Department of Internal Medicine

Division of Gastroenterology

Articles, Patents and Intellectual Property

Elitsur, Y, Majumdar, APN, Tureaud, J, Dossescu, J, Neace,  C, Velusamy, L and Moshier JA: Tyrosine Kinase and Ornithine Decarboxylase Activation in Children with Helicobacter Pylori Gastritis. Life Sciences 65: 1373-1380, 1999.

Jaszewski R, Khan A, Sarkar FH, Kucuk O, Tobi M, Zagnoon A, Dhar R, Kinzie J, and Majumdar APN: Folic Acid Inhibition of EGFR Mediated Proliferation in Human Colon Cancer Cell Lines. American Journal of Physiology (Cell Physiology) 277: C1142-C1148, 1999.

Jiang C-Y, Gangopadhyay, Berk T, Gallinger S, Cohen Z, Tobi M, Redston M, Bapat B.  STK11/LKB1 germ-line mutations are not identified in most Peutz-Jeghers Syndrome patients.  Clin Genetics 56:136-41, 1999.

Khan, AJ, Fligiel, SEG, Liu, L, Chandok, A, Jaszewski, R and Majumdar APN:  Induction of EGFR Tyrosine Kinase in the Gastric Mucosa of Diabetic Rats.  Proceedings of the Society for Experimental Biology and Medicine 221: 105-110, 1999.

Mutchnick, MG, Lindsay, KL, Schiff, ER, Cummings, GD, Appelman, HD, Peleman, RR, Silva, M, Roach, KC, Simmons, F, Milstein, S, Gordon, SC, Ehrinpreis, MN: Thymosin  (1 treatment of chronic hepatitis B: Results of a phase III multicenter, randomized double-blind and placebo controlled study. Journal of Viral Hepatitis 6: 397-403, 1999.

Naylor, PH,  Naylor, CW,  Hendrix, S and Leveque, FG:  Oral administration of interferon alpha induces a transient decline in oral mucosal immunoglobins and an increase in IL-5 concentrations. J Interferon Cytokine Research  19: 953-9, 1999.

Sondeen J, Dubick MA, Yu Y, and Majumdar APN: Expression of the Epidermal Growth Factor (EGF)  Receptor in Duodenum from Rabbits Subjected to Hemorrhage and Renal Ischemia Reperfusion. - Journal of Laboratory and Clinical Medicine  134: 641-648, 1999.

Tobi M, Kaila V, Hassan N, Gallinger S, Fligiel S, Hatfield J, Gesell M, Sakr W. MAb Adnab-9 defines a preneoplastic marker in epithelium at risk for small bowel adenocarcinoma- Human Pathology 30:467-73, 1999.

Xiao Z-Q, Yu Y, Khan A, Jaszewski R, Ehrinpreis MN and Majumdar APN: Induction of G1 Checkpoint in the Gastric Mucosa of Aged Rats. American Journal of Physiology (Gastrointestinal and Liver Physiology) 277: G917-G921, 1999.

Blatt, L, Mutchnick, MG, Tong, MJ, Tamburro, C, Klion, FM, et al.: Assessment of HCV RNA and HCV genotype from 6807 chronic HCV patients treated in community clinical practice in the United States. Journal of Viral Hepatitis (In Press).

Geng H, Naylor P, Doscescu J, Skunca M, Majumdar APN and Moshier JA: TGF-( is Required for Full Expression of the Transformed Growth Phenotype of NIH/3T3 Cells Expressing Ornithine Decarboxylase. Carcinogenesis  (In Press).

Turner JD, Liu L, Fligiel SEG, Jaszewski R, and Majumdar APN: Aging Alters Gastric Mucosal Responses to Epidermal Growth Factor and Transforming Growth Factor (. American Journal of Physiology. (Gastrointest. Liver Physiol.) (In Press).

Xiao Z-H, and Majumdar APN: Induction of Transcriptional Activity of AP-1 and NF-(B in the Gastric Mucosa During Aging.  American Journal of Physiology (Gastrointest. Liver Physiol.) -  (In Press). Method of Treating Hepatitis C in Non-Responders to Interferon Treatment United States Patent Number 6,001,799 December 14, 1999

Books, Chapters and Reviews

Jaszewski R, Ehrinpreis MN and Majumdar APN: Aging and Cancer of the Stomach and Colon. Frontiers in Bioscience 4: 322-328, 1999.

Majumdar APN: Nutrition and Gastrointestinal Cancer. In: Medicine in the Millenium (Ray P ed.), Marks Media Services, Calcutta, India.

Mutchnick MG:  Acute and Chronic Hepatitis B. In Gastroenterology & Hepatology, the Comprehensive Visual Reference: The Liver.  W.C. Maddrey, Editor, Current Medicine, Philadelphia, 2000.  (In Press).

Naylor, PH.  Zadaxin (thymosin alpha1) for the treatment of viral hepatitis.   Expert Opinion on Investigational Drugs  8: 281-287. 1999

Tobi M.  Polyps as Biomarkers.  Frontiers in Bioscience- Online Peer-Review Journal 4:d329-388, 1999.    HYPERLINK Òhttp://www.bioscience.orgÓ #www.bioscience.org

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals

Akhras, J, Kinzie, J: Enteroadherent bacteria and diarrhea in aids.   Gastroenterology 94:667A, 1999. (Presented  at ACG, Phoenix, Arizona 10/99) 

Khalid M, Tobi M, Bialor B.  A Case Report of Meningococcemia in a Jail Inmate with Advanced Liver Disease. J Gen Int Med 14;(2):183,1999

Khan A, Jaszewski R, Sarkar FH, Kucuk O, Ravishankar P, and Majumdar APN: Regulation of Folic Acid Induced Inhibition of CaCo-2 Cell Proliferation. 100th Annual Meeting of the American Gastroenterological Association (AGA), Orlando, FL. Gastroenterology 116: A1913, 1999.

Kinzie, JL. Naylor, PH. Ehrinpreis, MN, Khan, N, Siddiqui, FA, Peleman, RR, Mutchnick, MG: Reluctance of urban clinic patients to undergo treatment with interferon-alpha. Hepatology 30: 266A, 1999.   (Presented at AASLD, Dallas, TX  11/7/99).

Kulkarni, P, Singal, S, Kinzie, J: Pancreatic sarcoidosis presenting with pancreatic mass producing billiary obstruction and role of EUS in its diagnosis.  Gastroenterology 94:219A, 1999.

Kulkarni, P, Kinzie, J: Esophageal  stenosis at site of esophageal-colonic anastomosis in epidermolysis bullosa, a challenge for endoscopic management.  Gastroenterology, V116 (supplement) G0979, 04/99.

Kulkarni, P, Kinzie, J:  Methylene blue chromendography in the management of gastric misperfusion from hepatic intraarterial chemotherapy device. Gastroenterology, V116 (supplement) G1950, 04/99.

Liu, L, Khan A, Jaszewski R and Majumdar APN: Aging Enhances Ligand-Induced Internalization of EGF-Receptor (EGFR) in the Gastric Mucosa. 100th Annual Meeting of  the American Gastroenterological Association  (AGA), Orlando, FL. Gastroenterology 116: A2469, 1999.

Madhira M, Tobi M. Primary KaposiÕs Sarcoma of small bowel: Massive gastrointestinal bleeding as initial presentation. American Journal of Gastroenterology 94:2717, 1999.

Naylor, PH, Brown, KA, Gordon, SC, Moonka, D, Silverman, AL, Kinzie, JL, Ehrinpreis, MN, Peleman, RR, Mutchnick, MG:  Response to retreatment with interferon/ribavirin in caucasian and African American relapsers and nonresponders.  Hepatology 30: 373A, 1999 (Presented at AASLD, Dallas, TX  11/8/99).

Naylor, PH, Naylor, CW, Hendrix, S, and LeVeque, FG: Oral administration of interferon alpha induces a transient decline in oral mucosal immunoglobins and an increase in IL-5 concentrations.  An. Assoc. for Cancer Research,  Proceedings 40; A3802, 1999.

Naylor, PH, Renaud-Mauer, C, Shahzad S, Alloju M, and Tobi, M:  Hemoccult cards for screening with a monoclonal antibody to a premalignant colon cancer marker (Adnab-9). American Assoc. for Cancer Research, Proceedings 40: A386, 1999

Naylor, PH, Podzorski, R, Dhar R,  Ehrinpreis, MN, Kinzie, JL, Siddiqui, F and Mutchnick, MG:  Two laboratory methods for measuring serum HCV RNA in patients with hepatitis C are equal with respect to determining and predicting end of treatment response to interferon therapy.  Antiviral Therapy 4 (supplement 4) A87, 1999.

Siddiqui, F, Naylor, PH, Ehrinpreis, MN, Peleman, RR, Kinzie, JL, Mutchnick, MG:  Induction interferon treatment of African-Americans with chronic hepatitis C results in an enhanced response comparable to caucasians given standard interferon therapy. Gastroenterology 116: A820, 1999. (Presented at DDW, Orlando, FL 5/16/99).

Tobi M, Hatfield J, Fligiel SE, Renaud-Maher C, Sochacki P. Enhanced Immunohistochemical Expression of Adnab-9 Epitope in Frozen Sections of Adenomatous Polyps. Proceedings of the American Association for Cancer Research ;40:58, 1999.

Tobi M, Gollahon L, Lawson M.  Lower Telomerase Activity in Inflammatory Bowel Disease: An Etiologic Factor? Gastroenterology 116:A669, 1999

Tobi M, Hatfield J,  Adsay V, Galagan K, Kozarek R, Inagaki M, Kasai S, Tokusashi Y, Obara T, Lough J,  Barkun A, Jabbari M, Hruban R, Lawson M, Ruebner B, Sheikh R,. Fligiel S.  Adnab-9, A Prognostic Marker in Pancreatic Intraductal Papillary Mucin-Producing Neoplasms? Gastroenterology 116:A669,1999

Ullah, N, Siddiqui, FA, Naylor, PH, Kinzie, JL, Ehrinpreis, MN, Peleman, RR, Mutchnick, MG: Presence of hepatitis B virus core antibodies (Anti-HBC) in chronic hepatitis C patients is predictive of a decreased end of treatment response (ETR) to interferon.  Hepatology 30: 195A, 1999.  (Presented at AASLD, Dallas, TX 11/6/99).

Yeh R, Gupta B, Parks M, Boparai J, Renaud-Maher C, Tobi M.  Effect of Percutaneous, Endoscopic Gastrostomy Tube Placement on the Outcome Of the Fecal Occult Blood Test. Gastroenterology 116:A363, 1999

Yu Y, Moshier JA, Siddiq F, and Majumdar APN: Cloning of a Novel EGFR-Related Peptide (ERRP): A Putative Negative Regulator of EGFR. 100th Annual Meeting of  the American Gastroenterological Association  (AGA), Orlando, FL. Gastroenterology 116: A2865, 1999.

Akhras, J, Naylor, PH, Kiranmaia, J, Hemacha, A, Fliegiel, S and  Jaszewski, R:  Demographics and  treatment response of an urban veteran population infected with the Hepatitis C virus.  Gastroenterology (In press)

Khalifa-Al-Saleh, A, Naylor, PH, Kinzie, JL, Ehrinpreis, MN, Siddiqui, F, Dhar, R, Turner, JR, and Mutchnick, MG:  End of treatment response (ETR) to Intron A monotherapy in chronic hepatitis C is similar in patients with normal and elevated ALT.  Proceedings of the 10th International Symposium on Viral Hepatitis and Liver Disease (in press).

Mutchnick, MG, Naylor, PH, Upfal, MJ: Hepatitis C screening of urban emergency response personnel.  Gastroenterology (In press).

Naylor, PH, Kinzie, JL, Ehrinpreis, MN, Siddiqui, R, Dhar, R, and Mutchnick, MG:  Retreatment of interferon failures with combination therapy: log drop after 12 weeks of monotherapy predicts ETR to combination.  Proceedings of the 10th International Symposium on Viral Hepatitis and Liver Diseases (in press)

Ullah N, hatfield S, Fligiel S, David D, Ruebner B, Sheikh R, Lawson M, Tobi M.  Adnab-9 staining in mixed adenomatous colonic polyps.  Proceed. Am. Assoc. Can. Res. (In press)

Weidler, N, Naylor, PH, Patel, C, Chilukuri, S, Mendu, S, Janisse, J, Dhar, R, Ehrinpreis, M, Kinzie, J, Siddiqui, F, Turner, J, Mutchnick, MG:  Demographical and biochemical influences on quality of life scores in urban patients with Hepatitis C.  Gastroenterology (in press).  

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