi, D., Raz, A., Dehem, M., Yang, M., Kurkinen, M., and Fridman, R. (1996) Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells. Biochem. Biophys. Res. Comm. 228:530-538.
19. Otto, T., Bex, A., Schmidt, U., Raz, A., Rubben, H. (1997) Improved prognosis of patients with bladder carcinoma diseases. Amer. Jour. Path., 150:1919-1923.
20. Bresalier, R.S., Byrd, J.C., Wang, L., Lotan, R., and Raz, A. (1997) Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system. Cancer 80:776-787.
21. Takanami, I., Kodaira, S., Tanaka, F., Watanabe, H., and Raz, A. (1997) Autocrine motility factor receptor expression as a prognostic factor in pulmonary adenocarcinoma. Oncology Reports 4:949-951.
22. Niinaka, Y, & Raz, A. (1997) tumor cell motility and its receptor, Proceedings of the 1st International Conference on Gastroenterologic Carcinogenesis. Monduzzi Editore pp 153-160. [Medline]
23. Akahani, S., Nangina-Makker, P., Inohara, H., Kim, H-R.C. and Raz, A. (1997) Galectin-3: A novel anti-apoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res. 57:5272:5276
24. Warfield, P.R., Nangia-Makker, P., Raz, A., Ochieng, J. (1998) Adhesion of humam breast carcinoma to extracellular matrix proteins is modulated by galectin-3 Invasion and Metastasis 17:101-112
25. Silletti, S., Paku, S., and Raz, A. (1998) Autocrine motility factor and the extracellular matrix coordinately mediate the adhesion, spreading and migration of melanoma cells via focal contacts. Int. J. Cancer 76:101-112.
26. Silletti, S., Paku, S. and Raz, A. (1998) Degradation or remodeling of extracellular matrix components determines the motile response of melanoma cells. Int. J. Cancer 76:129-135.
27. Nangia-Makker, P., Sarvis, R., Visscher, D.W., Bailey-Penrod, J., Raz, A., and Sarkar, F.H. Galectin-3 and L1 retrotransposon in human breast carcinomas. Breast Cancer Res. Treat.
28. Hirono, Y., Fushida, S., Yonemura, Y., Yamamoto, H., Watanabe, H., Raz, A. (1996) Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer. British Journal of Cancer 74:2003-2007.
29. Niinaka, Y., Paku, S., Watanabe, H. and Raz, A. (1998) Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine factor by tumor cells. Cancer Research 58:2667-2674.
30. Takanami, I., Takeuchi, K., Naruke, M., Kodaira, S., Tanaka, F., Watanabe, H., and Raz, A. (1998) Autocrine Motility Factor in Pulmonary Adenocarcinomas Results of an Immunohistochemical Study. Tumor Biology 19:384-389.
31. Bresalier, R.S., Mazurek, N., Sternberg, L.R., Byrd, J.C., Yunker, C.K., Nangia-Makker, P., and Raz, A. (1998) Metastasis of human colon cancer is altered by modifying expression of the ß-galactoside binding protein galectin-3. Gastroenterology 115:287-296.
32. Inohara, H., Akahani, S. and Raz, A. (1998) Galectin-3 stimulates cell proliferation. Experimental Cell Research. 245:294-302.
33. Inohara, H., Honjo, Y., Yoshii, T., Akahani, S., Yoshida, J., Hattori, K., Okamoto, S., Sawada, T., Raz, A and Kubo, T. (1999) Expression of galectin 3 in fine needle aspirates as a differential diagnostic marker between benign and malignant thyroid neoplasms. Cancer 85:2475-2484.
34. Kim, H-R.C., Lin, H-M., Rahman, K.H., Akahani, S., and Raz, A. (1999) Galectin-3 upregulates cyclin D1-associated kinase activity and inhibits apoptosis-induced by loss of cell-substrate interaction. Cancer Research 59: 4148-4154.
35. Honjo, Y., Kubo, T., Yoshida, J., Hattori, K., Akahani, S., Sawada, T., Raz, A., and Inohara, H. (2000) Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. (Submitted).
36. Fang, S., Sharma, R.V. Hendrix, M.J.C. Raz, A. And Bhalla, R.C. (1999) Reciprocal regulation of paxillin and autocrine motility factor receptor (gp78) expression in injured rat carotid artery. (Submitted).
37. Gong, H.C., Nangia-Makker, P., Hogan, V., Bresalier, R., Mazurak, N. and Raz, A. (1999) The NH2 Terminus of Galectin-3 Governs Cellular Compartmentalization and Function. Cancer Research, 59: 6239-6245.
38. Nangia-Makker, P. Honjo, Y., Sarvis, R., Hogan, V. and Raz, A. (2000) Galectin-3 induces endothelial cell morphogenesis and angiogenesis. Amer. J. Path 156: 899-909.
39. Shimizu, K., Tani, M., Watanabe, H., Nagamachi, Y., Niinaka, Y., Shiroishi, T., Ohwada, S., Raz, A., and Yokota, J. (1999) The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Letters 456:295-300.
40. Talukder, A.H., Adam, L., Raz, A., Kumar, R. (2000) Heregulin regulation of autocrine motility factor expression in human tumor cells. Cancer Research 60:474-480.
41. Lagana, A., Duchaine, T., Raz, A., DesGroselillers, L. and Nabi, I.R. (2000). Expression of autocrine motility factor/phosphohexose isomerase in Cos7 cells. BBRC, 273:213-218.
42. Pacis, R.A., Pilat, M.J., Pienta, K.J., Wojno, K., Raz, A., Hogan, V., Cooper, C.R. (2000) Decreased galectin-3 expression in prostate cancer. The Prostate, 44:118-123.
43. Haga, A., Niinaka, Y. and Raz, A. (2000) Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein. Biochimica et Biophysica Acta, 1480:235-244.
44. Mazurek, N., Conklin, J., Byrd, J.C., Raz, A., and Breasalier, R.S. (2000). Phosphoryaltion of the $-Galactoside-binding protein, galectin-3 modulates binding to its ligands. J. Biol. Chem. 275:36311-3615.
45. Timar, J., Toth, K., Tovari, J., Paku, S., Raz, A. (2000) Autocrine motility factor (neuroleukin, phosphohexose isomerase) induces cell movement through 12-lipoxygenase-dependent tyrosine phosphorylation and serine dephosphorylation events. Clinical and Experimental Metastasis 17:809-816.
46. Le, P.U., Benlimame, N., Raz, A. and Nabi, R. (2000). Clathrin-mediated endocytois and recycling of Autocrine Motility Factor Receptor to fibronectin fibrils is a limiting factor for cell motility for NIH-3T3 cell motility. J. Cell Sci. 113:3227-3240.
47. Honjo, Y., Kubo, T., Yoshida, J., Hattori, K., Akahani, S., Sawada, T., Raz, A., and Inohara, H. (2001) Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin. Cancer Res. 6:4635-4640.
48. Yoshii, T., Inohara, H., Takenaka, Y., Honjo, Y., Akahani, S., Nomura, T., Raz, A., and Kubo, T. (2001) Galectin-3 maintains the transformed phenotype of thyroid papillary carcinoma cells. Int. J. Onc. 18:787-792.
49. Honjo, Y., Nangia-Makker, P., Inohara, H., and Raz, A. (2001) Down regulation of galectin-3 suppresses tumorigenicity of human breast carcinoma cells. Clin. Cancer Res. 7:661-668.
50. Funasaka, T., Haga,
A., Raz, A., and Nagase, H. (2001) Tumor autocrine motility factor
is an angiogenic factor that stimulates endothelial
cell motility. Biochem. Biophys. Res. Commun. 284:1116-1126.
51. Takanami, I., Takeuchi, K., Watanabe, H., Takashi, Y., Takagishi, K.
and Raz, A. (2001) Significance of autocrine motility factor receptor
gene expression as a prognostic factor in non-small-cell lung cancer. Int.
J. Cancer 95:384-387.
52. Luo, Y., Long, J.M., Lu, C., Chan, S.L., Spangler, E.L., Mascarucci, P.,
Raz, A., Longo, D., Mattson, M.P., Ingram, D.K. and Weng, N. (2002)
A Link between maze learning and hippocampal expression of neuroleukin and
its
receptor gp78. J. Neurochemistry 80:354-361
53. Niinaka, Y., Haga, A., Negishi, A., Yoshimasu, H., Raz, A., Amagasa,
T. (2002) Regulation of cell motility via high and low affinity autocrine
motility factor (AMF) receptor in human oral squamous carcinoma cells. Oral
Oncology 38:49-55.
54. Yoshii, T., Fukumori, T., Honjo, Y., Inohara, H., Kim, H-R. C., and Raz,
A. (2002) Galectin-3 phosphorylation is required for its anti-apoptotic
function and cell cycle arrest. Journal of Biological Chemistry 277:6852-6857.
55. Yu, F., Finley, R.L., Raz, A., and Kim, H-R. C. (2002) Galectin-3
translocates to the perinuclear membranes and inhibits cytochrome c release
from the mitrochondria: A role for synexin in galectin-3 translocation. Journal
of Biological Chemistry 277:15819-15827.
56. Gorelik, E., Galili, U. and Raz, A. (2001) On the role of cell surface carbohydrates
and their binding proteins (lectins) in tumor metastasis.
Adv. Cancer Res. (In Press).
57. Uemura, H., Tanaka,
N., Funasaka, Haga, A., Nagase, H., Raz, A., and Nakamura, K.T. (2001)
Crystallization and preliiminary X-ray
crystallographic studies of human autocrine motility factor. Protein andPeptide
Letters (In Press).
58. Tanaka N, Haga A, Uemura
H, Akiyama H, Funasaka T, Nagase H, Raz A, Nakamura KT. (2002) Inhibition
mechanism of cytokine activity of human autocrine motility factor examined by
crystal structure analyses and site-directed mutagenesis studies. J. Mol.
Biol.
59. Tsutsumi, S., Gupta,
S., Hogan, V., Collard, J. and Raz, A. (2002) Activation of small GTPase
for autocrine motility factor signaling.
Cancer Research (Submitted).
60. Nangia-Makker, P., Hogan, V., Honjo, Y., Baccarini, S., Tait, L., Bresalier, R., and Raz, A. (2002) Inhibition of human cancer growth and metastasis by oral intake of modified citrus pectin. Journal of National Cancer Institute (Submitted)