Features

Neurology

Chair: Robert Lisak, MD
8D University Health Center
(313) 577-1242

Articles
Adler, JE and Walker, PD. Cyclic AMP regulates substance P expression in developing and mature spinal sensory neurons. Neurosci. Res, 59:624-631, 2000.

Aldape, K, Simmons, ML, Davis, RL, Miike, R, Wiencke, J, Barger, GR, Lee, M, Chen, P, Wrensch, M. Discrepancies in diagnoses of neuroepithelial neoplasms: The San Franciso Bay Area Adult Glioma Study. Cancer, 88: 2342-2349, 2000.

Asano, E, Chugani, DC, Muzik, O, Shen, C, Juhasz, C, Janisse, J, Ager, J, Canady, A, Shah, JR, Shah, AK, Watson, C, Chugani, HT. Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis complex. Neurology, 54:1976-1984, 2000.

Awatramani, R, Beesley, J, Yang, H, Cambi, F, Grinspan, J, Garbern, J, Kamholz, J. Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity. J Neurosci Res, 61:376-387, 2000.

Broderick, JP, Lu, M, Kothari, R, Levine, SR, Lyden, PD, Haley, EC, Brott, TG, Grotta, J, Tilley, BC, Marler, JR, Frankel, M, and the NINDS rtPA Stroke Study Group. Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA Stroke Trial. Stroke, 31:2335-2341, 2000.

Cendes, F, Li, LM, Watson, C, Andermann, F, Dubeau, F, Arnold, DL. Is ictal recording mandatory in temporal lobe epilepsy? Not when the interictal electroencephalogram and hippocampal atrophy coincide. Arch Neurol, 57:497-500, 2000.

Chaturvedi, S, St. Pierre, E, Bertasio, B. Attitudes of Canadian and US neurologists regarding carotid endarterectomy for asymptomatic stenosis. Can J Neurol Sci, 27:116-119, 2000.

Chaturvedi, S, St. Pierre, E, Bertasio, B. Cerebral angioplasty practice at major medical centers in the United States. Neuroradiology, 42:218-220, 2000.

Chaturvedi, S, Aggarwal, R, Murugappan, A. Results of carotid endarterectomy with prospective neurologist follow-up. Neurology, 55:769-72, 2000.

Coplin, WM, Pierson, DJ, Cooley, KD, Newell, DW, Rubenfeld, GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med, 161:1530-1536, 2000.

D’Olhaberriague, L, Joshi, N, Chaturvedi, S, Mitsias, P, Coplin, W, Lewandowski, CA, Patel, SC, Levine, SR. Tissue plasminogen activator for acute ischemic stroke in patients with unruptured cerebral aneurysms. J Stroke Cerebrovasc Dis, 9:181-184, 2000.

Devlin, JW, Coplin, WM, Rengachary, SS, Wilson, RF. Nimodipine-induced acute hypoxemia: case report. Neurosurgery, 47:1243-1247, 2000.

Dyer, C.A, Kendler, A, Jean-Guillaume, D., Awatramani, R., Lee, A., Mason, L.M., and Kamholz, J. GFAP-positive non-myelinating oligodendrocytes in normal and pathologic adult brain. J. Neurosci Res, 60: 412-426, 2000.

Felice, KJ, Gomez-Lira, M, Natowicz, M, Grunnet, ML, Tsongalis, G, Sima, AAF, Kaplan, RF. Adult-onset metachromatic leucogystrophy: a novel mutation in the arylsulfatase A gene associated with an isolated polyneuropathy. Neurology, 55:1036-39, 2000.

Frankel, MR, Morgenstern, LB, Kwiatkowski, T, Lu M, Tilley, BC Broderick, JP, Libman, R, Levine, SR, Brott, T for the NINDS[MRF1] rt-PA Stroke Study Group: Predicting prognosis after stroke. A placebo group analysis from The National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial. Neurology, 55: 952-959, 2000.

Glauser, TA, Nigro, MA, Sachdeo, R, Bonet, HB, Weinstein, S, Abou-Khalil, B, Frank, M, Grinspan, A, TG, Betts, T, Kerrigan, J, Geoffroy, G, Jacobs, T, Mesenbrink, P, Kramer, L, D’Souza, J, and the Trileptal Pediatric Group. Adjunctive therapy with oxcarbazepine in children with inadequately controlled partial seizures: A multinational, multicenter, randomized, double-blind, placebo-controlled, parallel trial. Neurology, 54:2237-2244, 2000.

Hodes, ME, Woodward, K, Spinner, N, Emanuel, BS, Enrico, A, Kamholz, J, Zackai, E, Pratt, VM, Thomas, IT, Crandall, K, Dlouhy, SR, and Malcolm, S. Additional copies of the proteolipid protein gene causing Pelizaeus-Merzbacher disease arising by separate integration into the X chromosome. Am J Human Genet, 67: 14-22, 2000.

Huq, AHMM, Nigro, MA. XY sex reversal, spastic paraplegia, olivo-ponto-cerebellar atrophy, thin corpus callosum, and developmental delay: a new syndrome? Ped Neurol, 23: 357-360, 2000.

Jacobs, LD, Beck, RW, Simon, JH, Kinkel, RP, Brownscheidle, CM, Muarry, TJ, Simonian, NA, Slasar, PJ, Sandrock, A W, and the CHAMPS study group (Tselis, AC, WSU coordinator, Lisak, RP, Garbern, J, Kamholz, J, Lisak, D, members). Intramuscular interferon beta-1a initiated during a first clinical event consistent with multiple sclerosis. New Engl J Med, 343:898-904, 2000.

Jiang, H, Duchala, CS, Awatramani, R, Shumas, S, Carlock, L, Kamholz, J, Garbern, J, Scherer, SS, Shy, ME, Macklin, WB. Proteolipid protein mRNA stability is regulated by axonal contact in the rodent peripheral nervous system. J Neurobiol, 44:7-19, 2000.

Johnson, KP, Brooks, BR, Ford, CC, Goodman, A, Guamaccia, J, Kachuck, N, Lisak, RP, Myers, LW, Pantich, HS, Pruitt, A, Rose, JW, Wolinsky, JS and the Copolymer Multiple Sclerosis Study Group (Tselis, A, Khan, O, Garbern, J, Kamholz, J, members). Sustained clinical benefit of glatiramer acetate in relapsing multiple sclerosis observed for 6 years. Multiple Sclerosis, 6:255-266, 2000.

Juhasz, C, Chugani, DC, Muzik, O, Watson, C, Shah, J, Shah, A, Chugani, HT. Electroclinical correlates of flumazenil and flurodeoxyglucose PET abnormalities in lesional epilepsy. Neurology, 55: 825-34, 2000.

Juhasz, C, Chugani, DC, Muzik, O, Watson, C, Shah, J, Shah, A, Chugani, HT. Is epileptogenic Cortex truly hypometabolic on interictal positron emission tomography? Ann of Neurol, 48:88-96, 2000.

Juhasz, C, Chugani, DC, Muzik, O, Watson, C, Shah, J, Shah, A, Chugani, HT. Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy. J Clin Neurophysiol, 17:29-42, 2000.

Khan, OA, Rothman, MI. Reversibility of acute demyelinating lesions in relapsing- remitting multiple sclerosis. J Pakistan Med Assoc, 50:128-130, 2000.

Krajewski, K, Lewis, RA, Fuerst, D, Turansky, C, Hinderer, S, Garbern, J, Kamholz, J, Shy, ME. Neurological dysfunction and axonal degeneration in CMT1A. Brain, 12:1516-1527, 2000.

Krajewski, K, Shy, M. The neurologist and genetic testing in a neuromuscular clinic. J Clin Neuromuscular Dis, 1:172-174, 2000.

Liu, C, Blumhardt, LD and The Copolymer 1 Multiple Sclerosis Study Group(Lisak, R, Khan, O, Tselis, A, members). Benefits of glatiramer acetate on disability in relapsing-remitting multiple sclerosis: An analysis by area under disability/time curves. J Neuro Sci,18:33-37, 2000.

Lin, SH, Vincent, A, Shaw, T, Maynard, KI, and Maiese, K. Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab, 20:1380-1391, 2000.

Mahbubul, Huq, AH, Nigro, MA. XY Sex reversal and a nonprogressive neurologic disorder: A new syndrome? Pediatr Neurol, 23:357-360, 2000.

Maiese, K, Vincent, AM. Critical temporal modulation of neuronal programmed cell injury. Cell Mol Neurobiol 20:383-400, 2000.

Maiese, K, Vincent, AM, Lin, SH, Shaw, T. Group I and group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection. J Neurosci Res 62:257-272, 2000.

Maiese, K, Vincent, AM. Membrane asymmetry and DNA degradation: Functionally distinct determinants of neuronal programmed cell death. J Neurosci Res (Rapid Publication) 55:472-485, 2000.

Marler, JR, Tilley, BC, Lu, M, Brott, TG, Lyden, PD, Grotta, JC, Broderick, JP, Levine, SR, Frankel, MR, Horowitz, SH, Haley, EC Jr, Lewandowski, CA, Kwiatkowski, TP, for the NINDS rt-PA Stroke Study Group: Early stroke treatment associated with better outcome. The NINDS t-PA Stroke Study. Neurology, 55:1649-1655, 2000.

Muzik, O, da Silva, EA, Juhasz, C, Chugani, DC, Shah, J, Nagy, F, Canady, A, von Stockhausen, HM, Herholz, K, Gates, J, Frost, M, Ritter, F, Watson, C, Chugani, HT. Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology, 54:171-79,2000.

Muzik, O, Chugani, DC, Juhasz, C, Shen, C, Chugani, HT. Statistical parametric mapping: Assessment of application in children. NeuroImage, 12:538-549, 2000.

The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group (corresponding author SR Levine): Effect of intravenous rt-PA on ischemic stroke lesion size measured by computed tomography. Stroke, 31:2912-2919, 2000.

Nikhar, N, Shah, JR, Tselis, AC, Lewis, RA. Primary neurosarcoidosis: A diagnostic and therapeutic challange. Neurologist, 6:126-33,2000.

Noseworthy, JS, Wolinsky, JS, Lublin, FD, Whitaker, IN, Linde, A, Gjorstrup, P, Sullivan, HC and the North American Linomide Trialists (Lisak, RP, PI for WSU Center, Kamholz, J, Garber, J, Tselis, A, Lewis, R members). Linomide in relapsing and secondary progressive MS. I. Trial design and clinical results. Neurology 54:1726-1733,2000.

Paciaroni, M, Eliasziw, M, Sharpe, BL, Kappelle, LJ, Chaturvedi, S, Meldrum, HE, Barnett, HJM, for the NASCET group. Long-term clinical and angiographic outcomes in symptomatic patients with 70-99% carotid artery stenosis. Stroke 31:2037-42, 2000.

Pfund, Z, Chugani, DC, Juhasz, C, Muzik, O, Chugani, HT, Wilds, I, Seraji-Bozorgzad, N, Moore, GJ. Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and ¹H magnetic resonance spectroscopy in patients with epilepsy. J Cereb Blood Flow Metab, 20:871-878, 2000.

Pfund, Z, Chugani, HT, Juhasz, C, Muzik, O, Behen, MA, Chugani, DC, Nigro, MA,

Trock, GL, Squires, LA. Lissencephaly: Fetal pattern of glucose metabolism on positron emission tomography? Neurology, 55:1683-1688, 2000.

Rebuck, JA, Murry, KR, Rhoney, DH, Michael, DB, Coplin, WM. Infection related to intracranial pressure monitors in adults: analysis of risk factors and antibiotic prophylaxis. J Neurol Neurosurg Psychiatry, 69:381-384, 2000.

Rhoney, DH, Tipps, LB, Murry, KR, Basham, MC, Michael, DB, Coplin, WM. Anticonvulsant prescription and timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology, 55:258-265, 2000.

Selcen, D, Nigro, MA. High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis. Ped Neurol, 22:40-43, 2000.

Selcen D, Kupsky WJ, Benjamins D, Nigro MA. Myopathy wtih muscle spindle excess. Muscle and Nerve 24:138-143. 2001.

Selcen, D, Seidman, S, Nigro, MA. Otocerebral anomalies associated with topical tretinoin use. Brain & Development, 22:218-220, 2000.

Shah, AK, Tselis, A, Mason, B. Acute disseminated encephalomyelitis in a pregnant woman successfully treated with plasmapheresis. J Neurol Sci, 174:147-151, 2000.

Sima, AAF, Zhang, W, Xu, G, Sugimoto, K, Guberski, DL, Yorek, MA. A comparison of diabetic polyneuropathy in type-2 diabetic BBZDR/Wor-rat and in type 1 diabetic BB/Wor-rat. Diabetologia, 43:786-793, 2000.

Sloan, AE, Dansey, R, Zamorano, L, Barger, G, Hamm, C, Diaz, F, Baynes, R, Wood, G,.
Adoptive immunotherapy in patients with recurrent malignant glioma: preliminary results of using autologous whole-tumor vaccine plus granulocyte-macrophage colony-stimulating factor and adoptive transfer of anti-CD3-activated symphocytes. Neurosurgery Focus, 9: 1-8, 2000.

Sundkvist, G, Dahlin, L-B, Eriksson, KF, Lindgärde, F, Rosén, I, Lattimer, SA, Sima, AAF, Greene, DA. Sorbitol levels and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance. Diab Med, 17:259-268, 2000.

Sugimoto, K, Murakawa, Y, Sima, AAF. Diabetic Neuropathy-a Continuing Enigma. Diab/Metab Res Rev, 16:408-433, 2000.

Sugimoto, K, Murakawa, Y, Zhang, W-X, Xu, G, Sima, AAF. Insulin receptor in rat peripheral nerve: its localization and alternatively spliced isoforms. Diab/Metab Res Rev, 16:354-63, 2000.

Tanne, D, Gorman, M, Bates, VE, Kasner, SE, Scott, P, Verro, P, Binder, JR, Dayno, JM, Schultz, LR, Levine, SR, and the tPA Stroke Survey Group: Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and over. Stroke, 31:370-375, 2000.

Tipps, LB, Coplin, WM, Murry, KR, Rhoney, DH. Safety and feasibility of continuous infusion of remifentanil in the neurosurgical intensive care unit. Neurosurgery, 46:596-602, 2000.

Verweij, B, Muizelaar, J, Vinas, F, Peterson, P, Xiong, Y, Lee, CP. Improvement in mitrochondrial dysfunction as a new surrogate efficiency measure for preclinical trials: dose-response and time-window profiles for administration of the calcium channel blocker Ziconotide in experimental brain injury. J Neurosurg, 93:829-834, 2000.

Vinas, FC, Kazmierczak, C, Coplin, WM. Active intracerebral hemorrhage from the lateral posterior choroidal artery. Arch Neurol, 57: 889-890, 2000.

Vincent, AM, Maiese, K. The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death. Exp Neurol, 166:65-82, 2000.

Wolinksy, JS, Narayana, PA, Noseworthy, JH, Lublin, FD, Whitaker, IN, Linde, A, Gjorstrup, P, Sullivan, HC, the MRI Analysis Center of the University of Texas-Houston and the North American Linomide Trialists (Lisak, RP , PI for the WSU Center, Tselis, A, Kamholz, J, Garbern, J, Lewis, R, members). Lindomide in relapsing and secondary progressive MS. Part II. MRI results. Neurology, 54: 1734-1741, 2000.

Xu, W., Manichella, D., Jiang, H., Vallat, J.-M., Lilien, J., Kamholz , J., and Shy, M.E. Absence of P0 leads to dysregulation of myelin gene expression and myelin morphogenesis. J Neurosci Res, 60:714-724, 2000.

Zvartau-Hind, M, Din, MU, Gelani, A, Lisak, RP, Khan, 0. Topiramate relieves refractory trigeminal neuralgia in multiple sclerosis patients. Neurology, 55:1587-1588, 2000.

Articles In Press
Boullerne, AI, Nedelkoska, L, Benjamins, JA. The role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes. J Neurosci Res (in press).

Broderick, J, Lu, M, Jackson, C, Pancioli, A, Tilley, BC, Fagan, SC, Kothari, R, Levine, SR, Marler, JR, Lyden, PD, Haley, EC Jr, Brott, T, Grotta, JC, and the NINDS t-PA Stroke Study Group. Apo E phenotype and the effectiveness of intravenous t-PA in acute ischemic stroke. Ann Neurol (in press).

Chugani, DC, Muzik, O, Juhasz, C, Janisse, JJ, Ager, J, Chugani, HT. Ontogeny of human GABA_A receptors measured with positron emission tomography. Ann Neurol (in press).

Clark, L, Foster, N, Sima, AAF, Williamson, K. A survey of polymorphisms and mutations in the microtubule – associated protein tau gene in sporadic front temporal dementia and progressive supranuclear palsy. Am. J. Hum. Genetics (in press).

Coplin, WM. Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale and protocol for a randomized clinical trial. Neurol Res (in press).

Coplin, WM, Cullen, NK, Policherla, PN, Vinas, FC, Wilseck, JM, Zafonte, RD, Rengachary, SS. Safety and feasibility of craniectomy with duraplasty as the initial surgical intervention for severe traumatic brain injury. J Trauma (in press).

Coplin, WM, Cochran, MS, Levine, SR, Crawford, SL. Stroke after bone marrow transplantation: Frequency, etiology, and outcome. Brain (in press).

Dore-Duffy, P, Owen, C, Balabanov, R, Murphy, S, Beaumont, T, Rafols, JA. Pericyte response to traumatic brain injury (TBI): Elongation and migration from the microvascular wall. Microvascular Research (in press).

Ebright, J, Tselis, A, Stellini, M. Spinal epidural lipomatosis in an HIV positive patient on protease inhibitor therapy. Clin Infect Dis (in press).

Grotta, JC, Welch, KMA, Fagan, SC, Lu, M, Frankel, MR, Brott, T, Levine, SR, Lyden, PD, and the NINDS rt-PA Stroke Study Group: Clinical deterioration following improvement in The NINDS rt-PA Stroke Trial. Stroke (in press).

Joshi, N, Chaturvedi, S, Coplin, WM. Poor prognosis of acute stroke patients denied thrombolysis due to early CT findings. J Neuroimaging (in press).

Juhasz, C, Chugani, DC, Muzik, O, Watson, C, Shah, J, Shah, A, Chugani HT. Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Ann Neurol (in press).

Juhasz, C, Chugani, DC, Muzik, O, Watson, C, Shah, J, Canady, A, Shah, A, Chugani, HT. Relationship of [C] flumazenil and FDG PET abnormalities to the neocortical epilepsy surgery outcome. Neurology (in press).

Khan, 0, Tselis, A, Garbem, J, Kamholz, J, Lewis, R, Lisak, R. A prospective, controlled open label trial comparing the effects of IFN-B1a (Avonex@), IFN-JB1b (Betaseron@) and glatiramer acetate (Copaxone@) on the relapse rate of patients with relapsing-remitting multiple sclerosis. Eur J Neurol (in press).

Kluin, KJ, Gilman, S, Foster, NL, Sima, AAF, D’Amato, C, Bruch, LA, Bluemlein, RN, Little, R, Johanns, J. NeuroPathologic correlates of dysarthria in PSP. Arch. Neurology (in press).

Krajewski, KM. Genetic counseling issues in CMT. Acta Myologica (in press).

Lin, SH, Maiese, K. Group I metabotropic receptors prevent endothelial programmed cell death independent from MAP Kinase p38 activation in rat. Neurosci Lett (in press).

Lin, SH, Maiese, K. The metabotropic glutamate system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab (in press).

Lin, SH, Walraven, T, Chong, ZZ, Maiese, K. Nicotinamide: A nutritional supplement that provides protection against neuronal and vascular injury. J Med Food (in press).

Loeffler, DA , Sima, AAF, LeWitt, PA. Ceruloplasmin Immunoreactivity in Neurodegenerative Disorders. Free Radical Res (in press).

Lyden, PD, Lu, M, Levine, SR, Brott, TG, Broderick, J, and the NINDS rt-PA Stroke Study Group: A modified NIHSS for use in stroke clinical trials: Preliminary reliability and validity. Stroke (in press).

Maiese, K. The dynamics of cellular Injury: Transformation into neuronal and vascular protection. Histology and Histopathology (in press).

Mendell, JR, Barohn, RJ, Freimer, ML, Kissel, JT, King, W, Campbell, WW, Donofrio, PD, Jackson, CE, Lewis, RA, Shy, M, Simpson, DM, Parry, G, Rivner, MH, Thornton, CA, Bromberg, MB, Tanden, R, Wrubel, BT, Harati, Y, Giuliani, MJ and the Working Group on Peripheral neuropathy. Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy. Neurology (in press).

Minoshima, S, Foster, NL, Sima, AAF, Frey, KA, Albin, RL, Kuhl, DE. Brain Metabolic Characterization of Alzheimer’s Disease, and Pure Diffuse Lewy Body Disease. Ann Neurol (in press).

Ragheb, S, Abramczyk, S, Lisak, D, Lisak, R. Long-term therapy with glatiramer acetate in multiple sclerosis: effect on T-cells. Multiple Sclerosis (in press).

Ruan, B., Wilson, W. K., Pang, J., Gerst, N., Pinkerton, F. D., Tsai, J., Kelley, R. I., Whitby, F. G., Milewicz, D. M., Garbern, J. and George J. Schroepfer, J. Sterols in blood of normal and Smith-Lemli-Opitz subjects. J Lipid Res (in press).

Selcen, D, Kupsky, WJ, Benjamin, D, Nigro, MA. Myopathy with muscle spindle excess: A new congenital neuromuscular syndrome? Muscle & Nerve (in press).

Sima, AAF, Grunberger, G, Jörnvall, H, Wahren, J, C-peptide Study Group: Proinsulin C-peptide – A consensus statement. Internatl J Exp Diab Res (in press).

Skundric, DS, Dai, R, James, J and Lisak, RP. Activation of Il-1 signaling pathway in Schwann cells during diabetic neuropathy. Ann.NY Acad.Sci (in press).

Skundric, DS, Lisak, RP, Rouhi, M, Kieseier, BC, Jung, S and Hartung, H-P. Schwann cell specific regulation of IL-1 and IL-1Ra during EAN: possible relevance for immune regulation at paranodal regions. J.Neuroimmunol (in press).

Tirschwell, D, Coplin, WM, Becker, KJ, Vogelzang, P, Eskridge, J, Haynor, D, Cohen, W, Newell, DW, Winn, HR, Longstreth, WT Jr. Intra-arterial urokinase for acute ischemic stroke: factors associated with complications. Neurology (in press).

Wolinsky, JS, Narayana, PA, Johnson, KP and the Copolymer 1 Multiple Sclerosis Study Group (Lisak, RP, WSU Coordinator, Tselis, A, Khan, O, Kamholz, J, Garbern, J members). Magnetic resonance imaging and clinical correlations in a cross-sectional analysis of patients in the open-label extension of the US pivotal trial of glatiramer acetate for relapsing multiple sclerosis. Multiple Sclerosis (in press).

Wrensch, M, Weinberg, A, Wiencke, J, Miike, R, Kelsey, K, Barger, G. Prevalence of antibodies to four herpes viruses among adults with glioma and controls. Amer J Epidemiol (in press).

Xiong, Y, Peterson, PL, Lee, CP. Alteration in cerebral energy metabolism induced by traumatic brain injury. Neurol Res (in press).

Books, Chapters and Reviews
Chaturvedi, S, Halliday, A. Carotid endarterectomy: Current indications for symptomatic and asymptomatic stenosis. Curr Athero Reports, 2:115-19, 2000.

Chaturvedi, S. Carotid endarterectomy: Who needs it? Who Doesn’t? Emergency Medicine, 32:46-55, 2000.

Chaturvedi, S. Iatrogenic hemorrhagic stroke. Clinical Trends in Coagulation, Fibrinolysis and Immunology, 14:1-4, 2000.

Chugani, HT, Chugani, DC. Abnormal development and catastrophic epilepsies: The clinical picture and relation to neuroimaging. In: Brain Plasticity and Epilepsy, (J Engel, PA Schwartzkrkoin, SL Moshe, DH Lowenstein DH, eds.), Academic Press, 141-155, 2000.

Chugani, DC, Chugani, HT. Mapping of Serotonin Synthesis. In Functional Imaging in the Epilepsies, (TR Henry, JS Duncan, SF Berkovic, eds.). Adv Neurol, 83: 165-171, 2000.

Chugani, DC, Chugani, HT. New directions in PET neuroimaging for neocortical epilepsy. In Neocortical Epilepsies, (PD Williamson, AM Siegel, DW Roberts, VM Thadani, MS Gazzaniga, eds.), Adv Neurol, 84: 447-456, 2000.

Gorman, M. Transcranial Doppler assessment of cerebral embolic disorders. Prog Cardiovasc Dis, 43:135-150, 2000.

Jacobs, BS, Levine, SR. Antiphospholipid antibody syndrome. Current Treatment Options in Neurology, 2:449-457, 2000.

Kamholz, J, Menichella, D, Jani, A, Garbern, J, Lewis, RA, Krajewski, K, Lilien, J, Scherer, SS, Shy, ME. Charcot Marie Tooth Disease Type 1: molecular pathogenesis to gene therapy. Brain, 123:222-233, 2000.

Kapen, S. Sleep disorders associated with stroke. In: Neurobase (S Gilman, ed.), Arbor Publ Corp., San Diego, CA, 2000.

Khan, OA, Caon, C, Cochran, M. Treatment of multiple sclerosis: When ABC injections don't work ? MS Connection. National Multiple Sclerosis Society: 12-13, Summer 2000.

Krajewski, K, Greb, A. A Guide about Genetics for Patients: Charcot-Marie-Tooth Disease. Athena Diagnostics/Charcot-Marie-Tooth Association, 2000.

Levine, SR, Brey, RL, eds. Clinical Approach to Antiphospholipid Antibodies. Butterworth-Heinemann, Boston, MA, 2000.

Lewis, RA, Sumner, AJ, Shy, ME,. Electrophysiologic features of inherited demyelinating neuropathies: a reappraisal in the era of molecular genetics. Muscle & Nerve, 23:1472-1487, 2000.

Lewis, RA. Multifocal neuropathies. In: Intravenous Immunoglobulin in the Treatment of Neurological Disorders (G Said, ed.), Martin Dunitz, Ltd, London, pp.19-42, 2000.

Maiese, K, Lin, SH, Vincent, AM. Dual pathways of free radical injury in vascular endothelial cells: Loss of nuclear DNA integrity and membrane asymmetry during enhanced cysteine protease activity. In: Ischemic Blood Flow in the Brain, Keio University Symposia for Life Science and Medicine, (Y Fukuuchi, M Tomita, A Koto, eds.), vol 6, pp. 08-199, 2000.

Maiese, K. Brain Herniation. In: Neurobase (S Gilman, ed.), Arbor Publishing Corp., San Diego, CA, 2000.

Maiese, K. Persistent Vegetative State. In: Neurobase, (S Gilman, ed.), Arbor Publishing Corp., San Diego, CA, 2000.

Maiese, K. Metabolic Coma. In: Neurobase, (S Gilman, ed.), Arbor Publishing Corp., San Diego, CA, 2000.

Maiese, K. Sequelae of Cardiac Arrest. In: Neurobase, (S Gilman, ed.) Arbor Publishing Corp., San Diego, CA, 2000.

Maiese, K. Hypoxic-ischemic Encephalopathy. In: Neurobase, (S Gilman, ed.) Arbor Publishing Corp., San Diego CA, 2000.

Maiese, K. "Cerebral Ischemia: Molecular and Cellular Pathophysiology", The Quarterly Review of Biology, SUNY, 75:364-365, 2000.

Maiese, K. "Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy," The Quarterly Review of Biology, SUNY, 75:350-351, 2000.

Muzik, O, Chugani, DC, Juhasz, C, Shen, C, Chugani, HT. Statistical parametric mapping: Assessment of application in children. NeuroImage, 12:538-549, 2000.

Navarrete, MG, Brey, RL, Levine, SR. Cerebral disease in antiphospholipid syndrome. In: Hughes Syndrome Antiphospholipid Syndrome, (M Khamashta, ed.), Springer-Verlag, Surrey, United Kingdom, pp.43-58, 2000.

Nigro, MA. Chapter 121: Seizures and Status Epilepticus in Children. In: Emergency Medicine: A Comprehensive Study Guide, 5th ed. McGraw Hill, pp. 825-838, 2000.

Nikhar, N, Shah, K. POEMS syndrome. In: Neurobase. (S Gilman, GW Goldstein, SG Waxman, eds.), Arbor Publishing, La Jolla, CA, 2000.

Shah, JR, Chugani, DC, Chugani, HT. Diagnostic positron emission tomography. In: Intractable Focal Epilepsy: Medical and Surgical Treatment, (J Oxbury, C Polkey and M Duchowny eds.), W.B.Saunders, London, 311-322, 2000.

Shah, AK. Myasthenia Gravis. In: eMedicine Neurology Online Reference. Emedicine, Inc., St. Pete Beach.

Shah, AK. Preeclampsia and Eclampsia. In: eMedicine Neurology Online Reference. Emedicine, Inc., St. Pete Beach.

Sima, AAF, Shafrir, E. Preface. In: Animal Models of Diabetes, A Primer. Harwood Acad Press, Amsterdam, pp7-9, 2000.

Sima, AAF, Shafrir, E, eds. A Primer to Animal Models of Diabetes. Harwood Acad Publ., Amsterdam, 2000.

Tanne, D, Levine, SR, Kittner, SJ. Epidemiology of antiphospholipid antibodies and vascular disease. In: Clinical Approach to Antiphospholipid Antibodies, (SR Levine, RL Brey, eds.), Butterworth Heinemann, Boston, MA, pp. 1-18, 2000.

Tselis, A, Lavi, E. Cytomegalovirus infection of the adult nervous system. Chapter 4. In: Infections of the Nervous System. (PG Kennedy, and L Davis eds.), Butterworth-Heinemann, London, pp. 109-137, 2000.

Tselis, A and Booss, J. Prognosis of viral encephalitis. In: Prognosis of Neurological Disease. (RW Evans, DS Baskin, F Yatsu, eds.), Oxford University Press, New York, pp. 237-256, 2000.

Tselis, AC, Lisak, Khan, OA, Lisak, RP. Intravenous immunoglobulin in the treatment of MS. MS Quarterly Report 19:1-5, 2000.

Books, Chapters and Reviews In Press
Asan, E, Kuivaniemi, H, Huq, AHMM, Tromp, G, Behen, M, Rothermil, R, Herron, J, Chugani, DC. A study on novel polymorphisms in the upstream region of vasoactive intestinal peptide receptor type 2 gene in autism. J Child Neurol (in press).

Chaturvedi, S. Cerebral infarction. In: Saunders Manual of Critical Care. (JA Kruse, M Fink, eds.), WB Saunders, Philadelphia (in press).

Coplin, WM. Elective trepanation for acute epidural hematoma by Dr. Nicolaes Tulp (1593-1674) [comment]. Neurosurgery (in press).

Coplin, WM, Rengachary, SS. Neurologic emergencies: coma. In: Resuscitation and Emergency Medicine ( JM del Sol Carrasco, A de Paz Cruz, F del Aguila, eds.) (in press).

Garbern, J. Pelizaeus-Merzbacher disease. In: eMedicine, (K Heilman, N Lorenzo, H Lutsep, eds.) (in press).

George, EB. Clinical PERLs on the Web: Leveraging the Student-Teacher Interaction. Proceedings of the 2nd Annual Wayne State University TLTR Conference: Teaching with New Technologies, Wayne State University, Detroit, MI (in press).

George, EB. Neurology. In: USMLE Step 3 Recall, (M Ryan, ed.), Lippincott Williams and Wilkins (in press).

Goldstein, LB, Adams, R, Becker, K, Furberg, CD, Gorelick, PB, Hademenos, G, Hill, M, Howard, G, Howard, VJ, Jacobs, BS, Levine, SR, Mosca, L, Sacco, RL, Sherman, DG, Wolf, PA, del Zoppo, GJ. Primary prevention of ischemic stroke: a statement for healthcare professionals from the stroke council of the American Heart Association. Stroke (in press).

Guyot, AM, Quinones, L, Levine, SR. Early studies of thrombolytic therapy for stroke. In: Thrombolytic Therapy for Stroke, (PD Lyden, ed.), Humana Press (in press).

Guyot , AM, Levine, SR. Pre-clinical testing of thrombolytic therapy. In: Thrombolytic Therapy for Stroke, (PD Lyden, ed.), Humana Press (in press).

Jacobs, BS. Hypercoagulability and cerebral infarction. Biomedical Progress (in press).

Kadurrah, A, Moorjani, B. Benign epilepsies of childhood. In: e-medicine: Neurology, (KM Heilman, NY Lorenzo, HL Lutsep, eds.), eMedicine Corp, St. Petersberg (in press).

Lewis, RA. Guillain Barré Syndrome. In: Saunders Manual of Critical Care. (JA Krause, RW Carlson, M Fink, eds.) WB Saunders, Philadelphia (in press).

Lewis, RA. Toxic and deficiency neuropathies. In Mydoc.com (in press).

Lewis, RA, Sumnner, AJ, Shy, ME. Hereditary Neuropathies. In: Clinical Neurophysiology and Neuromuscular Diseases, (W Brown , C Bolton, M Aminoff, eds.) (in press).

Lisak. RP. Antibodies to myelin as mediators of the multiple sclerosis lesion: New emphasis on an old theory. In: Neurologic Commentary. (S Gilman, ed.) (in press).

Lisak. RP. Myasthenia gravis. In: Current Therapy in Neurologic Diseases. (RT Johnson, JW Griffin, J McArthur, eds.). BC Dekker, Philadelphia. (in press).

Lisak. RP. Myasthenia gravis. In: Saunders Manual of Critical Care. (JA Krause. RW Carlson. M Fink. eds.). WB Saunders, Philadelphia (in press).

Lisak, RP , Mendell, JR. Neuropathies in collagen-vascular diseases. In: Handbook of Peripheral Neuropathies, (JR Mendell, DR Comblath, eds.). Marcel Dekker, New York (in press).

Lublin, FD, Reingold. SC and the National Multiple Sclerosis Society (USA) Task Force on Placebo-Controlled Clinical Trials in MS (Lisak. RP , member). Placebo-controlled clinical trials in multiple sclerosis: Ethical considerations. Ann Neurol (in press).

Lynn, J., Kissel, J., Li, J., Myotonia disorders and periodical paralysis. In: Neurology in Five Minutes (in press).

Maiese, K. Brain Herniation. In: Neurobase, (S Gilman, GW Goldstein, and SG. Waxman, eds.),7 ed., Arbor Publishing Corp (in press).

Maiese, K. Persistent Vegetative State. In: Neurobase, (S. Gilman, G.W. Goldstein, and S.G. Waxman, eds.), 7 ed., Arbor Publishing Corp (in press).

Maiese, K. Metabolic Coma. In: Neurobase, (S Gilman, GW Goldstein, and SG Waxman, eds.), 7 ed., Arbor Publishing Corp (in press).

Maiese, K.: Sequelae of Cardiac Arrest. In: Neurobase, (S. Gilman, G.W. Goldstein, and S.G. Waxman, eds.), 7 ed., Arbor Publishing Corp (in press).

Maiese, K. Hypoxic-ischemic Encephalopathy. In: Neurobase, (S Gilman, GW Goldstein, and S.G. Waxman, eds.), 7 ed., Arbor Publishing Corp (in press).

Maiese, K, Caronna, JJ. Coma. In: The High Risk Patient: Management of the Critically Ill, (E Sivak, T Higgins and A Seiver, eds.), Lea and Febiger (in press).

Maiese, K, Caronna, JJ. Evaluating the outcome of ischemic cerebral injury. In: Principles and Practice of Neurocritical Care, (DF Hanley, ed.), Williams and Wilkins (in press).

Maiese, K. Molecular mechanisms of NO induced vascular injury. In: Thrombosis and Vascular Biology Newsletter, HealthScience Communications (in press).

Maiese, K, Ahmad, I. Cerebral Vascular Disease. In: Pearls of Wisdom Neurology Review Series, 2nd ed. (M Labanowski, ed.), Boston Medical Publishing, Inc (in press).

Maiese, K. Organic Brain Disease. In: Encyclopedia of the Human Brain, (VS Ramachandran, ed.), Academic Press (in press).

Maiese, K, Lin, SH, Chong, ZZ. The metabotropic glutamate receptor system: A novel pathway for the molecular protection against microvascular programmed cell death. In: Brain Activation and CBF Control, (R Buxton, M Tomita, U Dirnagl, E Hamel, and I Kanno, eds.), Japan Heart Foundation (in press).

Mitsias, P, Papamitsakis, NIH, Levine, SR. Cerebrovascular complications of Fabry disease. In: Stroke Syndromes, (J Bogousslavsky , L Caplan, eds.), Cambridge University Press (in press).

Mohamed, I, Moorjani, B. Chorea in childhood. In: e-medicine: Neurology, (KM Heilman, NY Lorenzo, HL Lutsep, eds.), eMedicine Corp, St. Petersberg (in press).

Moorjani, B. Neonatal injury in Child abuse. In: e-medicine: Neurology, (KM Heilman, NY Lorenzo, HL Lutsep, eds.), eMedicine Corp, St. Petersberg (in press).

Moorjani, B. Shaken baby syndrome. In: Neurobase , (S Gilman, ed.), Arbor Publishing Corp., San Diego, CA (in press).

Ragheb, S, Lisak, RP. The thymus and myasthenia gravis. In: Chest Surgery Clinics of North America, (P. Kirchner, ed.), WB Saunders, Philadelphia (in press ).

Shy, ME. Axonal loss in inherited demyelinating neuropathies; lessons from PMP-22 mutant mice.Neurology Network Commentary (in press).

Shy, ME, Hinderer, S, Lewis, RA, Kamholz, J, Garbern, J, Krajewski, KM. Charcot-Marie-Tooth disorders: an approach to diagnosis and treatment. In: Current Therapy in Neurological Disorders, (R Johnson, J Griffin, J McArthur, eds.) (in press).

Shy, ME, Lewis, RA. Inherited neuropathies. In: Neuromuscular Diseases.Butterworth Heinemann (R Pourmand, ed.) (in press).

Shy, ME, Balsamo, J, Lilien, J, Kamholz, J. A molecular basis for hereditary motor and sensory neuropathy disorders. Current Neuro and Neurosci Reports (in press).

Sima, AAF, Pierson, C. Metabolic control-experimental studies. In: Diabetic Neuropathy, (FA Gries, ed.), Georg Theime Verlag, Stuttgart (in press).

Sima, AAF, Shafrir, E, eds. Insulin Signaling: From Cultured Cells to Animal Models, Harwood Acad Publ., Amsterdam (in press).

Sima, AAF, Shafrir, E eds. Muscle Metabolism in Animal Models in Diabetes, Harwood Acad Publ., Amsterdam (in press).

Tselis, AC. Khan, OA. Multiple Sclerosis: case based review. J Clin Outcome Measures (In Press)

Xiong, Y, Peterson, PL, Lee, CP. Mitochondrial dysfunction following experimental traumatic brain injury: efficacy of blood brain barrier penetrating antioxidants. Mitochondria Ubiquinones (Coenzyme Q10); Biochemical, Functional, Medical and Therapeutic Aspects. In: Human Health and Disease, (M Ebadi, J Merwah, RR Chopra, eds.), Prominent Press, AZ (in press).

Xiong, Y, Peterson, PL, Lee, CP. Mitochondrial dysfunction following traumatic brain injury. In: Head Trauma: Basic, Preclinical and Clinical Aspects, (LP Miller, PL Accye, J Newcomb, eds.), John Wiley and Sons, New York (in press).

Zabad, R, Tselis, A, Shah, AK. Peritateritis nodosa. In: Neurobase, (S Gilman, GW Goldstein, SG Waxman, eds.), Arbor Publishing (in press).

Editorials, Letters to the Editor, Book Reviews and Articles in Non-Refereed Journals
Chaturvedi, S. Supplement to the AHA guidelines for the management of transient ischemic attacks. Stroke, 31:983, 2000.

Coplin, WM. Review of "Critical Care Neurology." Arch Neurol, 56:757, 2000.

Levine, SR. Book review: Central Nervous System Angiitis. JW Schmidley. Butterworth Heinemann, Woborn, Massachusetts. Ann Neurol (in press).

Lewis, RA. Editorial: The challenge of CMTX and connexin32 mutations. Muscle & Nerve, 23:147-149, 2000.

Lisak, RP. Type I interferons and chronic inflammatory demyelinating polyneuropathy: Treatment or cause. Muscle & Nerve, 23:307-309, 2000.

Shah, AK. Eclampsia and postpartal cerebral angiopathy: a response. J Neurol Sci, 178:77-78, 2000.

Shah, AK, Freij, W. Response to a letter to the Editor regarding “Dramatic headache relief after sumatriptan in a patient with pituitary macroadenoma”. Headache, 40:399-400, 2000.

Sima, AAF. Does insulin play a role in cardiovascular autonomic regulation? Diabetes Care, 23:724-725, 2000.

Sima, AAF, Shafrir, E. Editorial. Internatl. J Exp Diab Res, 1:2, 2000.

Tselis, A. Review of. Advances in Multiple Sclerosis. Clinical Research and Therapy. M Dunitz, Publisher, London, 1999 In: JNeurol Sci, 175: 74, 2000.

Abstracts Published
Acsadi, G, Anguelov, R, Lewis, RA, Jani, Yang, H, Ianakova, EP, Kamholz, J, Shy, ME. Adenoviral-mediated GDNF gene transfer in SOD 1 transgenic mice. Neurology, 54 (Suppl 3):A154, 2000.

Acsadi, G, Anguelov, R, Yang, Toth, G, Jani, J, Lewis, RA, Shy, ME. GDNF and CT-1 gene therapy prolongs the survival of SOD-1 mice. Am J Hum Genet, 67 (Suppl 2):A2413, 2000.

Acsadi, G, Anguelov, R, Lewis, RA, Jani, A, Yang, H, Ianakova, EP, Kamholz, J, Shy, ME. Adenoviral mediated GDNF gene transfer in SOD1 transgenic mice. Neurology, 54 (Suppl 3):A154, 2000.

Adler, JE, Skoff, AM, Walker, PD. GDNF regulates somatostatin content and release in adult sensory neurons. Soc Neurosci Abs, 511:17, 2000.

Asano, E, Chugani, DC, Juhasz, C, Muzik, O, Philip, S, Shah, J, Shah, A, Watson, C, Canady, A, Chugani, HT. Epileptogenic zone in tuberous sclerosis complex: Subdural EEG versus MRI and FDG PET. Epilepsia 2000, 41 (Suppl 7):128, 2000.

Brey, RL, Levine, SR, Thompson, JLT, Sacco, RL, Tilley, BC, Costigan, TM, Rhine, CB, Zidel, A, Ruzicka, J, Xu, D, Mohr, JP. APASS/WARSS Collaborative Study Investigators. Baseline frequencies, isotypes, and titers of antiphospholipid antibodies in the Warfarin Aspirin Recurrent Stroke Study/Antiphospholipid Antibody in Stroke Study (WARSS/APASS) Collaboration. Preliminary results. Stroke, 31:280, 2000.

Broderick, J, Lu,M, Jackson, C, Pancioli, A, Tilley, BC, Fagan, SC, Kothari,R, Levine, SR, Marler, JR, Lyden, PD, Haley, EC Jr, Brott, T, Grotta, JC. ApoE phenotype and the effectiveness of intravenous tissue-type plasminogen activator in acute ischemic stroke. Ann Neurol, 48:421, 2000.

Broderick, J, Lu, M, Jackson, C, Pancioli, A, Tilley, B, Fagan, S, Kothari, R, Levine, S, Marler, J, Lyden, P, Haley, E Jr, Brott, T, Grotta, J. The NINDS t-PA Stroke Study Group. ApoE phenotype and the efficacy of intravenous t-PA in acute ischemic stroke. Stroke, 31:2828, 2000.

Chabut, J, Hurst, R, Brey, P, Jacobs, BS, Oshi, K, Hickenbottom, S, Lewis, G, Hogan, J, Daley, S Crafton, M, Shearer, C, Levine, SR. A model for a state-based multidisciplinary approach to improve stroke awareness and care: the Michigan Stroke Initiative (MSI). Stroke, 31:320, 2000.

Chaturvedi, S, Kulkarni, V, Shah, AK, Caragine, L, Kazmierczak, C, Joshi, N, Banerjee, M, Dahn, MS,. Interspecialty measurement of carotid stenosis: Are we speaking the same language? Stroke, 31:334, 2000.

Chaturvedi, S, Kulkarni, V. Is angiography still useful in the evaluation of patients with carotid stenosis? Stroke, 31:2828-2829, 2000.

Chaturvedi, S. Results of cerebral angioplasty with prospective neurologist follow up. Ann Neurol, 48:501, 2000.

Chaturvedi, S. The spectrum of cerebral ischemia in oral contraceptive users. Can J Neurol Sci, 27 (Suppl 2):S34-35, 2000.

Chaturvedi, S, Coplin, WM, Tselis, AC. Thrombolysis for acute ischemic stroke resulting from cardiac procedures. Cerebrovasc Dis, 10 (Suppl 2):74, 2000.

Chong, Z, Lin, S-H, Zhang, Y, Lisak, R P, Maynard, K I, Maiese, K. Nicotinamide confers ischemic neuroprotection through the modulation of a cascade of cysteine protease activity. Soc Neurosci Abstr, 26:773, 2000.

Clark, WM, Schim, JD, Kasner, SE, Victor, SJ, the Fibroblast Stroke Study Investigators. Trafermin in acute ischemic stroke: Results of a phase II/III randomized efficacy study. Neurology, 54 (Suppl 3):A88, 2000.

Coplin, WM, Mujawar, AH. "A day in the life": two years experience of a physician's acute stroke call. Neurology, 54 (Suppl 3):A302, 2000.

Devlin, JW, Coplin, WM, Swarczinski, C, Leacock, RO, Lewis, RA, Kruse, JA. Accuracy of train-of-four assessment for ICU patients receiving continuous neuromuscular blockade. Crit Care Med, 27:A72, 2000.

Devlin, JW, Coplin, WM, Swarczinski, C, Leacock, RO, Lewis, RA, Kruse, JA. Reliability of nursing train-of-four assessment for ICU patients receiving continuous neuromuscular blockade. Crit Care Med, 27:A131, 2000.

Din, MU, Zvartau-Hind, M, Gelani, M, Lisak, RP, Khan, 0. Topiramate relieves refractory trigeminal neuralgia in multiple sclerosis patients. Neurology, 54 (Suppl 3):A60. 2000.

Elkhatib, EA, Zamorano, L, Sloan, A, Wood, G, Baynes, R, Barger, G, Levin, K, Parez-de la Torre, R, Kugelman, S, Diaz, F. Initial experience in cancer antigen specific adoptive immunotherapy in malignant brain tumors. Congress of Neurological Surgeons Annual Meeting Poster Program Book. A82, 2000.

Elkhatib, EA, Zamarano, L, Barger, G, Wood, G, Baynes, R, Levin, K, Parez de la Torre, R, Kugleman, S, Diaz, F. Clinical experience of active and adoptive immunotherapy in malignant brain tumors. Congress of Neurological Surgeons Annual Meeting Poster Program Book. A62, 2000.

England, G, Zamorano, L, Gaspar, L, Barger, G, Diaz, F. Use of the gamma knife for the treatment of recurrent GBM. AANS/CNS Section on Tumors: Fourth Biennial Satellite Symposium Scientific Program Abstracts. A122, 2000.

Feurst, D, Watson, C, Hayman-Abello, B, Ergh, T, Yamamoto, A, Hayman-Abello, S, Poore, Q, Shah, A, Shah, J. Influence of IQ on IAP memory performance. Epilepsia, 41 (Suppl 7):155, 2000.

Frankel, MR, Morgenstern, LB, Kwiatkowski, T, Lu, M, Tilley, BC, Broderick, JP, Libman, R, Levine, SR, Brott, T and the NINDS rt-PA Stroke Trial Investigators. Predicting poor prognosis after acute ischemic stroke: An analysis of the placebo group from the NINDS rt-PA Stroke Trial. Neurology, 54 (Suppl 3):A89, 2000.

Gammans, RE, Sherman, DG. ECCO 2000 Study of citicoline for treatment of acute ischemic stroke: Final results. Stroke, 31:278, 2000.

Garbern, JY, Griffiths, IR, Moore, GJ, Faulk, M, Shy, ME, Kamholz, JA. Proteolipid protein is necessary for axonal integrity. J Neurochem, 74:S94, 2000.

George, EB, Chen, W-J, Deng L-P. Localization of L-type and N-type calcium channels in cultured murine sensory neurons is consistent with L-Type calcium channel involvement in axonal injury. Neurology, 54 (Suppl 3):A133, 2000.

Greenstein, JI and MSTRAC Investigators Group (Khan, O, member). Quality of life of patients enrolled in the registry of MSTRAC. Impact of treatment and disease progression. Neurology, 54 (Suppl 3):A340, 2000.

Hobson, GM, Sistermans, EA, de Coo, IFM, Stabley, D, Kolodny, EH, Funanage, VL, Garbern, JY and Marks, HG. Analysis of splice site mutations of the proteolipid protein (PLP) gene in Pelizaeus-Merzbacher disease. Am J Hum Genet, 67:2093, 2000.

Huq. M, Gilani, A, Mohan, K, Lisak, R, Khan, 0. Clinical and pararclinical features of juvenile and childhood multiple sclerosis (MS): Application of adult diagnostic criteria for MS in children. Neurology, 54 (Supp13): A351, 2000.

Jacobs, LD and MSTRAC Investigators Group (Khan, O, member). A comparison of the MSTRAC and New York State Multiple Sclerosis Consortium registries. Neurology, 54 (Suppl 3):A340, 2000.

Jacobs, BS, Ottney-Schweiss, C, Choate, LM, Hall, LH, Hubbert, K, Jones, K, Parliament, C, Pfalzgraf, B, Schuster, A, Lewandowski, CA, Levine, SR. Operation

stroke: a tri-county surveillance of pre-hospital and hospital stroke treatment capabilities. Stroke, 31:310, 2000.

Juhasz, C, Watson, C, Chugani, DC, Muzik, O, Shah, J, Shah, A, Chguani, HT. Epileptogenicity of ‘metabolic borderzones’ in human neocortical epilepsy. Neurology, 54 (Suppl 3):A107-A108, 2000.

Juhasz, C, Muzik, O, Chugani, DC, Rothermel, RD, Behen, ME, Chugani, HT. Ontogeny of human GABA_A receptors studied by positron emission tomography. Ann Neurol, 48:517, 2000.

Juhasz, C, Muzik, O, Chugani, DC, Chugani, HT. GABA_AReceptors in Epileptic Children: Age Related Changes and Effect of Antiepileptic Drugs. Epilepsia, 41:83, December 2000.

Kapen, S, Anderson, SLP, Mozahem, K. Sleep onset REM periods in obstructive sleep apnea patients: results of treatment. Neurology, 54 (Suppl 3):A29, 2000.

Kasner, SE, Saver, J, Levine, SR. Highlights from the 25^th Annual International Stroke Conference. February 10-12, 2000, New Orleans, La. Medscape Neurology, Available at: www.medscape.com.

Khan, O, Zvartou-Hind, M, Kamholz, J, Garbern, J, Lewis, R, Cochran, M, Lisak, D, Lisak, R. Efficacy and tolerability of monthly intravenous (IV) cyclophosphamide (CTX) in rapidly deteriorating MS patients resistant to conventional therapy. Neurology, 54 (Suppl 3):A336, 2000.

Khan, OA, Tselis, AC, Kamholz, J, Garbern, J, Lewis, RA, Lisak, RP. A prospective, controlled, open-label trial comparing the effect of Avonex, Betaseron, Copaxone on the relapse rate in patients with multiple sclerosis: Results after 18 months of follow up. J Neurol, 247 (Suppl 3):III/21, 2000.

Khan. O, Zvartau-Hind, M, Gilani, A, Zhai, H, Lewis, R, Kamholz, J, Lisak, R. Recurrent transverse myelitis in African-Americans. Ann Neurol, 48:451, 2000.

Lee, JS, Asano, E, Juhasz, C, Pfund, Z, Behen, M, Muzik, O, Chugani, DC, Chugani, DC. Sturge-Weber syndrome with unihemispheric involvement: Correlation between clinical characteristics and positron emission tomography flurodeoxyglucose indings. Ann Neurol, 48:531, 2000.

Lee J, Asano E, Juhasz C, Pfund Z, Muzik O, Chugani DC, Chugani HT. Sturge-Weber syndrome with unilateral leptomeningeal angioma: Degree and extent of glucose hypometabolism are related to epileptiform pattern. Epilepsia, 41:188, 2000.

Levine, SR. Stroke and telemedicine: Real-world applications. Telemed J, 6:92, 2000.

Levine, SR, Brey, RL, Tilley, BC, Thompson, JLP, Sacco, RL, Xu, D, Costigan, TM, Triplett, DA, Mohr, JP, and the WARSS-APASS Collaborative Study Investigators. The WARSS-APASS Collaborative Study: Baseline aPL Prevalence. J Autoimmunity, 15:A8, 2000.

Lewis, RA, Krajewski, K, Tate, B, Shy, ME. Motor unit number estimation (MUNE) of proximal and distal upper extremity muscle in CMT1A, CMTX and CMT2. Neurology, 54 (Suppl 3):A70, 2000.

Li, Q, Loeb, JA Regulation of acetylcholine receptor genes by neuregulin-extracellular matrix interactions. Soc Neurosci Abs, 26:61, 2000.

Li, J, Petajan, J, Bromberg, M. Needle electromyogram of sternocleidomastoid muscle in amyotrophic lateral sclerosis. Neurology, 54 (Suppl 3):A401, 2000.

Li, Z-G, Zhang, W-X, Grunberger G, Sima AAF. C-peptide corrects IFG’s and prevents apoptosis in type 1 BB/-rat hippocampus. Diabetes, 49 (Suppl 1):A229, 2000.

Li, Z-G, Qiang, X, Mathews, ST, Sima, AAF, Grunberger, G. C-peptide inhibits protein tyrosine phosphatase and promotes glycogen synthesis. 3^rd International Motor City Diabetes Symposium, Detroit, Michigan, 2000.

Lin, SH, Vincent, A, Shaw, T, Wright, J, Maiese, K. Group I metabotropic glutamate receptors selectively and specifically inhibit cysteine protease activity during ischemic nitric oxide exposure. Stroke, 30:281, 2000.

Lin, SH, Daffu, G, Vincent, A M, Miller, J, Zhang, Benjamins, JA, Maynard, KI, Maiese, K. Prevention of nitric oxide-induced neuronal injury through the modulation of discrete pathways of programmed cell death. Soc Neurosci Abs, 26:773, 2000.

Lisak, D, Cochran, M, Caon, C, Zvartau-Hind, M, Letcher, B, Tselis, A, Lisak, R, Khan, 0. Effect of variable dosing regimens of intravenous methylprednisilone (IVMP) on recovery during an acute exacerbation in multiple sclerosis patients admitted to the hospital. J MS Care, 2:6, 2000.

Lisak, RP, Bealmear, B Benjamins, JA , Skoff, AM. IFN-g , TNF-a and TGF-Jb inhibition of cyclic AMP (cAMP) induction of Schwann cell (SC) differentiation in vitro. J Neurochem, 74 (Suppl); S84A, 2000.

Lyden, P, Lu, M, Jackson, C, Marler, J, Kothari, R, Brott, T, Zivin, Jm, and the NINDS rt-PA Stroke Trial Investigators. Underlying structure of the NIH Stroke Scale: Results of a factor analysis. Stroke, 31:307, 2000.
Maiese, K, Vincent, A, Shaw, T, Wright, J. Selective ischemic nuclear DNA cleavage is dependent upon the free radical generation of caspase-3 and the specific induction of neuronal endonuclease genes. Keio University Symposia for Life Science and Medicine, 6:108, 2000.

Mendell, JR, Barohn, RJ, Kissel, JT, Sanders, MC, King, WM, Campbell, WW, Donofrio, PD, Jackson, CE, Lewis, RA, Simpson, DM, Parry, GJ, Thornton, CA, Bromberg, MB, Rivner, MH, Tandan, R, Harati, Y, Wrubel, BT, Giuliani, MJ and the Peripheral Neuropathy Study Group. Intravenous immunoglobulin (IVIg) in untreated patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Neurology, 54 (Suppl 3):A212, 2000.

Miller, J, Lin, SH, Zhang, Y, Chong, Z, Reeves, SA, Maiese, K. The tyrosine phosphatase SHP2 is a primary determinant of neuronal programmed cell death. Soc Neurosci Abstr, 26: 807, 2000.

Murugappan, A, McAllen, KJ, Coplin, WM, King, JJ, Redman, ME, Schwamm, LH, Wechsler, L, Saver, JL, Broderick, JP, Smoot, K, Rordorf, G, Starkman, S, Duckwiler, G, Tietjen, GE, Levine, SR. Thrombolytic therapy for acute ischemic stroke during pregnancy. Neurology, 54:390, 2000.

Nedelkoska, L, Benjamins, JA. Inhibition of initiator caspase 8 protects mature mouse oligodendrocytes from killing by nitric oxide or calcium ionophore, but not thapsigargin, J Neurochem, 74 (Suppl):S59C, 2000.

The NINDS rt-PA Stroke Study Group (levine, S, member). The effect of rt-PA on CT lesion volume over time. Stroke, 31:2828, 2000.

Parker, R, Kyshtoobayeva, A, Mehta, R, Brem, H, Brem, S, Vanier, V, Barger, J, Fruehauf, JP. In Vitro Drug Response (IVDR) and prognostic parker (M) profiles in primary brain tumors (BT). Proc Amer Assoc Cancer Res, 41: A1637, 2000.

Pfund, Z, Chugani, DC, Juhasz, C, Muzik, O, Chugani, HT, Wilds, IB, Seraji-Bozorgzad, N, Moore, GJ. Evidence for coupling between glucose metabolisma and glutamate cycling using FDG PET and ¹H MRS in epilepsy patients. Epilepsia, 41:67, 2000.

Pierson, CR, Zhang, W-X, Murakawa, Y, Wahren, J, Sima, AAF. Molecular pathology of the Node of Ranvier in type I diabetic neuropathy: A role for insulin and C-peptide deficiencies? 3^rd International Motor City Diabetes Symposium, Detroit, Michigan, 2000.

Pratt, CA, Tilley, B, Levine, S, Chopp, M, Chase, G. Stroke knowledge, prevention practices, and preferred approaches to stroke education. Towards developing a new ethnically specific, culturally sensitive survey tool. Stroke, 31:293, 2000.

Qiang, X, Mathews, ST, Li, Z-G, Sima, AAF, Grunberger, G. C-peptide Signaling – is it mediated through insulin receptor? 3^rd International Motor City Diabetes Symposium, Detroit, Michigan, 2000.

Ragheb, S, Lisak, RP. Lymphocyte proliferative response to glatiramer acetate in normal humans is dependent on both major histocompatibility complex (MHC) class I and II molecules. J Neurology, 247 (Suppl 3):III/119, 2000.

Rhoney, DH, Somerville, AL, Coplin, WM. Physician specialty and cost variation in the treatment of status epilepticus at an urban medical center. Crit Care Med, 27:A46, 2000.

Rhoney, DH, McAllen, KJ, Murry, KR, Coplin, WM. Prescribing practices of antihypertensive agents in patients with ischemic stroke: impact on patient outcome. Neurology, 54 (Suppl 3):A376, 2000.

Rhoney, DH, Somerville, AL, Coplin, WM. Status epilepticus: cost burden at an urban medical center. Crit Care Med, 27:A44, 2000.

Saver, S, Kasner, SE, Levine, SR. Stroke research clarifies many questions. 52^nd Annual Meeting of the American Academy of Neurology. Medscape Neurology & Neurosurgery 2000. Available at: www.medscape.com.

Shaw, T, Vincent, A, Lin, SH, Maiese, K. The transcription factor E2F represents a novel molecular checkpoint in post-mitotic neurons against ischemic cell cycle induction and neuronal programmed cell death. Stroke, 30:344, 2000.

Shy, ME, Garbern, J, Mancias, P, Lewis, RA, Kamholz, J. PLP neuropathies: proving the null hypothesis. Neurology, 54 (Suppl 3):A70, 2000.

Shy, M, Lewis, R, Krajewski, K, Kamholz, J, Garbern, J. Peripheral Neuropathy in Pelizaeus-Merzbacher Disease. Neurology, 54 (Suppl 3):A69, 2000.

Sima, AAF. C-peptide deficiency plays a prominent pathogenetic role in type 1 diabetic neuropathy. Leipzig 2000, International Symp, Leipzig, Germany, 2000.

Sima, AAF, Sugimoto, K, Zhang, W-X, Pierson, C, Murakawa, Y. C-peptide prevents nodal and paranodal structural and molecular changes in type 1 diabetic neuropathy. Diabetes 49 (Suppl 1):A167, 2000.

Sima, AAF. Diabetic Neuropathy – A Continuing Enigma. Sendai Symposium on Diabetic Neuropathy, Sendai, Japan, 2000.

Sima, AAF. The pathogenetic role of C-peptide deficiency in type 1 diabetic neuropathy. Amer Neurochem 74 (Suppl):S47, 2000.

Sima, AAF. The pathogenetic role of C-peptide deficiency in type 1 diabetic neuropathy. 3^rd International Motor City Diabetes Symposium, Detroit, Michigan, 2000.

Sugimoto, K, Murakawa, Y, Sima, AAF. Fine structural localization of insulin receptor in rat dorsal root ganglion and spinal cord. Diabetes 49 (Suppl 1):A168, 2000.

Skundric, DS, Rouhi, M, Madala, SR, Lisak, RP. Regulation of IL-1RA by Schwann cells (SC) during their differentiation in vivo. J Neurochem, 74 (Suppl):593, 2000.

Slivka, A., Li, J., Notestine, MA, Clinical predictors of cerebrovascular occlusion in acute stroke. Neurology, 54 (Suppl 3):A300, 2000.

Sloan, AE, Kabrossi, B, Barger, G, Zamorano, L, Diaz, F, Baynes, R, Wood, G. Vaccination of patients with recurrent malignant astrocytoma with autologous tumor and granulocyte macrophage colony stimulating factor (GM-CSF). AANS/CNS Section on Tumors: Fourth Biennial Satellite Symposium Scientific Program Abstracts. A30, 2000

Sloan, AE, Kabrossi, B, Barger, GR, Zamorano, L, Baynes, R, and Wood, G. Vaccination of patients with recurrent malignant astrocytoma with autologous tumor and granulocyte macrophage colony stimulating factor (GM-CSF). Proc Amer Soc Clin Oncology, 19: A1821, 2000.

Sohrab, S, Chaturvedi, S, Tselis, A. Carotid stent thrombosis: report of two fatal cases. J Stroke Cerebrovasc Dis, 9:203, 2000.

Tate, B, Krajewski, KM, Lewis, RA, Shy, ME. Preliminary genotype-phenotype correlations in CMTX. Neurology, 54 (Suppl 3):A69, 2000.

Vinas, FC, Gorman, MJ, Rengachary, SS, Coplin, WM, Dujovny, M, Michael, DB. Clinical evaluation of a ventriculostomy with a microimplantable strain gauge sensor. 50th Annual Meeting of the Congress of Neurological Surgeons, 2000.

Vincent, AM, Lin, SH, Zhang, Y, Miller, J, Maiese, K. Free radical generated cysteine proteases determine independent pathways of neuronal programmed cell death. Soc Neurosci Abstr, 26: 807, 2000.

Vincent, A, Wright, J, Lin, SH, Maiese, K. Free radical induction of acidic endonuclease activity is a potential regulatory therapeutic target against neuronal apoptosis. Stroke, 30: 282, 2000.

Warach, SJ, Sabounjian, LA, Interneuron Pharmaceuticals. ECCO 2000 Study of citicoline for treatment of acute ischemic stroke: Effects on infarct volumes measured by MRI. Stroke, 31:278, 2000.

Watson, C, Fuerst, D, Erg, T, Hayman-Abello, B, Shah, J, Shah, A, Adams, K, Poore, Q. Effects of age at onset and duration of seizure disorder on severity of hippocampal sclerosis and cognitive dysfunction in TLE. Ann Neurol, 48:463,2000.

Watson, C, Fuerst, D, Poore, Q, Shah, J, Shah, A, Hutchinson, A, Johnson, R, Canady, A, Chugani, HT. Is hippocampal sclerosis (HS) a progressive disorder? Epilepsia, 41(Suppl 7):68, 2000.

Whitty, JE, Lee, M, Shah, A, Kruger, M, Cotton, DB. Eclampsia - A modern inner city experience. J Soc Gyn Invest, 7:295A, 2000.

Wrensch, M, Weinberg, A, Wiencke, J, Miike, R, Kelsey, K, Barger, G.Prevalence of antibodies to four herpes viruses among adults with glioma and controls. Neuro-Oncology, 2:A238, 2000.

Wright, J, Shaw, Vincent, A, Maiese, K. Trophic factor protection against ischemic neurodegeneration is mediated by the regulation of genomic DNA transcription. Stroke, 30:344, 2000.

Yap, CW, Rhoney, DH, Murry, KR, Lesperance, ME, Yap, J, Michael, DB, Coplin, WM. Results of implementing a multidisciplinary protocol favoring continuous infusion gastric feeding in a neurology/neurosurgery intensive care unit (NICU). Neurology, 54 (Suppl 3):A411, 2000

Yost, R, Ahmad, I, Lin, S-H, Zhang, Y, Miller, J, Maiese, K. Metabotropic glutamate receptors: Molecular protection against endothelial cell programmed cell death. Soc Neurosci Abstr, 26: 504, 2000.

Zamorano, L, Elkhatib, E, Wood, G, Baynes, R, Barger, G, Parez de la Torre, R, Sloan, A, Kozlo, S. Feasibility and initial experience in immune therapy of malignant brain tumors. Congress of Neurological Surgeons Annual Meeting Poster Program Book. A364, 2000.

Zhang, Y, Lin, SH, Miller, J, Wu, R, Reeves, SA, Maiese, K. Peptide growth factors invoke the activation of the tyrosine phosphatase SHP2 during neuronal programmed cell death. Soc Neurosci Abstr, 26:781, 2000.

Zhai, H, Chaturvedi, S. Coagulation abnormalities and cardiac findings in patients with Sneddon’s syndrome. Cerebrovasc Dis, 10 (Suppl 2):18, 2000.

Zhai, H, Chaturvedi, S. Delay in the diagnosis of Sneddon’s syndrome. J Stroke Cerebrovasc Dis, 9:203, 2000.

Zvartau-Hind, M, D’Olhaberriague, L, Chaturvedi, S. Mechanisms of ischemic stroke in young African American and Caucasian patients. Stroke, 31:320, 2000.

Abstracts In Press
Chaturvedi, S, Raman, R, Leurgans, S, Gorelick PB. Are African American stroke patients receiving appropriate carotid ultrasound exams? Stroke (in press).

Chaturvedi, S, Joshi, N, Coplin, WM. Poor prognosis of patients with early CT change. J Neuroimaging, (in press).

Chaturvedi, S, Levine, S. Utility of venous ultrasound in patients with patent foramen ovale and cryptogenic stroke. J Neuroimaging (in press).

Coplin, WM, Rhoney, DH, Johnson, SL, Johnson, RR II, Zafonte, RD, Levine, SR. National survey of the use of anticonvulsant prophylaxis after aneurysmal subarachnoid hemorrhage: interim findings. J Neurosurg (in press).

Coplin, WM, Cochran, MS, Levine, SR, Crawford, SW. Stroke after bone marrow transplantation: frequency, etiology, and outcome. Stroke (in press).

Fuerst, D, Watson, C, Poore, Q, Hayman-Abello, B, Ergh, T, Hutchinson, A, Mast, B, Hayman-Abello, S, Yamamoto, A, Adams, K. Lateralizing TLE and HS using Wada memory scores and WMS-R LM and VR subtests. J Int Neuropsychol Soc (in press).

Grunberger, G, Qiang, X, Mathews, ST, Li, Z-G, Sima, AAF, Sbrissa, D, Shisheva, A. C-peptide stimulates glycogen synthesis via a Wortmannin-sensitive and Akt-independent pathway. Diabetes (in press).

Guyot, AM, Schuster, A, Daley, S, Ottney-Schweiss, C, Skolnik, S, Jacobs, BS, Lewandowski, CA, Levine, SR. Will your stroke be treated in Detroit? Stroke (in press).

Maiese, K, Lin, SH, Vincent, A. Membrane asymmetry and genomic DNA cleavage employs nitric oxide induced cysteine protease activity and endonuclease gene induction. First International Symposium on HO/CO (in press).

Maiese, K, Lin, SH., Chong, ZZ, Walraven, T. SHP2 tyrosine phosphatase is a molecular checkpoint for trophic factor protection against programmed cell death. J.Cereb. Blood Flow Metab (in press).

Maiese, K, Lin, SH, and Chong, ZZ. The metabotropic glutamate receptor system: A novel pathway for the molecular protection against microvascular programmed cell death. Proceedings of Brain Activation and CBF Control (in press).

Qiang, X, Srinivas, PR, Mathews, ST, Riedel, H, Sima, AAF, Grunberger, G. C-peptide stimulates glycogen synthesis in L6 myoblasts. J Diab Comp (in press).

Rhoney, DH, Murry, KR, Yap, CW, Coplin, WM. Tolerability of bolus versus continuous gastric feeding in brain injured patients. Crit Care Med (in press).

Sima, AAF, Sugimoto, K, Zhang, W-X, Pierson, C, Murakawa, Y. Nodal and paranodal structural and molecular changes in type1 diabetic neuropathy are preventable by C-peptide. J Neuropath Exp Neurology (in press).

Sugimoto, K, Zhang, W-X, Xu, G, Sima, AAF. Localization of insulin receptor isoforms in rat peripheral nerve. J Diab Comp (in press).

Xu, G, Jiang, HY, Shy, ME, Sima, AAF. Delayed initiation of regeneration in diabetic nerve is preceeded by attenuation of immediate early gene responses. J Diab Comp (in press).

Zhang, W-X, Sima, AAF. The effect of C-peptide on cell growth in human neuroblastoma cells with and without insulin and IGF-1. J Diab Comp (in press).

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research