Annual Report

2000-2001

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Features:
Letter from the Dean

Academia and Industry Working Together for Biomedical Advances

WSU Considered Model Program in Prenatal Genetic Analysis

WSU Gets Early Access to Corning Technologies

Dr. Joan Dunbar:  Research Matchmaker

Best Oncology Practices Standardized by Innovative Solutions

Freezing the Deadly Spread of Cancer

Combining Technology and Expertise to Discover New Genes in Epilepsy

General Motors Supports Prevention Program

Cell Therapy Center Advances Immunotherapies for Clinical Application

Robust Partnerships Aid Development of Cancer Vaccines

The Year in Review

Neurological Surgery

Chair: Fernando G. Diaz, MD, PhD
6E University Health Center
(313) 745-4661

Articles, Patents and Intellectual Property
Barami K, Diaz FG:  Cellular transplantation and spinal cord injury.  Journal of  Neurosurgery; Vol 47, No 3 pp 691-700; 2000.Tipps LB,

Coplin WM, Murry KR, Rhoney DH; Safety and feasibility of continuous infusion of remifentanil in the neurosurgical intensive care unit. Neurosurgery 46:596-602, 2000.

Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD; Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med 161:1530-1536, 2000.

Rhoney DH, Tipps LB, Murry KR, Basham MC, Michael DB, Coplin WM; Anticonvulsant prescription and timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology 55:258-265, 2000.

D’Olhaberriague L, Joshi N, Mitsias P, Coplin W, Lewandowski CA, Patel SC, Chaturvedi S, Levine SR; Tissue plasminogen activator for acute ischemic stroke in patients with unruptured cerebral aneurysms. J Stroke Cerbrovasc Dis 9:181-184, 2000.

Rebuck JA, Murry KR, Rhoney DH, Michael DB, Coplin WM; Infection related to intracranial pressure monitors in adults: analysis of risk factors and antibiotic prophylaxis. J Neurol Neurosurg Psychiatry 69:381-384, 2000.

Coplin WM; Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale and protocol for a randomized clinical trial. Neurol Res - in press.

Joshi N, Chaturvedi S, Coplin WM; Poor prognosis of acute stroke patients denied thrombolysis due to early CT findings. J Stroke Cerbrovasc Dis – in press.

Coplin WM, Cochran MS, Levine SR, Crawford SW; Stroke after bone marrow transplantation: frequency, etiology, and outcome. Brain – in press.

Allison, JD, Melzer, P, Ding, YC., Bonds, AB, and Casagrande, VA (2000) Differential contributions of parallel pathways to primate visual cortex. Visual Neuroscience. 17: 76-86.

Lai Q, Ding YC,  Erbaugh J: Motor timing performance and learning: A developmental effect.  Research Quarterly for exercise and Sport, 71, S31., 2000.

Lai Q, Ding YC, Erbaugh SJ, Canady AI:  Motor learning impairment of shunted hydrocephalic children. Journal of Sport and Exercise Psychology, 22, S71, 2000.

Ding Y, Yao B, Lai Q, McAllister JP:  Impaired motor learning following traumatic brain injury in the rat.  Neurological Research Special issue on Neurotrauma (In press).

Ding Y, McAllister JP, Yao B, Yan N,  Canady AI:  Neuron Tolerance during Hydrocephalus. Neuroscience (In press).

Ding Y, Lai Q, McAllister JP, Canady AI:  Impaired motor learning in children with hydrocephalus. Pediatric Neurosurgery (In press).

Ding Y, McAllister JP, Yao B, Yan N, Canady AI:  Axonal Damage Associated with Enlargement of Ventricles during Hydrocephalus: A Silver Impregnation Study.  Neurological Research. (In press).

Abdolvahabi RM, Mitchell JA, Diaz FG, McAllister JP II:  Effects of Chronic Hydrocephalus on the Gonadotropin Releasing Hormone System: Implications for Amenorrhea and Precocious Puberty.  Neurological Research, 22: 123-126, 2000.

Kriebel RM, McAllister JP II:  The Pathology of the Hippocampus and Basal Forebrain Nuclei in Experimental Hydrocephalus.  Neurological Research, 22: 29-36, 2000.

McAllister JP II: Hydrocephalus Enters the New Millennium. Neurological Research, 22: 2-3, 2000.

Fessler RD, Ringer AJ, Qureshi AI, Guterman LR, Hopkins LN: Intracranial stent placement to trap an extruded coil during endovascular aneurysm treatment: Technical note. Neurosurgery 46:248-53, 2000

Qureshi AI, Suri MFK, Shatla AA, Ringer AJ, Fessler RD, Ali Z, Guterman LR, Hopkins IN: Intraarterial Recombinant Tissue Plasminogen Activator for Ischemic Stroke: An Accelerating Dosing Regimen, Neurosurgery 47:473-479, August 2000

Ringer AJ, Fessler RD, Qureshi AI, Guterman LR, Hopkins LN: Angioplasty for Arterial Occlusion Resistant to Thombolysis in Acute Stroke. J Neurosur 92:211, 2000

Qureshi AI, Suri MFK, Khan J, Fessler RD, Guterman LR, Hopkins LN:  Abcixmab as an Adjunct to High-Risk Carotid or Vertebrobasilar Angioplasty:  Prelimary Experience.  Neurosurgery 46:1316-1325, June 2000.

Qureshi AI, Suri MFK, Shatla AA, Ringer AJ, Fessler RD, Ali Z, Guterman LR, Hopkins LN:  Intraarterial Recombinant Tissue Plasminogen Activator for Ischemic Stroke:  An Accelerating Dosing Regimen.  Neurosurgery 47:473-479, August 2000.

Ringer AJ, Fessler RD, Qureshi AI, Guterman LR, Hopkins LN:  Angioplasty for Arterial Occlusion Resistant to Thrombolysis in Acute Stroke (abstr). J Neurosurg 92:211, January 2000.

Ringer AJ, Fessler RD, Qureshi AI, Guterman LR, Hopkins LN: Horner’s Syndrome After Carotid Artery Stenting: Case Report, Surg Neurol (in press, 2000).

Fessler RD, Wakhloo AK, Lanzino G, Guterman LR, Hopkins LN: Transradial approach for vertebral artery stenting: Technical report. Neurosurgery: In press, 2000.

Park HK,  Dujovny M, Lee JB, Basse E, Diaz FG: Impact simulation on pre-formed prosthesis for large cranial defect, Biomedical Sciences Instrumentation ; Vol. 36:269-73, 2000.

Park HK,  Dujovny M,  Park T, Diaz FG: Application of Finite Element Analysis in Neurosurgery, Child’s Nervous System, 17, pp87-96, 2001.

Caragine, LP, Galaniuk, A, Rogers, AB, Kuldjanov, D, Michael, DB, Coplin, WM: Anticonvulsant prophylaxis and timing of seizures after aneurysmal subarachnoid hemorrhage.  Neurology 55: 258-265, 2000.

Caragine, LP., Galaniuk, A, Rogers, AB, Kuldjanov, D, Michael, DB: Computer assisted design (CAD), pre-cast craniofacial reconstruction using boneSourceŇ osteoconductive bone substitute material.  Accepted Neurological Research. 

Cummings, TJ, Johnson, RR, Diaz, FG, Michael, DB:  The relationship of blunt head trauma, subarachnoid hemorrhage, and rupture of pre-existing intracranial saccular aneurysms.  Neurological Research 22(2)165-170, 2000.

Rebuck, JA, Murry, KR, Coplin, WM, Michael, DB, Rhoney, DH: Intracranial pressure (ICP) monitoring infection in adult neurosurgical patients: analysis of risk factors and antibiotic prophylaxis. J. Neurol Neurosurg Psych, 69:381-384, 2000.

Rhoney, DH, Tipps, LB, Murry, KR, Basham, MC, Michael, DB, Coplin, WM: Anticonvulsant Prophylaxis and timing of seizures after aneurysmal subarachnoid hemorrhage.  Neurology, 55:258-265, 2000. 

Pisarev VM, Parajuli P, Mosley RL, Sublet J, Kelsey L, Sarin PS, Zimmerman DH, Winship MD, Talmadge JE.  Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine.  Int. J. Immunopharmac, 22(11):865-876, 2000.

Robinson S, Mosley RL, Parajuli P, Pisarev V, Sublet J, Steffel A, Ulrich A, Talmadge JE.  Comparison of the Hematopoietic  Activity of Flt3 Ligand (FL) and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Acting Alone, or in Combination. J. Hematother  Stem Cell  Res, 9(5):711-720, 2000.

Barami K, Rengachary SS: Atlas Fractures. Contemporary Neurosurgery 22:2, 2000.

Rengachary SS: Suprascapular entrapment neuropathy. Techniques in Neurosurgery, 6:14-18, 2000.

Devlin JW, Coplin WM, Murry KR, Rengachary SS, Wilson RF: Nimodipine-induced Acute Hypoxemia: Case Report. Neurosurgery 47:1243-1248, 2000.

Sloan, AE, Sundrum H, Zamorano L, Diaz F, Baynes R & Wood G:   Vaccination of Patients with Recurrent Malignant Astrocytoma with Autologous Whole Cell Vaccine and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF).   Neurosurgical Focus 9 (6): Article 9 1-8, 2000.

Dohmen BM, Shield AF, Grierson J, Kuntzsh M., Sloan AE, Reimold M, Machulla H-J, and Bares R.   [F-18]FLT-PET in Brain Tumors.   Journal of Nuclear Medicine (in press).

Ramiro Perez-de la Torre MD, Lucia Zamorano MD Dr Med, George England MD, Paul Chuba, MD PhD, Fernando Diaz MD PhD: Gamma Knife Radiosurgery for Trigeminal Neuragia, 2000.

Vinas F, Zamorano L, Gaspar L, Matter A, Shamsa F, Diaz FG: Permanent I-125 interstitial radiation therapy in the treatment of non-GBM high grade gliomas.  Journal of Radiosurgery;  Vol 3:3, pp 91-98, 2000.

Zamorano L, Vinas F,  Chuba P, Matter A, Gaspar L, Portillo G, Shamsa F, Diaz F: Permanent Iodine-125 Implants in the Treatment of Low-Grade Gliomas, Journal of Radiosurgery, Vol.3, No.3, pp 147-154, 2000.

Guyot LL, Diaz FG, O’Regan MH, Song D, Phillis JW:  Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.  Hormone and Metabolic Research 2000; 32: 6-9.

Guyot LL, Kazmierczak CD, Michael DB; Adult rhombencephalosynapsis.  Case report.  J Neurosurg. 2000 Aug; 93(2):323-5.

Guyot LL, Diaz FG, O’Regan MH, Song D, Phillis JW; The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.  Brain Res. 2000 Jul 28; 872(1-2):29-36.

Guyot LL, Diaz FG, O’Regan MH, Song D, Phillis JW:  The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.  Neurosci Lett. 2000 Jul 7; 288(1):61-5.

Guyot LL, Diaz FG, O’Regan MH, Song D, Phillis JW:  Topical insulin and accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.  Proc Soc Exp Biol Med. 2000 May; 224(1):28-31.

Guyot LL, Michael DB:  Post-traumatic hydrocephalus.  Neurol Res. 2000 Jan; 22(1):25-8.  Review.

Romeike BF, Diaz FG, Mathog R, Michael DB:  An unusual subdural empyema: case report.  Neurol Res. 2000 Sep; 22(6):597-600.

Lesley WS, Kupsky WJ, Guthikonda M:  Intravascular papillary endothelial hyperplasia arising within a posteroinferior cerebellar artery aneurysm: case report and review of the literature.  Neurosurgery.2000 Oct; 47(4):961-5; discussion 955.  Review.

Panigrahi M, Vinas FC, Guthikonda M:  Endoscopic third ventriculostomy:  outcome analysis of 100 consecutive procedures.  Neurosurgery. 2000 Jun; 46(6):1534-5. 

Asano E, Chugani DC, Muzik O, Shen C, Juhasz C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson C, Chugani HT.  Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis.  Neurology, Volume 54, pp1976-1984, 2000.

Barami K, Sood S, Ham SD, Canady A.  Postural Changes in intracranial pressure in chronically shunted patients. Pediatric Neurosurgery, Volume 33, pp64-69, 2000.

Gilmer-Hill H, Kline DG.  Neurogenic tumors of the cervical vagus nerve.  Neurosurgery, Volume 46, pp1498-1503, 2000. 

Gilmer-Hill H, Boggan JE, Ellis WG.  Spinal oligodendroglioma with leptomeningeal gliomatosis in a child.  Journal of Neurosurgery, Volume 92, pp109-113, 2000.

Koo BK, Ham S, Canady A, Beierwaltes P.  Eeg synchronization of epileptiform activity in patients implanted with vagal nerve stimulator (vns) results in favorable seizure control.  Neurology, Volume 54, ppA131-134, 2000. 

Ralph K, Moylan P, Canady A, Simmons S:  The effects of multiple shunt revisions on neuropsychological functioning and memory.  Neurol Res. 2000 Jan.; 22 (1): pp 131-6.

Muzik O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, Canady A, von Stockhausen HM, Herholz K, Gates J, Frost M, Ritter F, Watson C, Chugani HT.  Intracranial eeg versus flumazenil and glucose pet in children with extratemporal lobe epilepsy.  Neurology, Volume 54, pp171-179, 2000.

Sood S, Canady A, Ham S.  Evaluation of shunt malfunction using shunt site reservior.  Pediatric Neurosurgery, Volume 32, pp179-185, 2000.

Sood S, Canady A, Ham S.  Surgery for choroid plexus papilloma in children.  Neurosurgical Operative Atlas, Volume 9, pp83-89, 2000.

Panigrahi M, Vinas FC, Guthikonda: Endoscopic third ventriculostomy: outcome analysis of 100 consecutive procedures.Neurosurgery. 2000 Jun;46(6):1534-1535.

Lesly WS, Guthikonda  M: Intravascular papillary endothelial hyperplasia: case report and review of literature. Neurosurgery. 2000 Oct;47(4):961-5; discussion 966. Review.

Books, Chapters and Reviews
Coplin WM: Review of "Critical Care Neurology." Arch Neurol 56:757, 2000.

Coplin WM. Elective trepanation for acute epidural hematoma by Dr. Nicolaes Tulp (1593-1674) [comment]. Neurosurgery - in press.

Coplin WM, Rengachary SS. Neurologic emergencies: coma. In del Sol Carrasco Jimenez M, de Paz Cruz A, del Aguila F. (eds.): Resuscitation and Emergency Medicine - in press.

Diaz FG,  Guthikonda M, Velardo B, Gordon V, Lazo, A: Intracranial angioplastic techniques, Techniques in Neurosurgery, ed Lippincott Williams & Wilkins, Inc., Philadelphia; 2000, Vol.6, No 2, pages 139-151.

Fessler RD, Diaz FG :  Carotid Endarterectomy.  In: Operative Neurosurgery ed. Kaye & Black. Churchill-Livingstone. (2000).

Fessler RD, Qureshi AI, Ringer A, Guterman LR, Hopkins LN : Carotid Artery Stenting: Patient Selection, Complications, and Periprocedural Considerations, in Veith FJ and Amor M (eds): Endovascular Therapies: Current Status of Carotid Bifurcation Angioplasty and Stenting, New York: Marcel Dekker, Inc. (in press, 2000).

Guterman LR, Fessler RD, Hopkins LN: Cervical Carotid Revascularization. Neurosurg Clin N Am. 11:39-48, January 2000.

Fessler RD, Guterman LR, Hopkins, LN: Carotid Artery Stenosis: Medical Surgical and Endovascular Approaches.  Techniques in Vascular and Interventional Radiology 3:71-74, June 2000.

Fessler RD, Guterman LR, Lanzino G, Gibbons KJ: Vertebroplasty, in Rengachary SS (ed): Operative Atlas of Neurosurgery, American Association of Neurological Surgeons, pp 33-240, 2000.

Lanzino G, Fessler RD, Guterman LR, Hopkins LN: Neuroendovascular Surgical Procedures for Extracranial Cerebrovascular Disease, in Harbaugh R, Batjer HH, Loftus C (eds): Textbook of Neurological Surgery.  Philadelphia, Lippincott Williams & Wilkins. (In press, 2000).

Lanzino G, Fessler RD, Mericle RA, Wakhloo AK, Guterman LR, Hopkins LN: Angioplasty and stenting for Carotid Artery Stenosis.  Indications, Technique, Results, and Complications.   Neurosurgery Quarterly 10 (2):83-99, June 2000.

Zamorano L, Perez R, Li QH: Stereotactic Volumetric Resection of Malignant Gliomas. Neurosurgical Atlas Vol 9, Edit by Setti Rengachary. Page 113-122, 2000.

Abdolvahabi R, Michael DB: Penetrating Injuries (Invited Review), Neurological Research, In press.

Dutcher S, Michael DB: Gene Expression in Neurotrauma (Invited Review) Neurological Research, In press

Guyot LL, Michael DB: Post-traumatic hydrocephalus (Invited) Neurological Surgery, 2000; 22:1 pp 25-28. 

Michael DB: Neurotrauma Today (Invited Editorial) Neurological Surgery, In press.

Michael DB: Intracranial Hypertension in Saunders Manual of Critical Care, Edited by Richard Carlson, James Kruse, and Mitchell Frank.  In press

Michael DB: Intracranial Pressure Monitoring in Saunders Manual of Critical Care, Edited by Richard Carlson, James Kruse, and Mitchell Frank.  In press

Caragine LP, Kelly JK, Michael DB, Johnson RR,  Diaz FG: Bilateral atlantoaxial rotatory dislocation.  Neurological Research. In Press.

Guyot LL, Kasmciek C, Michael DB: Adult rhomboencephalosynapsis.  Journal of Neurosurgery 93:323-325, 2000. 

Romeike BFM, Diaz FG, Mathog R, Michael DB: An unusual subdural empyema: case report. Neurological Research, In Press.

Rengachary SS, Editor; Neurosurgical Operative Atlas, Volume 9, American Association of  Neurological Surgeons; 2000

Raghavan R, Krumerman J, Rushing EJ, White CL, Chason DP, Watson ML, Coimbra C: Recurrent (non-familial) hemangioblastomas involving spinal nerve roots: case report. Comments by Rengachary SS. Neurosurgery 47:1443-1448, 2000.

Rengachary SS, editor. Neurosurgical Operative Atlas Volume IX. American Association of Neurological Surgeons, in press.

Rengachary SS, Alton SM: Resuscitation and early medical management of the spinal cord injury patient. In: Contemporary Management of Spinal Cord Injury, Second Edition. Benzel EC and Tator CH, editors. American Association of Neurological Surgeons, Illinois, in press.

Guyot LL and Rengachary SS:  Compressive Lesions in the Peripheral Nerves. In: Atlas of Neurosurgical Techniques. Fessler RG, editor. Thieme Medical and Scientific Publishers, New York, in press.

Sloan AE, reviewer; Immunotherapy of  Malignant Gliomas.   ABTA News (in press)

Sloan AE, Perez R,  Diaz FG:  Stereotactic Approaches for the Treatment of Metastatic Brain Tumors.  In Neurosurgery Operative Color Atlas, (S. Rengachary, Ed.), Williams and Wilkins, New York,  2000.

Sloan AE, Krauss M;  Treatment of Metastatic Sarcoma of the Brain.   In Treartment of Metastatic Brain Tumors, (R. Sawaya, Ed.), Williams and Wilkins, Baltimore 2000 (in press).

Zamorano L, Vinas F, Chuba P, Matter A, Gaspar, L, Portillo G, Shamsa F, Diaz F: Permanent Iodine-125 Implants in the Treatment of Low-Grade Gliomas. Journal of Radiosurgery, Vol. 3, No. 3, 2000, pp 147-154

Abstracts, Letters to the Editor and Articles in Non‑Refereed Journals
Vinas FC, Kazmierczak C, Coplin WM. Active intracerebral hemorrhage from the lateral posterior choroidal artery. Arch Neurol 57: 889-890, 2000.

Devlin JW, Coplin WM, Rengachary SS, Wilson RF. Nimodipine-induced acute hypoxemia: case report. Neurosurgery. Neurosurgery 47:1243-1247, 2000.

Rhoney DH, Somerville AL, Coplin WM. Status epilepticus: cost burden at an urban medical center. Crit Care Med 27:A44, 2000.

Rhoney DH, Somerville AL, Coplin WM. Physician specialty and cost variation in the treatment of status epilepticus at an urban medical center. Crit Care Med 27:A46, 2000.

Devlin JW, Coplin WM, Swarczinski C, Leacock RO, Lewis RA, Kruse JA. Accuracy of train-of-four assessment for ICU patients receiving continuous neuromuscular blockade. Crit Care Med 27:A72, 2000.

Devlin JW, Coplin WM, Swarczinski C, Leacock RO, Lewis RA, Kruse JA. Reliability of nursing train-of-four assessment for ICU patients receiving continuous neuromuscular blockade. Crit Care Med 27:A131, 2000.

Coplin WM, Mujawar AH. "A day in the life": two years experience of a physician's acute stroke call. Neurology 54:A302, 2000.

Rhoney DH, McAllen KJ, Murry KR, Coplin WM. Prescribing practices of antihypertensive agents in patients with ischemic stroke: impact on patient outcome. Neurology 54:A376, 2000.

Murugappan A, McAllen KJ, Coplin WM, King JJ, Redman ME, Schwamm LH, Wechsler L, Saver JL, Broderick JP, Smoot K, Rordorf G, Starkman S, Duckwiler G, Tietjen GE, Levine SR: Thrombolytic therapy for acute ischemic stroke during pregnancy. Neurology 54:A390, 2000.

Yap CW, Rhoney DH, Murry KR, Lesperance ME, Yap J, Michael DB, Coplin WM:  Results of implementing a multidisciplinary protocol favoring continuous infusion gastric feeding in a neurology/neurosurgery intensive care unit (NICU). Neurology 54:A411, 2000.

Vinas FC, Gorman MJ,  Rengachary SS, Coplin WM, Dujovny M, Michael DB:  Clinical evaluation of a ventriculostomy with a microimplantable strain gauge sensor. 50th Annual Meeting of the Congress of Neurological Surgeons, 2000. pp 56.

Chaturvedi S, Joshi N, Coplin WM:  Poor prognosis of patients with early CT change. J Neuroimaging, 2000 - in press.

Qureshi AI, Suri MFK, Khan J, Fessler RD, Guterman LR, Hopkins LN: Abcisimab as an Adjunct to High Risk Carotid or Vertebrobasilar Angioplasty: Preliminary Experience (Abstract P 142) Stroke 31:325, June 2000.

Ringer AJ, Fessler RD, Qureshi AI, Guterman, LR, Hopkins LN: Angioplasty for Arterial Occlusion Resistant to Thrombolysis in Acute Stroke (abstr). J Neurosurg 92:211, January 2000.

Qureshi AI, Suri MFK, Khan J, Fessler RD, Guterman LR, Hopkins LN:  Abcixmab as an Adjunct to High Risk Carotid or Vertebrobasilar Angioplasty:  Prelimary Experience (Abstract P142). Stroke 31:325, February 2000.

Ringer AJ, Fessler RD, Qureshi AI, Guterman LR, Hopkins LN:  Angioplasty for Arterial Occlusion Resistant to Thrombolysis in Acute Stroke (abstr). J Neurosurg 92:211, January 2000.

Fessler RD, Guterman LR, Qureshi AI, Ringer A, Wakhloo AK, Hopkins LN: Endoluminal Reconstruction of Basilar Artery Fusiform Aneurysms (abstr). J Neurosurg 92:205, January  2000.

Ringer AJ, Fessler RD, Qureshi AI, Guterman LR, Hopkins LN: Angioplasty for arterial occlusion resistant to thombolysis in acute stroke. J Neurosurg 92:211, 2000.

Fessler RD, Guterman LR, Qureshi AI, Ringer A, Wakhloo AK, Hopkins LN: Endoluminal recontruction of basilar artery fusiform aneurysms. J Neurosurg 92:205, 2000.

Fessler RD, Wakhloo AK, Lanzino G, Lieber BB, Guterman LR, Hopkins LN. Altered intraaneurysmal flow patterns after stenting. AANS, San Francisco, CA, April 8-13, 2000; pp39.

Fessler RD, Guterman LR, Qureshi AI, Ringer AJ, Wakhloo AK, Hopkins LN. Endoluminal Reconstruction of Basilar artery Fusiform Aneurysms. AANS, San Francisco, CA, April 8-13, 2000; pp 27.

Fessler RD, Wakhloo AK, Lieber BB, Miskolczi L, Hopkins LN. Hemodynamic Changes in Canine Bifurcation Aneurysms Following Stenting: Preliminary Report AANS, San Francisco, CA, April 8-13, 2000; pp 27.

Fessler RD, Wakhloo AK, Stancampiano AP, Gounis MJ, Lieber BB, L Miskolczi, LN Hopkins: Hemodynamic Changes in Canine Bifurcation Aneurysms Following Stenting: Preliminary Report AANS, San Francisco, CA, April 8-13, 2000; pp 27.

Fessler RD, AI Qureshi, AJ Ringer, LR Guterman, LN Hopkins. Endovascular Stent Placement to Trap an Extruded Guglielmi Detachable Coil (GDC) after Aneurysm Coiling: Case Report. AANS, San Francisco, CA, April 8-13, 2000; pp 48.

Fessler RD, Qureshi AI, Ringer AJ, Guterman LR, Lieber BB, Hopkins LN: Treatment of Intracranial disease with Endovascular Stents (abstr 815).  Neurosurgery 47:533, August 2000.

Fessler RD, Guterman LR, Qureshi AI, Ringer A, Wakhloo AK, Hopkins LN: Endoluminal Reconstruction of Basilar Artery Fusiform Aneurysms.  J Neurosurg 92:205, 2000

Park HK, Dujovny M,  Lee JB,  Diaz FG: The Application of Pre-formed Pellet Implant for Large Cranial Defect, Oral presentation at the 19th Southern Biomedical Engineering Conference, pp73, April, 2000.

Park HK, Dujovny M, Diaz FG:  Biomechanical Analysis of Pediatric Large Cranial Defect, Oral presentation at the 11th International Conference on Mechanics in Medicine and Biology, pp299-pp301, April, 2000.

Park HK, Dujovny M, Lee JB, Diaz FG:  Analysis of Pellet Implant for Cranioplasty, Oral presentation at the World Congress on Medical Physics and Biomedical Engineering, Medical Physics, Vol.27, No.6, pp1446, July 2000.

Li QH, Zamorano L, Gong JX, Pandya A,Diaz FG: The application accuracy of different registration methods in frameless computer assisted neurosurgery. The 68th Annual Meeting of The American Association  of Neurological Surgeons. April 2000; pp 125.

Pandya A, Li QH, Zamorano L, Perez-de la Torre R: The Application accuracy of the neuromate robot ---- a   quantitative comparison with frameless infrared and frame based surgical localization systems, COAS USA 2000, Pittsburg, Pennsylvania, June 15-17, 2000, pp 261.

Li QH, Zamorano L, Guthikonda M, Pandya A, Perez., Diaz FG: The application accuracy of intraoperative registration and related factors in image guided neurosurgery. Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp173.

Li QH, Zamorano L, Pandya A, Pittet P, Badano F:  The kinematic accuracy of surgical robots: accuracy evaluation of the neuromate system.   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 174.

Zamorano L, Li QH, Perez-de la Torre R,  Elkhatib E, Pandya A:   Clinical Implementation of robtic open neurosurgery: the beginning of a new era.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 158.

Zamorano ., Pandya A, Siadat M, Gong J, Li QH, Maida J.: Augmented reality for tele-operations. Bioastronautics Investigators’ Workshop January 17-19, 2001, p 26-27.

Pandya A., Siadat M., Gong J., Li Q., Zamorano L., Maida J:  Towards using augmented reality for neurosurgery. The 9th Annual Medicine Meets Virtual Reality Conference. January 24-27, Newport Beach, California. P 128-129.

Vaitkevicius H, Lockette W:  Verification of a model to estimate anion exchanger activity in intact platelets. FASEB J, 2000, 14(4):A352.

MacKenzie S, Lockette W:  Effects of clonidine and palmitate on glucose-induced insulin secretion from isolated islets in chloride free media. FASEB J, 2000, 14(4):A91.

Ding Y, Yao B, Lai Q, McAllister JP II, Diaz FG:  Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury.  Restorative Neurology and Neuroscience, 16: 220 (P185), 2000.

McAllister JP II, Abdolvahabi RM, Mitchell JA, Lawson DM, Diaz FG, Canady AI:  Ventricular shunting in an animal model of fetal-onset hydrocephalus – hypothalamic alterations and functional outcome. Restorative Neurology and Neuroscience, 16: 155 (P185), 2000.

Parajuli P, Pisarev V, Sublet J,  LaFace D,  Mosley L,  Talmadge JE:  A wild type p53 genetic vaccine co-administered with Flt3 ligand Induces a tumor-specific type 1 T-cell response. 91st Annual Meeting of American Association of Cancer Research, San Francisco, CA, April 1-5, 2000. Proceedings of AACR 41:796 (abstract No. 5062), 2000.

Pisarev VM, Parajuli P,  Mosley RL, Sublet J, Zimmerman D, Sarin P, Winship MD,  Talmadge, JE:  Enhanced immunogenecity of an HIV GAG peptide by conjugation wo MHCIIb2 or IL-1b epitopes is augmented, with type 1 T-cell responses, by Flt3 Ligand. Immunology 2000,Seattle, WA, May 12-16, 2000. FASEB J.14 (6): A943 (abstract No. 40.20), 2000.

Mosley RL, Parajuli P, Pisarev F,  Sublet J, Steffel A, Ulrich, A,. Talmadge, JE:  Flt3 Ligand augmentation of T cell function by selective expansion of dendritic cells and effector T cells. Immunology 2000,Seattle, WA, May 12-16, 2000. FASEB J.14 (6): A1051 (abstract No. 95.22), 2000.

Sloan AE, Anderson F, Asher A, Bernstein M, Chang S, Hartman L and Laws E.   Malignant Gliomas:  An Update of the Glioma Outcome Project.   J. Neuro-Oncology, 46: 267, 2000.

Sloan AE, Kabrossi B, Barger G, Zamorano L, Diaz F, Baynes R, and Wood G:   Vaccination of Patients with Recurrent Malignant Astrocytoma with Autologous Tumor and Granulocyte Macrophage Colony Stimulating Factor (GM-CSF).   J. Neuro-Oncology, 46:270, 2000.

Sloan AE, Abella E, Chuba P, Bhambhani K, Baynes R, and Wood G.   New Therapeutic Approaches for Recurrent Malignant Gliomas in Infants and Small Children:  Peripheral Stem Cell Transplantation Followed by Cellular Immunotherapy.  J. Neuro-Oncology, 46: 272, 2000.

Torre de la Perez, R, Zamorano, L, England G, Diaz FG:  Radiosurgical treatment of trigeminal neuralgia: the Wayne State University experience.  American Association of  Neurological Surgeons Annual Meeting (AANS), San Francisco, California, April 8-13, 2000; pp 92.

Li QH, Zamorano L, Gong J, Pandya A, Diaz, FG:   The application accuracy of different registration methods in frameless computer-assisted surgery.  American Association of Neurological Surgeons Annual Meeting (AANS), San Francisco, California, April 8-13, 2000; pp 125.

Torre, R,  Zamorano L, Elkhatib E, Gasper L, Shamsa F, Fontanesi F,  Ezzel G, Yakar G, Kozlo S, Diaz FG:  Permanent iodine implant for recurrent malignant gliomas.   American Association of Neurological Surgeons and Congress of Neurological Surgeons (AANS/CNS Section on Tumors): San Francisco, California, April 13-14, 2000; pp 120.

England G,  Zamorano L,  Sloan A, Gaspar L,  Maki H,  Diaz FG:  Gamma knife treatment of brain metastases.  American Association of Neurological Surgeons and Congress of Neurological Surgeons (AANS/CNS Section on Tumors): San Francisco, California, April 13-14, 2000; pp 120.

Zamorano L, Elkhatib E,  Perez-de la Torre R,  Shamsa F,  Kozlo S, Diaz FG:  Brachytherapy with I125 implants in the up-front management of non-GBM malignant gliomas:  American Association of Neurological Surgeons and Congress of Neurological Surgeons (AANS/CNS Section on Tumors): San Francisco, California, April 13-14, 2000; pp 120.

Perez-de la Torre R,  Zamorano L, England G, Diaz FG: Correlation between anatomical functional areas and neurological outcome in brain lesion resection: results in 315 patients with awake craniotomy. (AANS)  San Francisco, California, April 8-13, 2000; (Poster) pp128.

Zamorano L, Elkhatib E,  Perez-de la Torre R,  Shamsa F,  Kozlo S, Diaz FG:  Brachytherapy with iodine-125 permanent implants in the up-front management of non-glioblastoma multiforme malignant gliomas,.  (AANS) San Francisco, California, April 8-13, 2000; (Poster) pp 185.

Perez-de la Torre R, Zamorano L, Gaspar L,  Shamsa F,  Kozlo S, Diaz FG:  Brachytherapy with iodine-125 implants in the up-front management of primary glioblastoma multiforme.  (AANS) San Francisco, California, April 8-13, 2000; (Poster) pp 188.

Pandya A, Li QH,  Zamorano L, Perez-de la Torre R: The Application accuracy of the neuromate robot ---- a quantitative comparison with frameless infrared and frame based surgical localization systems.  COAS USA 2000, Pittsburg, PA, June 15-17, 2000, pp 261.

Elkhatib E, Zamorano L, Barger G, Wood G, Baynes R, Levin K, Perez-de la Torre R, Kugelman S, Diaz FG: Clinical experience of active and adoptive immunotherapy in malignant brain tumors.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 136.

Sloan A, Sundrum H, Zamorano L,  Diaz FG, Wood G:  Vaccination of patients with recurrent malignant astrocytoma with autologous whole cell vaccine and granulocyte macrophage colony stimulating factor (GM-CSF).   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 44.

Elkatib E, Zamorano L, Sloan A,  Wood G, Baynes R,  Barger G,  Levin K, Perez-de la Torre R, Kugelman S, Diaz FG:  Initial experience in cancer antigen specific adoptive immunotherapy in malignant brain tumor.   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 46.

Perez de-la-Torre R, Zamorano L, England G, Premsagar I, Elkhatib E, Li QH, Diaz FG: Interactive image-guided resection of cerebral cavernous angioma.   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 101.

Zamorano L, Elkhatib E, Wood G, Baynes R,  Barger G, Perez-de la Torre, Sloan A, Kozlo S: Feasibility and initial experience in immune therapy of malignant brain tumors.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 185.

England G, Zamorano L, Sloan A, Diaz FG:  MRI format standard for the evaluation of CNS metastasis.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 190.

England G, Zamorano L, Sloan A, Diaz FG: Gamma knife treatment of brain metastasis.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 191.

England G, Zamorano L, Sloan A, Diaz FG:  Use of the gamma knife for the treatment of recurrent glioblastoma (GBM).   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 207.

Perez de-la-Torre R,  Zamorano L,  ElKhatib E,  Fontanesi J,  Levin K,  Shama F, Kozlo S,  Diaz FG:  Brachytherapy with I-125 implants in the up-front management of primary glioblastoma multiforme.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 208.

Perez de-la-Torre R,  Zamorano L,  ElKhatib E, Tekyi Mena S,  Fontanesi J, Levin K,  Diaz FG: Brachytherapy implants with I-125 in recurrent non-GBM malignant gliomas, long-term follow-up.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 208.

Premsagar I,  Shamsa F, Diaz FG:  Interactive image guided surgery in malignant gliomas.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 209.

Zamorano L, Elkhatib E, Perez-de la Torre R, Shamsa F, Levin K,  Fontanesi J, Kugelman S, Diaz FG:  Brachtherapy with I-125 implants in the up-front managemetn of primary malignant non-GBM.  Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 210.

Premsagar I, Zamorano L, Elkhatib E, Perez R, Levin K, Fontanesi J, Shamsa F,  Diaz FG: Survival analysis following brachytherapy with I-125 implant in the treatment of recurrent glioblastoma multiforme. , Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp 224.

England G,  Zamorano L, Sloan A, Diaz FG: Gamma knife treatment outcomes of multiple brain metastasis by volume.   Congress of Neurological Surgeons Annual Meeting, September 23-28, 2000, San Antonio, Texas; pp229.

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

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2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

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