Annual Report

2000-2001

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Features:
Letter from the Dean

Academia and Industry Working Together for Biomedical Advances

WSU Considered Model Program in Prenatal Genetic Analysis

WSU Gets Early Access to Corning Technologies

Dr. Joan Dunbar:  Research Matchmaker

Best Oncology Practices Standardized by Innovative Solutions

Freezing the Deadly Spread of Cancer

Combining Technology and Expertise to Discover New Genes in Epilepsy

General Motors Supports Prevention Program

Cell Therapy Center Advances Immunotherapies for Clinical Application

Robust Partnerships Aid Development of Cancer Vaccines

The Year in Review

Otolaryngology

Chair: Robert Mathog, MD
SE University Health Center

(313) 577-0804

Articles
Shibuya T, Wei WZ, Zormeier M, Ensley J, Sakr W, Mathog RH, Meleca R, Yoo GH, June CH, Levine B, Lum LG:  Anti-CD3/Anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma.  Arch Otolaryngol Head Neck Surg 126(4):473-479, 2000

Shibuya TY, Doerr TD, Mathog RH, Burgio DL, Meleca R, Yoo GH, Guthikonda M:  Functional outcomes of the retromaxillary-infratemporal fossa dissection for advanced head and neck/skull base lesions.  Skull Base Surg 10(3):109-117, 2000

Rachel J, Mathog R:  Nasal alar necrosis.  Laryngoscope 110:, 2000

Meleca R, Dworkin J, Zormier M, Simpson M, Shibuya T, Mathog R:  Videostrobscoyy of the pharyngoesophageal segment in laryngectomy patients treated with botulinum toxin.  Otolaryngol Head Neck Surg 123:1:Part 1:38-43, 2000

Adam T, Finlayson P, Schwarz D:  Membrane properties of principal neurons of the lateral superior olive.  J Neurophysiol (in press), 2001

Robb G, Marunick M, Martin J, Zlotolow, I:  Midface reconstruction:  Surgical reconstruction versus prosthesis.  Head and Neck (accepted and in press), 2000

Marunick M, Menaldi C:  Maxillary dental arch form related to voice classification a pilot study.  J of Voice 14-1:82-91,2000

Marunick M, Bahu S, Aref A:  Osteoradionecrosis of the maxillary-orbital complex post neutron radiation therapy.  J Otolaryn Head and Neck Surg 123:224-8, 2000

Yoo GH, Hocwald E, Korkmaz H, Du W, Logani S, Kelley JK, Sakr W, Jacobs JR:  Assessment of carotid artery invasion in patients with head and neck cancer.  Laryngoscope 110(3):386-390, 2000

Korkmaz H, Aref A, Zamorano L, Purser S, Fontanesi J, Jacobs JR:  Case report of stereotactic brochytherapy for advanced head and neck cancers.  Turkish Journal of Ear Nose and Throat-Head and Neck Surgery (revised), 2000

Jacobs JR, Korkmaz H, Marks SC, Kline R, Berguer R:  One stage carotid artery resection/reconstruction in radiated head and neck carcinoma.  American Journal of Otolaryngology, in press, 2000

Hocwald E, Korkmaz H, Yoo, GH, Adsay V, Shibuya T, Tekyi-Mehsah S, Jacobs J:  Prognostic factors in major salivary gland cancer.  Laryngoscope (accepted and in press), 2000

Korkmaz H, Maciorowski Z, Pietraszkiewicz H, Sakr W, Jacobs JR, Ensley JF:  Pseudoaneuploid subpopulations in normal upper aerodigestive tract mucosa consistent with physiological apoptosis in normally differentiating squamous mucosa.  Cytometry (accepted and in press), 2000.

Burgio DL, Siddique S, Haupert M, Meleca RJ:  MRI of the facial nerve in children with idiopathic facial paralysis.  Otolaryngol Head Neck Surg 122:556-559, 2000

Dworkin JP, Meleca RJ, Abkarian GG:  Muscle tension dysphonia:  Current Opinion in Otolaryngology and Head and Neck Surgery 8(3):169-173, 2000

Meleca RJ, Dworkin JP, Zormeier MM, Simpson ML, Shibuya T, Mathog RH:  Videostroboscopy of the pharyngoesophageal segment in laryngectomees treated with botulinum toxin injection for spasmodic tracheoesophageal voice treated with botulinum.  Otolaryngol Head Neck Surg 123(7): 38-43, 2000

Dworkin JP, Meleca RJ, Simpson M, Garfield I:  Use of topical lidocaine in the treatment of muscle tension dysphonia.  Journal of Voice 14:567-75, 2000

Shibuya TY, Wei-Zen W, Johnson RD, Zormeier M, Mathog RH, Meleca RJ, Ensley J, Sakr W:  Anti-CD3/Anti-CD28 costimulation increases IL-2 and IFN-gamma production in regional lymph node lymphocytes (LNL) from immunosuppressed head and neck squamous cell carcinoma (HNSCC) patients.  Archives of Otolaryngology-Head and Neck Surgery, in press, 2000

Dworkin JP, Meleca RJ:  Techniques of voice evaluation in the laboratory:  Roundtable discussion.  Phonoscope, in press, 2000

Kaltenbach JA, Afman C:  The topography of dorsal cochlear nucleus hyperactivity after intense sound exposure and its resemblance to tone-evoked activity:  A physiological model for tinnitus.  Hearing Res. 140, 165-172, 2000

Kaltenbach JA, Zhang J, Afman CE:  Plasticity of neural activity in the dorsal cochlear nucleus after intense sound exposure.  Invited paper for special issue of Hearing Research 147, 282-292, 2000

Ahsan S, Meleca RJ, Dworkin JP:  Botulinum toxin injection for cricopharyngeal spasm.  Otolaryngol Head Neck Surg 122(5):691-5, 2000

Drescher MJ, Khan KM, Hatfield JS, Shakir AH, Drescher DG: Immunohistochemical localization of adenylyl cyclase isoforms in the lateral wall of the rat cochlea. Mol. Brain Res. 76: 289-298, 2000

Zhang JS, Kaltenbach JA:  Modulation of spontaneous activity by muscarinic receptors in the rat dorsal cochlear nucleus in vivo.  Hear Res., 140(1-2):7-17, 2000

Ahsan S, Meleca R, Dworkin JP:  Botox of the criopharyngeal muscle for treatment of dysphagia.  Otolaryngology Head and Neck Surgery.  112, 691-695, 2000

Piechocki MP, Toti R, Fernstrom MJ, Burk RD, Ruch RJ:  Liver cell-specific transcriptional regulation of connexin32.  Biochim Biophys Acta, 1491(1-3):107-122, 2000

Ledirac N, Delescluse C, Lesca P, Piechocki MP, Hines RN, de Sousa G, Pralavorio M, Rahmani R:  Dibenzuron, a benzoyl-urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells.  Toxicol. Appl. Pharmacol. 164(3):273-279, 2000

Wei WZ, Piechocki MP, Pilon S, Kelly C:  erbB-2 DNA vaccines.  Biotech Lab International, January-February, 13-15, 2000

Yoo GH, Washington J, Piechocki M, Shibuya TY, Ensley JF, Oda D, Wei W-Z:  The progression of head and neck cancer in an in-vitro model.  Arch Otolaryngol Head Neck Surg.  126:1313-1318, 2000

Christopherson, I, Piechocki M, Liu G, Ratner S, Galy A:  Regulation of L-selectin expression by a dominant negative ikaros protein.  Journal of Leukocyte Biology, in press, 2000

Sanchez-Cespedes M, Esteller M, Li Wu, Nawroz-Danish H, Yoo GH, Koch W, Jen J, Herman JG, Sidransky D:  Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.  Cancer Res 60(4):892-5, 2000

Mabrie DC, Francis HW, Zinreich SJ, Sciubba J, Yoo GH.  Radiology forum:  Imaging quiz case 4:  Dentigerous cyst.  Arch Otolaryngol Head Neck Surg, 126:1269-73, 2000

Kim HK, Krug MA, Han I, Ensley JF, Yoo GH, Forman JD, Choi Kim HR:  Neutron radiation enhances cis-platinum cytotoxicity Independent of apoptosis in head and neck carcinoma cells.  Clin Cancer Res, 6:4142-7, 2000

Monsell EM, Holzer SS:  The role of the specialty society in outcomes assessment:  The development of COG*ENT.  Laryngoscope (in press), 2000. 

Books, Chapters and Reviews
Mathog RH:  Discussion:  Relationship between the extent of fracture and the degree of enophthalmos in isolated blowout fractures of the medial orbital wall.  J Oral Maxillofac Surg 58:6:620-621, 2000.

Shibuya T, Zormeier M, Mathog R:  Mandible fractures in treatise on otolaryngology-head and neck surgery.  Proyectos Medicos S.L., Guadalajara Spain.  Notice of publication 12/4/2000

Barretto R, Marunick M, Donat T, Maisel R, Mathog R:  Injuries of the mouth, pharynx and esophagus.  Pediatric Otolaryngology, 4th Edition.  Bluestone CD, Stool SE (accepted and in press), 2000

Pasha R, Stachler RJ, Shibuya TY:  General otolaryngology.  Otolaryngology Head and Neck Surgery.  Clinical Reference Guide.  121-217, Singular Thompson Learning, 2001

Pasha R, Dworkin JP, Meleca RJ:  Laryngology, In Pasha R (Ed):  Otolaryngology Head and Neck Surgery:  A Comprehensive Review.  San Diego, California, Singular Publishing Group, Inc, 2000

Kaltenbach JA, Heffner HE, Zhang JS, Mathog TA and Zacharek, MA:  Neurophysiological mechanisms related to noise-induced tinnitus.  In:  Prasher D, Henderson D, Salvi RJ, Hamernik RP, Kopke R (Eds.), Proceedings of the Sixth International Symposium on Noise Induced Hearing Loss, Cambridge, England, July, 2000.  NRN Publishers, London, England, in press, 2000

Pasha R, Yoo GH, Jacobs J:  Head and neck cancer.  In Pocket Guide to Otolaryngology.  Singular Publishing Group, San Diego, California, 2000

Yoo GH, Clayman G:  Gene therapy for head and neck cancer.  In Head and Neck Cancers.  Academic Press, San Diego, California, in press, 2000

Ottero J, Yoo GH, Jacobs J:  Carotid artery resection for patients with head and neck cancer.  In Head and Neck Cancers.  Academic Press, San Diego, California, in press, 2000

Monsell EM, Cass SP, Rybak LP, Nedzelski JM:  Chemical treatment of the labyrinth.  In:  Brackmann DE (Ed.).  Otologic Surgery, W.B. Saunders, Philadelphia, Pennsyslvania, 1994, 2nd Edition (in press), 2000

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals

Drescher MJ, Myers SF, Swanson GJ, Beisel KW, Drescher DG:  Detection of cyclic nucleotide-gated ion channel transcripts in inner-ear epithelia.  Assoc. Res. Otolaryngol. Abstr. 23: 3, 2000

Khan KM, Drescher MJ, Hatfield JS, Drescher DG:  Immunohistochemical localization of muscarinic receptor subtypes in the rat cochlea.  Assoc. Res. Otolaryngol. Abstr. 23: 130, 2000 

Drescher DG, Khan KM, Drescher MJ, Hatfield, JS:  Immunohistochemical localization of the alpha-1E subunit of the voltage-gated calcium channel in the vertebrate inner ear.  Assoc. Res. Otolaryngol. Abstr. 23: 131, 2000 

Siddique S, Drescher MJ, Khan KM, Hatfield JS, Drescher DG:  Expression of GABAB receptor subunit transcript and protein in the rat cochlea and microdissected subfractions.  Assoc. Res. Otolaryngol. Abstr. 23: 133, 2000

Ramakrishnan NA, Swanson GJ, Perin P, Pasha R, Myers SF, Drescher DG:  Functional analysis of an N-Type, alpha-1B calcium channel coding sequence from the vestibular hair-cell layer of the trout sacculus.  Assoc. Res. Otolaryngol. Abstr. 24, in press, 2000

Lakhani RS, Ramakrishnan NA, Drescher MJ, Swanson GJ, Ahsan SX, Myers SF, Drescher DG:  Coding sequence of calcium channel alpha-1D from the vestibular hair-cell layer of the rainbow trout sacculus. Assoc. Res. Otolaryngol. Abstr. 24, in press, 2000 

Myers SF, Drescher MJ, Drescher DG:  Is the nicotinic acetylcholine receptor subunit from the trout saccular hair-cell sheet an alpha-9 orthologue?:  Assoc. Res. Otolaryngol. Abstr. 24, in press, 2000

Barretto RL, Drescher MJ, Khan KM, Hatfield JS, Drescher DG:  Cyclic nucleotide-sensitive, hyperpolarization-activated cation channel isoforms expressed in the rat cochlea.  Assoc. Res. Otolaryngol. Abstr. 24, in press, 2000

Oh CK, Drescher MJ, Drescher DG, Myers SF:  Detection of serotonin 5-HT1A receptor transcript in a teleost hair cell layer.  Assoc. Res. Otolaryngol. Abstr. 24, in press, 2000 

Drescher MJ, Chaturvedi D, Drescher DG:  Cyclic nucleotide gated ion channel subunit expression in the rat cochlea.  Assoc. Res. Otolaryngol. Abstr. 24, 143, 2000

Bahu S, Shibuya TY, Meleca R, Mathog RH, Yoo GH, Stachler RJ:  Necrotizing fasciitis of the head and neck:  A ten year experience.  Otolaryngology Head and Neck Surgery:123;2:69, 2000

Hocwald E, Korkmaz H, Yoo GH, Adsay V, Jacobs JR:  Prognostic factors in major salivary gland cancers.  Proceedings of the Triological Society Middle Section Meeting, January 21-23, 2000, Cincinnati, Ohio

Korkmaz H, Jacobs JR, Adsay V, Yap J, Tekyi-Mensah S, Yoo GH, Sakr W, Kim H:  Prognostic importance of p27 and p53 in early laryngeal cancer.  82nd Annual Meeting of the American Radium Society, 33-34, April 1-5, 2000, London, England

Korkmaz H, Ngeyuen T, Yoo GH, Kucuk O, Ensley J, Hocwald E, Jacobs JR: Distant metastasis in major salivary gland cancers.  International Conference on Head and Neck Cancer, July 29-August 2, 2000, San Francisco, California

Monsell EM, Cody DD, Peck DJ, Divine GW:  Measurement of acoustic neuroma volume with magnetic resonance imaging and digital image analysis:  Measurement precision.  American Neurotology Society, May 13, 2000, Orlando, Florida

Bahu S, Kaltenbach JA, Hnatiuk M, Khariwala S, Zhang J.  Expression of c-fos in the dorsal cochlear nucleus as a function of stimulus frequency in the hamster.  Abstracts of the Association for Research in Otolaryngology 23, 396

Zhang J, Kaltenbach JA:  Modulation of spontaneous activity by GABA-B receptors in the dorsal cochlear nucleus of the hamster.  Abstracts of the Association for Research in Otolaryngology 23, 111

Afman CE, Kaltenbach JA:  Tonotopic distribution pattern of hyperactivity induced in the dorsal cochlear nucleus by intense sound exposure resembles that of tone-evoked activity.  Abstracts of the Association for Research in Otolayngology 23, 271

Rachel J, Kaltenbach JA:  Cisplatin-induced increases in spontaneous activity in the dorsal cochlear nucleus.  Abstracts of the Association for Research in Otolaryngolgoy 23, 288

Zhang JS, Kaltenbach JA:  GABAergic modulation of spontaneous activity of the dorsal cochlear nucleus of hamsters in vivo.  Assoc. Res. Otolaryngol. 23:111, 2000

Bahu SJ, Kaltenbach JA, Hnatuik M, Khariwala S, Afman C, Zhang JS:  Tonotopic mapping of c-fos expression in the dorsal cochlear nucleus of hamsters.  Assoc. Res. Otolaryngol. 23:113, 2000

Dworkin J, Culatta R, Abkarian G:  Laryngeal anesthetization to treat adventitious stuttering.  ASHA, November, 2000

Abkarian G, Dworkin J:  Genderlect.  ASHA, November, 2000

Pasha R, Meleca R, Dworkin J:  Functional outcomes & quality of life issues for TL vs. SCL patients.  Otolaryngology Head and Neck Surgery, 120 (2), 2000

Piechocki MP, Pilon S, Wei W-Z:  ERBB-2 (E2) DNA vaccines containing EBV gly-ala or pro-ala repeat (GAr or PAr) sequence.  Proceedings of AACR Vol 41, 796, #5059, March 2000

Pilon SA, Piechocki MP, Wei W-Z:  IL-2 or GMCSF substitute for CD4 T cell help in cyterbB-2 DNA vaccination to induce antitumor immunity.  Proceedings of AACR Vol. 41, 796, #5060, March, 2000

Koffler L, Piechocki MP, Ruch RJ:  Positive regulation of connexin32 transcription by HNF-1.  Proceedings of AACR Vol 41, 162, #1039, March, 2000

Piechocki MP, Pilon S, Wei W-Z:  Development of ERBB2(E2) DNA vaccines.  AAI/CIS Immunology, #53.20, 2000

Piechocki MP, Pilon S, Wei W-Z:  ERBB-2 with glycine-alanine (GAr) repeat insertion was processed by proteosome and induced tumor rejection.  AAI/CIS Immunology, #53-21, 2000

Ratner S, Piechocki MP, Galy A:  Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendages.  AAI/CIS Immunology, #148.28, 2000

Korkmaz H, Yoo GH, Hocwald E, Adsay V, Tekyi-Mensah S, Marks S, Jabobs JR:  Predictive factors of regional metastasis in major salivary gland cancer.  Middle Section Programs, Triological Society, 81, 2000

Korkmaz H, Yoo GH, Hocwald E, Adsay V, Tekyi-Mensah S, Marks S, Jacobs JR:  Predictive factors of regional metastasis in major salivary gland cancer.  103rd Annual Meeting Program, 43, 2000

Sanchez-Cespedes M, Esteller M, Li Wu, Nawroz-Danish H, Yoo GH, Koch W, Jen J, Herman JG, Sidransky D:  Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.  Proceedings AACR-Annual Meeting, 41:810, 2000

Wei WZ, Shibuya T, Yoo GH, Ratner S:  Foreign peptides as therapeutic agents against solid tumors.  Proceedings AACR-Annual Meeting, 41:114, 2000

Lakhani RS, Shibuya TY, Mathog RH, Marks SC, Burgio DL, Yoo GH:  Titanium mesh repair of the severely comminuted frontal sinus fracture:  Cosmetic and functional results.  Skull Base Surgery, 17, March, 2000

Reynolds T, Alberts D, Gershenson D, Gleich L, Glisson B, Hanna E, Huang L, Hung MC, Kenady D, Ueno N, Villaret D. Yoo G:  Activity of E1a in human clinical trials.  Proceedings Annual Meeting ASCO, 19:1809, 2000

Jaffe RI, Wiggins B, Wherry C, Hermann MG, Brustrom JE, Neimyer DM, Yoo GH, Brennan JA:   Use of real-time polymerase chain reaction for detection of p53 gene mutations in head and neck squamous cell carcinoma.  Proceedings:  5th International Conference on Head and Neck Cancer, #065, 32, 2000

Korkmaz H, Nyugen T, Yoo GH, Kucuk O, Ensley J, Adsay V, Hocwald E, Jacobs JR:  Distant metastasis in major salivary gland cancer.  Proceedings:  5th International Conference on Head and Neck Cancer, #PA152, 222, 2000

Villaret D, Gleich L, Glisson B, Hanna E, Kenady D, Yoo G, Carey M, Reynolds T:  A multicenter phase II study of E1A lipid complex for intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma.  Proceedings:  5th International Conference on Head and Neck Cancer, #PA196, 233, 2000

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research

Center for Molecular Medicine and Genetics

Community Medicine

Dermatology and Syphilology

Emergency Medicine

Family Medicine

Immunology and Microbiology

Internal Medicine

Neurological Surgery

Neurology

Obstetrics and Gynecology

Ophthalmology

Orthopaedic Surgery

Otolaryngology

Pathology

Pediatrics

Pharmacology

Physical Medicine and Rehabilitation

Physiology

Psychiatry and Behavioral Neurosciences

Radiation Oncology

Radiology

Surgery

Urology