Annual Report

2000-2001

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Features:
Letter from the Dean

Academia and Industry Working Together for Biomedical Advances

WSU Considered Model Program in Prenatal Genetic Analysis

WSU Gets Early Access to Corning Technologies

Dr. Joan Dunbar:  Research Matchmaker

Best Oncology Practices Standardized by Innovative Solutions

Freezing the Deadly Spread of Cancer

Combining Technology and Expertise to Discover New Genes in Epilepsy

General Motors Supports Prevention Program

Cell Therapy Center Advances Immunotherapies for Clinical Application

Robust Partnerships Aid Development of Cancer Vaccines

The Year in Review

Internal Medicine

Chair:  John O’Connell
1 Webber South Harper Hospital
(313) 745-8241

Division of Cardiology
Articles

Cala, SE: GRP94 hyperglycosylation and phosphorylation in Sf21 cells. Biochim. Biophys Acta, 1496, 296-310, 2000.

Daher, E, Dione, DP, Heller, EN, DeMan, P, Shen, M, Hu, J, Sinusas, AJ.  Alteration in coronary flow reserve in remote nonischemic regions with increasing level of ischemic dysfunction in an acute canine model.  J Nucl Cardiol 2000;7:112-22

Fan, QI, Chen, B, Marsh, JD. Transcriptional regulation of L-type calcium channel expression in cardiac myocytes. J Molec Cell Cardiol 32:841-850, 2000

Golden, KL, Fan, QI, Chen, B, O’Connor, JRJ and Marsh, JD. Adrenergic stimulation regulates Na+/Ca2+ exchanger mRNA levels in rat cardiac myocytes. J Mol Cell Card 32: 611-620, 2000.

Golden, KL, Ren, J, O’Connor, J, DiCarlo, SE, Marsh, JD.  In vivo regulation of Na/Ca exchanger expression by adrenergic effectors.  Am J Physiol, in press, 2001

Golden, KL, Fan, QI, Chen, B, Marsh JD.  Adrenergic  stimulation regulates Na/Ca exchanger expression in cardiac myocytes.   J Molec Cell Cardiol 32:611-620, 2000

Golden, KL, Ren, J, O’ Connor, J, Dean, AR, Dicarlo, S and Marsh, JD.  In vivo effects of hypertrophic agents on Na+/Ca2+ exchanger expression in adult rat heart. Amer J Physiol 280: H1376-H1382, 2001.

Gordon, PR & Edwards, P.  Dyslipidemia in the Menopausal Patient.  Clinics in GYN Enco.  In press

Liu, L, Fan, QI, El-Zaru, MR, Vanderpool, K, Hines, RN, Marsh, JD. Regulation of DHP receptor expression by elements in the 5’ flanking sequence. Am J Physiol 278:H1153-H1162, 2000

Liu, L, O’Hara, DS, Poornima, I, Cala, SJ, Hines, RH, Marsh, JD. Developmental regulation of dihydropyridine receptor expression in heart. Molec Cell Bioch:205:101-109: 2000

Liu, L, O’Hara, D, Cala, SE, Poornima, I, Hines, RN, and Marsh, JD. Developmental regulation of dihydropyridine receptor expression in heart.  Mol Cell Biochem 188, 101-109, 2000.

Pandrangi, H, Lieberman, RA, Meissner, MD, Hill, M.  Differences in Inhibited versus triggered biventricular pacing:  Induction of ventricular arrhythmias in heart failure patients (PACE, 2000)

Rodriguez-Cruz, E, Karpawich, PP, Lieberman, RA, Tantengco, MV: Biventricular Pacing as Alternative Therapy for Dilated Cardiomyopathy Associated with Congential Heart Disease. PACE 2001: 24:XXX-XXX

Oh, SP, Seki, T, Goss, KA, Imamura, T, Yi, Y, Donahoe, PK, Li, L, Miyazono, K, ten Dijke, P, Kim, S, and Li, E (2000). Activin receptor-like kinase 1 modulates transforming growth factor-1 signaling in the regulation of angiogenesis. PNAS  97:2626-2631

Wynne, J, Wheeler, JRC, Smith DG:  Hospital financial management in the new millennium: Discussions with chief financial officers.  Health Affairs, 2001, in press.

Books, Chapters and Reviews
Artz, G, Wynne, J: Restrictive Cardiomyopathy. Current Treatment Options in Cardiovasular Medicine: 2:431-438, 2000.

Daher, E: Exercise and the heart.  Victor F. Froelicher and Jonathan N. Myers, editors. Philadelphia (PA): WB Saunders Company; 2000. 456 pages.  J Nucl Cardiol 2000;7:725-6

Lieberman, RA, Meissner, MD, Siddiqui, MA:  "Pulseless Electrical Activity".  In:Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors; W.B. Saunders Company, 2000, (Chap. 35) in press.

Lieberman, RA, Meissner, MD, Siddiqui, MA:  "Ventricular Fibrillation and Tachycardia".  In: Saunders Manual of Critical Care.  Kruse, JA, Carlson, RW, Fink, MP, Editors; W.B. Saunders Company, 2000, (Chap. 36), in press.

Marsh, JD. Dissolving blood clots during heart attacks. In State of the Heart, Stephenson LW and Rodengen JL, Ed, Write Stuff Enterprises, Ft. Lauderdale, Fl, 2000

Meissner, MD, Lieberman, RA, Siddiqui, MA:  "Conduction disturbances".  In:Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors; W.B.Saunders Company, 2000, (Chap 37), in press.

Meissner, MD, Lieberman, RA, Siddiqui, MA:  "Supraventricular Tachycardia". In: Saunders Manual of Critical Care, Kruse JA, Carlson RW, Fink MP, Editors; W.B. Saunders Company, 2000, (Chap. 34), in press.

Meissner, MD, Lieberman, RA:  "Electrophysiologic Testing to Identify Patients at Risk for Sudden Death" New England Journal of Medicine. 343 (24); 1813, 2000

Meissner, MD and Lieberman, RA:  Electrophysiologic testing to identify patients at risk for sudden death; (Letter); N Engl J Med 2000; 343: 1813

Meissner, MD and Lieberman, RA:  “Supraventricular Tachycardia”. In:  Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors, W.B. Saunders Company, 2000,  (Chap. 34), in press.

Meissner, MD, Lieberman, RA, Siddiqui, MA:  “Pulseless Electrical Activity”. In: Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors; W.B. Saunders Company, 2000,  (Chap. 35),in press.

Lieberman, RA and Meissner, MD:  “Ventricular Fibrillation and Tachycardia”. In: Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors, W.B. Saunders Company, 2000, (Chap. 36), in press.

Meissner, MD and Lieberman, RA:  “Conduction disturbances”. In: Saunders Manual of Critical Care.  Kruse JA, Carlson RW, Fink MP, Editors, W.B. Saunders Company, 2000, ( Chap. 37), in press.

Racine, E, Marsh, JD. Common drugs for heart patients. In State of the Heart, Stephenson LW and Rodengen JL, Ed, Write Stuff Enterprises, Ft. Lauderdale, Fl, 2000

Smith, DG, Wheeler, JRC, and Wynne, J: Financial Management in Michigan Hospitals & Health Systems: Discussions with Chief Financial Officers of Selected VHA Health Care Systems and Affiliates. White Paper, VHA Michigan, 2001.

Wynne, J: Miscellaneous Conditions of the Heart: Tumors, Trauma, and Systemic Disease, Cecil Textbook of Medicine, 21st Edition, L Goldman and JC Bennett (Editors), Philadelphia: W. B. Saunders, 372-374, 2000.

Wynne, J: Valvular Heart Disease, Office Practice of Medicine, W Branch (Editor), 4th Edition, Philadelphia: W.B. Saunders, 2001, in press.

Wynne, J and Braunwald, E: The Cardiomyopathies and Myocarditides:  Toxic, Chemical and Physical Damage to the Heart, Heart Disease, E Braunwald, D Zipes, P Libby (Editors), 6th Edition, Philadelphia: W.B. Saunders, 1751-1806, 2001

Abstracts, Letters to the Editor and Articles in Non-Referred Journals
Cala, S: Dual cellular pathways lead to GRP94 hyperglycosylation or phosphorylation on sites sensitive to cytosolic CK2.  Mol. Biol. Cell 11 (suppl), 419a, 2000

Dixon, SR, O’Neill, WW, Bartorelli, AL, David, SW, Spears, JR, Qureshi, MA, Grinberg, I, Pepi, M, Tabattoni, D, Fabbiocchi, F, Motorsi, P, Marcovitz, P.  Global and regional left ventricular function after intracoronary hyperoxemic perfusion with the aqueous oxygen system in acute myocardial infarction.  Circulation 102 (Suppl. II):  II-386, 2000.

Kronenberg, M, Cohen, GI, Mladsi, T, DiCarli, M. Myocardial oxidative metabolism is impaired in patients with nonischemic dilated cardiomyopathy.  To be presented at the American Heart Associate, 2000.

Marsh, JD, Antman, EA. T-type calcium channel blockade in the management of chronic ischemic heart disease. Cardiovascular Drugs and Therapy. 14:459-461, 2000

Marsh, JD. Phytoestrogens and vascular therapy.  J Am Coll Cardiol  35:1986-87, 2000

Pandrangi, H, Lieberman, RA, Meissner, MD, Hill, M.  Differences in Inhibited versus triggered biventricular pacing: Induction of ventricular arrhythmias in heart failure patients (PACE, 2000)

Spears, JR, Henney, C, Prcevski, P, Xu, R, Li, L, Brereton, GJ, Dicarli, M, Spanta, A, Crilly, RJ, Sulaiman, AM, Hadded, S, Lavine, S, Patterson, WR, Creach, J, vander Heide, R.  Reperfusion microvascular ischemia: attenuation with aqueous oxygen.  Circulation 102 (Suppl. II): II-646, 2000.

Division of Endocrinology
Articles
Cintron, VJ, Ko, MSH, Gross, JP, Chi, KD, Srinivas, PR, Goustin, AS, and Grunberger, G:  Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase:  The mouse ortholog of human  
a2-HS glycoprotein.  Int J of Exp Diabetes Research, in press.

Fitzgerald, JT, Gruppen, LD, Anderson, RM, Funnell, MM, Jacober, SJ, Grunberger, G, and Aman, LC: The influence of treatment modality and ethnicity on attitudes in type 2 diabetes.  Diabetes Care 23: 313-318, 2000.

Frank, RN, and Grunberger, G:  Cancer in a patient receiving IGF-1 therapy.  Diabetes Care 23: 435-436, 2000.

Grunberger, G, Dole, JF, and Freed, MI:   Rosiglitazone monotherapy significantly lowers HbA1c levels in treatment-naïve type 2  diabetic patients.  Diabetes 49; Suppl 1: A109, 2000

Kleerekoper, M.  Book Review on Atlas of Clinical Endocrinology:  Volum III Osteoporosis.  Journal of Bone and Mineral Research 15(5): 990, 2000.

Li, Z-G, Zhang, W, Grunberger, G, and Sima, AAF: C-peptide corrects IGF's and prevents apoptosis in type 1 BB/W-rat.  Diabetes 49; Suppl 1: A229, 2000.

Matthews, ST, Chellam, N, Srinivas, PR, Cintron, V, Leon, MA, Goustin, AS, and Grunberger, G:   a2-HS glycoprotein, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor.  Mol and Cell Endocrinology 164: 87-98, 2000.

Matthews, ST, Singh, GP, Qiang, X, Goustin, AS, Jahnen-Dechent, W, and Grunberger, G:  Mice null for Ahsg gene suggest a new physiological role for fetuin in insulin control of glucose homeostasis.  Diabetes 49; Suppl 1: A6, 2000.

Ladenson, PW, Singer, PA, Ain, KB, Bagchi, N, Bigos, ST, Levy, EG, Smith, SA, Daniels, GH.  American thyroid association guidelines for detection of thyroid dysfunction.  Archives of Internal Medicine 160:1573-1575, 2000.

Looker, AC, Bauer, DC, Chestnut III, CH, Grundberg, CM, Hochberg, MC, Klee, G, Kleerekoper, M, Watts, NB, Bell, NH:  <review article> Clinical Use of Biochemical Markers of Bone Remodeling:  Current Status and Future Directions.  Osteoporos Int 11(6): 467-480, 2000.

Victorina, WM and Grunberger, G:  Thiazolidinediones:  Finally treating the disease.  Practical Diabetology 19: 7-12, 2000.

Books, Chapters and Reviews
Kleerekoper, M:  Macadores Bioquimicos da Remodelacão  Óssea.  Osteoporose 1a  edição,  MEDSI Editora Médica e Científica Ltda.  pp 69-85, 2000.

Kleerekoper, M:  The Evaluation of the Patient with osteoporosis or at risk for osteoporosis.  Osteoporosis, 2nd edition R Marcus (ed).  Academic Press, San Diego, CA.  In Press 2000.

Bagchi, N:  Thyroid disorders in practical strategies in obstetrics and gynecology (ed:  S. B. Ransom et al), W. B Saunders, 2000, pp. 581-592.

Grunberger, G and Roth, J:  Insulin interaction with its specific receptor on target cells.  In:  Clinical Diabetes Mellitus JK Davidson (Editor), Thieme, New York,  pp 111-122, Third Edition, 2000.

Grunberger, G.:  Insulin Resistant Syndromes:  The role of the insulin receptor and its signal transduction pathways.  In:  Clinical Diabetes Mellitus  JK Davidson (Editor),  Thieme, New York, pp 123-140, Third Edition, 2000.

Grunberger, G:  Diabetes mellitus.  In:  Contemporary Therapy in Obstetrics and Gynecology, SB  Ransom, MP Dombrowski, MI Evans (Editors), WB Saunders, in press.

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Talpos, GB, Rao, DS, Bone, HG, Parfitt, AM, Kleerekoper, M, Alarm, M, Honasoge M, Divine, G:  Ramdomized trial of parathyroidectomy in mild, asymptomatic primary hyperparathyroidism as measured by the SF-36 health Survey.  2000

Vesper, HW, Demers, LM, Eastell, R, Garnero, P, Kleerekoper, M, Robins, SP, Srivastava, AK, Warnick, RG, Watts, NB:  Guidelines on preanalytical criteria for the measurement of pyridinoline and dexypyridinoline as bone resorption markers in urine.  Clin Chem 46(6) A37, 2000.

Hermann, ME, Wojcik, EM, Siziopikou, KP, Curry, J, Rydstedt, LL, Thomas, C:  FISH evaluation of archival specimens of pituitary and breast tissues for chromosome copy number and oncogene amplification.  National Pathology Conference, St. Louis, MO, June 2000.

Freeland, BS, Grunberger, G, and Janisse, JJ:  Seeing beyond the clinical pathway for diabetic ketoacidosis.  Diabetes 49; Suppl 1: A342, 2000.

Grunberger, G, Qiang, X, Matthews, ST, Li, Z-G, Sima, AAF, Sbrissa, D, and Shisheva, A:  C-peptide stimulates glycogen synthesis via a wortmannin-sensitive and Akt-independent pathway.  Diabetes 49; Suppl 1: A447, 2000

Di Carli, MF, Afonso, L, Campisi, R, Ramappa, P, Bianco-Battles, D, Grunberger, G, and HR Schelbert:  Coronary vascular dysfunction in premenopausal diabetic women:  A mechanism for loss of gender differential?  Circulation, in press, 2000.

Matthews, ST, Singh, GP, Santa Ana, L, Buison, EJ, Jen, K-LC, Goustin, AS, and Grunberger, G:  Increased insulin sensitivity in mice lacking fetuin (AHSG) gene.  Diabetoligia 43, Suppl 1: A34, 2000

Grunberger G, Sugimoto, K, Murakawa, Y, Zhang, W-X, and Sima, AAF:  C-peptide prevents and ameliorates chronic type 1 diabetic neuropathy in the BB/WOR rat.  Diabetoligia 43, Suppl 1: A49, 2000.

Li, Z-G, Zhang, W, Grunberger, G, Krause, G, and Sima, AAF:  Hippocampal neuronal apoptosis and suppressed IGF activities in type 1 diabetic BB/W rats.  Annual Meeting of the Society for Neuroscience, 2000.

Di Carli, MF, Janisse, J, Grunberger, G, Jacober, S, and Ager, J:  Effect of  diabetes type on coronary microvascular function.  Annual Meeting of the American College of Cardiology, 2000.

Grunberger, G:  Regulation of signaling pathways by C-peptide.  3rd Annual International Motor City Diabetes Symposium, 2000.

Qiang, X, Matthews, ST, Li, Z-G, Sima, AAF, and Grunberger, G:  C-peptide signaling - is it mediated through insulin receptor?  3rd Annual International Motor City Diabetes Symposium, 2000.

Division of Gastroenterology
Articles and Patents

Blatt, L, Mutchnick, MG, Tong, MJ, Tamburro, C, Klion, FM, et al.: Assessment of HCV RNA and HCV genotype from 6807 chronic HCV patients treated in community clinical practice in the United States. Journal of Viral Hepatitis 7: 196-202, 2000.

Geng, H, Naylor, P, Doscescu, J, Skunca, M, Majumdar, APN and Moshier, JA: TGF-a is Required for Full Expression of the Transformed Growth Phenotype of NIH/3T3 Cells Expressing Ornithine Decarboxylase.   Carcinogenesis 21(4): 567-572, 2000

Kinzie, JL, Naylor, PH, Nathani, MG , Peleman, RR, Ehrinpreis, MN, Lybik, M, Turner, JR, Janisse, JJ, Massanari, M,  Mutchnick, MG: African Americans with genotype 1 treated with interferon for chronic hepatitis C have a lower end of treatment response than Caucasians.  Journal of Viral Hepatitis (in press)

McHutchison, JG, Blatt, LM, deMedina, M, Craig, JR, Conrad, A, Schiff, ER,Tong, MJ, Ehrinpreis, MN, et al:  Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology.  J Gastroenterol Hepatol 15: 945-51, 2000.

Moragoda, L, Jaszewski, R, Majumdar APN: Curcumin Induced Modulation of Cell Cycle and Apoptosis in Gastric and Colon Cancer Cells. Anticancer Ressearch – In Press.

Milton G. Mutchnick, M. D.:  Method for the Treatment of Hepatitis - United States Patent Number 6,106,868 August 22, 2000

Nathani, MG, Naylor, PH, Turner, JR, Peleman, RR, Ehrinpreis, MN, Kinzie, JL, Lybik, M, Siddiqui, FA, Mutchnick, MG: Serum HCV RNA as a factor in deciding to escalate or terminate the dose of interferon-alpha in patients with CHC studied in an urban clinic population. (In Press)

Siddiqui, FA, Naylor, PH, Ehrinpreis, M: A cost effective approach to determining the prevalence of hepatitis A and B immunity in patients with chronic HCV.  American Journal of Gastroenterology (In Press ).

Siddiqui, F, Mutchnick, M, Kinzie, J, Peleman, R, Naylor, P, Ehrinpreis, M: Prevalence of hepatitis A virus and hepatitis B virus immunity in patients with PCR-confirmed hepatitis C: Implications for vaccination strategy. Amer J Gastro (in press)

Turner JD, Liu L, Fligiel SEG, Jaszewski R, and Majumdar APN: Aging Alters Gastric Mucosal Responses to Epidermal Growth Factor and Transforming Growth Factor a.  American Journal of Physiology: Gastrointestinal and Liver Physiology. 278: G805-G810, 2000.

Xiao, Z-Q and Majumdar, APN: Increased In Vitro Activation of EGFR by Memberane-bound TGF-a from Gastric and Colonic Mucosa of Aged Rats. American Journal of Physiology: Gastrointestinal and Liver Physiology – In Press.

Xiao, Z-Q, and Majumdar, APN: Induction of Transcriptional Activity of AP-1 and NF-kB in the Gastric Mucosa During Aging.  American Journal of Physiology: Gastrointestinal and Liver Physiology. 278: G855-G865, 2000.

Xiao, Z-Q, Jaszewski, R, and Majumdar, APN: Aging Enhaces G1 Phase in the Colonic Mucosa of Rats.  Mechanisms of Ageing and Development 116: 1-14, 2000

Yu, Y, Rishi, A, Turner, JR, Liu, D, Black, E, Moshier, JA and Majumdar, APN: Cloning of a Novel EGFR  Related Peptide: Negative Regulator of EGFR.  American Journal of Physiology: Cell Physiol. – In Press

Books, Chapters and Reviews
Ehrinpreis, MN:  Toxic Megacolon, Diarrhea, Lower Gastrointestinal Hemorrhage (3 chapters).  The Saunders Manual of Critical Care, JA Kruse  (Editor), W.B.Saunders Company, Orlando, FL. (In press)

Majumdar, APN: Nutrition and Gastrointestinal Cancer. In: Medicine in the Millenium

(Ray P ed.), Marks Media Services, Calcutta, India, 2000

Majumdar, APN: Role of Nutrition in Gastric and Colon Cancers.  International Review of Allergology and Clinical Immunology, 6 (4): 145-149, 2000.

Mutchnick, MG: Acute and Chronic Hepatitis B. In: Atlas of the Liver, 2nd Edition. W.C.  Maddrey,  Editor,  Current Medicine, Philadelphia, 2000.

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Akhras, J, Murthy, R: Salmonella Java Colitis mimicking exacerbation of Crohn's colitis; Poster presented at the annual AGA meeting in New York, October 2000.

Akhras, J, Naylor, PH, Kiranmaia, J, Hemacha, A, Fliegiel, S and Jaszewski, R: Demographics and treatment response of an urban veteran population infected with the Hepatitis C virus.  Gastroenterology (In press).

Akhras, J, Zagnoon, A, Tobi, M: Endoscopic fibrin sealant injection with application of hemostatic clips: A novel method of closing a refractory gastrocutaneous fistula. Gastrointestinal Endoscopy 51:AB110 (abstract#3501), 2000.

Alawad, G, Naylor, PH, Hemacha, A, Jamma, K, Weidler, N, Kinzie, JL, Ehrinpreis, MN, Dhar, R, Mutchnick, MG: Differences in side effect profiles and response to combination ribavirin and interferon a2b (IFN) therapy between Caucasians and African Americans with chronic hepatitis C. Hepatology 32: 368A, 2000 (Presented at AASLD, Dallas, TX. 10/30/00).  

Khalifa-AlSaleh, A, Naylor, PH, Kinzie, JL, Ehrinpreis, MN, Siddiqui, F, Dhar, R, Turner, JR and Mutchnick, MG:  End of treatment response (ETR) to Intron A monotherapy in chronic hepatitis C is similar in patients with normal and elevated ALT. Antiviral Therapy 5, C190, 2000 (Presented at 10th Int'l Symposium on Viral Hepatitis and Liver Disease, Atlanta, GA, April 10, 2000).

Khalifa-AlSaleh, A, Kinzie, JL,  Siddiqui, F : Symptomatic gastric sarcoidosis and the role of steroids. American Journal of Gastroenterology-Vol 95, 586, No. 9, 2000.  (Presented at American College of Gastroenterology Meeting in New York, Oct 2000).

Kulkarni, PM, Kinzie, JL, Ehrinpreis, MN:  Argon plasma coagulator treatment in the management of hematochezia secondary to chronic radiation proctopathy. Am J Gastroenterol 2000; 95:2539.

Madhira, M, Tobi, M.  Isolated Gastrointestinal spider nevi: potential clinical significance.  Am J Gastroenterology-95 #10;26-27, 2000.

Marepally, R, Tobi, M. High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis.  Am J Gastroenterology - In press

Mutchnick, MG, Naylor, PH, Upfal, MJ: Hepatitis C screening of urban emergency response personnel.  Gastroenterology 118: A1001, 2000 (Presented at DDW, San Diego, CA.  5/22/00).

Naylor, PH, Kinzie, JL, Ehrinpreis, MN, Siddiqui, F, Dhar, R, and Mutchnick, MG: Retreatment of interferon failures with combination therapy: log drop after 12 weeks of monotherapy predicts ETR to combination.  Antiviral Therapy 5, C191, 2000 (Presented at 10th Int'l Symposium on Viral Hepatitis and Liver Disease, Atlanta, GA, April 10, 2000).

Naylor, PH, Meja, L, Kinzie, JL, Ehrinpreis, MN, Dhar, R, Siddiqui, F, Turner, JR, Mutchnick MG: Tumor necrosis factor a and chronic hepatitis C:  Lower serum levels in African Americans as compared to Caucasians.  Hepatology 32: 263A, 2000 (Presented at AASLD, Dallas, TX. 10/29/00) 

Tobi, M, Hatfield, J, Fligiel, S, Adsay, V, Galagan, K, Kozarek, R, Inagaki, M, Kasai, S, Tokusashi, Y, Obara, T, Hruban, R, Lough, J, Barkun, A, Jabbari, M, Abbruzzese, JL, Evans, DB, Sheikh, R, Ruebner, B, Lawson, M.  Adnab-9, A Prognostic Marker in Pancreatic Neoplasia. Gastroenterology, 118,A648,2000.

Ullah, N, Hatfield, S, Fligiel, S, David, D, Ruebner, B, Sheikh, R, Lawson, M, Tobi, M.  Adnab-9 staining in mixed adenomatous colonic polyps.  Proceed. Am Assoc Can Res.-41:585,2000 (abstract#4355).

Ullah, N, Hatfield, J, David, D, Fligiel, S, Lawson, M, Ruebner, B, Sheikh, R, Tobi, M.  Do mixed polyps confer increased risk for colorectal neoplasia.   Gastroenterology. 118,A269,2000.

Ullah, N, Yeh, R, Ehrinpreis, MN.  Fatal hyperphosphatemia after oral phospho-soda preparation for colonoscopy: a case report and review of the literature. Am J Gastroenterol 2000; 95:2613.

Weidler, N, Naylor, PH, Patel, C, Chilukuri, S, Mendu, S, Janisse, J, Dhar, R, Ehrinpreis, M, Kinzie, J, Siddiqui, F, Turner, J, Mutchnick, MG: Demographical and biochemical influences on quality of life scores in urban patients with Hepatitis C.  Gastroenterology 118: A995, 2000 (Presented at DDW, San Diego, CA.  5/22/00).

Xiao, Z-Q, Fligiel, SEG, Hatfield, J, Jaszewski, R, and Majumdar, APN:  Aging is Associated With Increased Proliferation and Decreased Apoptosis in the Colonic Mucosa. 101st  Annual Meeting of  the American Gastroenterological  Association  (AGA), San Diego, CA. Gastroenterology 118: A2868, 2000.

Xiao, ZQ, Jaszewski, R, Majumdar, APN: Aging enhances G1 to S phase transition in the colonic mucosa.  Gastroenterology 118: 2873, 2000   (Presented at AGA, May, 2000).

Xiao, Z-Q, and Majumdar, APN: Induction of Transcriptional Activity of AP-1 and NF-kB in the Gastric Mucosa During Aging. 101st  Annual Meeting of  the American Gastroenterological  Association  (AGA), San Diego, CA. Gastroenterology 118: A2872, 2000.

Yeh R, Ullah N, Ehrinpreis MN.  Role of lamivudine in the treatment of acute hepatitis B infection associated with polyarteritis nodosa. Am J Gastroenterol 2000; 95:2615.

Yu, Y, Xiao, Z-Q, Rishi, A, and Majumdar, APN: Regulation of ERRP Induced Inhibition of Proliferation  in HCT-116 Colon Cancer Cell Line. 101st Annual Meeting of  the American Gastroenterological  Association  (AGA), San Diego, CA. Gastroenterology 118: A2847, 2000.

Division of General Medicine
Articles

Afonso, N. Clinical Teaching, Learning and the World Wide Web: Editorial. Morning Report Reviews. 2000 Nov; 1 (3).

Afonso, N, Jast, H, Alangaden, G: Tuberculosis of the ribs presenting as bilateral pseudogynecomastia.  Submitted for publication, Clinical Infectious Disease, 2000.

Afonso, N, Jasti, H, Alangaden, G:  Tuberculosis of the ribs presenting as bilateral pseudogynecomastia.  In press, Clinical Infectious Disease, 2000.

Burack, RC, Simon, MS, Stano, M, George, J, Coombs, J.  Follow-up among women with an abnormal mammogram in an HMO: is it complete, timely and efficient?  American Journal of Managed Care 2000; 6:1102-1113.

Burack, RC, George, J, Gurney, JG.  Mammography use among women as a function of age and patient involvement in decision-making.  Journal of American Geriatrics Society.  2000;48(7):817-821.

Douglas, MA and Levine, DP: Hallucinations in an Elderly Patient Taking Recommended Doses of Cyclobenzaprine.  Arch Intern Med 160:1373, 2000.

Estrada, C, Bloch, R, Antonacci, D, Basnight, L, Patel, SR, Patel, SC, Wiese, W.  Reporting and Concordance of Methodologic Criteria Between Abstracts and Articles in Diagnostic Test Studies.  J Gen Intern Med 2000:15:183-187.

Franklin, J, Wiese, W, Meredith, J, Lalikos, J, Dolezal, J, Brigham, D, Wooden, W, Ohl, C. Hurricane Floyd: Experiences of the Pitt County Medical Community, NCMJ January/February 2000, Vol 61, No 1.

Gimotty, P, Burack, RC, George, J.  Delivering preventive health services for breast cancer control: A longitudinal view of a randomized controlled trial.  Health Services Research (in press).

Hopper, JA, Craig, KA: Sources of environmental tobacco smoke exposure in urban children.  Pediatrics  106(4):e47, 2000.

Kanno, M, Pore, G and Levine, DP:  Recurrent Group B Streptococcus Bacteremia Menstruation. (In Press).

Melgar, T, Schubiner, H, Burack, R, Aranha, A, Musial, J.  A time-motion study of the activities of attending physicians in an Internal Medicine and Internal Medicine-Pediatrics resident continuity clinic.  Acad. Med. 2000;75:1138-1143.

Patel, SR, Wiese, W, Patel, SC, Ohl, C, Byrd, JC, Estrada, CA.  Evidence Based Medicine a Meta-Analysis of Diagnostic Tests for Vaginal Trichomoniasis.  Journal of Investigative Medicine.  January 2000 Vol 48, No 1.

Patel, SR, Wiese, W, Patel, SC, Ohl, CA, Estrada, C.  A Systematic Review of Diagnositic Tests for Vaginal Trichomoniasis, Infectious Diseases in Obstetrics and Gynecology, August 2000.

Schubiner, H, Tzelepis, A, Kelly, B, Lockhart, N, Kruger, M, Schoener, E: Prevalence of Attention Deficit Hyperactivity Disorder among substance abusers.  Journal of Clinical Psychiatry, 2000:61:244-251.

Schuh, LM, Schuster, CR, Hopper, JA, Mendel, CM: Abuse liability assessment of sibutramine, a novel anorectic agent.  Psychopharmacology  147:339-346, 2000.

Simon, MS, Gimotty, PA, Moncrease, A, Dews, P, Burack, RC.  The effect of patient reminders on the use of screening mammography in an urban health department primary care setting.  Breast Cancer Treatment and Detection 2001;65:63-70.

Tam, VH, McKinnon, PS, Levine, DP, Brandel, SM and Rybak, MJ: Once-Daily Aminoglycoside Treatment of Enterococcus faecalis Endocarditis.  Pharmacotherapy 20(9):1116-1119, 2000.

Wiese, W, Becker, K, Ohl, C. Impact of Hurricane Associated Flooding in Eastern North Carolina Medicina Interna deMexico Vol 16, S2000.

Wiese, W, Patel SR, Patel, SC, Ohl, CA, Estrada, C.  A Meta-Analysis of the Wet Mount and Papanicolaou (PAP) Smear for the Diagnosis of Vaginal Trichomoniasis, American Journal of Medicine, March 2000, Vol 108, Issue 4.

Wiese, W, Patel, SR, Patel, SC, Ohl, CA, Estrada, C.  A Meta-Analysis of the Wet Mount and Papanicolaou (PAP) Smear for the Diagnosis of Vaganal Trichomoniasis Review: Papanicolaou and wet-mount smears have low sensitivity but high specificity for detecting vaginal trichomoniasis, Harper D ACP Journal Club.  2000 Nov/Dec; 113.

Books, Chapters and Reviews
Hopper, JA. Acute Otitis Media in USMLE Step 3 Recall.  M. Ryan, Senior Editor.  Chapter submitted 12/00.

Levine, DP, Brown, PD:  Infections in Injection Drug Users.  In:  Principles and Practice of Infectious Disease, Fifth Edition.  GL Mandell, JE Bennet and R Dolin (Editors), Churchill and Livingstone Publishers, New York, NY, 2;3112-3126, 2000.

Levine, DP: Endocarditis. In: Kruse JA, Carlson RW, Fink MP, Eds.  Saunders Manual of Critical Care Practice, Philadelphia, PA, (In Press).

Levine, DP: Gram Positive Infections. In: Kruse JA, Carlson RW, Fink MP, Eds.  Saunders Manual of Critical Care Practice, Philadelphia, PA, (In Press).

Levine, DP: Gram Negative Infections. In: Kruse JA, Carlson RW, Fink MP, Eds.  Saunders Manual of Critical Care Practice, Philadelphia, PA, (In Press).

Levine, DP: Infective Endocarditis.  In: Conn’s Current Therapy, 2002 Edition, Houston, TX, (In Press).

Melgar, T, Schubiner, H, Burack, R, Aranha, A, Musial, J.  Activities of the attending  physicians in an Internal Medicine and Med-Peds resident continuity clinic.  Academic Medicine, November 2000. 75:1138-1143, 2000.

Schubiner, H, Tzelepis, A, Kelley, B, Lockhart, N, Kruger, M, Schoener, E.  Prevalence of Attention Deficit/Hyperactivity Disorder and Conduct Among Substance Abusers.  Journal of Clinical Psychiatry 2000;61:244-251.

Schuh, KJ, Schubiner, H, Johanson, CE.  Discriminability of intranasal cocaine.  Behaviorial Pharmacology.  2000; 11:511-515. 

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Barth-Jones, D, Chapleski, E, Dunkle, R, Steinberg, J, Wintermute, T.  A comprehensive collaborative model for assessing and disseminating needs of older adults in the inner core of a large urban city.  Presented at the Gerontologic Society of America annual meeting.  Wahington, D.C.  November 2000.

Burack, RC, Gimotty, PA, Effectiveness of computerized reminders in ambulatory care JAMA, 2000; 284:2872.

Downey, KK, Hopper, JA, Henderson, M, Corby, E, Helmus, T and Schuster, CR:  Treatment of heroin dependent poly-drug abusers with vouchers and buprenorphine.  NIDA Research Monograph Series.  In Press.

Jasti, H, Afonso, N, Alangaden, G: Tuberculosis of the ribs masquerading as gynecouastia.  Submitted to SGIM National Meeting, May 2000.

Schuh, KJ, Schubiner, H, and Johanson, CE.  (in press) Discrimination of Intranasal Cocaine: Effects of Intranasal Benzocaine.  In Problems of Drug Dependence, 2000: Proceedings of the 61st Annual Scientific Meeting of the College on Problems of Drug Dependence, Inc.  In Government Printing Office.  September 2000, 11(6):511-5.

Schuh, KJ, Schubiner, H, and Johanson, CE.  (in press) Discrimination of Intravenous Cocaine in Humans.  In Problems of Drug Dependence, 2000:  Proceedings of the 61st Annual Scientific Meeting of the College on Problems of Drug Dependence, Inc.  In L.S. Harris (Ed.), NIDA Research Monograph #___.  Washington, DC:  US Government Printing Office, p. __.

Siddique, M, Munasinghe, R, Sharma, S, Bergsman, KL. "The Agony of Hospital Mergers".  Abstract-poster presentation, Accreditation Council for Graduate Medical Education, Chicago, IL, March, 2000.

Siddique, M, Munasinghe, R, Sharma, S, Bergsman, KL. "The Agony of Hospital Mergers".  Abstract-poster presentation, Association of Program Directors in Internal Medicine, Philadelphia, PA, April, 2000.

Munasinghe, R, Sharma, S, Siddique, M.  "Meeting RRC Guidelines for Resident Days Off".   "Abstract-poster  presentation, Accreditation Council  for Graduate Medical Education, Chicago, IL, March, 2000.

Munasinghe, R, Sharma, S, Siddique, M.  "Meeting RRC Guidelines for Resident Days Off".  Abstract-poster presentation, Association of Program Directors in  Internal Medicine, Philadelphia, PA, April, 2000.

Sharma, S, Charochak, A, Munasinghe, R, Siddique, M.  "Novel Teaching Methods for Resident Education for the Millenium and Beyond" Abstract-poster presentation, Accreditation Council for Graduate Medical Education, Chicago, IL, March, 2000.

Sharma, S, Charochak, A, Munasinghe, R, Siddique, M.  "Novel Teaching Methods for Resident Education for the Millenium and Beyond" Abstract-poster presentation, Association of Program Directors in Internal Medicine, Philadelphia, PA, April, 2000.

Verma, A, Aranha, A, Steinberg, J.  Falls among older assisted-living demented residents.  Presented at the American Geriatrics Society annual meeting.  Nashville, Tennessee May 2000.

Verma, A, Aranha, A, Steinberg, J.  Assistive device use for ambulation in demented elderly and the risk of falls.  Presented at the American Geriatrics Society annual meeting.  Nashville, Tennessee.  May 2000.

Division of Hematology and Oncology
Articles

Ahmed, I, Al-Katib, A, Beck, FWJ, Mohammad, RM. Sequential treatment of a resistant CLL-patient with Bryostatin 1 followed by 2-Chlorodeoxyadenosine: Case Report. Clinical Cancer Research, 6: 1328-1332, 2000.

Alhasan, S, Ensley, J, Sakar Fazul, H,  Genestein induced molecular changes in a squamous cell  carcinoma cell line. Int J Oncol, 16:333-338, 2000.

Ali, MA,  Kraut, MJ, Valdivieso, M, Wozniak, AJ, Cummings, G, Kalemkerian, GP. “Phase II study of mitomycin-C, etoposide and cisplatin in advanced non-small cell lung cancer".  Cancer Invest, 18(1): 1-5, 2000.

Aref, A, Berkey, BA, Schwade, JG, Ensley, J, Schuller, DE, Haselow, RE, Ervin, TJ, Laramore, GE. The influence of beam energy on the outcome of postoperative radiotherapy in head and neck cancer patients: secondary analysis of RTOG 85-03. Int J Radiat Oncol Biol Phys, 1;47(2):389-94,  2000.

Baer, MR, Stewaart, CC, Dodge, RK, Leget, GA, Sule, N, Mrozek, KA, Schiffer, CA, Powell, BL, Kolitz, JE, Davey, F, Carroll, AJ, Larson, RA, Bloomfield, CD.  High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for minimal residual disease detection (Cancer and Acute Leukemia Group B study 8361).  Blood, (in press).

Bakshee, S, Abella, E, Baynes, R. Aplastic anemia. e-medicine (in press).

Baynes, RD, Dansey, RD, Klein, JK, Karanes, C, Abella, E, Cassells, L, Wei, WZ, Galy, A, Wood, G,  Peters, WP.  High dose chemotherapy and peripheral blood progenitor cell transplantation in patients with breast cancer.  Invited review.  Cancer Investigation, 18:440-455, 2000.

Baynes, RD, Dansey, RD, Klein, JK, Karanes, C, Abella, E, Cassells, L, Peters, WP.  High dose chemotherapy and peripheral blood progenitor cell transplantation for breast cancer.  Seminars in Oncology (in press).

Baynes, RD, Dansey, RD, Klein, JK, Karanes, C, Abella, E, Cassells, L, Wei, WZ, Galy, A, Wood, G, Peters, WP. High dose chemotherapy and peripheral blood progenitor cell transplantation in patients with breast cancer. Invited review. Cancer Investigation, 18: 440-455, 2000.

Baynes, RD,  Dansey, RD,  Klein, JK,  Peters, WP.  High dose chemotherapy and peripheral blood progenitor cell transplantation in patients with breast cancer.  The Oncologist, 5:1-13, 2000.

Baynes, RD, Dansey, RD, Klein, JK, Peters, WP.  The role of high dose chemotherapy for adjuvant treatment in high risk breast cancer.  Critical Reviews in Oncology/Hematology (in press).

Baynes, RD,  Dansey, RD,  Klein, JL,  Abella, E, Hamm, C, Campbell, M, Galy, A, Peters WP.  Bone Marrow Transplantation in Breast Cancer.  Current Opinion in Oncology (in press).

Baynes, RD, Hamm, C, Dansey, RD, Klein, JK, Cassells, L, Karanes, C, Abella, E, Peters, WP.  Bone marrow and peripheral blood hematopoietic stem cell transplantation: a focus on autografting.  Clin Chem, 46:1239-1251, 2000.

Baynes, RD, Zielinsky, I, Dansey, RD.  Large volume leukapheresis.  Cobe Monograph (in press).

Beck, FWJ, Al-Katib, AM, Ahmad, I, Wall, NR, Liu, KZ, Mantsch, HH, Mohammad, RM. Bryostatin 1-induced modulation of nucleoside transporters and 2-chlorodeoxyadenosine influx in WSU-CLL cells. Int J Mol Med, 4: 341-347, 2000.

Blum, J, Dieras, V, LoRusso, PM, Horton, J, Burger, HU, Osterwalder, B, Laws, S, Buzdar, A.  Multicenter, phase II study of Capecitabine in taxane-pretreated metastatic breast cancer patients.  Submitted, Cancer, December, 2000.

Burack, RC, Simon, MS, Stano, M, George, J, Coombs, J.   Follow-up among women with an abnormal mammgram in an HMO:  Is it complete, timely and efficient.  American Journal of Managed Care, Vol 6, # 10: 151-162, 2000.

Chandrasekar, PH, Abraham,  OC, Klein, J, Alangaden, G, Chalasani, G, Cassells, L, Dansey, R, Abella, S, Karanes, C, Peters, W, Baynes, R.  Low infectious morbidity following intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer.  Ann Int Med (in  press).

Chen, C, Karanes, C, Pettit, GR, Chen, B.  Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitors induced cytochrome c-dependent apoptosis. Cancer Res,  60: 4377-4385, 2000.

Chen, C,  Lin, H, Chen, B.  Bcl-2 antibodies induce hemoglobin release by red blood cells loaded with in vitro translated Bcl-2 and its cleaved fragment. Biochem Biophys Res Commun,  270:816-820, 2000.

Cheson, BD, Bennett, JM, Kantarjian, H, Pinto, A, Schiffer, CA, Nimer, SD, Lowenberg, R, Beran, M, de Witte, TM, Stone, RM, Mittelman Sanz, GF, Wijermans, PW, Gore, S, Greenberg, PL.  Report of an international working group to standardize response criteria for myelodysplastic syndromes.  Blood, 96:3671-74, 2000.

Davis, JN, Muqim, N, Bhuiyan, M, Kucuk, O, Pienta, KJ, Sarkar, FH.  Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol, 16:1091-1097, 2000.

Djuric, Z, Heilbrun, LK, Lababidi, S, Berzinkas, E, Simon, MS, Kosir, MA.   Levels of 5-Hydroxymethyl-2’-dexoyuridine in DNA from Blood of Women Scheduled for Breast Biopsy.  Cancer Epidemiology Biomarkers and Prevention, 2000 (in press).

Duanmu, Z, Dunbar, J, Falany, CN, Runge-Morris, M.   (2000) Induction of Rat Hepatic Aryl Sulfotransferase (SULT1A1) Gene Expression by Triamcinolone Acetonide: Impact on Minoxidil-Mediated Hypotension. Toxicol Appl Pharmacol, 164(3, pt.1): 312-320.

Evelhoch, JL, Gillies, RJ, Karczmar, GS, Koutcher, JA, Maxwell, RJ, Nalcioglu, O, Raghunand, N, Ronen, SM, Ross, BD, Swartz, HM.  Applications of Magnetic Resonance in Model Systems: Cancer Therapeutics.  Neoplasia, 2:152-165, 2000.

Ferlazzo, G, Klein, J, Paliard, X, Wei, W-Z, Galy, A.   Dendritic cells generated from CD34+ progenitor cells with flt3-ligand, c-kt-ligand, GM-CSF, TNF-" and IL-4 are functional antigen-presenting cells resembling mature monocyte-derived dendritic cells.  Journal of Immunotherapy, 23(1):48-58, 2000.

Flaherty, LE, Atkins, M, Sosman, J, Weiss, G, Clark, JI, Margolin, K, Dutcher, J, Gordon, MS, Lotze, M, Mier, J, Sorokin, P, Fisher, RI, Appel, C, Du, W.   Outpatient Biochemotherapy with Interleukin-2 and Interferon Alpha in Patients with Metastatic Melanoma – Results of Two Phase II Cytokine Working Group Trials. Submitted J Clin Oncol, August 2000.

Fouad, M, Corbie Smith, G, Curb, D, Howard, B, Mouton, C, Simon, MS, Talbavera, G, Thompson, J, Wang, C, White, C, Young, R.   Special populations recruitment for the WHI: Successess and limitations.  Clinical Journal of Womens Health. December 2000 (in press).

Galy, A, Rudraraju, S, Baynes, R, Klein, J.  Recovery of lymphocyte and dendritic cell subsets after autologous CD34+ cell transplantation. Bone Marrow Transplantation, 25:1457-1452, 2000.

Gillies, RJ, Bhujwalla, ZM, Evelhoch, JL, Garwood, M, Neeman, M, Robinson, SP, Sotak, CH, van der Sanden, B.   Applications of Magnetic Resonance in Model Systems: Tumor Biology and Physiology.  Neoplasia, 2:139-151, 2000.

He, Z, Evelhoch, JL, Mohammad, RM, Adsay, NV, Pettit, GR, Vaitkevicius, VK, Sarkar, FH.  Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer. Pancreas, 21: 69-76, 2000.

Hensley, ML, Peterson, B, Silver, RT, Larson, RA,  Schiffer, CA, Szatrowski, T   Risk factors for severe neuropsychiatric toxicity in patients receiving alpha interferon 2b and low dose cytarabine for chronic myelogenous leukemia: analysis of Cancer and Leukemia Group B 9013.  J Clin Oncol, 18:1301-08, 2000.

Hussain M, Fisher EI, Petrylak DP, Wood DP, Small EJ, Eisenberger A, Crawford ED:  Androgen deprivation + 4 courses fixed schedule suramin in patients with newly diagnosed metastatic prostate cancer: A Southwest Oncology Group Study.  J Clin Oncol 18, 1043-  ,2000 .

Hussain, MH, Glass, TR, Forman, J, Sakr, W, Smith, DC, Al-Sarraf, M, Jones, J, Balcerzak, SP, Crawford, ED, Grosssman, HB.  Combination cisplatin, 5-fluorouracil and radiation therapy in locally advanced unresectable or medically unfit bladder cancer patients. A Southwest Oncology Group study.  J Urology, 2000 ( in press).

Keyes, KA, Albella, B, LoRusso, PM, Bueren, JA, Parchment, RE.  Cytotoxic Chemotherapy regimens that increase dose per cycle (dose intensity) by extending daily dosing from 5 consecutive days to 28 consecutive days and beyond.  Clin Cancer Res, 6(6):2474-2481, 2000

Kim, HK,  Krug, MA,  Han, I,  Ensley, JF,  Yoo, GH,  Forman, JD,  Choi Kim, HR. Neutron radiation enhances cis-platinum cytotoxicity independent of apoptosis in head and neck carcinoma cells. Clin Cancer Res,  6:4142-7, 2000.

Kirkwood, JM, Ibrahim, JG, Sondak, VK, Richards, J, Flaherty, LE,  Ernstoff, MS, Smith, TJ, Rao, U, Steele, M, Blum, RH.   High and Low Dose Interferon ALFA-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190” ,J Clin Oncol, 18:2444-2458, 2000.

Klein, JL, Rey, PM, Dansey, RD, Karanes, C, Du, W, Abella, E, Cassells, L, Hamm, C, Peters, WP, Baynes, RD.  Cardiac sequelae of doxorubicin and paclitaxel as induction chemotherapy prior to high-dose chemotherapy and peripheral blood progenitor cell transplantation in women with high-risk primary or metastatic breast cancer.  Bone Marrow Transplantation, 25:1047-1052, 2000.

Kucuk, O, Fisher, E, Moinpour, C, Sartor, AO, Chatta, G, Coleman, D, Eisenberger, M, Hussain, M, Crawford, D.  Phase II trial of Casodex in advanced prostate cancer patients who failed conventional hormonal manipulation: A Southwest Oncology Group (SWOG) Study. Urology, 2001 (in press).

Kucuk, O, Kilton, L, Wade, J, Houston, J, Blough, R, Watkins, A, Benson, A. Menogaril in the treatment of multiple myeloma and chronic lymphocytic leukemia: An Illinois Cancer Center Study. Am J Clin Oncol, 23:379-383, 2000.

Küçük, Ö, Pandya, K, Shevrin, D, Bonomi, P.   Phase II trial of cisplatin, 5-fluorouracil and etoposide in advanced measurable non-small cell lung cancer:  An ECOG pilot study.  Am J Clin Oncol, 23:371-375, 2000.

Kucuk, O, Young, M, Habermann, T, Wolf, B, Jimeno, J, Cassileth, P.   Phase II trial of Didemnin B in previously treated non-Hodgkin's lymphoma: An Eastern Cooperative Oncology Group (ECOG) Study. Am J Clin Oncol, 23:273-277, 2000.

Leethanakul, C, Patel, V, Gillespie, J,  Pallente, M, Ensley, JF,  Liotta, LA,  Emmert-Buck, M, Gutkind, JS.   Distinct Pattern of Expression of Differentiation and Growth-Related Genes In Squamous Cell Carcinomas of the Head and Neck Revealed by the Use of Laser Capture Microdissection and cDNA arrays. Oncogene, 19:3220-3224, 2000.

Leethanakul, C,  Patel, V,  Gillespie, J,  Shillitoe, E,  Kellman, RM, Ensley, JF, Limwongse, V, Emmert-Buck, MR, Krizman, DB, Gutkind, JS.  Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries. Oral Oncology, 36: 474-483, 2000.

Lin, H, Zhang, XM, Chen, C, Chen, B.  Apoptosis of mo7e leukemia cells is associated with the cleavage of bcl-2 into a shortened fragment that is not functional for heterodimerization with bcl-2 and Bax.  Exp Cell Res, 261(1):180-6, 2000.

LoRusso, PM.  Oxaliplatin in Tumors Other Than Colorectal Cancer.  Supp Onc, No. 11, 14(12):33-41, 2000.

LoRusso, PM, Foster, BJ, Wozniak, A, Heilbrun, LK, McCormick, JI, Ruble, PE, Graham, MA, Purvis, J, Rake, J, Drozd, M, Lockwood, GF, Corbett, TH.  Phase I pharmacokinetic study of the novel antitumor agent SR233377.  Clin Cancer Res 6(8):3088-3094, 2000.

LoRusso, PM, Foster, BJ, Wozniak, AJ, Graham, MAE, Purvis, J, Rake J, Drozd, M, Lockwood, G, Corbett, TH, Valdivieso, M.  Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR 233377. Clinical  Cancer Research.

LoRusso, PM, Prakash, S, Wozniak, A, Flaherty, L, Zalupski, M, Shields, AF, Sands, H, Parchment, RE, Jasti, BR.   Phase I Clinical Trial of 5-Fluoro-Pyrimidinone (5FP), an Oral Prodrug of 5-Fluorouracil (5FU).  Submitted, Inv New Drugs, November 2000.

Mohammad, RM, Wall, NR, Dutcher, JA, Al-Katib, A.  The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. Clin Cancer Research, 6: 4950-4956, 2000.

Moore, RD, Charache, S, Terrin, ML, Barton, FB, Ballas, SK, the Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.  Cost-effective of hydroxyurea in sickle cell anemia.  Am J Hematol, May 64 (1): 26-31, 2000.

Morrissey, C, Lakins, J, Moquin, A, Hussain, M, Tenniswood, M.   An antigen capture assay for the measurement of serum clusterin concentrations.  J Biochemical and Biological Methods, 2000 (in press).

Nabha, SM, Wall, NR, Mohammad, RM, Pettit, GR, Al-Katib, A.  Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines. Anti-Cancer Drugs, 11: 31-40, 2000.

Negrin, R, Atkinson, K, Leemhuis, T, Hanania, E, Juttner, C, Tierney, K, Hu, W, Johnston, L, Shizuru, J, Stockert-Goldstein, K, Blume, K, Weissman, I, Bower, S, Baynes, R, Dansey, R, Karanes, C, Peters, W,  Klein, J.   Transplantation of Highly Purified CD34+Thy-1+Hematopoietic Stem Cells in Patients with Metastatic Breast Cancer.  Biology of Blood and Marrow Transplantation, 6:262-271, 2000.

Newman, L, Carolin, K, Bouwman, D, Simon, MS, Peters, W, Demers, RY, Schwartz, AG, Visscher, D.  Impact of Breast Cancer on African American Women:  The Detroit Experience. Cancer, 2000 (in press).

Ozer, H, Armitage, JO, Bennett, CL, Crawford, J,  Demetri, GD,  Pizzo, PA, Schiffer, CA,  Smith, TJ,  Somlo, G, Wade, JC,  Wade III, JL,  Winn, RJ, Wozniak, AJ, Somerfield, MR, for the ASCO Growth Factors Expert Panel. 1999.

Ozer, H, Armitage, JO, Bennett, CL, Crawford, J, Demetri, GD, Pizzo, PA, Schiffer, CA, Smith, TJ, Somlo, G, Wade, JC, Wade, JL III, Winn, RJ, Wozniak, AJ, Somerfield, MR, for the ASCO Growth Factors Expert Panel.  2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. J Clin Oncology, 18: 3558-3585, 2000.

Patel, V, Ensley, JF, Gutkind, S, Yeudall, A.   Induction of apoptosis in head and neck carcinomas by gamma-irradiation and bleomycin is P53 independent. Int J Cancer (in press).

Patel, V, Ensley, JF, Robbins, KC, Yeudall, WA, Overexpression of laminin-5 in SCCHN. Oral Oncology, (in press).

Perez, E, Crowley, JJ, Flaherty, LE, Kelly, K, Franklin, WA, Fisher, RI, Barlogie, B, Livingston, RB,  Gandara, DR.   Phase II Trial of High-Dose Tamoxifen Plus Cisplatin Chemotherapy in Metastatic Non-Small Cell Lung Cancer: A Southwest Oncology Group (SWOG) Trial. Submitted – Cancer – November 2000.

Peters, WP, Baynes, RD, Cassells, L, Dansey, RD, Klein, JL, Hamm, C, Karanes, C, Abella,  E.  Outpatients transplantation.  Oncology,  14:191-192, 2000.

Peters, WP, Dansey, RD, Klein, JK, Baynes, RD.   High dose chemotherapy and peripheral blood progenitor cell transplantation in patients with breast cancer.  The Oncologist, 5:1-13, 2000.

Peters, WP, Hamm, C, Baynes, RD.   Autologous hematopoietic stem cell transplantation.  Cancer Medicine 5th Edition.  Bast J, Kufe D, Pollock, Weichselbaum, Holland, Frei E. (Eds) Pp 890-910.  Decker, Hamilton and London, 2000.

Pienta, KJ, Fisher, EI, Eisenberger, MA, Mills, GM, Goodwin, JW, Akhter, S, Hynes, HE, Crawford, ED, Hussain, MH.  A phase II trial of estramustine and etoposide in hormone refractory prostate cancer: A Southwest Oncology Group trial (SWOG-9407). Prostate, 2000 (in press).

Polin, L, White, K, Kushner, J, Paluch, J, Simpson, C, Pugh, S, Edelstein, MK, Hazeldine, S, Fontana, J, LoRusso, PM, Horwitz, JP, Corbett, TH.  Preclinical Efficacy Evaluations of XK-469: Dose Schedule, Route and Cross-Resistance Behavior in Tumor Bearing Mice.  Submitted, Inv New Drugs, August 2000.

Prakash, S, Wozniak, A, Jasti, B, Flaherty, L, Zalupski, M, Shields, AF, Sands, H, Parchment, R, LoRusso, PM.  Phase I Clinical Trial of 5-Fluoro-Pyrimidine (5FP) Submitted – Invest. New Drugs, December 2000.

Rai, KR, Peterson, BL, Kolitz, J, Elias, L, Shepherd, L, Hines, J, Threatte, GA, Appelbaum, FR, Larson, RA, Cheson, BD, Schiffer, CA.  Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia.  N Engl J Med 343:1750-57, 2000.

Rusch, VW, Giroux, DH, Kraut, MJ, Crowley, J, Hazuka, M, Johnson, D, Goldberg, M, Detterbeck, F, Shepherd, F, Burkes, R, Winton Deschamps, C, Livingston, R, Gandara, D.   “Induction Chemotherapy and Surgical Resection for Non-small Lung Carcinomas of the Superior Sulcus:  Inititial Results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160)” Journal of Thoracic & Cardiovascular Surgery, (in press).

Schiffer, CA, Miller, K, Larson, RA, Amrein, PC, Antin, JH, Zani, VJ, Stone, RM. A double-blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia.  Blood, 95:2530-35, 2000.

Schiffer, CA.  Acute myeloid leukemia in adults: Where have we been and where do we go from here?  Cancer Chemotherapy and Pharmacology, (in press).

Shibuya, TY, Wei, WZ, Zormeier, M, Ensley, J, Sakr,W, Mathog, R, Meleca,  J, Yoo, G, June, CH, Levine, B, Lum, LG.   Anti-CD3/anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma.  Archives of Otolaryngology-Head and Neck Surgery, 126:473-479, 2000.

Shillitoe, EJ, May, M, Patel, V, Lethanakul, C, Ensley, JF, Strausberg, RL,  Gutkind, JS.   Genome-wide analysis of oral cancer - Early results from the Cancer Genome Anatomy Project. Oral Oncology, Eur J Cancer, 36:8-16, 2000.

Simon, MS, Djuric, Z, Dunn, B, Stephens, D, Lababidi, S, Heilbrun, L.K.  An Evaluation of Plasma Antioxidant Levels and the Risk of Breast Cancer:  A Pilot Case Control Study.  The Breast Journal, 2000 (in press).

Simon, MS, Gimotty, PA, Moncrease, A, Dews, P, Burack, RC.   The effect of patient reminders on the use of screening mammography in an urban health department primary  care setting.  Breast Cancer Research and Treatment, 2000 (in press).

Simon, MS, Heilbrun, LK, Stephens, D, Lababidi, S, Djuric.  Recruitment for a pilot case control study  of oxidative DNA damage and breast cancer risk.  Am J Clin Oncol (CCT) 23(3): 283-287, 2000.

Simon, MS, Uhley, V, Djuric, Z, Lababidi, S, Depper, J, Kresge, C, Klurfeld3, a DM, Heilbrun1, LK.   Comparison of Dietary Assessment Methods in a Low Fat Dietary Intervention Program.  Submitted 10/30/00 to Nutrition and Cancer: an international journal.

Sloan, AE, Dansey, R, Zamorano, L, Barger, G, Hamm, C, Diaz, F, Baynes, R, Wood, G.   Adoptive immunotherapy in patients with recurrent malignant glioma: Preliminary results using autologous whole-tumor vaccine and granulocyte-macrophage colony-stimulating factor and adoptive transfer of anti-CD3 activated lymphocytes.  Neurosurgical Focus, 9:1-8, 2000.

Sondak, VK, Liu, PY, Tuthill, RJ, Kempf, RA, Unger, JM, Sosman, JA, Thompson, JA, Weiss, GR, Redman, BG, Jakowitz, JG, Noyes, RD, Flaherty, LE.   Adjuvant Immunotherapy of Resected, Intermediate- Thickness Node-Negative Melanoma with an Allogeneic Tumor Vaccine: A Randomized Trial of the Southwest Oncology Group. Submitted to New Engl J Med, September 2000.

Stone, RM, Berg, DT, George, SL, Dodge, RK, Paciucci, PA, Schulman, PP, Lee, EJ, Moore, JO, Powell, BL, Baer, MR, Bloomfield, CD, Schiffer, CA.   Post remission therapy in older patients with de novo acute myeloid leukemia (AML): A randomized trial comparing mitoxantrone/intermediate dose cytarabine with standard dose cytarabine (CALGB study 8923).  Blood, (in press).

Swerdlow, PS.   Use of Humans in Biomedical Experimentation, in Scientific Integrity, an Introductory Text with Cases, 2nd edition, Macrina, FL, ed. ASM Press, Washington DC, 2000.

Tallman, MS, Anderson, JW, Schiffer, CA, Appelbaum, FR, Feusner, JH, Ogden, A, Shepherd, L, Rowe, JM, Francois, C, Larson, RS, Wiernik, PH.   Clinical Description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome.  Blood, 95:90-95, 2000.

Transplantation of highly purified CD34+ hematopoietic stem cells in patients with metastatic breast cancer.  Biology of Blood and Marrow Transplantation, 6:262-271, 2000.

Trivedi, C, Redman, B, Flaherty, LE, Kucuk, O, Du, W, Heilbrun, LK, Hussain, M. Weekly 1-Hour Infusion of Paclitaxel: Clinical Feasibility and Efficacy in Patients with Hormone Refractory Prostate Cancer. Cancer, 89:431-436, 2000.

Tubb, JW, Xi, H, Ge, Y, Dutcher, JA, Stout, MJ, Mohammad, RM, Ravindranath, Y, Matherly, LH. Cystathionine-B-synthase cDNA transfection alters the sensitivity and metabolism of cytosine arabinoside in CCRF-CEM leukemia cells in vitro and in vivo: A model of down syndrome and leukemia. Cancer Research, 60: 6421-6426, 2000.

Tuthill, RJ, Unger, JM, Liu, PY, Flaherty, LE, Sondak, VK.   Risk Assessment in Localized Primary Cutaneous Melanoma: A Southwest Oncology group Study Evaluating Nine Factors and a Test of the Clark Logistic Regression Prediction Model. Submitted to Cancer September 2000.

Unger, J, Flaherty, L, Liu, PY,  Albain, KS,  Sondak, VK.  Gender Differences and Independent Predictors of Survival in Patients with Metastatic Melanoma on SWOG Trials. Accepted– Cancer – 12/2000.

Update of Recommendations for the use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines.  J Clin Oncol, 18 (20): 3558-3585, 2000.

Vaishampayan, U, Glode, M, Kraft, A, Hudes, G, Wright, J, Hussain, M.   Phase II study of dolastatin –10 in patients with hormone refractory metastatic prostate cancer. Clin Cancer Res, 6:4205-4208, 2000.

Vaishampayan, U, Hussain, M.  Adjuvant chemohormonal trials for locally advanced prostate cancer. Current Oncology Reports, 2:402-408, 2000.

Varterasian, ML, Mohammad, RM, Shurafa, MS, Hulburd, K, Pemberton, PA, Rodriguez, DH, Eilender, DS, Murgo, A, Wall, N, Al-Katib, A.  Phase II trial of bryostatin 1 in patients with relapsed low grade non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. Clinical Cancer Research, 6: 825-828, 2000.

Varterasian, ML, Graff, JJ,  Severson, R, Weiss, L,  Al-Katib, A, Kalemkarian, GP. Non-Hodgkin’s lymphoma: An analysis of the Metropolitan Detroit SEER database. Cancer invest, 18 (4): 303-308, 2000.

Wall, NR, Mohammad, RM, Reddy, KR, Al-Katib, AM.   Bryostatin 1 induces the ubiquitination and proteasome degradation of Bcl-2 in the human early pre-B acute lymphoblastic leukemia cell line, reh.  Int. J Mol Med, 5: 165-171, 2000.

Whitehead, RP, Unger, JM, Flaherty, LE, Kraut, EH, Mills, GM, Klein, CE, Chapman, RA, Doolittle, GC, Hammond, N, Sondak, VK.  A Phase II Trial of Pyrazine Diazohydroxide in Patients with Disseminated Malignant Melanoma and No Prior Chemotherapy, A Southwest Oncology Group Study. Submitted – Invest. New Drugs, April 2000.

Whitehead, R.P, Unger, J.M, Flaherty, L.E, Eckardt, J.R, Taylor, S, Didolkar, MS, Samlowski, W, Sondak, V.K.  Evaluation of CI-980 in Patients with Disseminated Melanoma and No Prior Chemotherapy, A Phase II Southwest Oncology Group Study. Accepted - Invest. New Drugs 11/2000.

Wu, W, Kocarek, TA, Runge-Morris, M.   (2001) Sex-Dependent Regulation by Dexamethasone of Murine Hydroxysteroid Sulfotransferase Gene Expression. Tox. Letters, (in press)

Yoo, GH; Washington J.; Piechocki M; Shibuya TY; Ensley, JF; Oda D; Wei WZ. The Progression of Head and Neck Cancer in an In-Vitro Model. Arch Otolaryngol Head Neck Surg. Arch Otolaryngol Head Neck Surg Nov;126(11):1313-8, 2000.

Zhang, Y, Mohammad, RM, Rishi, A, Farhana, L, Dawson, M, Feng, KC, Leid, M, Peterson, V, Zhang, XK, Edelstein, M, Eilender, D, Biggar, S, Wall, N, Reichert, U, Fontana, JA.  Induction of apoptosis of human B-CLL and B-ALL cells by a novel retinoid and its non-retinoidal analog. Blood, (in press). 

Books, Chapeters and Reviews
Baynes, RD.   Interactions of alcohol, iron and hemochromatosis.  In: Hemachromatosis.  Barton JC and Edwards CQ, Eds.  Chapter 45, pp 468-474 Cambridge University Press, Cambridge, 2000.

Baynes, RD, Peters, WP.  High-Dose Chemotherapy and Stem Cell Transplantation for Breast Cancer. Advanced Therapy for Breast Cancer eds Singletary SE, Robb GL (eds). Pp 291-305, Decker Hamilton, 2000.

Baynes, RD, Stipanuk, MH.  Iron. In: MH Stipanuk ed.  Biochemical and Physiological Aspects of Human Nutrition. Chapter 31, pp 711-741. Sanders Philadelphia, 2000.

Evelhoch, JL.  pH and Therapy of Human Cancers.  In:  Causes and Consequences of Acidic pH in Tumors – No. 240.  Novartis Foundation Symposium, R.J. Gillies.  J. Wiley & Sons, Ltd, London, UK, (in press).

George, V, Hussain, M.   Is Early Hormonal Therapy Preferrable.  In Advanced Therapy of Prostatic Disease.  M Resnick & I. Thompson (eds.).  B.C. Decker Inc, Hamilton, Canada,  Pg. 332-339, 2000.

Hussain, M.   Chemotherapy for prostate cancer: Systemic therapy for high risk localized disease. Am Soc Clin Oncol Educational Book, 578-584, 2000.

Kaur, J, Turner, JR, Singh, P, Al-Katib, AM.   Multiple myeloma in the liver. Am J. Hematol, 65(4):290, 2000.

Kucuk, O.  Complementary and Alternative Medicine in the Treatment of Cancer: Current Research and Future Directions. Oncology Issues 15:17-19, 2000.

Mohammad, RM,  Beck, FWJ,  Al-Katib, A,  Masters, J.  (Ed) Non-Hodgkin’s Lymphoma Cell Lines. In: Human Cell Culture Vol. III. Cancer Cell lines Part3: Leukemias and Lymphomas, In: Masters J.R.W and Palsson, B.O (Eds), Chapter nine, Kluwer Academic Publishers, Boston, USA pp  295-320.

Mohammad, RM, Beck, FWJ,Wall, N, Al-Katib, A.   B-Lymphoid Cell Lines. In: Human Cell Culture Vol. III. Cancer Cell lines Part3: Leukemias and Lymphomas, In: Masters J.R.W and Palsson, B.O (Eds), Chapter three, Kluwer Academic Publishers, Boston, USA pp  61-80, 2000.

Peters, WP, Hamm, C, Baynes, RD.  Autologous hematopoietic stem cell transplantation. Cancer Medicine 5th Edition. Bast J, Kufe D, Pollock, Weichselbaum, Holland, Frei E. (Eds) Pp 890-910. Decker, Hamilton and London,  2000 (in press).

Schiffer, CA, Anderson, K.   Platelet Transfusion Therapy.  ASCO Educational Book, 36th Annual Meeting ASCO  pp 290-298, 2000.

Schiffer, CA, Larson, RA.   Acute lymphocytic leukemia in adults.  In: Cancer Medicine, 5th Edition.  Holland Jf, Frei E, Bast RC, Kufe DW, Pollack RE, Weichslbaum RR, eds.  B.C. Decker.  pp 1979-1988, 2000.

Schiffer, CA, Stone, R.   Acute myeloid leukemia in adults.  In: Cancer Medicine, 5th Edition.  Holland Jf, Frei E, Bast RC, Kufe DW, Pollack RE, Weichslbaum RR, eds.  B.C. Decker.  pp 1947-1970, 2000.

Schiffer, CA.   Hematopoietic growth factors in patients with leukemia.  In: Treatment of Acute Leukemia: New directions for clinical research.   Pui CH, ed Humana Press, Inc.  (in press).

Wozniak, AJ, Kraut, MJ.   Clinical Presentation of Lung Cancer. In:Lung Cancer: Principles and Practice. H.I. Pass (Ed), Lippincott-Raven, May 2000.

Wozniak, AJ,Kraut, MJ.   Clinical Presentation of Lung Cancer. In: Lung Cancer: Principles and Practice. HI, Pass (Ed), Lippincott-Raven, May 2000.

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Abella, E, Dansey, R, Karanes, C, Klein, J, Cassells, L, Hamm, C, AlKatib, A, Eilender, D, Peters, W, Baynes, R.   STAMP I with amifostine and autologous stem cell rescue is an active combination in advanced NHL: A phase I trial. Proc Am Soc Clin Oncol, 2000 19: 61a.

Adelstein, DJ, Adams, GL, Li, Y, Wagner, H, Kish, JA, Ensley, JF, Schuller, DE, Forasatiere, AA.   A phase III comparison of standard radiation therapy (RT) versus RT plus concurrent cisplatinum (DDP)  versus split course RT plus concurrent and 5-Fluorouracil (5FU) in patients with unresectable squmaous cell head and neck cancer (SCHNC) An Intergroup Study. Proc ASCO 19:1624, 2000.

Adelstein, DJ, Adams, GL, Li, Y, Wagner, H, Kish, JA, Ensley, JF, Schuller, DE, Forasatiere, AA. Int 0126, A phase III comparison of standard radiation therapy (RT) versus RT plus concurrent cisplatinum (DDP)  versus split course RT plus concurrent and 5-Fluorouracil (5FU) in patients with unresectable squmaous cell head and neck cancer (SCHNC). 5th Int Conf H&N Cancer, San Francisco, 2000.

Ahmad, I, Al-Katib, AM, Beck, FWJ, Wall, NR, Mohammad, RM.  Sequential treatment of a resistant CLL-patient with bryo 1 followed by 2-chlorodeoxyadenosine. Proceedings of the American Association for Cancer Research, 41:756 (#4804) 2000.

Ahmed, S,  Vaitkevicius, VK,  Zalupski, MM, Du, W,  Arlauskas, P, Gordon, C, Kellogg, C,  Shields, AF.    Cisplatin, cytarabine , caffeine  and continuously  infused  5-fluorouracil  (PACE)  in  the  treatment  of  advanced  pancreatic  carcinoma: a  phase  II  study, Am J Clin Oncol, 23:420-424, 2000.

Ahunbay, EE, Evelhoch, JL, Pipe, JG.   Comparison of Propeller, Spiral And Variable Density Spiral Trajectories by Computer Simulations for Dynamic Contrast Enhanced MRI of Cancer, Workshop on MR in Experimental & Clinical Cancer Research, Geiranger, Norway, August, 2000.

Alangaden, GJ, Jamma, K, Chandrasekar, PH, Karanes, C, Klein, J, Cassells, L, Dansey, R, Abella, S, Peters, W, Baynes, R.  Clostridium difficile associated diarrhea during hematopoietic stem cell transplantation. Proc Inf Dis Soc Am 2000 Abstract #395.

Alhasan, SA, Ensley, JF, Sarkar, FH.   Inhibition of tumor cell invasion is accomplished by down regulation of ERBB-2 expression and MMP secretion in a head and neck squamous cell carcinoma lien (HNSCC). AACR, 2000.

Al-Sukhun, A, Aboubakr, SE, Girgis, RE, Swerdlow, PS.   Pulmonary Hypertension is Present in 10-30% of Adult Patients with Sickle Cell Disease, ASH Poster, San Francisco, CA, 2000.

Arias-Mendoza, F, Brown, TR, Schwarz, A, Leach, MO, Zakian, K, Koutcher, JA, Stubbs, M, Griffiths, JR, Nelson, SJ, Heershap A, Glickson, JD, Charles, HC, Evelhoch, JL.   Preliminary Results of a Multi-Institutional Trial to Demonstrate Clinical Predictive Value of In Vivo Localized ³¹P MR Spectroscopy Data in Human Non-Hodgkin's Lymphoma, 8th Mtg. Int. Soc. Magn. Reson. Med, Denver, CO, April 2000.

Baselga, J, Herbst, R, LoRusso, P, Rischin, D, Ranson, M, Plummer, R, Raymond, E, Maddox, A, Kaye, SB, Kieback, DG, Harris, A, Ochs, J.   Continuous Administration of ZD1839 (Iressa), a Novel Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EFGR-TKI), in Patients with Five Selected: Evidence of Activity and Good Tolerability.  Proc. of ASCO, 19:686, May, 2000.

Bayne, RD, Dansey, RD, Klein, JL, Cassells, L, Karanes, C, Abella, E, Hamm, C, Parchment, R, Baumgart, J, Bach, F, Peters, WP.   A phase I trial of escalating Treosulfan in combination with high dose Dacarbazine and Melphalan followed by peripheral blood progenitor cell transplant (PBPCT) in recurrent metastatic ovarian and breast cancer.  Proceedings of the European Bone Marrow Transplant Society Meeting 2000.

Baynes, RD, Dansey, RD, Klein, JL, Cassells, L, Karanes, C, Abella, E, Hamm, C, Parchment, R, Baumgart, J, Bach, F, Peters, WP.   A phase I trial of escalating Treosulfan in combination with high dose Dacarbazine and Melphalan followed by peripheral blood progenitor cell transplant (PBPCT) in recurrent metastatic ovarian and breast cancer.  Blood, 96:170a, 2000.

Baynes, RD, Parchment, R, Dansey, RD, Klein, JL, Karanes, C, Hamm, C, Abella, E, Cassells, L, LeVeque, G, Baumgart, J, Bach,  F, Peters, WP.   Phase I Evaluation of High Dose Melphalan, DTIC and Treosulfan (MDT in Previously Treated Metastatic Breast and Ovarian Cancer. Proc Am Soc Clin Oncol, 19:148a, 585, 2000.

Baynes, RD. Anemia in malignancy: Treatment and non-invasive markers of an erythropoietic response. Proceedings of the Chemotherapy Foundation Symposium: Innovative cancer therapy for tomorrow. Bone Marrow Transplantation, 2000 :26:S33.

Berenson, J.R, Ravera, C, Ma, P, Deckert, F, Sasaki, Y, Saeki, T, Takashima, S, LoRusso, P, Goodin, S, Seaman, J, Schran, H, Zhou, H.  Population Pharmacokinetics (PK) of Zometa.  Proc. of ASCO 19:814, May, 2000.

Broome, C, Hussain, M, Vaughn, D.   Phase II trial of weekly paclitaxel in patients with previously treated advanced urothelial cancer. Proc Am Soc Clin Oncol 19, # 1381, 2000.

Chen, C, and Chen, B.  Pore-forming ability of cleaved bcl-2 releases hemoglobin from sheep red blood cells.  Proc Am Assoc Cancer Res,  41:154a, 2000.

Chu, A, Pipe, JG, Evelhoch, JL.   A Strategy to Decrease Motion Artifacts in Diffusion Weighted Imaging with Multiple-shot Spiral Imaging to Increase Sensitivity, 8th Mtg. Int. Soc. Magn. Reson. Med, Denver, CO, April 2000.

Dansey, RD, Karanes, C, Klein, JL, Abella, E, Cassells, LJ, Hamm, C, Baynes, RD, King, R, Peters, WP.   Updated Results of Autologous Stem Cell Transplantation for Relapsed/Refractory Hodgkin’s Disease Using Cyclophosphamide Platinum and BCNU (CPB/Stamp I). Proc Am Soc Clin Oncol, 19:64a, 247. 2000.

Dansey, RE, Karanes, C, Klein, JL, Abella, E, Cassells, L, Hamm, C, King, R, Peters, WP, Baynes, RD.   Updated results of autologous stem cell transplantation for relapsed/ refractory Hodgkin’s disease using cyclophosphamide, platinum and BCNU (CPB/STAMP1). Proc Am Soc Clin Oncol 2000: 19: 64a.

Dohmen, BM, Wei, R, Grierson, JR, Shields, AF, Reimold, M, Machula, H-J, Bares, R. FLT-speicherung in malignen tumoren: Erste ergebnisse einer pilotstudie.  Nuklearmedizin 39: A44, 2000. At Nuclear Medicine Congress 2000, Munich, March 2000.

Dohmen, BM, Kuntzsch, M, Grierson, JR, Shields, AF,  Eschmann, M, Machula, H-J, Ganzkorperverteilung von [F-18]FLT. Nuklearmedizin  39: A94, 2000.  At Nuclear Medicine Congress 2000, Munich, March 2000.

Dohmen, BM, Shields, AF, Grierson, JR, Kuntzsch, M, Reimhold, M, Sloan, A, Machulla, H-J, Bares, R.   [18F]FLT-PET in brain tumors. J Nucl Med. 5:74P, 2000

Du, W, Touchette D, Vaitkevicius, VK, Peters, WP,  Shields, AF.   Costs of Pancreatic Cancer Treatment - A Single Institution Experience.  Cancer, 89:1917-1924, 2000.

Duanmu, Z, Runge-Morris, M,  (2000) Cloning and dexamethasone regulation of the rat aryl sulfotransferase (SULT1A1) gene. The Toxicologist, The Toxicologist, 54(1), 215, abstr.1009.

EORTC-AACR symposium on new drugs in cancer therapy, November 7-10, Amsterdam, Netherlands, 87 (#221), 2000.

Evelhoch, JL, Brown, T, Chenevert, T, Clarke, L, Daniel, B, Degani, H, Hylton, N, Knopp, M, Koutcher, J,  Lee, TY, Mayr, N, Sullivan, D, Taylor, J, Tofts, P, Weisskoff, R.   Consensus Recommendation for Acquisition of Dynamic Contrasted-Enhanced MRI Data in Oncology, 8th Mtg. Int. Soc. Magn. Reson. Med, Denver, CO, April 2000.

Fernández-Madrid F, Karvonen RL, Ensley J, Kraut M,Granda JL, and JE Tomkiel. Patients with squamous cell carcinomas of the head and neck produce a different spectrum of antinuclear antibodies than patients with lung squamous cell carcinomas.Center for Molecular Medicine and Genetics and Department of Medicine, Wayne State University. Impact of Biotechnology in Cancer, Geneva, Switzerland, Oct 28-31, 2000.

Forastiere, A, Berkley, B, Maor, M, Weber, R, Goepfert, H, Morrison, WH, Glisson, BH, Trotti, A, Ridge, RA, Peters, G, Chao, C, Lee, DJ,, Leaf, A,  Ensley, J.   Phase III trial to preserve the larynx: Induction Chemotherapy and radiotherapy versus concomitant chemoradiotherapy versus radiotherapy alone.  Intergroup Trial R91-11. Proc. ASCO, 4/ 2001, Plenary Session, San Francisco, CA.

Garcia-Carbonero, R, Eder, J.P, Clark, JW, Supko, J.G, Ryan, DP, Roper, K, Deluca, P, Wozniak, A, Campbell, A, Rothermel, J, LoRusso, PM. Phase I and Pharmacokinetic Study of 4’-n-benzoyl-staurosporine (PKC412) Combined with 5-Fluorouracil in Patients with Advanced Solid Malignancies.  ASCO 2001.

Grierson, JR,  Shields, AF.    Radiosynthesis of 3’-deoxy-3’-[F-18]fluorothymidine: [F‑18]FLT for imaging cellular proliferation in vivo.  Nuclear Med Biol, 27:143-156, 2000.

Grignon, D, Jimenez, RE, Hussain, M, Tabazcka, P, Sakr, W, Pontes, JE, Wood, D. Prognostic significance of Her-2/neu overexpression in muscle invasive urothelial carcinoma of the bladder. Modern Pathology, 12(3):100A, 2000.

Hamm, CM, Klein, J, Dansey, RD, Karanes, C, Abella, E, Cassells, L, Peters, WP, Baynes, RD.  CD 34 Selected PBPC Peripheral Blood Progenitor Cell Transplantation (PBPCT) after High-Dose Cyclophosphamide, Cisplatin and Carmustine (CPB) for Breast Cancer Metastatic to Bone or Bone Marrow: Safety and Supportive Care Data. Proc Am Soc Clin Oncol 2000, 19: 57a.

Hamm, C, Klein, J, Dansey, R, Baynes, R, Karanes, C, Abella, E, Vartaresian, M, Mohamed, A, Aref, A, Al Katib, A.   High dose melphalan and total body irradiation with peripheral stem cell transplantation followed by interferon for multiple myeloma.  Proceedings of the 2001 ABMTR/IBMTR tandem meetings.

Hu, J, Evelhoch, JL.  High Spatial Resolution ¹H Lipid MRS of Healthy Human Muscles, 8th Mtg. Int Soc Magn Reson Med, Denver, CO, April 2000.

Hussain, M, Baranowski, K, Marsack, C, Flaherty, L.  Weekly paclitaxel, 13-cis-retinoic acid and alpha interferon: A bio-chemotherapy regimen for metastatic renal cell cancer. Proc Am Soc Clin Oncol 19, #1400, 2000.

Ibrahim, D, Hussain, M, LoRusso, PM, Flaherty, L.  Rebeccamycin Analog (BMY-27557-14) in Renal Cell Cancer: Preliminary Results of a Phase II Trial.   ASCO 2001.

Isoflavones. DOD Meeting in Atlanta. June 8-12, 2000.

Jimenez, RE, Grignon, D, Vaishampayan, U, Hussain, M.   Analysis of Her-2/neu overexpression in primary and metastatic transitional cell carcinoma of the bladder. Proc Am Soc Clin Oncol 19, # 1294, 2000, (Oral Presentation).

Kantarjian, H, Sawyers, C, Hochhaus, A, Guilhot, F, Schiffer, C, Resta, D, Druker, B.   The International STI 571 study group.  Phase II study of STI571, a tyrosine kinase inhibitor, in patients with resistant or refractory Philadelphia chromosome positive chronic myeloid leukemia.  ASH 2000.

Klein, JL, Dansey, R, Karanes, C, Hamm, C, Cassells, L, Peters, WP, Baynes, RD. High-dose chemotherapy STAMP 1 and peripheral blood progenitor cell transplantation following adriamycin induction chemotherapy for high-risk primary and locally advanced breast cancer. Proc Am Soc Clin Oncol 2000: 19: 60a.

Klein, JL, Dansey, R, Karanes, C, Hamm, C, Cassells, L, Peters, WP, Baynes, RD.  High-Dose Chemotherapy STAMP 1 and Peripheral Blood Progenitor Cell Transplantation Following Adriamycin Induction Chemotherapy  for High-Risk Primary and Locally Advanced Breast Cancer.  Proc Am Soc Clin Onc, 19:60a, 234, 2000.

Kucuk, O, Sarkar, F, Bouwman, D, Djuric, Z, White, M, Hryniuk, W, Visscher, D, Banerjee, M.   Modulation of Growth and Differentiation in Breast cancer with Soy

Kucuk, O.   Prostate Cancer Chemoprevention. MIUC Meeting, New Delhi, India. November 3-5, 2000.

Lamba, R, Karanes, C, Abella, E, Dansey, R, Hamm, C,  Klein, J, Baynes, R.   A long term study of allogeneic bone marrow transplantation in myelodysplastic syndromes. Blood, 96; 410a, 2000.

Lim, EH, Shields, AF.   The role of PET scanning the non-small cell lung cancer.  J of  Oncology Index & Reviews, IV (number 4):3-5, 2001.

Lin, H, Chen, C,  Chen, B.   The expression of x-linked inhibitor of apoptosis protein (XIAP) is associated with the resistance to apoptosis in bone marrow-derived macrophages.  Proc. Am. Assoc Cancer Res  (in press).

Lin,H, Zhang, XM, Chen, C, Chen, B.   Mitochondrial cytochrome c release in apoptotic Mo7e human leukemia cells is associated with the cleavage of Bcl-2 into a shortened fragment that is not functional for heterodimerization with Bax.  Proc Am Assoc Cancer Res,  41:153a, 2000.

LoRusso, P, Snads, H, Wozniak, A, Jasti, B, Parchment, R, Prakash, S.  Phase I Clinical Trial of 5-Fluoro-Pyrimidine.  Proc. of ASCO, 19:747, May, 2000.

Mankoff, DA, Dehdashti, F, Shields, AF.    Characterizing tumors using metabolic imaging:  PET imaging of cellular proliferation and steroid receptors.  Neoplasia, 2:71-88, 2000.

Nabha, SM, Mohammad, RM, Wall, N, Dutcher, J, Al-Katib, A.  Combretastatin A-4 prodrug and lymphoma: In vivo antitumor and antiangiogenic activity. Proceedings of the 2000 NCI-EORTC, AACR, Vol. 6 , 4521s (#278), 2000.

Nabha, SM, Mohammad, RM, Wall, N, Dutcher, J, Pettit, GR, Al-Katib, A. Combretastatin A-4 prodrug and lymphoma: In vivo antitumor and antiangiogenic activity. Blood, 95: (#4504), 2000.

Nabha, SM, Mohammad, RM, Wall, NR, Dutcher, JA, Pettit, GR, Al-Katib, AM. Activity of Combretastatin A-4 against B cell leukemia and lymphoma. Proceedings of the American Association for Cancer Research, 41:59 (#379) 2000.

Nathan, W, Mohammad, RM,  Al-Katib, A.  Acquired resistance to bryostatin 1 and 2-CdA in a human chronic lymphocytic leukemia cell line is due to modulation of induced IAP expression, bad phosphorylation and bcl:bax protein modulation. Proceedings of the 2000 NCI-EORTC, AACR, Vol. 6 , 4510s (#221), 2000.

Nelson, DA, Bhattacharyya, T, Rizvi, Ss, Edwards, H, Swerdlow, PS.   Patients with Sickle Cell Disease Have Decreased Cortial but Normal Trabecular Bone Density.  ASH Poster, San Francisco, CA, 2000.

Philip, PA, Pernick, NL, Vaishampayan, U, Simon, MS, LoRusso, P, Chaplen, R, Biernat, L, Flaherty, LE.   Phase II Study of Doxorubicin, Docetaxel, and 5-Fluorouracil (FAT) in Patients with Locally Advanced Breast Cancer.  Proc. of ASCO 19:510, May, 2000.

Prakash, S, Wozniak, A, Foster, B, Flaherty, L, Shields, A, Parchment, R, LoRusso, P.  Phase I Clinical Trial of KRN5500.  Proc. of ASCO 19:788, May, 2000.

Prakash, S, Wozniak, A, Foster, B, Flaherty, L, Shields, A, Parchment, R, LoRusso, P.    Phase I clinical trial of KRN5500. Proceeding of ASCO 19:202a, 2000.

Qureshi, MA, Baynes, RD, Soubani, AO.  The value of bronchoscopy in the diagnosis of pulmonary complications following autologous peripheral stem cell transplantation for breast cancer. American Thoracic Society meeting 2000.

Qureshi, MA, Gugnani, MK, Swerdlow, PS, Girgis, RE.   Decreased Exhaled Nitric Oxide (NO) In Patients with Sickle Cell Disease.  ASH Poster, San Francisco, CA, 2000.

Rizzieri, DA, Johnson, JL, Niedzwiecki, D, Lee, EJ, Vardiman, JW, Powell, BL, Schiffer, CA,  Peterson, BA, Canellos, GP, Larson, RA.   Efficacy and toxicity of brief duration, high intensity chemotherapy for small, noncleaved cell lymphoma/L-3 acute lymphoblastic leukemia (L3ALL): results of CALGB 9251.  ASH 2000.

Serrai, H, Loevner, LA, Zakian, K, Arias-Mendoza, F, Rijpkema, M, Koutcher, JA, Brown, TR, Charles, HC, Leach, MO, Griffiths, JR, Nelson, SJ, Evelhoch, JL, Heershap, A, Glickson, JD.   Monitoring Response of Head & Neck Tumors to Therapy Using In Vivo Localized ³¹P Decoupled MR Spectroscopy : A Preliminary Study, 8th Mtg Int Soc Magn Reson Med, Denver, CO, April 2000.

Shields, AF, Dohmen, BM, Mangner, TJ, Kuntzsch, M, Bares, R, Stayanoff, J, Muzik, O, Machulla, H.-J.    Metabolism of 18F-FLT in patients. J Nucl Med. 5:36P, 2000.

Shields, AF, Dohmen, BM, Mangner, TJ, Lawhorn-Crews, J, Machulla, H, Muzik, O,  Bares, R.   Imaging of thoracic tumors with [18F]FLT. J Nucl Med. 5:74P, 2000.

Sloan, AE, Kabrossi, B, Barger, G, Zamorano, L, Baynes, R, Wood, G.   Vaccination of patients with recurrent malignant astrocytoma with autologous tumor and granulocyte macrophage colony stimulating factor (GM-CSF). AANS 2000.

Sloan, AE, Kabrossi, B, Barger, G, Zamorano, L, Baynes, R, Wood, G.   Vaccination of patients with recurrent malignant astrocytoma with autologous tumor and granulocyte macrophage colony stimulating factor (GM-CSF). Proc Am Soc Clin Oncol 2000: 19: 464a.

Stone, RM, Larson, RA, Miller, K, Moore, JO, Amrein, PC, Karp, JE, Antin, JH, Zani, VJ, Schiffer, CA.   A randomized, placebo-controlled, double-blind trial of a loading dose of pegylated recombinant human megakaryocytic growth and development factor (MGDF) as an adjunct to chemotherapy for acute myeloid leukemia (AM).  ASCO 19:14, 2000.

SWOG Update, German Oncology Congress, April 2000Update on Lung Cancer, Helsinski, Stockholm, Manchester, Liverpool, London, April 2000.

Sun, H, Collins, JM,  Mangner, TJ, Muzik, O, Shields,  AF.   Biodistribution and metabolism of 18F-FAU:  A potential chemotherapeutic drug and PET imaging agent. J Nucl Med. 5:264p-265P, 2000.

Trivedi, C, Fontana, J, Forman, J, Banerjee, M, Kucuk, O, Sarkar, F, Wood, D, Hussain, M.   Modulation of PSA in patients with prostate cancer by soy isoflavones. Proc Am Soc Clin Oncol 19, # 1363, 2000.

Update on Gempac, Gemzar Investigator's Meeting, March 2000

Updated analysis of patients with non Hodgkins lymphoma patients receiving either  autologous or allogeneic transplants over a 12 year period. Dansey R, Abella E, Karanes C, Klein J, Hamm C, El Rayes B, Baynes R. Proceedings of the 2001 ABMTR/IBMTR tandem meetings.

Vaishampayan, U, Glode, M, Crawford, D, Kraft, A, Hudes, G, Wright, J, Hussain, M.   Phase II study of dolastatin-10 in patients with hormone refractory metastatic prostate cancer.    Proc AACR;41:46, abstr#297, 2000.

Vaishampayan, U, Smith, DC, Dickow, B, Hussain, M.   Carboplatin, paclitaxel and gemcitabine in advanced urothelial carcinoma:  Updated results. Proc Am Soc Clin Oncol 19, #1343, 2000.

Wall, NR, Al-Katib, AM, Mohammad, RM.    Acquired Resistance to Bryostatin 1 and 2-CdA in a Human Chronic Lymphocytic Leukemia Cell Line is Associated with Modulation of IAP Expression, Bad Phosphorylation and Bcl-2:Bax Ratio. 11th NCI-

Wall, NR, Al-Katib, AM, Nabha, SM, Mohammad, RM.   Acquired Resistance to 2-Chloro-Deoxyadenosine in Human Chronic Lymphocytic Leukemia is Associated with Modulation of Inhibitor of Apoptosis Proteins, Bad Phosphorylation and Bcl-2:Bax Ratio.  Blood, (#418) 2000.

Wall, NR, Mohammad, RM, Nabha, SM,. Pettit, GR, Al-Katib, AM.   Bryostatin 1 mediates c-IAP1 induction through NF-kB transactivation in the human pre-B ALL cell line, Reh. Proceedings of the American Association for Cancer Research, 41:758 (#4818) 2000.

Wood, G, Dansey, RD, Klein, J, Karanes, C, Hamm, C, Abella, E, Cassells, L, Skikne, BS, Peters, WP, Baynes, RD.  Combined Modality High-Dose Chemotherapy Followed by Adoptive Immunotherapy to Eliminate Minimal Residual Disease in Metastatic Breast Cancer.  Proc Am Soc Clin Onc, 19:101a, 390, 2000.

Wozniak, A, Kraut, M, Kalemkerian, G, Kucucu, O.   Phase II Study of GEMPAC (Gemicitabine and Paclitaxel) inn patients (pts) with Advanced Non-Small Cell Lung Cancer (NSCLC). Proc ASCO 19: 2015, 2000.

Yap, J, Aref, A, Nabha, S, Wall, NR, Mohammad, RM, Al-Katib, A.   Potentiation of radiation effect by bryostatin in chemotherapy-resistant intermediate-grade non-Hodgkin’s lymphoma. Proceedings of the American Association for Cancer Research, 41:371 (#2356) 2000.

Zalupski, M, O’Shaughnessy, JA, Vukelja, SJ, Shields, AF, Diener, KM, Grove, W. Phase II trial of CI-994 in patients with advanced pancreatic cancer. Proceeding of ASCO 19:285a, 2000.

Zonder, JA, LoRusso, P, Heilbrun, L, Flaherty, LE.   Phase II Trial of Weekly Paclitaxel as 2nd Line Treatment of Metastatic Malignant Melanoma (MMM).  Proc of ASCO 19:2249, May, 2000.

Division of Infectious Disease
Articles

Abraham, OC, Klein, J, Alangaden, GJ, Chalasani, G, Cassells, L,  Dansey, R, Abella, S, Karanes, C, Peters, W, Baynes, R, Chandrasekar, PH.  Low Infectious Morbidity Following Intensive Chemotherapy and Autologous Peripheral Blood Progenitor Cell Transplantation in the Outpatient Setting for Women with Breast Cancer. Clinical Infectious Diseases (In Press).

Alangaden, GJ. Miscellaneous Fungi. Current Treatment Options in Infectious Diseases 2000: 2;499-506.

Al-Harthi, L, Wright, D, Anderson, D, Cohen, M, Matityahu, D, Cohn, J, Cu-Uvin, S, Burns, D, Reichelderfer, P, Beckner, S, Landay, A. The impact of the menstural cycle on cytokine production:  evaluation of systemic, cervicovaginal and salivary compartments.  Journal of Interferon and Cytokine Research 2000;20(8):719-724.

Bhargava, P, Chandrasekar, PH.  Serious Fungal Infections: Review.  Hospital Physician 37:27-28, 2001.

Birk, TJ, McGrady, A, MacArthur, RD, Khuder, S. The effects of massage therapy alone and in combination with other complementary therapies on immune function and quality of life in HIV. The Journal of Alternative and Complementary Medicine; 6:405-14, 2000

Brown, PD, Crane, LR. A vascular necrosis of bone in patients with human immunodeficiency virus infection: a report of six cases and review of the literature.  Clin Infect Dis (in press).

Brown, PD, Foxman, B.  Pathogenesis of urinary tract infections:  the role of sexual behavior and sexual transmission.  Curr Infect Dis Reports 2000; 2:513-517.

Cannon, MJ, Dollard, SM, Smith, DK, Klein, RS, Schuman, P, Rich, J, Pellett, P.  Bloodborn and sexual transmission of HIV-8 in US women.  New Eng J. Med.(In press).

Chandrasekar, PH, Abraham, OC, Klein, J, Alangaden, GJ, Chalasani, G, Cassells, L, Dansey, R, Abella, S, Karanes, C, Peters, W, Baynes, R. Low infectious morbidity following intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer. Clin Infect Dis.  2001;32:546-551.

Chandrasekar, PH, Alangaden, G, Manavathu, E.  Aspergillus – A rising problem in tertiary care hospitals? Clinical Infectious Diseases 30:984, 2000. 

Chandrasekar, PH, Arnow, PM.  Cefepime versus Ceftazidime as Empiric Therapy for Fever in Neutropenic Patients with Cancer.  Annals of Pharmacotherapy 34:989-995, 2000.

Chandrasekar, PH, Cutright, J, Manavathu, E.  Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea pig model.  The Journal of Antimicrobial Chemotherapy 45:673-676, 2000.

Chandrasekar, PH.  Empiric Antifungal Therapy for Persistent Fever in Neutropenic Patients.  Clinical Infectious Diseases 32:320-321, 2001.

Chandrasekar, PH, Manavathu, EK.  Voriconazole: A Second Generation Triazole.  Drugs of Today (In Press).

Chandrasekar, PH.  Management of fever in neutropenic cancer patients: Review.  Hospital Physician, February 2000, 37-38.

Cinti, SK, Kaul, DR, Sax, PR, Crane, LR, Kazanjian, PH: Recurrence of Mycobacterium avium Infection in Patients Receiving Highly Active Antiretroviral Therapy and Antimycobacterial Agents.  Clinical Infectious Diseases, (in press).

Cohen, RA, Boland, R, Paul, R, Tashima, KT, Schoenbaum, EE, Celentano, DD, Schuman, P, Smith, DK, Carpenter, CJ.  Neurocognitive performance enhanced by highly active antiretroviral therapy in HIV-infected women.  AIDS, 2001, 15: 1-5.

Cu-Uvin, S, Wright, D, Anderson, D, Kovacs, A, Watts, H, Cohn, J, Landay, A, Reichelderfer, P for the WHS 001 and WHS 001a study teams.  Hormonal levels among HIV-1 seropositive women during the menstrual cycle. Journal of Women’s Health and Gender Based Medicine 2000;9:1-7.

Deziel, P, McGuire, N, Brown, PD.  Group B streptococcal meningitis complicating elective abortion:  report of two cases.  Clin Infect Dis 2000; 31:1115.

Dimmock, JR, Maniyan, PP, Puthucode, RN, Nazarali, AJ, Motag anahalli, NL, Zello, GA, Quail, JW, Oloo, EO, Kraatz, H-B, Prisciak, JS, Allen, TM, Santos, CL, Balzarini, J, Clercq, ED and Manavathu, EK. A Conformational and structure- activity relationship study of cytotoxic 3,5-bis-arylidene-4-piperidones and related N-acryloyl analogs. Journal of Medicinal Chemistry (in press).

Donabedian, S, Hershberger, E, Thal, LA, Chow, JW, Clewell, DB, Robinson-Dunn, B, Zervos, MJ. PCR fragment length polymorphism analysis of vancomycin-resistant Enterococcus faecium. J Clin Microbiol 2000; 38:2885-2888. 

El-Sadr, WM, Burman, WJ, Bjorling, Grant L, Matts, JP, Crane, L, Zeh, D, Gallagher, B, Mannheimer, S, Martinez, A, Hafner, R, and Gordin, F: Discontinuation of Prophylaxis against Mycobacterium avium complex in HIV-infected patients who have a response to antiretroviral therapy.  New Engl J Med, 2000, 1085-1092.

Espinel-Ingroff, A, Warnock, DW, Vazquez, JA and Arthington-Skaggs, BA. In vitro antifungal susceptibility methods and clinical implications of antifungal resistance. Medical Mycology 38 (Supplement1):293-304, 2000.

Fidel, PL, Vazquez, JA, and Sobel, JD.  Candida glabrata: An important fungal pathogen for the 21st century.  Clinical Microbiology (In Press).

Foxman, B, Barlow, R, d’Aray, H, Gillespie, B, Sobel, JD.  Urinary Tract Infection: Self-reported incidence and associated costs. Ann Epidemiol (In press).

Foxman, B, Barlow, R, d’Arcy, H, Gillespie, B, Sobel, JD.  Candida vaginitis: self-reported incidence and associated costs.  Sex Trans Dis 27:230-235, 2000.

Foxman, B, Gillespie, B, Koopman, J, Zhang, L, Palin, K, Tallman, P, Marsh, JV, Spear, S, Sobel, JD, Marty, MJ, Marrs, CF.  Risk factors for second urinary tract infection among college women.  Am J Epidemiol 151(12):1194-1205, 2000.

Foxman, B, Somsel, P, Tallman, P, Gillespie, B, Raz, R, Colodner, R, Kandula, D, Sobel, JD.  Urinary tract infection among women aged 40-65:  Behavioral and  sexual risk factors. J.Clin. Epidem. (In press).

Golemi, D, Maveyraud, L, Vakulenko, S, Tranier, S, Ishiwata, A, Kotra, LP, Samana, J-P, and Mobashery, S.  The first structural and mechanistic insights for Class D b-lactamases: evidence for a novel catalytic process for turnover of b-lactam antibiotics.  J Am Chem Soc 122:6132-6133, 2000.

Graybill, JR, Sobel, JD, Saag, M, VanderHorst, C, Powderly, W, Cloud, G, Riser, L, Hamill, R, Dismukes, W.  Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis.  Clin Infect Dis 30:47-54, 2000.

Harlow, S, Schuman, P, Cohen, M, Ohmit, SE, Cu, Uvin, S, Lin, X, Anastos, K, Burns, D, Young, M, Mucerspach, L, Rompalo, A, Minkoff, H, Warren, D, Greenblatt, R.  The Effect of HIV infection on Menstrual Cycle Length.  J Acquir Immune Defic Syndr 24(1):68-75, 2000.

Hedderwick, SA, Lyons, MJ, Vazquez, JA, Kauffman, CA.  Epidemiology of yeast colonization in the intensive care unit.  European Journal of Clinical Microbiology and Infectious Diseases 19:663-670, 2000.

Hershberger, E, Coyle, E, Kaatz, GW, Zervos, M, Rybak, MJ: Comparison of a rabbit model of bacterial endocarditis and an in vitro infection model with simulated endocardial vegetations.  Antimicrob. Agents Chemother. 44:921-1924, 2000.

Hidalgo, J, Brown, W, Vazquez, JA.  C. dubliniensis infection in an HIV-negative patient: A new opportunistic fungal pathogen.  Infectious Diseases in Clinical Practice 9:176-178, 2000.

Hidalgo, JA, Logani, S, MacArthur, RD. Pulmonary mucormycosis in a patient with AIDS: case and review. Infectious Diseases in Clinical Practice 2000; 9:182-6.

Hidalgo, JA, Alangaden, GJ, Akins, RA, Abrams, GW, Eliott, D, Puklin, J, Vazquez, JA. Fungal endophthalmitis diagnosis by detection of Candida albicans DNA in intraocular fluid by use of a species-specific polymerase chain reaction assay.  Journal of Infectious Diseases 181:1198-1201, 2000.

Hidalgo, JA, MacArthur, RD, Crane, LR: An Overview of HIV Infection and AIDS. Sem Cardiovasc Surg, 12:130-139, 2000.

Ickovics, J, Moore, J, Vlahov, D, Schuman, P, Schoenbaum, EE.  CD4 cell decline and mortality following depressive symptoms in HIV seropositive women.   JAMA (In press).

Kaatz, GW, Seo, SM, O'Brien, L, Wahiduzzaman, M, Foster, TJ: Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus.  Antimicrob. Agents Chemother. 44:1404-1406, 2000.

Kak, V, Donabedian, SB, Zervos, MJ, Kariyama, R, Kumon, H, Chow, JW.  Efficacy of ampicillin plus arbekacin versus ampicillin alone in experimental rabbit endocarditis caused by Enterococcus faecalis with high-level gentamicin resistance.  Antimicrob Agents Chemother 2000;  44:2545-2546.

Kak, V, MacArthur, RD, Crane, LR: Treatment of HIV disease in the new millennium. Sem Cardiovasc Surg, 12:140-144, 2000.

Kak, V, You, I, Zervos, MJ, Kariyama, R, Kumon, H, Chow, JW. In-vitro synergistic activity of the combination of ampicillin and arbekacin against vancomycin- and high-level gentamicin-resistant Enterococcus faecium with the aph(2")-Id gene.  Diagn Microb Infect Dis 2000; 37:297-299. 

Kanno, M, Chandrasekar, PH, Bentley, G, Vander Heide, RS, and Alangaden, GJ. Disseminated Cytomegalovirus Disease in Non-Conventional Hosts (No-AIDS/No -Transplant Patients).  Clinical Infectious Diseases 32:313-316, 2001.

Kao, SJ, You, I, Clewell, DB, Donabedian, SM, Zervos, MJ, Petrin, J, Shaw, KJ, Chow, JW. Detection of the high-level aminoglycoside resistance gene, aph(2")-Ib, in Enterococcus faecium.  Antimicrob Agents Chemother 2000; 44:2876-2879. 

Kariyama, R, Mitsuhata, R, Chow, JW, Clewell, DB, Kumon, H. Simple and reliable multiplex-PCR assay for surveillance isolates of vancomycin-resistant enterococci. J Clin Microbiol 2000; 8:3092-3095.

Kauffman, C, Vazquez, JA, Sobel, JD, Gallis, HA, McKinsey, DS, Karchmer, AW, Sugar, AM, Sharkey, PK, Wise, GJ, Mangi, R, Mosher, A, Lee, JY, Dismukes, WE, and the NIAID Mycoses Study Group  A prospective multicenter surveillance study of funguria in hospitalized patients.  Clin Infect Dis 30:14-18, 2000.

Kazanjian, P, Armstrong, W, Hossler, PA, Richardson, J, Crane, LR, Katz, J, Burman, R, Meshnick, S: Pneumocystis carinii mutations are associated with duration of sulfa prophylaxis and with sulfa treatment failure and in AIDS Patients. Journal of Infectious Diseases; 182:551-557, 2000.

Klein, RS, Smith, D, Sobel, JD, Flanigan, T, Margolick, JB.  A prospective study of positive tuberculin reactions in women with or at risk for HIV infection. International J TB and Lung Dis 4:688-690, 2000.

Klein, R, Arnstein, J, Sobel, JD.  Oropharyngeal Candida colonization and Human  Immunodeficiency Virus Type-1 infection.  J Infect Dis 181:812, 2000.

Kotra, LP, Vakulenko, S, Mobashery, S.  From genes to sequences to antibiotics: Prospects for future developments from microbial genomics.  Microbes Infect 2:651-658, 2000.

Kotra, LP, Golemi, D, Vakulenko, S, Mobashery, S.  Bacteria fight back.  Chemistry & Industry, 10:339-341, 2000.

Lee, W, Li, Z-H, Vakulenko, S, and Mobashery, S.  A light-inactivated antibiotic.  J Med Chem 43:128-132, 2000.

Leigh, JE, Barousse, M, Myers, T, Swoboda, R, Hager, S, Wolf, NA, Cutwright, JL, Sobel, JD, Fidel, PL.  I. Infect. Dis. 183:277-285, 2001.       

Lundstrom, TS, Pugliese, G, Bartley, J, Guither, C, Cox, J. Organizational and work environment factors that affect worker health and safety and patient outcomes.  Am J Infect Control (In press).

Lundstrom, T, Sobel, JD.  Nosocomial Candiduria.  Clin Infect Dis. (In press).

MacArthur, RD, Lederman, MM, Benson, CA, et al. Effects of treatment for MAC infection on cytokine expression in HIV-infected persons: results of AIDS Clinical Trials Group protocol 853. Journal of Infectious Diseases 2000;181:1486-90.

MacArthur, RD. Sequencing antiretrovirals. The AIDS Reader 2000; 10:359-64.

MacArthur, RD. An updated, user-friendly guide to genotype interpretation. The AIDS Reader 2000; 10:652-7.

MacArthur, RD, Chen, L, Mayers, D, Besch, CL, Novak, R, van den Berg-Wolf, M, Yurik, T, Peng, G, Schmetter, B, Brizz, B, Abrams, D. The rationale and design of the CPCRA FIRST Trial. Controlled Clinical Trials 2001, In Press.

Manavathu, E, Cutright, J, Chandrasekar, PH.  A Comparative Study of the In Vitro Susceptibilities of Clinical and Laboratory-Selected Resistant Isolates of Aspergillus Species to Amphotericin B, Itraconazole, Voriconazole and SCH 56592.  Journal of Antimicrobial Chemotherapy 46:229-234, 2000.

Manavathu, EK, Ben-Josef, AV, Sobel, JD.  Proton translocating ATPase mediated fungicidal activity of a novel complex carbohydrate:  CAN-296.  Internat J Antimicrob Ag 13:287-295, 2000.

Manavathu, EK, Dimmock, JR, Vashishtha, SC, Chandrasekar, PH. Inhibition of H+ -ATPase mediated proton pumping in  Cryptococcus neoformans by a novel conjugated styryl ketone.  Journal of Antimicrobial Chemotherapy (In press).

Manavathu, EK, Abraham, OC, Chandrasekar, PH. Isolation and in vitro susceptibility to amphotericin B, itraconazole and posaconazole of voriconazole-resistant laboratory isolates of Aspergillus fumigatus. Clinical Microbiology and Infection ( in press).

Manavathu, EK, Nune, U, Kanuri, K, Chandrasekar, PH, Abraham, OC. Effect of test medium on in vitro susceptibility testing results for Aspergillus fumigatus. Revista   Iberoamericana de Micologia 17: 107-110, 2000.

Maveyraud, L, Golemi, D, Kotra, LP, Tranier, S, Vakulenko, S, Mobashery, S, Samana, J-P. Insights into Class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa. Structure 8:1289-1298, 2000.

McNeil, SA, Clark, NM, Chandrasekar, PH, Kauffman, CA.  Successful Treatment of Vancomycin-Resistant Enterococcus faecium bacteremia with Linezolid after failure of treatment with Synercid (Quinupristin/Dalfopristin). Clinical  Infectious Diseases 30:403-404, 2000.

Newberry, EC, Foxman, B, Leaman, D, Sobel, JD.  Desquamative inflammatory vaginitis:  An exploratory case-control study.  Sex Trans. Inf. (In press).

Ormerod, D, Pucklin, J, Sobel, JD:  Syphilitic posterior uveitis.  Clin Infect Dis (In press).

Lundstrom, TS, Sobel, JD. Antibiotics for gram-positive bacterial infections: Vancomycin, Teicoplanin, Quinupristin/ Dalfopristin and Linezolid in: Infect Dis Clin N Am (D. Kaye, ed) WB Saunders Co, Philadelphia, Pennsylvania. 14(2): pp 463-74, 2000.

Nyirjesy, P, Sobel, JD, Weitz, V, Leaman, D, Small, MJ, Gelone, SP.  Cromolyn cream for recalcitrant idiopathic vulvar vestibulities:  Results of a placebo-controlled study. Sex Trans. Inf. 77:53-57, 2001.

O’Neil, WM, Drobitch, RK, MacArthur, RD, Farrough, MJ, Doll, MA, Fretland, AJ,  Hein, DW, Crane, LR, Svensson, CK: Acetylator phenotype and genotype in patients infected with HIV: Discordance between methods for phenotype determination and genotype.  Pharmacogenetics, 2000. 10:171-182

Prasad, AS, Fitzgerald, JT, Bao, B, Beck, FWJ, Chandrasekar, PH.  Duration of Symptoms and Plasma Cytokine Levels in Patients with the Common Cold Treated with Zinc Acetate.  Annals of Internal Medicine 133: 245-252, 2000.

Reichelderfer, PS, Coombs, RW, Wright, DJ, Cohn, J, Burns, D, Cu-Uvin, S, Baron, P, Cohen,  M, Landay, A, Beckner, S, Lewis, S, and Kovacs, A for the WHS 001 Study Team.   Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. AIDS 2000;14:2101-2107.

Rex, JH, Sobel, JD.  Prophylactic therapy in the Intensive Care Unit Clin Infect Dis (In press).

Rex, J, Cloud, GA, Denning, DW, De Pauw, BE, Edwards, JE, Hiemenz, JW,

Kauffman, CA, Lopez Bernstein, G, Martino, P, Sobel, JD, Stevens, DA, Sylvester, R, Tollemar, J, Viviani, MA, Viscoli, C, Wu, T.  Need for alternative trial designs and evolution strategies for therapeutic studies of invasive mycoses.  Clin Infect Dis. (In press).

Rex, JH, Walsh, TJ, Sobel, JD, Filler, SG, Pappa, PG, Dismukes, WE, Edwards, JE:

Practice guidelines for the treatment of candidiasis.  Clin Infect Dis 30:662-78, 2000

Saag, MS, Graybill, JR, Larsen, RA, Pappas, PG, Perfect, JR, Powderly, WG, Sobel, JD, Dismukes, WE:  Guidelines for the management of cryptococcal disease.  Clin Infect Dis 30: 2000.

Samuel, J, Alangaden, G, and Chandrasekar, PH.  Cervical adenitis due to Mycobacterium fortuitum in a patient with AIDS.  Infectious Diseases in Clinical Practice 9:221-222, 2000.

Sankar, A, Luborsky, M, Schuman, P, Roberts, G.  Adherence to Anti-Retroviral Therapy Among African American Women:  Resources and Challenges.  AIDS Care (In Press).

Schuman, P, Ohmit, SE, Moore, J, Schoenbaum, EE, Boland, R, Rompalo, A, Solomon, L. Utilization of Mental Services by women participating in a longitudinal cohort Study of HIV infection in women.  Journal of the American Medical Womens’ Association, Winter 2000; 56 (1): 1-6.

Schuman, P, Ohmit, SE, Cohen, M, Sacks, H, Schoenbaum, E, Richardson, J, Rompalo, A, Young, M, Gardner, L.  Adherence to Anti-retroviral Therapy among Women in The HIV Epidemiology Research Study (HERS) and Women’s Inter-Agency HIV Study (WIHS).  AIDS and Behavior (In press).

Sobel, JD, Epidemiology and management of fungal vaginitis.  Rev Med Microbiol (In press)

Sobel, JD:  Bacterial vaginosis.  Ann Rev Med 51:29-49, 2000.

Sobel, JD:  Gynecologic infections in HIV seropositive women.  Clin Infect Dis 31:1225-1233, 2000.

Sobel, JD, Kapernick, PS, Zervos, MJ, Reed, BD, Hooton, T, Soper, I, Nyirjesy, P, Heine, W, Willems, J, Panzer, H, Wittes, H.  Treatment of complicated Candida vaginitis; Comparison of single and sequential doses of fluconazole. Am. J. Ob Gyn ( In press).

Sobel, JD:  Management of infections caused by C. glabrata.  Curr Infect. Dis Report 2: 424-428, 2000.

Sobel, JD:  Managing vulvovaginal candidiasis.  The Female Patient 20:29-45, 2000.

Sobel, JD, McKinsey, D, Kauffman, C, Zervos, MJ, Vazquez, JA, Lee, J and the Mycosis Study Group, NIAID.  Candiduria: A randomized, double blind study of treatment with fluconazole and placebo.  Clinical Infectious Diseases 30:19-24, 2000.

Sobel, JD:  Non trichomonal purulent vaginitis: Clinical approach. Curr Rep Infect Dis 2:501-505, 2000.

Sobel, JD, Ohmit, SE, Schuman, P, Klein, RS, Mayer, K, Duerr, A, Vazquez, JA, Rompalo, A.  The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from HIV seropositive and at-risk HIV-seronegative women.  J Infect Dis 183:286-293, 2001.

Sobel, JD, Peipert, JF, McGregor, JA, Livergood, C, Martin, M, Robbins, J, Wajszczuk, CP.  Efficacy of clindamycin vaginal ovule (3 day treatment) vs. Clindamycin vaginal cream (7 day treatment) in bacterial vaginosis.  Infect. Dis. In Ob-Gyn. (In press).

Sobel, JD, Rex, JH.  Risk factors for candidemia in surgical ICU.  Clin Infect Dis. (In press).

Sobel, JD:  Use of antifungal drugs in pregnancy. Drug Safety 23: 77-85, 2000.

Sobel, JD.  Vaginal Mucormycosis.  Infect Dis OB/GYN. (In press).

Sobel, JD: Failure of Metronidazole to prevent preterm delivery in women with asymptomatic bacterial vaginosis.  Curr Infect Dis Rpts  2: 499-500, 2000.

Tiraboschi, N, Bennett, JE, Kaufman, CA, Rex, JH, Girmenias, C, Sobel, JD, Menichettis, F.  Deep Candida infections in the neutropenic and non-neutropenic host. Medical Mycol 38: 1999-204, 2000.

Thomas, DL, Rich, J, Schuman, P, Astemborski, J, Nolt, K, Klein, RS.  Multicenter evaluation of hepatitic C RNA levels among female injection drug users. J Inf Dis, (In press).

Vazquez, JA, Arganoza, MT, Boikov, D, Vaishampayan, JK, Akins, RA.  In vitro susceptibilities of Candida and Aspergillus species to melaleuca alternafolia (Tea Tree) Oil.  Rev. Iberoamericana de Micologia 17(2):60-63, 2000.

Vazquez, JA, Hidalgo, JA, and De Bono, S.  Use of Sargramostim (rh-GM-CSF) as adjunctive treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS: A pilot study.  HIV Clinical Trials 1 (3):23-29, 2000.

Vazquez, JA, Peng, G, Sobel, JD, Steele-Moore, L, Schuman, P, Holloway, W, Neaton, JD, for the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA).  Evolution of antifungal susceptibility among Candida species recovered from HIV-infected women receiving fluconazole prophylaxis.  Clinical Infectious Diseases (In press).

Vazquez, JA.  Therapeutic Options for the management of Oropharyngeal and Esophageal Candidiasis in HIV/AIDS Patients.  HIV Clinical Trials 1(1) 47-59, 2000.

Villanueva, A, Sahouri, MJ, Ormerod, LD, Puklin, JE, Reyes, MP. Posterior uveitis in patients with positive serology for syphilis. Clin Infect Dis 2000; 30:479-485.

You, I, Kariyama, R, Zervos, MJ, Kumon, H, Chow, JW.  In-vitro activity of arbekacin alone and in combination with vancomycin against gentamicin- andmethicillin- resistant Staphylococcus aureus. Diagn Microb Infect Dis 2000; 36:37-41. 

Books, Chapters and Reviews
Alangaden, GJ. Infections in neutropenic cancer patients. The Saunders Manual of Critical Care. (In Press).

Alangaden, GJ. Leptospirosis. In: Humes HD, ed. Kelly’s Textbook of Internal Medicine 4th ed. Lippincott Williams & Wilkins. 2000.

Brown, PD, Levine, DP.  Infections in Injection Drug Users.  Mandell, Douglas andBennett’s Principles and Practice of Infectious Diseases 5th ed. Philadelphia, PA: Churchill Livingston, 2000: 3112-26.

Chandrasekar, PH.  Chapter:  Herpes Infections.  In: Manual of Critical Care. W.B. Saunders Co, Philadelphia, PA, (In Press).

Chandrasekar, PH.  Chapter: Infections in Patients Undergoing Blood and Marrow Transplantation (BMT).  In: Manual of Critical Care. W.B. Saunders Co, Philadelphia, PA, (In Press).

Chandrasekar, PH.  Fungi – Other: Management of Infections in Oncology Patients. Edited by Bowden RA and Wingard JR.  ISIS Medical Media Limited.  (In Press).

Chow, JW, Rice, LB. Enterococcus species. 2nd edition. (Internet version). In: Yu VL, Merigan TC, Jr, Barriere SL, eds. Antimicrobial Therapy and Vaccines.

Fidel PL Jr, Sobel JD.  Murine models of Candida vaginal infection.  In: Handbook of animal models of infection.  Zak O, Sande M (Editors), Academic Press, Guersney UK, Chapter 3, (In press).

Hidalgo, J, Alangaden, GJ. Potts’s Disease (Tuberculous spondylitis). In Emedicine Online Internal Medicine Textbook (www.emedicine.com ).

Hidalgo, JA, Vazquez, JA, Candidiasis.  In:  Medicine, OB-GYN, psychiatry and Surgery. Michael Zevitz (Ed.), E-medicine.com, Inc. (In Press). 

Lundstrom TS, Sobel JD:  Fungal infections.  In:  Association for Professionals, Infect Cont Epid Curr, R Olmstead (Editor), Mosby Year Book Publishers, Chicago, IL (In press).

Lundstrom TS, Sobel JD.  Vancomycin, Teicoplanin, Quinupristin/ Dalfopristin and Linezolid in: Infect Dis Clin N Am (D. Kaye, ed) WB Saunders Co, Philadelphia, Pennsylvania. 14(2): pp 463-74, 2000.

Lundstrom, TS, Crane, LR.  Chapter 62: Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome.  APIC Infection Control and Applied Epidemiology: Principles and Practice.  R. Olmsted, (Editor), Mosby-Yearbook, Inc, St. Louis, Missouri 2000.

MacArthur RD, Abbas M.  Sepsis and Septic Shock. In:  Scholossberg D, ed. Current Therapy of Infectious Disease.  Philadelphia:  Mosby. 2000

Rex, J, Sobel, JD, Powderly, W:  Candida Infections. In: Antimicrobial chemotherapy (2nd edition) Merigan T, Barrier SL, Yu VL (Editors) Williams, Wilkins Publishers, Baltimore (In press).

Rex, J, Sobel, JD, Powderly, W: Treatment of candidiasis in HIV-infected persons. In:  Antimicrobial Therapy in AIDS.  Yu VL, Merigan T, Barrier SL (Editors), Williams, Wilkins Publishers, Baltimore (In press).

Sobel, JD, Kaye, D.  Urinary Tract Infections.  In: Principles and Practice of Infectious Diseases, Mandell G, Bennett J, Dolin R (Editors), Churchill Livingston, Philadelphia, PA, 5th Edition, Vol 1, Chapt 62, pp 773-805, 2000.

Sobel, JD. Urinary tract infections and infections of the female pelvis In:  Essential Atlas of Infectious Diseases 2nd edition.  Editor Mandell G. Churchill Livingston (In press).

Sobel, JD.  Mucocutaneous candidiasis.  In: Fungal Infections, R Diamond (Editor), Atlas of Infectious Diseases. Churchill Livingston,   Chapter 8; 118-136, 2000.

Sobel, JD:  Candida vaginitis.  In: Infectious Diseases in Obstetrics and Gynecology, S Faro, D Soper (Editors), WB Saunders, 1st edition  p39-54, 2001.

Sobel, JD:  Candida vaginitis.  In: Vulvovaginal Disease, Ledger W and Witkin J (Editors), W.B. Saunders Co, New York, NY, (In press).

Sobel, JD:  Candiduria.  In:  Current Therapy of Infectious Diseases, Schlossberg D (Editor), Mosby Year Book, Philadelphia, PA, p 233-236, 2nd edition, 2000.

Sobel, JD:  Cervicitis.  In:  America College of Physicians (In press).

Sobel, JD:  Fungal infections of the genitourinary tract.  In: Clinical Mycology, E Anaissie, M McGinnis, M. Pfaller (Editors), WB Saunders, (In press).

Sobel, JD:  Genital candidosis.  In:  International Standard Book for Infectious Diseases in Obstetrics, Gynecology, Dermatology, Urology, and Clinical Immunology, Weissenbacher ER (Editor), Medifact Publishing House, Munich, Germany (In press).

Sobel, JD:  Prostatitis.  In:  Best Practice of Medicine (In press).

Sobel, JD:  Urinary tract infections.  In:  Best Practice of Medicine (In press).

Sobel, JD:  Vaginitis.  In:  American College of Physicians (In press).

Sobel, JD:  Vulvitis, vaginitis and cervicitis.  In: Infectious Disease, D Armstrong, Cohen, J (Editors), Mosby, London, United Kingdom, Chap. 52, 52.1-52.8, 2000.

Sobel, JD: Vulvovaginal candidosis.  In: Medicine, Sexually transmitted Infection Medicine Publishing Co, Oxford, UK, Vol 29: 7, 2001.

Vazquez, JA.  Zygomycosis.  In: Medicine, OB-GYN,  Psychiatry and Surgery. Michael Zevitz (Ed.), E-medicine.com, Inc.  (In Press). 2000.

Abstracts, Letters to the Editor and Articles in Non-Referred Journals
Abad Santos, S, Zaide, S, Brown, WJ, Reyes, MP. Levofloxacin: Is it adequate for serious Streptococcus viridans infections? Presented at the Annual Meeting of the
Michigan Infectious Disease Society, March 2000, St. John Hospital.

Akins, R, Allen, G, McKinnon, P, Kaatz, GW, Rybak, MJ:  Pharmacodynamic comparison and activity of moxifloxacin, ciprofloxacin, gatifloxacin, gemifloxacin and levofloxacin against clinical isolates of Streptococcus pneumoniae and Staphylococcus aureus.  Program and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract 303, page 10, 2000.

Alangaden, GJ, Jamma, K, Chandrasekar, PH, Karanes, C, Klein, J, Cassells, L, Dansey, R, Abella S, Peters W, Baynes R. Clostridium difficile associated diarrhea during hematopoietic stem cell transplantation. In the Abstracts of the IDSA 38th Annual Meeting, September 7-10, New Orleans, Louisiana. Clin Infect Dis. 2000;29:1014.

Alangaden, GJ, Thompson, E, Yoon, S, Akins, R, Chandrasekar, P, Vazquez, J. Diagnosis of invasive fungal infections by detection of fungal DNA in clinical specimens using a species-specific PCR. IN: Programs and Abstracts of the 38th Annual Meeting of the Infectious Diseases Society of America, September 7-10, 2000, New Orleans, Louisiana. (Abstract #273) Antibiotic Resistance. Washington, DC: American Society for Microbiology, p.45. 

Allen, G, Kaatz, GW, Blondeau, J, and Rybak, MJ: Evaluation of the mutant prevention concentration in Staphylococcus aureus and Streptococcus pneumoniae - effect of varying fluoroquinolone dosage regimens on the development of resistance in an in vitro pharmacodynamic infection model.  Program and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract 299, page 9, 2000.

Berman, W, Crane, LR: Low Rates of All Opportunistic Infections Among Patients with Advanced HIV Disease Responding to Antiretroviral Therapy—the CPCRA 048 Cohort.  Abst #L61p 7th Conference on Retroviruses and Opportunistic Infections.San Francisco, February 2000.

Brown, PD, Crane, LR. Avascular necrosis of bone in patients with human immunodeficiency virus infection.  Infectious Diseases Society of America 38thAnnual Meeting. New Orleans, Louisiana 2000.

Chandrasekar, PH, Cutright, JL, Manavathu, EK.  Antifungal Susceptibility, Frequency of Isolation and Species Diversity of Clinical Isolates at Detroit Medical Center Over a 6-Year Period.  IN: Programs and Abstracts of the 11th International Symposium on Infections in the Immunocompromised Host, Halifax, Nova Scotia, June 18-21, 2000.

Chilukuri, S, Alangaden, G, Karanes, C, Klein, J, Cassells, L, Dansey, R, Abella, S, Peters, W, Baynes R, Chandrasekar PH.  Antifungal Chemoprophylaxis in Bone Marrow/Stem Cell Transplantation: An International Survey.  IN: Programs and Abstracts of the 11th International Symposium on Infections in the Immuncompromised Host.  Halifax, Nova Scotia, June 18-21, 2000.

Donabedian, SM, Bozigar, PS, Perri, MB, Thal, LA, Hershberger, E, Jones, R, Bartlett, P, Chow JW, Zervos MJ. 2000. Prevalence of antimicrobial resistance and antimicrobial use in cows, turkeys, and swine. Abstract #150. In: Program Abstr. 40th Intersci. Conf. Antimicrob. Agents Chemother. p. 68. 

Ebright, J, Moldenhauer, J, Gonik, B.  “Nonsurgical Management of Post Ceasarean Endomyometritis with Myometrial Gas Formation”  Infectious Diseases in Obstetrics and Gynecology 8: 181-183.

Jamma, K, Chandrasekar, PH, Karanes, C, Klein, J, Cassells, L, Dansey, R, Abella, S, Peters, W, Baynes, R, Alangaden, GJ.  Spectrum of Clostridium difficile Diarrhea during Stem Cell Transplants (SCT).  IN: Programs and Abstracts of the 11th International Symposium on Infections in the Immunocompromised Host.  Halifax, Nova Scotia, June 18-21, 2000.

Kaatz, GW, Seo, SM, Abad Santos, S, Hartford, 0, Foster, TJ: Introduction of point mutations within norA and their effect on NorA function.  Program and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract 443, page 75, 2000.

Kak, V, Chow, J. 2000. Outbreak of meningococcal infection in a homeless shelter. Abstract #243. In: Abstr. Infectious Diseases Society of America 38th Annual Meeting, p. 82.  

Kariyama, R, Kumon, H, Araake, M, Tabata, M, Zervos, MJ, Chow, JW. 2000. In vitro activity of the combination of ampicillin and arbekacin against b-lactam-,glycopeptide-, and high-level gentamicin-resistant Enterococcus faecium. Abstract #531. In: Program Abstr. 40th Intersci. Conf. Antimicrob. Agents Chemother, p. 170. 

Kazanjian, P, Armstrong, W, Hossler, PA, Richardson, J, Crane, LR, Katz, J, Burman, R, Meshnick, S: Pneumocystis carinii mutations are associated with duration of sulfa prophylaxis and with sulfa treatment failure and in AIDS Patients. 7th Conference on Retroviruses and Opportunistic Infections.  San Francisco, February 2000.

MacArthur RD, Kosmyna J, Crane LR: A dual protease inhibitor (PI)-based regimen including indinivir (IDV) 800 mg twice daily (bid) plus ritonavir (RTV) 200 mg bid shows early promise in lowering serum HIV RNA levels in HIV-infected persons with extensive protease (pr) mutations. P34 Fifth International Congress on Drug Therapy in HIV Infection.  Glasgow, UK, October 22-26, 2000.

MacArthur R, Miller M, Panacek E, et al. Analysis of the relationship between Mortality and appropriateness of antibiotic treatment in the MONARCS (monoclonal  anti-TNF: a  randomized controlled sepsis) trial. Abstracts of the 40th ICAAC, 2000, 823. 

MacArthur, RD, Crane, LR, Cohn, JA. Antiretroviral Recommendations, Detroit Medical Center.  March, 2000.  Updated annually; adopted by the State of Michigan AIDS Drug Assistance Program, and distributed widely to health care professionals (multistate area).

Manavathu, EK, Baskaran, I, Alangaden, GJ, Chandrasekar, PH.  Differential susceptibility of itraconazole resistant Aspergillus fumigatus isolates to triazoles.  IN: Programs and Abstracts of the 101st General Meeting of the American Society for Microbiology, May 20-24, 2001, Orlando, Florida, Abstract A-18.

Manavathu, EK, Baskaran, I, Alangaden, GJ, Chandrasekar, PH.  Molecular characterization of the P450-dependent lanosterol demethylase gene from clinical isolates of Aspergillus fumigatus.  IN:  Programs and Abstracts of the 101st General Meeting of the American Society for Microbiology, May 20-24, 2001, Orlando, Florida, Abstract F-20.

Manavathu, EK, Dimmock, JR, Cutright, JL, Chandrasekar, PH.  Proton-translocating-ATPase-targeted antifungal activity of a novel conjugated styryl ketone: kinetics of inhibition of Candida albicans H+-ATPase.   IN:  Programs and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, September 17-20, 2000.  Abstract No. 1095.

Manavathu, EK, Krishnan, S, Cutright, JL, Chandrasekar, PH.  A comparative study of the in vitro susceptibility of Aspergillus fumigatus to antifungal agents individually and in combinations by the fractional inhibitory concentration index, tetrazolium reduction and radiometric assays.  IN: Programs and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, September 17-20, 2000.  Abstract No. 931.

Manavathu, EK, Krishnan, S, Cutright, JL, Chandrasekar, PH. A comparative study of the in vitro susceptibility of Aspergillus fumigatus to antifungal agents individually and in combinations.  In Abstracts of the 11th international symposium on infections in the immunocompromised host. Halifax, Nova Scotia, Canada. June 18-21, 2000.

Manheimer S, Friedland G, Matts J, Chen L, Child C, MacArthur R, Kostman J, Brizz B, Chesney M. Self-reported antiretroviral adherence correlates with HIV viral load and declines over time. Abstracts of the 13th International AIDS Conference,2000 (TuOrB421).

Moosa, MYS, Alangaden, GJ, Manavathu, E, Cutright, JL, Chandrasekar, PH. Does emergence of resistance to amphotericin B during treatment for invasive aspergillosis contribute to a poor outcome?  IN:  Programs and Abstracts of the 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, September 17-20, 2000. 

Panacek, E, Albertson, T, Hicklin, G, Miller, M, MacArthur, R, et al. SEPTEST, a rapid, immunostrip test for serum IL-6 concentrations, prospectively defined a population of patients with sepsis at greater risk for mortality in the MONARCS (monoclonal anti- TNF: a randomized controlled sepsis) trial.  Abstracts of the 40th ICAAC, 2000, 824.

Puklin, JE, Hidalgo, JA, Alangaden, GJ, Eliott, D, Akins, RA, Abrams, GW, Vazquez, JA.  Fungal endophthalmitis diagnosed by detection of Candida albicans DNA in intraocular fluid using a species-specific PCR assay. Presented at the All-India Uveitis Conference: 2000, Aravind Eye Hospital, Madurai, India, January 13, 2000.

Reichelderfer, P, Wright, D, Cohen, M, Cohn, J, Cu-Uvin, S, Watts, H, Kovacs, A. Relationship between detection of genital tract infections and the menstrual cycle in HIV-1-infected women.  XIII International AIDS Conference, Durban South Africa July 8 2000 (abstract# MoPeB2274).

Raghavan, SS, Chen, L, El-Sadr, W, Grunfeld, C, Peng, G, Yurik, T, MacArthur, R. Prevalence and factors associated with fasting hypercholesterolemia, hypertriglyceridemia, and hyperglycemia in ethnically diverse antiretroviral naïve patients (CPCRA 058). Abstracts of the 13th International AIDS Conference, 2000 (WePeB4269).

Schuman, P, Ohmit, SE, Vazquez, JA, Klein, RS, Mayer, K, Rompalo, A, Jamieson, D, Sobel JD.  Longitudinal assessments of oral and vaginal Candida colonization, species, and fluconazole susceptibility in HIV-seropositive women.  The HER Study. In Programs and Abstracts of the 7th Conference on Retroviruses and Opportunistic Infections.  San Francisco, California, January 30-February 2, 2000.

Vazquez, JA, Hidalgo, J, DeBono, S.  Use of Sargramostim (rhGM-CSF) as adjunctive treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS.  IN: Programs and Abstracts of the 11th International Symposium on Infections in the Immunocompromised Host.  Halifax, Nova Scotia, June 18-21, 2000.

Vazquez, JA, Yoon, S, Leaman, D, Akins, RA, Sobel, JD.  Utility of PCR in the diagnosis and management of normal pH, KOH and culture-negative Candida vaginitis.  A longitudinal study in 27 patients.  IN: Programs and Abstracts of the Annual Meeting of the Infectious Diseases Society of Obstetrics and Gynecology, Lake Tahoe, Nevada, August 2-5, 2000.

Vazquez, JA.  Clinical implications of antifungal resistance.  In Programs and Abstracts of the 14th  Congress of the International Society for Human and Animal Mycology.  Buenos Aires, Argentina, May 8-12, 2000.

Vergis, EN, Hayden, MK, Chow, JW, Snydman, DR, Zervos, MJ, Linden, PK, Wagener, MK, Muder RR. 2000. Blood isolates of Enterococcus faecium with diminished susceptibility to uinupristin/dalfopristin: clinical correlations in a multicenter bacteremia study. Abstract #148. In: Abstract #148. In: Program Abstr. 40th Intersci. Conf. Antimicrob. Agents Chemother, p. 67. 

Winston DJ,  Yeager AM, Chandrasekar PH, Snydman D, Peterson FB and the Valaciclovir Study Group.  Randomized Comparison for Prophylaxis of CMV Disease and Other Complications after Allogeneic Bone Marrow Transplantation. 2nd International Conference on Transplant Infectious Diseases, Stockholm, Sweden, May 2000.

Division of Nephrology
Articles

Hammond, RL, Augustyniak, RA, Rossi, NF, Churchill, PC, Papaowski, K, O’Leary, DS. Heart failure alters the strength and mechanisms of the muscle metaboreflex.  Am J Physiol 278:H818-H828, 2000.

Rossi, NF, O’Leary, DS, Woodbury, D, Chen, H.  Endothelin-1 in hypertension in the baroreflex-intact SHR: a role independent from vasopressin.  Am J Physiol 279:E18-E24, 2000.

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Scislo, M, Scislo, TJ, Chen, H, O’Leary, DS, Rossi, NF. Baroreflex sensitivity of renal sympathetic nerve activity increases after AT1 receptor blockade in streptozotocin diabetic rats. FASEB J 14:A625, 2000.

Jena, M, Ye, M, Sowers, JR, Rossi, NF. An inositol-1,4,5-triphosphate insensitive, mechanosensitive intracellular calcium store in vascular smooth muscle cells. FASEB J 14:A581, 2000.

Division of Pulmonary, Critical Care andSleep Medicine
Articles

Aboussouan, LS. A 45-year-old woman with HIV infection and slowly progressive dyspnea. In: Heffner JE, Sahn SA, eds. Internal Medicine Pearls 2nd edition. pp: 130-132. Philadelphia: Hanley & Belfus, 2000.

Angus, DC, Birmingham, MC, Balk, RA, Scannon, PJ, Collins, D, Kruse, JA, et al. E5 murine monoclonal anti-endotoxin antibody in Gram-negative sepsis.   A randomized controlled trial.  JAMA. 283:1723-1730, 2000.

Badr, MS, Zahn, B.  Upper airway resistance syndrome: Images in clinical medicine. N Engl J Med, 432(19):1399-1408, 2000.

Morrell, MJ, Finn, L, Kim, H, Peppard, P, Badr, MS, Young, TB.  Sleep fragmentation, daytime blood pressure and sleep disordered breathing in a population-based study.  Am J Resp Crit Care Med 162(6):2091-6, 2000.

Rowley, JA, Aboussouan, LS, Badr, MS. The use of clinical prediction models in the diagnosis of Obstructive sleep apnea. Sleep 23:929-938, 2000.

Yang, EH, McHorney, CA, Havighurst, T, Badr, MS, Weber, S, Hla, KM.  Sleep apnea and quality of life.  Sleep, 23 535-541, 2000.

Zhou, XS, Shahabuddin, S, Zahn, BR, Babcock, MA, Badr, MS.  Effect of gender on the development of hypocapnic central apnea/hypopnea during NREM sleep.  J Applied Physiol 89:192-199, 2000.

Books, Chapters and Reviews
Aboussouan, LS. A 45-year-old woman with HIV infection and slowly progressive dyspnea. In: Heffner JE, Sahn SA, eds. Internal Medicine Pearls 2nd edition. pp: 130-132. Philadelphia: Hanley & Belfus, 2000.

Aboussouan, LS, Stoller, JK. The Hepatopulmonary syndrome. Baillieres Best Pract Res Clin Gastroenterol. 2000 Dec;14(6):1033-1048. [Invited].

Aboussouan, LS, Stoller, JK. Flow-volume loops. UpToDate in Medicine 4(2-3), 1996; 5(1-3), 1997; 6(1-3), 1998; 7(1-3), 1999, 8(1-3), 2000. [Invited Review. CD ROM publication].

Aboussouan, LS. Emphysema-like disease in HIV. UpToDate in Medicine 4(2-3), 1996; 5(1-3), 1997; 6(1-3), 1998; 7(1-3), 1999, 8(1-3), 2000. [Invited Review. CD ROM publication].

Aboussouan, LS. Role of mucolytics in COPD. UpToDate in Medicine 4(2-3), 1996; 5(1-3), 1997; 6(1-3), 1998; 7(1-3), 1999, 8(1-3), 2000. [Invited Review. CD ROM publication].

Clark, VL, Kruse, JA. Cardiogenic shock. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Clark, VL, Kruse, JA. Aortic dissection. In: Kruse JA, Carlson RW, Fink MP (eds).

Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Douglass, MA, Kruse, JA. Anticoagulants. In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Guzman, JA, Hypocalcemia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders

Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Guzman, JA, Kruse, JA. Hypercalcemia. In: Kruse JA, Carlson RW, Fink MP (eds).

Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Guzman, JA, Kruse, JA. Hypermagnecemia. In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Guzman, JA, Kruse, JA. Hypomagnecemia. In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Jamil, T, Aboussouan, LS. Adult patient with new onset stridor. In: Stoller JK, Bakow ED, Longworth D, eds. Critical Diagnostic Thinking for the Respiratory Clinician: A Case-Based Approach. [Invited, In Press].

Kissner, DG.  The role of Progestational agents in the treatment of undernourished patients with cystic fibrosis.  Pediatr Pulmonol 2000, 29:244.

Kruse, JA.  Hyperosmolar syndromes.  In:  Dries DJ (ed). Critical Care Refresher course, 4th ed. Anaheim, CA:  Society of Critical Care Medicine, 2000, pp 205-212.

Kruse, JA.  Diagnosis and treatment of hyperosmolar emergencies.  In: Vincent JL (ed).  2000 Yearbook of Intensive Care and Emergency Medicine.  New York:  Springer-Verlag, 2000, pp 544-559.

Kruse, JA.  Endocrine crises.  In:  Albert RK, Dries DJ, (ed).  Combined critical care course, multidisciplinary review, and board preparation.  Northbrook, IL:  Society of Critical Care Medicine and American College of  Chest Physicians, 2000, pp 97-107.

Kruse, JA. Acid-base disorders. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders

Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Adrenal insufficiency.  In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Pheochromocytoma. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders

Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Thyroid storm. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual  of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Myxedema coma. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders

Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Diabetes insipidus. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders

Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hypoglycemia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Diabetic ketoacidosis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hyperosmolar nonketotic coma.  In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Syndrome of inappropriate diuresis.  In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hyponatremia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hyperkalemia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Lactic acidosis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Methemoglobinemia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hyperphosphatemia. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Alcoholic ketoacidosis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Rhabdomyolysis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Central venous catheterization. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Arterial catheterization. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Fast flush test. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Pulmonary artery catheterization. In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Temporary transvenous pacemaker. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Hemodynamic monitoring. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Intravenous fluids. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Chest tube thoracostomy. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Thoracentesis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Paracentesis. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Endotracheal intubation. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Methanol and related poisoning. In: Kruse JA, Carlson RW, Fink MP (eds).  Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Kruse, JA. Blood lactate levels in sepsis. In: Vincent J-L, Carlet J, Opal S (eds). Sepsis. Norwell, MA:Kluwer Academic Publishers, (in press).

Prasad, JK, Kruse, JA. Electrical and lightening injuries. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Rowley, JA, Badr, MS. Obstructive sleep apnea: new insights aid in diagnosis. J Respir Dis 21:505-515, 2000.

Rowley, JA, Badr, MS. Obstructive sleep apnea : the latest treatment strategies. J Respir Dis 21:577-580, 2000.

Rowley, JA, Badr, MS.  Obstructive sleep apnea:  New insights aid in diagnosis.  Journal of Resp Dis 21, (8) 505-515, 2000.

Rowley, JA, Badr MS.  Obstructive sleep apnea:  the latest treatment strategies.  J Respir Dis 21:577-580, 2000.

Ruffing, MJ, Kruse, JA. Benzodiazepine agonist and antagonist drugs. In: Kruse JA, Carlson RW, Fink MP (eds). Saunders Manual of Critical Care Practice. Philadelphia: W.B. Saunders, (in press).

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Abdel-Rahman, K, Siddiqi, S, Majumdar, AP, Dubaybo BA.  Similar mechanisms regulate fibroprolifrative responses in human and rat lung fibrotic syndromes. Proceedings of the Annual Research Month Forum, John D. Dingell VAMC, Detroit, MI, April 2000.

Aboubakr, S, Dubaybo, B.  Managing Off-Site Training Rotations. Proceedings of the Annual meeting of the Accreditation Council for Graduate Medical Education, Chicago, IL.  Page 1P, March 2000. *

Aboubakr, S, Dubaybo,  BA.  Managing off-site  training rotations. Proceedings of the Annual meeting of the Accreditation Council for Graduate Medical Education, Chicago, IL.  Page 1P, March 2000.

Anthi, A, Dimopoulou, I, Michalis, A, Tzelepis, GE. Functional status and quality of life in long term survivors of cardiac arrest after cardiac surgery. Critical Care, 2000 4(Suppl 1): P216.

Babcock, MA, Taylor, A, Badr, MS.  Determinants of long term facilitation in sleeping humans. 2000 ATS International Conference, 161(3):A485, May 2000.

Campbel, ML, Khanchandani, G, Natarajan, M, Guzman, JA. Timing, goals, and outcomes of do not resuscitate (DNR) orders in a medical intensive care unit. Am J Resp Crit Care Med. 2000:161(suppl); C 38.

Campbel, ML, Guzman, JA. Patterns of care for critically ill demented patients. Chest 2000:118(suppl);S126.

Campbel, ML, Guzman, JA. Impact of a proactive approach to end-of-life care for patients with global cerebral ischemia following cardiac arrest. Crit Care Med. 2000:28 (suppl); A58.

Devlin, JW, Coplin, WM, Swarczinski, C, Leacock, RO, Lewis, R, Kruse, JA.  Reliability of nursing train-of-four assessment for ICU patients receiving continuous neuromuscular blockade.  Crit Care Med. 2000; 27:A131.

Devlin, JW, Coplin, WM, Swarczinski, C, Leacock, RO, Lewis, R, Kruse, JA.  Accuracy of train-of-four assessment for ICU patients receiving continuous neuromuscular blockade.  Crit Care ed. 2000; 27:A72.

Dimopoulou, I, Anthi, A, Michalis, A, Tzelepis, GE. Long term survival following cardiac arrest after cardiac surgery. Presented at The Fourth State of the Art Interdisciplinary Review Course, Athens, March 2000.

Guzman, JA, Rosado, AE, Artinian, V, Kruse, JA.  Systemic and gut hemodynamic effects of a dopamine-1 receptor agonist.  Crit Care Med. 2000; 27: A143.

Guzman, JA, Artinian, V, Rosado, AE, Khanchandani, G, Natarajan, M, Kruse, JA.  Dopamine-1 reeptor stimulation attenuates the splanchinc and systemic hemodynamic response to hemorrhage.  Am J Resp Crit Care Med.  2000: 161 (suppl):A35.

Guzman, JA, Rosado, AE, Artinian, V, Kruse, JA. Systemic and gut hemodynamic effects of a dopamine-1 (DA1) receptor agonist.  Crit. Care Med. 2000:27(suppl): A143.

Guzman, JA, Artinian, V,  Rosado, AE, Khanchandani, G, Natarajan, M, Kruse, JA. Dopamine-1 receptor stimulation attenuates splanchnic and systemic hemodynamic response to hemorrhage. Am J Resp Crit Care Med. 2000:161(suppl); A 35.

Guzman, JA, Rosado, AE, Talib, M, Kruse, JA. Dopamine 1 (DA-1) receptor agonist stimulation increases gut critical oxygen delivery during sequential hemorrhage. Crit Care Med. 2000:28 (suppl); A123.

Guzman, JA, Rosado, AE, Talib, M, Kruse, JA.  Dopamine 1 (DA-1) receptor agonist stimulation increases gut critical oxygen delivery during sequential hemorrhage.  Crit Care Med. 2000:28 (suppl); A123.

Rowley, JA, Al-Atassi, E, Zahn, BR, Sanders, CC, Badr, MS.  Effect of gender on nasopharngeal caliber and compliance.  2000 ATS International Conference, 161(3):A251, May 2000

Rowley, JA, Al-Atassi, E, Zahn, BR, Sanders, CC, Badr, MS. Effect of gender on nasopharyngeal caliber and compliance.  Am J Respir Crit Care Med 161:A251, 2000.

Siddiqi, S, Abdel-Rahman, K, Majumdar, AP, Dubaybo, BA.  Transduction of the mitogenic response of transforming growth factor alpha: specificity of early activation of c-jun and c-fos. Presented at the Annual meeting of the American Thoracic Society in Toronto, CA, May 2000.

Siddiqi,  SF, Abdelrahman, K, Majumdar, AN, Dubaybo BA.  Regulation of human lung fibrosis by transforming growth factor alpha is mediated by c-fos and c-jun activation. Eur. Resp. J.  15: 256A, 2000.

Tashkandi, YN, Rowley, JA, Badr, MS.  Effect of gender on PSG indices of sleep-disordered breathing. 2000 ATS  International Conference, 161(3):A680, May 2000.

Veerapan, B, Soubani, AO:  Successful treatment of rhinocerebral mucormycosis in a kidney transplant recipient.  American College of Physicians meeting, Traverse City, MI  September 2000.

Vergine, I, Babcock, M, Zhou, X, Rowley, J, Badr, MS.  Gender difference in the mechanics of the upper airway.  2000 ATS International Conference, 161(3):A85, May 2000.

Yacoub, GS, Siddiqi, S, Fligiel, SEG, Dubaybo, BA.  Epidermal growth factor receptor in neonatal lung growth and maturation. Presented at the annual meeting of the American Thoracic Society in Toronto, CA, May 2000.

Yacoub, GS, Siddiqi, S, Fligiel, SEG, Dubaybo, BA. Regulation of neonatal lung growth and maturation. Proceedings of  the Annual Research Month Forum, John D. Dingell VAMC, Detroit, MI, April 2000.

Zhou, XS, Badr, MS.  Hypocapnic apneic threshold in postmenopausal females during NREM sleep.  2000 ATS International Conference, 161(3):A251, May 2000.

Division of Rheumatology
Articles

Arnett, FC, Cho, M, Chatterjee, S, Aguilar, MB, Reveille, JD, Mayes, MD. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three U.S. cohorts. Arthritis Rheum, in press.

Clements, PJ, Hurwitz, EL, Wong, W-K, Seibold, J, Mayes, M, White, B, Wigley, F, Weisman, M, Barr, W, Moreland, L, Medsger, Jr, T, Steen, V, Martin, R, Collier,D, Weinstein, A, Lally, E, Varga, J, Weiner, S, Andrews, B, Abeles ,M, Furst, DE.  Skin score as a predictor and correlate of outcome: high-dose vs low-dose penicillamine trial. Arthritis Rheum 43:2445-2454, 2000.

Fernández-Madrid, F, Tomkiel, JE.  Antinuclear Antibodies as Potential Markers of Lung Cancer. In, Autoimmunity in Cancer.  Y Shoenfeld and M E Gershwin, Eds. Elsevier,  2000 pp 151-158.

Furst, DE, Clements, PJ, Wong, WK, Mayes, MD, Wigley, F, White, B, Weisman, M, Barr, W, Moreland, L, Martin, R, Medsger, Jr, TA, Steen, V, Collier, D, Weinstein, A, Lally E, Varga J, Weiner SR, Andrews B, Abeles M, Peter JB, and Seibold JR.  Entering patients into an SSc trial following the new SSc trial guidelines may change the nature of the patient population: baseline characteristics of the 134 systemic sclerosis (SSc) patients entering the D-Penicillamine trial compared to the previous literature.  Rheumatology, in press.

Seibold, JR, Korn, JH, Simms, R, Clements, PJ, Moreland, LW, Mayes, MD, Furst, DE, Rothfield, N, Steen, V, Weisman, M, Collier, D, Wigley, FM, Merkel, PA, Csuka, ME, Hsu, V, Rocco, S, Erikson ,M, Hannigan, J, Harkonen, WS, Sanders, ME.  Recombinant human relaxin in the treatment of scleroderma: A randomized double-blind, placebo-controlled multicenter trial.  Ann Intern Med 132:871-879, 2000.

Books, Chapters and Reviews
Mayes, MD.  Photopheresis in autoimmune diseases.  In Panush R (ed): Rheumatic Disease Clinics of North America, 26:75-82. Philadelphia, W.B. Saunders Company, 2000.

Mayes, MD. The establishment and utility of a population-based registry to understand the epidemiology of systemic sclerosis. Current Rheumatology Reports 2:512-516, 2000.

Miller, F, Hess, E, Clauw, D, Hertzman, P, Pincus, T, Silver, R, Mayes, M, Varga, J, Medsger, Jr, T, Love, L.  Approaches for identifying and defining environmentally associated rheumatic disorders.  Arthritis Rheum 43:243-249, 2000.

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Chatterjee, S, Severson, RK, Weiss, LK, Kau, TY, Mayes, MD. Risk of Malignancy in Scleroderma. Arthritis Rheum 43 (Supp): S315, 2000.

Fernández-Madrid, F, Karvonen, RL, Ensley, J, Kraut, M, Granda, JL, Tomkiel, JE.  Patients with squamous cell carcinoma of the head and neck produce a different spectrum of antinuclear antibodies than patients with lung squamous cell carcinoma.  Cancer Detection and Prevention, 24 Supplement S-236, 2000.

Furst, DE, McSweeney, P, Nash, R, Holmberg, I, Viganego, F, Nelson, L, Wener, M, McDonagh, K, Crofford, L, Storek, J, Agee, G, Ryan, K, Prather, K, Mayes, M, Dansey, R, Sullivan, K. High-dose immunosuppressive therapy (HDIT) with autologous stem cell transplantation (SCT) for systemic sclerosis (SSc): results in the first 8 patients. Arthritis Rheum 43 (Supp): S392, 2000.

Gérard, H, Mosley-Williams, A, Whittum-Hudson, J, Schumaker, R.  Production of mRNA for DNA Replication vs cytokinesis-related genes in Chlamydia  Pneumoniae persistently infecting the synovium.  Arthritis Rheum 43 (Suppl)  S187, 2000

Gillis, M, Lumley, M, Mosley-Williams,  A, Leisen, J.  Relationships of three types of social support to depression among women with systemic lupus erythematosus.  Abstract published in Psychosomatic Medicine, 62, 136-137, 2000.

Nash, RA, Dansey, R, Storek, J, Sullivan, KM, Pavletic, S, McDonagh, KT, Kraft, GH, Mayes, MD, Forman, SJ, Holmberg, LA, McSweeney, PA. Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after high-dose immunosuppressive therapy (HDIT) and autologous CD34-selected stem cell transplantation (SCT) for severe autoimmune diseases.  American Society of Hematology, 2000.

Tomkiel, JE, VandeVord, P, Granda, JL, Virgin, J, Alansari, H, Fernández-Madrid, F.  Autoimmunity to nuclear antigens in breast cancer patient sera.  International Journal of Molecular Medicine, 6 Supplement 1, S-40, 2000.

Wang, J, Whittum-Hudson, JA , Schumacher, HR, Gérard, HC. Cytokine production in Chlamydia trachomatis-infected synovial tissue as defined by real-time RT-PCR. Hudson, AP, Arthr. Rheum. 43 (Suppl): S187, 2000. (platform talk, HCG)

Whittum-Hudson, JA, Rudy, D, Gérard, HC, Hudson, AP. Control of gene expression in persistent vs active infection by Chlamydia trachomatis, Arthr. Rheum. 43 (suppl): S387, 2000. (platform talk, APH)

Whittum-Hudson, JA, Rao, JP, Hudson, AP. Competitive PCR shows vaccination reduces chlamydial DNA in synovium. Arthr. Rheum. 43 (Suppl): S174, 2000. (platform talk, JWH)

Whittum-Hudson, JA, Aboukameel, A, Hudson, AP, Schumacher, HR. Does the HLA-B27 transgene alter murine Chlamydia-associated reactive a Arthritis? Arthr. Rheum. 43 (Suppl): S190, 2000.

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research

Center for Molecular Medicine and Genetics

Community Medicine

Dermatology and Syphilology

Emergency Medicine

Family Medicine

Immunology and Microbiology

Internal Medicine

Neurological Surgery

Neurology

Obstetrics and Gynecology

Ophthalmology

Orthopaedic Surgery

Otolaryngology

Pathology

Pediatrics

Pharmacology

Physical Medicine and Rehabilitation

Physiology

Psychiatry and Behavioral Neurosciences

Radiation Oncology

Radiology

Surgery

Urology