Features

Immunology and Microbiology

Chair: Paul Montgomery, PhD
7374 Scott Hall
(313) 577-1591

Articles
Dong Z, Ghabrial M, Katar M, Fridman R, Berk RS. Membrane – type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci 41:4189-4194, 2000

Todt JC, Whitfield JR, Ivard SR, Boros DL. Downregulation of interleukin-12, interleukin-12R expression/activity mediates the switch from Th1 to Th2 granuloma response during Schistosomiasis mansoni. Scand J Immunol 52:385-392, 2000.

Chen Y, Boros DL. The Schistosoma mansoni egg-derived r38 peptide-induced Th1 response affects the synchronous pulmonary but not the asynchronous hepatic granuloma growth. Parasite Immunol (in press).

Lundy SK, Lerman SP, Boros DL. Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL+ T and B cells during murine Schistosoma mansoni infection. Infect Immun (in press).

Abdel-Hag NM, Asmar BI, Abuhammour WM, Brown WJ. Yersinia enterocolitica infection in children. Pediatr Infect Dis J 19:954-958, 2000.

Chen L, Hazlett LD. Heparan sulfate is required for P aeruginosa adherence to the basement membrane of the wounded mouse cornea. Curr Eye Res 20:260-267, 2000.

Kernacki KA, Barrett R, Hobden J, Hazlett LD. MIP-2 is a mediator of PMN influx in ocular bacterial infection. J Immunol 164:1037-1045, 2000.

Hazlett LD, McClellan SA, Kwon B, Barrett R. Increased severity of P aeruginosa corneal infection in strains of mice designated as Th1 vs Th2 responsive. Invest Ophthalmol Vis Sci 41:805-810, 2000.

Pillar CM, Hazlett LD, Hobden JA. The role of Pseudomonas aeruginosa alkaline protease in corneal infections. Curr Eye Res 21:730-739, 2000.

Rudner XL, Kernacki KA, Barrett RP, Hazlett LD. Prolonged elevation of IL-1 in Pseudomonas aeruginosa ocular infection regulates MIP-2 production, PMN persistence and corneal perforation. J Immunol 164:6576-6582, 2000.

Kernacki KA, Barrett RP, McLellan SM, Hazlett LD. Aging and PMN response to P aeruginosa infection. Invest Ophthalmol Vis Sci 41:3019-3025, 2000.

Danjo Y, Hazlett LD, Gipson IK. Strain-dependent phenotype in Muc 1 null mice. Invest Ophthalmol Vis Sci 41:4080-4084, 2000.

Hazlett LD, McClellan SA, Barrett R, Rudner XL. B7/CD28 co-stimulation is critical in susceptibility to Pseudomonas aeruginosa corneal infection: a comparative study using monoclonal antibody blockade and CD28-deficient mice. J Immunol (in press).

Chen L, Hazlett LD. Human corneal epithelial extracellular matrix perlecan serves as a site for P aeruginosa binding. Curr Eye Res (in press).

Sosne G, Chan CC, Thai K, Kennedy M, Szliter EA, Hazlett LD, Kleinman HK. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res (in press).

Heppner GH, Miller FR, Shekhar PVM. Non-transgenic models of Breast Cancer. Breast Cancer Res 2:331-334, 2000.

Visscher D, Nangia-Makker P, Heppner GH, Shekhar PVM. Tamoxifen suppresses histologic progressions to atypia and DCIS in the MCF10AT Xenograft model of early human breast cancer. Breast Cancer Research and Treatment (in press).

Santner SJ, Dawson PJ, Tait L, Soule HD, Eliason J, Mohammed AN, Wolman SR, Heppner GH, Miller FR. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Research and Treatment (in press).

Estrellas PS Jr, Alionte LG, Hobden JA. A Pseudomonas aeruginosa strain isolated from a contact lens-induced acute red eye (CLARE) is protease-deficient. Curr Eye Res 20:157-165, 2000.

Pillar CM, Hazlett LD, Hobden JA. Alkaline protease-deficient mutants of Pseudomonas aeruginosa are virulent in the eye. Curr Eye Res 21:730-739, 2000.

Ferlazzo G, Klein J, Paliard X, Wei WZ, Galy A. Dendritic cells generated from CD34+ progenitor cells with flt3-ligand, c-kit-ligand, GM-CSF, TNF-alpha and IL-4 are functional antigen-presenting cells resembling mature monocyte-derived DC. J Immunotherapy 23:48-58, 2000

Galy A, Christopherson I, Perlazzo G, Liu G, Spits H, Georgopoulos K. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 95:128-137, 2000.

Baynes, RD, Dansey RD, Klein JL, Karanes C, Cassells L, Abella E, Wei, WZ, Galy A, Du W, Wood G, Peters WP. High-dose chemotherapy and autologous stem cell transplantation for breast cancer. Cancer Invest 18:440-455, 2000.

Galy A, Rudraraju S, Klein J. Differential recovery of dendritic cell subsets after stem cell transplantation. Bone Marrow Transplantation 25:1249-1255, 2000.

Nicholson R, Pantano S, Eliason J, Galy A, Weiler S, Kaplan J, Hughes M, Ko M. PehmX, a novel mouse gene expressed during hematopoiesis, maps to the imprinted cluster on distal chromosome 7. Genomics 68(1):13-20, 2000.

Cheema MA, Rahman MU, Whittum-Hudson JA, Hudson AP. Cervical Chlamydia trachomatis in women at low risk for infection. Am J Med Sci 319:123-125, 2000.

Wagner AD, Gerard HC, Fresemann T, Schmidt WA, Gromnica-Ihle E, Hudson AP, Zeidler H. Detection of Chlamydia pneumoniae in giant cell vasculitis and correlation with the topographical arrangement of tissue-infiltrating dendritic cells. Arthritis Rheum 43:1543-1551, 2000.

Henry CH, Hughes CV, Hudson AP, Wolford LM. Reactive arthritis: preliminary microbiological analysis of the human temporomandibular joint. J Oral Maxillofac Surg 58:1137-1142, 2000.

Gerard HC, Schumacher HR, El-Gabalawy H, Goldback-Mansky R, Hudson AP. Chlamydia pneumoniae infecting the human synovium are viable and metabolically active. Microb Pathogen 29:17-24, 2000.

Dreses-Werringloer U, Padubrin I, Jurgens-Saathoff B, Hudson AP, Zeidler H, Kohler L. Persistence of Chlamydia trachomatis is induced by ciprofloxacin and orofloxacin treatment in vitro. Antimicrob Ag Chemother 44:3288-3297, 2000.

Freise J, Gerard HC, Bunke T, Whittum-Hudson JA, Zeidler H, Kohler L, Hudson AP, Juipers JG. Optimized sample DNA preparation for detection of Chlamydia trachomatis in synovial tissue by PCR and LCR. Arch Rheumat Dis (in press).

Gruber A, Kan-Mitchell J, Kuhen KL, Mukai T, Wong-Staal F. Efficient and non-disturbing transduction of dendritic cells by HIV-1 vectors to elicit HIV specific T-lymphocytes in vitro. Blood 96:1327-1333, 2000.

Mitchell MS, Kan-Mitchell J, Minev B, Edman C, Deans RJ. Identification of a novel melanoma gene (MG50) – likely the gene for IL-1 receptor antagonist – that encodes six epitopes recognized by human cytolytic T lymphocytes. Cancer Res 60:6448-6456, 2000.

Chou SR, Brownell A, Ko M, Kaplan J. Intereferon gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recongition by self-reactive NK cells. Cell Immunol 200:88-97, 2000.

Kaplan J, Genyea C, Secord E. Potential for prevention of inhibitor formation by immune tolerance. Sem Thrombosis Hemostatsis 26:173-177, 2000.

Nicholson RH, Pantano S, Eliason JF, Kaplan J, Ko MSH. Phemx, a novel mouse gene expressed during hematopoiesis, maps to the imprinted cluster on distal chromosome 7. Genomics 68:13-21, 2000.

Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Gouston AS, Grunberger G. Alpha2-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Mol Cell Endocrinol 164:87-98, 2000.

Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasar PJ, Sandrack AW, Lisak RP and the CHAMPS study group. Intramuscular interferon beta-1a initiated during a first clinical event consistent with multiple sclerosis. New England J Med 343:898-904, 2000.

Johnson KP, Brooks BR, Ford CC, Goodman A, Guarnaccia J, Kachyck N, Lisak RP, Myers LW, Pantich HS, Pruitt A, Rose JW, Wolinsky JS and the Copolymer Multiple Sclerosis study group. Sustained clinical benefit of glatiramer acetate in relapsing multiple sclerosis observed for 6 years. Multiple Sclerosis 6:255-266, 2000.

Noseworthy JS, Wolinsky JS, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC and North American Linomide Trialists (Lisak RP, PI for WSU Center). Linomide in relapsing and secondary progressive MS. I. Trial design and clinical results. Neurology 54:1726-1733, 2000.

Wolinksy JS, Narayana PA, Noseworthy JH, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC, MRI Analysis Center University of Texas-Houston and North American Linomide Trialists (Lisak RP, PI for the WSU Center). Linomide in relapsing and secondary progressive MS. II. MRI results. Neurology 54:1734-1741, 2000.

Zvartau-Hind M, Din MU, Gelani A, Lisak RP, Khan O. Topiramate relieves refractory trigeminal neuralgia in multiple sclerosis patients. Neurology 55:1587-1588, 2000.

Podzorski RP, Baker J, Merline JR, Qureshi R, Holsinger JE. Utility of restriction fragment analysis for typing herpes simplex virus amplicons following PCR of targets in the DNA polymerase gene. Diag Microbiol Infect Dis 37:289-291, 2000.

Minev BR, Chavez FL, Dudouet BM, Mitchell MS. Synthetic insertion signal sequences enhance Class I presentation of a peptide from the melanoma antigen MART-1. Eur J Immunol 30:2115-2124, 2000.

O’Sullivan NL, Skandera CA, Montgomery PC. Lymphocyte lineages at mucosal effector sites: rat salivary glands. J Immunol (in press).

Christopherson I, Piechocki M, Liu G, Ratner S. Regulation of L-selectin by a dominant negative form of Ikaros. J Leukocyte Biol (in press).

Reddy TR, Weidong X, Wong-Staal F. General effect of Sam68 on Rev/Rex regulated expression of complex retroviruses. Oncogene 19:4071-4074, 2000.

Reddy TR, Tang H, Weidong X, Wong-Staal F. Sam68, RNAhelicase A and Tap co-operate in the post-transcriptional regulation of retroviral mRNA. Oncogene 19:3570-3575, 2000.

Reddy TR. A single point mutation in the nuclear localization signal (NLS) of Sam68 blocks the Rev/RRE-mediated post-transcriptional regulation of HIV-1. Oncogene 19:3110-3114, 2000.

Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F. A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element. J Biol Chem 275:21396-21401, 2000.

Craig H, Reddy TR, Riggs NL, Dao PP, Guatelli J. Interactions of HIV-1 Nef with the mu-subunits of adaptor protein complexes-1, 2 and 3: role of the dileucine-based sorting motif. Virology 271:9-17, 2000.

Balachandran S, Roberts PC, Kipperman T, Compans RW, Archer DR, Bhalla KN, Barber GN. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 Death Signaling pathway. J Virol 74:1513-1523, 2000.

Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR, Barber GN. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 13:129-141.

Schmelz EM, Roberts PC, Kustin EM, Hill RL, Dillehay DL, Merrill, AH Jr. Tumor suppression and redistribution of intestinal beta-catenin in APC min/- mice fed sphingolipids. Cancer Res (in press).

Krieger NR, Fathman CG, Shaw MK, Ridgway WM. Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+ T cells in vitro and in vivo. Transplantation 27:69(4):605-609, 2000.

Sobel JD, Kauffman CA, McKinsey D, Zervos D, Vazquez JA, Panzer H, Dismukes W. Candiduria in a randomized double blind study of treatment with fluconazole and placebo. Clin Infect Dis 30:19-24, 2000.

Graybill JR, Sobel JD, Saag M, VanderHorst C, Powderly W, Cloud G, Riser L, Hamill R, Dismukes W. Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis. Clin Infect Dis 30:47-54, 2000.

Kaufmann C, Vazquez JA, Sobel JD, Gallis HA, McKinsey DS, Karchmer AW, Sugar AM, Sharkey PK, Wise GJ, Mangi R, Mosher A, Lee JY, Dismukes WE, and NIAID Mycoses Study Group. A prospective multicenter surveillance study of funguria in hospitalized patients. Clin Infect Dis 30:14-18, 2000.

Manavathu EK, Ben-Josef AV, Sobel JD. Proton translocating ATPase mediated fungicidal activity of a novel complex carbohydrate: CAN-296. Int J Antimicrob Ag 13:287-295, 2000.

Foxman B, Barlow R, d’Arcy H, Gillespie B, Sobel JD. Candida vaginitis: self-reported incidence and associated costs. Sex Trans Dis 27:230-235, 2000.

Foxman B, Gillespie B, Koopman J, Zhang L, Palin K, Tallman P, Marsh JV, Spear S, Sobel JD, Marty MJ, Marrs CF. Risk factors for second urinary tract infection among college women. Am J Epidemiol 151(12):1194-1205, 2000.

Klein RS, Smith D, Sobel JD, Flanigan T, Margolick JB. A prospective study of positive tuberculin reactions in women with or at risk for HIV infection. Int J TB and Lung Dis 4:688-690, 2000.

Sobel JD, Ohmit SE, Schuman P, Klein RS, Mayer K, Duerr A, Vazquez JA, Rompalo A. The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from HIV seropositive and at-risk HIV-seronegative women. J Infect Dis 183:286-293 (in press).

Leigh JE, Barousse M, Myers T, Swoboda R, Hager S, Wolf NA, Cutwright JL, Thompson J, Sobel JD, Fidel PL Jr. Candida-specific systemic cell-medicated immune reactivities in HIV-infected persons with mucosal candidiasis. J Infect. Dis. 183:277-285 (in press).

Sobel JD. Failure of metronidazole to prevent preterm delivery in women with asymptomatic bacterial vaginosis. Curr Infect Dis Rep 2:499-500, 2000.

Sobel JD, Rex JH. Risk factors for candidemia in surgical ICU. Clin Infect Dis (in press).

Klein RS, Sobel JD, Flanigan T, Smith D, Marolick JB. Stability of cutaneous anergy in women with or at risk for HIV infection. J Acquir Immun Def Synd Hum Retrovir (in press).

Sobel JD, Kapernick PS, Zervos MJ, Reed BD, Hooton T, Soper I, Nyirjesy P, Heine W, Willems J, Panzer H, Wittes H. Treatment of complicated Candida vaginitis: comparison of single and sequential doses of fluconazole. Am J Ob Gyn (in press).

Foxman B, Somsel P, Tallman P, Gillespie B, Raz R, Colodner R, Kandula D, Sobel, JD. Urinary tract infection among women aged 40-65: behavioral and sexual risk factors. J Clin Epidem (in press).

Sobel JD, Peipert JF, McGregor JA, Livergood C, Martin M, Robbins J, Wajszczuk CP. Efficacy of clindamycin vaginal ovule (3 day treatment) vs. Clindamycin vaginal cream (7 day treatment) in bacterial vaginosis. Infect Dis In Ob-Gyn (in press).

Newbern EC, Foxman B, Leaman D, Sobel JD. Desquamative inflammatory vaginitis: an exploratory case-control study. Sex Trans Infect (in press).

Nyirjesy P, Sobel JD, Weitz V, Leaman D, Small MJ, Gelone SP. Cromolyn cream for recalcitrant idiopathic vulvar vestibulities: results of a placebo-controlled study. Sex Trans Infect (in press).

Foxman B, Barlow R, d’Aray H, Gillespie B, Sobel JD. Urinary Tract Infection: self-reported incidence and associated costs. Ann Epidemiol (in press).

Kolodsick J, Stepaniak JA, Hu W, Sundick RS. Mutational anaylsis of chicken interleukin-2. Cytokine (in press).

Lenz DC, Swanborg RH. Suppressor cells in demyelinating disease: a new paradigm for the new millennium. J Neuroimmunol 100:53-57, 2000.

Lenz DC, Wolf NA, Swanborg RH. Parental genes do not codominantly confer susceptibility to experimental autoimmune encephalomyelitis to F1 rats. J Neuroimmunol (in press).

Shibuya TY, Wei WZ, Zormeier M, Ensley J, Sakr W, Mathog R, Meleca RJ, Yoo G, June CH, Levine B, Lum LG. Anti-CD3/anti-CD28 bead overcomes T cell unresponsiveness in HNSCC patients. Arch of Otolaryngology-Head and Neck Surgery, 126:473-479, 2000.

Yoo GH, Washington J, Piechocki M, Shibuya TY, Ensley JF, Wei WZ. The progression of head and neck cancer in an in-vitro model. Arch Otolaryngology Head Neck Surgery 126:1313-1318, 2000.

Jabs DA, Lee B, Whittum-Hudson J, Prendergast RA. Th1 vs Th2 immune responses in autoimmune lacrimal gland disease in MRL/Mp mice. Invest Ophthalmol Vis Sci 41:826-831, 2000.

Traboulsi EI, Whittum-Hudson JA, Mir S, Maumenee IH. Further association of defective fibrillin expression in patients with Marfan Syndrome and lens abnormalities. Ophthalmic Genet 21:9-15, 2000.

Jabs DA, Lee B, Whittum-Hudson JA, Prendergast RA. The role of Fas-Fas ligand-mediated apoptosis in autoimmune lacrimal gland disease in MRL/MpJ mice. Invest Ophthalmol Vis Sci (in press).

Nelson DA, Vandevord P, Wooley PH. Polymorphism in the vitamin D receptor gene and bone mass in African-American and White mothers and children: a preliminary report. Ann Rheum Dis 59:626-630. 2000.

Baltzer AW, Lattermann C, Whalen JD, Wooley PH, Weiss K, Grimm M, Ghivizzani SC, Robbins PD, Evans CH. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 7 (9):734-739, 2000.

Satoh M, Richards HB, Shaheen VM, Yoshida H, Shaw M, Naim JO, Wooley PH, Reeves WH. Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane. Clin Exp Immunol 121(2):399-405, 2000.

Baltzer AW, Lattermann C, Whalen JD, Ghivizzani S, Wooley PH, Krauspe R, Robbins PD, Evans CH. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop 379S:120-125, 2000.

Wooley PH, Morren R, Sud S, Mayton L, Andary J, Nasser S. Inflammatory responses to metallic and polymeric particles in the murine air pouch model. Biomaterials (in press).

Corrigall VM, Bodman-Smith MD, Fife MS, Canas D, Myers LK, Wooley PH, Soh C, Staines NA, Pappin DJC, Berlo SE, vanEden W, vanderZee RJ, Lanchbury JS, Panayi GS. The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol (in press).

Yoshimura FK, Wang T, Yu F, Kim HR, Turner JR. Mink cell focus-forming nurine leukemia virus infection induces apoptosis of thymic lymphocytes. J Virology 74:8119-8126, 2000.

Yoshimura FK, Wang T. Role of the LTR region between the enhancer and promoter in mink cell focus-forming murine leukemia virus pathogensis. Virology (in press).

Books, Chapters and Reviews
Galy A. Generation of dendritic cells from lymphoid precursors. In: Dendritic Cell Protocols. Methods in Molecular Medicine, (Stagg, Robinson, eds.), Humana Press (in press).

Wu L, Galy A. The development of dendritic cells from hematopoietic precursors. In: Biology and Clinical Application: Dendritic Cells, 2nd ed. (MT Lotze, A Thompson, eds.), Academic Press (in press).

Kurpakus-Wheater, Kernacki KA, Hazlett LD. How the “Window” stays clear. Prog Histochem and Cytochem (in press).

Miller FR, Heppner GH. Methods in mammary gland biology and cancer research: xenograft models of human breast cancer lines and the MCF10AT model of human premalignant, proliferative breast disease. In: Int J Mammary Gland Biol and Neoplasia (IP Ash, ed.), p 37-49, 2000.

Gerard HC, Whittum-Hudson JA, Balin BJ, Hudson AP. Chlamydia pneumonia, APOE genotype, and Alzheimer’s disease. Proc of the State-of-the-Art Workshop. Chlamydial Basis of Chronic Diseases. The Robert Koch Institute, Springer Verlag, Berlin, p 121-136, 2000.

Inman RD, Whittum-Hudson JA, Schumacher HR, Hudson AP. Chlamydia-associated arthritis. Curr Opinion in Rheum 12:254-262, 2000.

Hudson AP. Chlamydia pneumoniae and Alzheimer’s disease: an etiologic relationship? Biomed Prog 13:1-5, 2000.

Kan-Mitchell J, Wong-Staal F. Pseudotyped nonreplicative lentiviral vectors to elicit virus-specific T cell responses. In: AIDS Vaccine Research in Perspective. (F. Wong-Staal, RC Gallo, eds.), Marcel Dekker, Inc, New York (in press).

Kaplan J. Coagulation inhibitors. In: Sem Thrombosis and Hemostasis (in press).

Kaplan J, Genyea C, Secord E. Potential for prevention of inhibitor formation by imme tolerance. Sem Thrombosis and Hemostasis (in press).

Kong YM, David CS. New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. Int Rev Immunol 19:573-585, 2000.

Carayanniotis G, Kong YM. Pathogenic thyroglobulin peptides as model antigends: insights on the inductionand maintenance of autoimmune thyroiditis. Int Rev Immunol 19:557-572, 2000.

Lisak RP. Type I interferons and chronic inflammatory demyelinating polyneuropathy: treatment or cause. Muscle and Nerve 23:307-309, 2000.

Tselis AC, Khan OA, Lisak RP. Intravenous immunoglobulin in the treatment of MS. MS Quarterly Report 19:1-5, 2000.

Lisak RP, Mendell JR. Neuropathies in collagen-vascular disease. In: Handbook of Peripheral Neuropathies, (JR Mendell, DR Cornblath, eds.), Marcel Dekker, New York (in press).

Lisak RP. Antibodies to myelin as mediators of the multiple sclerosis lesion: new emphasis on an old theory. In: Neurologic Commentary. (S Gilman, ed.) (in press).

Lisak RP. Myasthenia gravis. In: Current Therapy in Neurologic Disease. (RT Johnson, JW Griffin, JW McArthur, eds.) (in press).

Lisak RP. Myasthenia gravis. In: Saunders Manual of Critical Care. (JA Krause, RW Carlson, M Fink, eds.), WB Saunders, Philadelphia, PA (in press).

Lublin FD, Reingold SC, National Multiple Sclerosis Society (USA) Task Force on Placebo-controlled clinical trials in MS (Lisak RP, member). Placebo-controlled clinical trials in multiple sclerosis: ethical considerations. Ann Neurol (in press).

Ragheb S, Lisak RP. The thymus and myasthenis gravis. Chest Surgery Clinics of North America (in press).

Mitchell MS. Principles of biologic therapy. In: Cancer Treatment, 5th ed. (CM Haskell, ed.), WB Saunders, Philadelphia, PA (in press).

Mitchell MS. Biologic agents approved for use. In: Cancer Treatment, 5th ed. (CM Haskell, ed.), WB Saunders, Philadelphia, PA (in press).

Mitchell MS. Cancer vaccines comes of age. In: Frontiers of Bomedicine. (AL Goldstein, ed.), Plenum, New York (in press).

Mitchell MS. Allogeneic melanoma vaccines for treatment and prevention of recurrence. In: Biology and Treatment of Melanoma. (FG Haluska, ed.), Kluwer, New York (in press).

Shaw MK, DalCanto R, Fathman CG. Gene therapy for multiple sclerosis. In: Gene Therapy in Inflammatory Diseases. (CH Evans, PD Robbins, eds.), Birkhauser Verlag (in press).

Sobel JD, Kaye D. Urinary tract infections. In: Principles and Practice of Infectious Diseases, 5th ed. (G. Mandell, J Bennett, R Dolin, eds.), Churchill Livingston, Philadelphia, PA, Vol 1, Chapter 62, p 773-805, 2000

Sobel JD. Candiduria. In: Current Therapy of Infectious Diseases, 2nd ed. (D Schlossberg, ed.), Mosby Year Book, Philadelphia, PA, p 233-236, 2000.

Sobel JD. Mucocutaneous candidiasis. In: Fungal Infections. Atlas of Infectious Diseases (Diamond R, ed.), Churchill Livingston, 2000.

Sobel JD. Vulvitis, vaginitis and cervicitis. In: Infectious Disease. (D Armstrong, J Cohen, eds.), Mosby, London, United Kingdom, Chapters 52, 52.1-52.8, 2000.

Lundstrom TS, Sobel JD. Vancomycin, teicoplanin, quinupristin/dalfopristin and linezolid. In: Infectious Disease Clinics of North America. (D Kaye, ed.), 14:463-474, 2000.

Sobel JD. Candida vaginitis. In: Vulvovaginal Disease. (W Ledger, J Witkin, eds.), W.B. Saunders Co, New York, NY (in press).

Sobel JD. Genital candidosis. In: International Standard Book for Infectious Diseases in Obstetrics, Gynecology, Dermatology, Urology, and Clinical Immunology. (ER Weissenbacher, ed.), Medifact Publishing House, Munich, Germany (in press).

Lundstrom TS, Sobel JD. Fungal infections. In: Association for Professionals, Infect Cont Epid Curr (R Olmstead, ed.), Mosby Year Book Publishers, Chicago, IL (in press).

Sobel JD. Fungal infections of the genitourinary tract. In: Clinical Mycology. (E Anaissie, M McGinnis, M Pfaller, eds.), WB Saunders (in press).

Sobel JD. Candida vaginitis. In: Infectious Diseases in Obstetrics and Gynecology. (S Faro, M Martens, D Soper, eds.), WB Saunders (in press).

Fidel PL Jr, Sobel JD. Murine models of Candida vaginal infection. In: Handbook of Animal Models of Infection, Chapter 3. (O Zak, M Sande, eds.), Academic Press, Guersney UK (in press).

Sobel JD. Vaginitis. American College of Physicians (in press).

Sobel JD: Cervicitis. America College of Physicians (in press).

Rex J, Sobel JD, Powderly W. Treatment of candidiasis in HIV-infected persons. In: Antimicrobial Therapy in AIDS. (VL Yu, T Merigan, SL Barrier, eds.), Williams, Wilkins Publishers, Baltimore (in press).

Sobel JD. Urinary tract infections. Best Practice of Medicine (in press).

Sobel JD: Prostatitis. Best Practice of Medicine (in press).

Rex J, Sobel JD, Powderly W: Candida Infections. In: Antimicrobial chemotherapy, 2nd edition. (T Merigan, SL Barrier, VL Yu, eds.), Williams, Wilkins Publishers, Baltimore (in press).

Sobel JD. Urinary tract infections and infections of the female pelvis In: Essential Atlas of Infectious Diseases, 2nd edition. (G Mandell, ed.), Churchill Livingston (in press).

Hu W, Kolodsick JE, Stepaniak JE, Sundick RS. Enhanced humoral immune responses to Marek’s disease virus glycoprotein B by co-injection with recombinant chicken IL-2. Avian Immunol Conf Proc (in press).

Kolodsick JA, Stepaniak JA, Hu W, Sundick RS. Mutational analysis of chicken IL-2. Avian Immunol Conf Proc (in press).

Tse HY, Shaw MK. Autoimmunity and diseases. In: ASM Textbook of Immunology. (GB Pier, LM Wetzler, JB Lyczak, eds.), ASM Press (in press).

Wei WZ, Pitchocki M, Pilon S, Kelly C. erbB-2 DNA vaccines. Biolab Tech Int, p 13-15, 2000.

Jabs DA, Prendergast RA, Whittum-Hudson JA. Pathogenesis of autoimmune lacrimal gland disease in MRL/MpJ mice. Lacrimal Gland, Tear Film and Dry Eye Syndrome (in press)

Wooley PH. Pristane-induced arthritis. In: Rheumatoid Arthritis. Methods and Protocols. (DS Bradley, ed.), Humana Press, NJ (in press).

Wooley PH. Animal models of Arthritis. In: Rheumatology, 3rd edition. (MC Hochberg, LJ Silman, JS Smolen, ME Weinblatt, MH Weisman, eds.), Harcourt International, London, Chapters 7, 5 (in press).

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals Katar M, Ghabrial M, Dong Z, Fridman R, Berk RS. Corneal protease activity in mice infected with Pseudomonas aeruginosa. Invest Opthalmol Vis Sci 41:154, 2000.

Berk RS, Katar M, Day D. Corneal plasminogen activator response in naïve and immunized mice infected with Pseudomonas aeruginosa. Invest Opthalmol Vis Sci 41:133, 2000.

Berk RS, Katar M, Dong Z. Inflammatory response of naïve and immunized mice to intracorneal infection by Pseudomonas aeruginosa. 16th Int Cong Eye Res Symp S76, 2000.

Lundy SK, Boros DL. B lymphocyte-mediated and parasite egg entigen induced apoptosis of CD4+ T lymphocytes in murine schistosomiasis mansoni. FASEB J 14:A1124, 2000.

Wesa A, Laderach D, Galy A. Immunological characteristics of human lymphoid related dendritic cells. 6th Int Symposium on Dendritic Cells, Port Douglas, Australia, 2000.

Galy A, Christopherson I, Guo L, Movassagh M. Ikaros and the control the human dendritic cell hematopoiesis. 6th Int Symposium on Dendritic Cells, Port Douglas, Australia, 2000.

Movassagh M, Galy A. Effects of a dominant negative Ikaros protein on dendritic cell production from hematopoeitic progenitor cells. 13th Int Symposium on Molecular Biology of Hematopoiesis. New York, 2000.

Laderach D, Galy A. The role of 4-1BB ligand in CD D8+ T cell responses. Autumn Immunol Conf, Chicago, IL, 2000.

Wesa A, Galy A. Interleukin-1b regulates the production of interleukin-12 by monocyte-derived dendritic cells. Autumn Immunol Conf, Chicago, IL, 2000.

Galy A, Laderach D. The role of 4-1BB ligand in CD8+ T cell responses. 42nd ASH Meeting, San Francisco, CA, 2000.

Galy A, Wesa G. Regulation of T cell cytokine produciton by dendritic cells generated in vitro from hematopoietic progenitor cells. 42nd ASH Meeting, San Francisco, CA, 2000.

Galy A, Movassagh M. The role of Ikaros proteins on human dendritic cell development. 42nd ASH Meeting, San Francisco, CA., 2000

Kernacki KA, Hazlett LD. Discordant expression of MMP-9 and MMP-13 in cornea following Pseudomonas aeruginosa infection. Invest Ophthal Vis Sci 41:153, 2000.

Rudner XL, Kernacki KA, Barrett RP, Hazlett LD. Role of IL-1 in mediating corneal stromal destruction after Pseudomonas infection. Invest Ophthal Vis Sci 41:151, 2000.

Chen LL, Hazlett LD. Heparan sulfate in the basement membrane of corneal epithelium serves as a receptor for Pseudomonas aeruginosa binding. Invest Ophthal Vis Sci 41:153, 2000.

McClellan SA, Kernacki KA, Hazlett LD. MIP-2 contributes to the dysregulated PMN response in aged mice infected with Pseudomonas aeruginosa. Invest Ophthal Vis Sci 41:151, 2000.

Hazlett LD, Kernacki KA, Szliter EA. In vitro detection of cytokine and chemokine mRNA in wounded and unwounded cornea after Pseudomonas aeruginosa challenge. Invest Ophthal Vis Sci 41:151, 2000.

Esco M, McDermott ML, Kurpakus M, Hazlett LD. Extracellular matrix deposited chronically hypoxic corneal epithelium is a preferred substrate for bacterial binding. Invest Ophthal Vis Sci 41:153, 2000.

Sosne G, Kernacki KA, Barrett R, Szliter B, Kleinman I, Hazlett LD. Thymosin beta 4 promotes wound healing and decreases inflammation after corneal alkali burn. 5th Int Symp Ocular Trauma, Montreal, Quebec, Canada, 2000.

Shekhar M, Nangia-Makker P, Heppner GH, Visscher D. Tamoxifen suppresses atypia and DCIS in the MCF10AT xenografts. Proc AACR 41:470, 2000.

Miller BE, Heppner GH. Order-dependent drug interactions between ganciclovir and conventional chemotherapy after HSV-TK gene therapy in mouse mammary tumor cells. Proc AACR 41:2405, 2000.

Pillar CM, Solem AC, Hobden JA. ICAM-2 and Pseudomonas aeruginosa keratitis. Am Soc Microbiol E-94:315, 2000.

White CD, Hobden JA. The role of Pseudomonas aeruginosa staphylolytic protease (LasA) in adherence. Am Soc Microbiol B-97:62, 2000.

Hobden JA. Pseudomonas aeruginosa proteases and corneal virulence. Proc Int Soc Eye Res 16-591:S183, 2000.

Whittum-Hudson JA, Rao JP, Hudson AP. Vaccination reduced chlamydial DNA in synovium: route-dependent immunity? J Rheumatol 27-S59:16, 2000.

Hudson AP. Long-term host-microbe interaction in Chlamydia-associated reactive arthritis. J Rheumatol 27-S59:14, 2000.

Kuipers JG, Freise J, Gerard H, Bunke T, Whittum-Hudson JA, Zeidler H, Koehler L, Hudson AP. Different sample preparations of synovial tissue prior to PCR for C trachomatis. J Rheumatol 27-S59:37, 2000.

Byrne GI, Ouellette SP, Lu L, Rao JP, Hudson AP. C trachomatis and C pneumoniae continue to express DNA replication-related genes during persistence. Proc 4th European Chlamydia Congress, Helsinki, Finland, p 34, 2000.

Whittum-Hudson JA, Rudy D, Vora G, Hudson AP, Saltzman WM, Stuart E. Protection against murine genital infection by the anti-idiotypic antibody mimic (mAb2) of chlamydial GLXA: Th1-dependent immunity? Proc 4th European Chlamydia Congress, Helsinki Finland, p 424, 2000.

Kuipers JG, Freise J, Gerard HC, Bunke T, Whittum-Hudson JA, Zeidler H, Kohler L, Hudson AP. Comparison of different sample DNA preparations and molecular biological techniques for detection of Chlamydia trachomatis in synovial tissue. Proc 4th European Chlamydia Congress, Helsinki Finland, p 107, 2000.

Gerard HC, Wang Z, Wang GF, Li Y, Majeed W, Gabalawy H, Goldbach-Mansky R, Ngai N, Hudson AP, Schumacher HR. Chromosomal DNA from a variety of bacterial species is present in synovial tissue in patients with various forms of arthritis. Arthritis Rheum 43:S187, 2000.

Wagner AD, Prabst A, Schmidt WA, Gromnica-Ihle E, Vorpahl K, Hudson AP, Zeidler H. Dendritic cells localize in the immediate vicinity of activated CD45RO+ T cells surrounded by rho GTPase in granulomatous infilitrates in giant cell arteritis. Arthritis Rheum 43:S388, 2000.

Gerard HC, Whittum-Hudson JA, Rudy D, Hudson AP. Control of gene expression in persistent vs active infection by Chlamydia trachomatis. Arthritis Rheum 43:S387.

Hudson AP, Henry C, Wolford L, Gerard HC. Chlamydia psittaci infection may influence development of temporomandibular joint dysfunction. Arthritis Rheum 43:S174, 2000.

Gerard HC, Mosley-Williams A, Whittum-Hudson JA, Schumacher HR, Hudson AP. Production of mRNA from DNA replication- vs cytokinesis-related genes in Chlamydia trachomatis persistently infecting the synovium. Arthritis Rheum 43:S187, 2000.

Hudson AP, Wang Z, Whittum-Hudson JA, Schumacher HR, Gerard HC. Cytokine production in Chlamydiaa trachomatis-infected synovial tissue as defined by real-time PT-PCR. Arthritis Rheum 43:S187, 2000.

Whittum-Hudson JA, Rao JP, Hudson AP. Competitive PCR shows vaccination reduces chlamydial DNA in synovium. Arthritis Rheum 43:S174, 2000.

Whittum-Hudson JA, Aboukameel A, Hudson AP, Schumacher HR. Does the HLA-B27 transgene alter murine Chlamydia-associated reactive arthritis? Arthritis Rheum 43:S190, 2000.

Lenz DC, Lu L, Whittum-Hudson J, Hudson JP, Swanborg RH. Induction of MS-like disease in Lewis rats by immunization with a C pneumoniae antigen. 29th Autumn Immunol Conf, p 48, 2000.

Kan-Mitchell J, Gruber A, Bereta M, Wong-Staal F. T cell stimulatory capacity of human dendritic cells transduced by pseudotyped HIV-1 vector. Molecular Therapy 1: S8, 2000.

Bereta M, Bisikirska B, Wong-Staal F, Piao WH, Wainstein JA, Lage AP, Mitchell MS, Kan-Mitchell J. Nonspecific binding of MHC-tetramers to cultured human T cells. FASEB J 14:A1229, 2000.

Mitchell MS, Kan-Mitchell J, Minev B, Edman C, Deans RJ. Identification of a novel human melanoma gene, likely the IL-1 receptor antagonist, encoding epitopes recognized by cytolytic T cells. FASEB J 14:A1004, 2000.

Wan Q, Panos J, Yan Y, Giraldo AA, David CS, Kong YM. Characterization of H2A- E+ (Ab0 Eak) transgenic mice susceptible to foreign but not self thyroglobulin in auto immune thyroiditis. FASEB J 14:A999, 2000.

Banga JP, Gardas A, Wan Q, Panos J, Giraldo AA, David CS, Kong YM. Contrasting immunogenicity of thyroglobulin and thyroid peroxidase in HLA-DR and –DQ transgenic mice. Endocrine J 47S:255, 2000.

Din MU, Zvartau-Hind M, Gelani M, Lisak RP, Khan O. Topiramate relieves refractory trigeminal neuralgia in multiple sclerosis patients. Neurology 54S3:A60, 2000.

Huq M, Gilani A, Mohan K, Lisak R, Khan O. Clinical and pararclinical features of juvenile and childhood multiple sclerosis (MS): application of adult diagnostic criteria for MS in children. Neurology 54S3:A351, 2000.

Khan O, Zvartau-Hind M, Kamholz J, Garbern J, Lewis R, Cochran M, Lisak D, Lisak R. Efficacy and tolerability of monthly intravenous (IV) cyclophosphamide (CTX) in rapidly deteriorating multiple sclerosis resistant to conventional therapy. Neurology 54S3:A337, 2000.

Khan O, Zvartau-Hind M, Gilani A, Zhai H, Lewis R, Kamholz J, Lisak R. Recurrent transverse myelitis in African-Americans. Ann Neurol 48:451, 2000.

Lisak D, Cochran M, Caon C, Zvartau-Hind M, Leutcher B, Tselis A, Lisak R, Khan O. Effect of variable dosing regimens of intravenous methylprednisilone (IVMP) on recovery during an acute exacerbation in multiple sclerosis patients admitted to the hospital. J MS Care 2:6, 2000.

Lisak RP, Bealmear B, Benjamins JA, Skoff AM. IFN-gamma, TNF-alpha and TGF-beta inhibition of cyclic AMP (cAMP) induction of Schwann cell (SC) differentiation in vitro. J Neurochem 74S:882, 2000.

Ragheb S, Lisak RP. Lymphocyte proliferative response to glatiramer acetate in normal humans is dependent on both major histocompatibility complex (MHC) class I and II molecules. J Neurology 247S:3III/119, 2000.

Skundric DS, Rouhi M, Madala SR, Lisak RP. Regulation of IL-1RA by Schwann cells (SC) during their differentiation in vivo. J Neurochem 74S:593, 2000.

Ratner S, Piechocki MP, Galy A. A role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendages. FASEB J 14:A1144, 2000.

Reddy, TR, Hengli T, Weidong X, Wong-Staal F. Sam68, RNA helicase A and TAP co-operate in the post-transcriptional regulation of retroviral mRNA. CSHL Retrovirus Meeting, NY, 2000.

Balachandran S, Roberts PC, Archer D, Barber GN. Essential role of the dsRNA-dependent protein kinase, PKR, in innate immunity to viral infection. 11th Int Conf Negative Strand Viruses, Quebec City, Canada, 2000.

Roberts PC, Kipperman T, Compans RW. Virus-mediated cell-to-cell fusion in a polarized human endometrial cell line. Keystone Symposia: Cell Biology of Virus Entry, Replication and Pathogenesis, Taos, New Mexico, 2000.

Kolodsick JE, Stepaniak JA, Hu W, Sundick RS. Mutational analysis of chicken IL-2. FASEB J 14:A1125, 2000.

Hu W, Stepaniak JE, Kolodsick JE, Shah PK, Sundick RS. Attenuated actaA mutant (del Act A) Listeria monocytogenes - a delivery vehicle for DNA vaccines. FASEB J 14:A1125, 2000.

Swanborg RH, Wolf NA. NK cells maintain immune homeostasis. FASEB J 14:A700, 2000.

Lenz DC, Wolf NA, Swanborg RH. Parental genes do not equivalently confer susceptibility to experimental autoimmune excephalomyelitis to F1 rats. FASEB J 14:A1121, 2000.

Ho PP, Shaw MK, Tse HY. MHC Class I and CD1 are essential for induction and development of adoptive experimental autoimmune encephalomyelitis. AAI Immunology Meeting, Seattle, WA, 141:3, 2000.

Shaw MK, Ho PP, Chugthai N, Tse HY. Cytokine-T cell gene therapy for EAE: disease amelioration correlates with the ability of modified T cells to traffic to depots of antigen. AAI Imunology Meeting, Seattle, WA, 104:10, 2000.

Li J, Ho PP. Shaw MK, Tse HY. H-2b mice are susceptible to experimental autoimmune encephalomyelitis induced by peptides of MOG, MBP and PLP. AAI Immunology Meeting, Seattle WA, 141:14, 2000.

Piechocki MP, Pilon S, Wei WZ. ERBB-2 (E2) DNA vaccines containing EBV gly-ala repeat (GAr) sequence. Proc AACR 41:796, 2000.

Pilon SA, Piechocki MP, Naishiasaka N, Wei WZ. IL-2 or GM-CSF substitute for CD4 T cell help in cyt ERBb-2 DNA vaccination to induce a anti-tumor immunity. Proc AACR 41:796, 2000.

Wei WZ, Shibuya T, Yoo G, Ratner S. Foreign peptides as therapeutic agents against solid tumors. Proc AACR 41:114, 2000.

Piechocki MP, Pilon S, Wei WZ. ERBB-2 with glycine-alanine repeat (GAr) insertion was processed by proteasome and induced tumor rejection. FASEB J 14:A1003, 2000.

Piechocki MP, Pilon S, Wei-WZ. Development of erbB2 (E2) DNA vaccines. FASEB J 14:A1003, 2000.

Jabs DA, Prendergast RA, Whittum-Hudson JA. Cytokines in autoimmune lacrimal gland disease in MRL/MpJ mice. Cornea 19:S6:S97, 2000.

Vasquez M, Jabs DA, Lee B, Whittum-Hudson JA, Prendergast RA. The role of the Fas-Fas ligand-mediated apoptoisi in autoimmune lacrimal gland disease in MRL/MpJ mice. Invest Opthalmol Vis Sci (in press).

Wooley PH, Song Z, Mayton L, Nasser S, Cho U, Shen M, Hsu S. Variations in UHMWPE particle morphology result in different cellular and cytokine responses in the murine air pouch model. Trans 6th World Biomaterials Cong, 479, 2000.

Wooley PH, Yang SY, Nasser S, Song Z, Robbins PD, Evans CH. Gene Therapy to regulate the inflammatory response to orthopaedic biomaterials. Trans 6th World Biomaterials Cong, 480, 2000.

Sieving AL, Nasser S, Wooley PH. Macrophage responses to polymethylmethacrylate particles. Trans 6th World Biomaterials Cong, 885, 2000.

Vandevord PJ, Schaefer CJ, Wilson RB, Canady A, Gupta N, Vinuya RZ, Wooley PH. Immune responses to silicone-based ventriculoperitneal shunts in children with shunt malfunction. Trans 6th World Biomaterials Cong, 1189, 2000.

Wooley PH, VandeVord PJ, DeSilva SP, Wu B, Mayton ML, Matthew, HW. Evaluation of the biocompatibility of chitosan in a mouse model: a preliminary report. Trans 6th World Biomaterials Cong, 1428, 2000.

Shealy DJ, Emmell E, Treacy G, Wagner CL, Mayton ML, Wooley PH. Treatment with anti-TNFalpha antibody allows joint damage to heal in polyarthritic Tg197 transgenic mice. Ann Rheum Dis 59:001, 2000.

Yang SY, Park YS, Wu B, Hsu S, Nasser S, Wooley PH. Different cellular responses to variant shapes of UHMWPE particles in a murine air pouch model of inflammation. Arthritis Rheum 43:S214, 2000.

Yang SY, Ren W, Mayton, ML, Nasser S, Wooley PH. A novel model for osteolysis in aseptic loosening; femoral implants within the inflammatory murine air pouch. Arthritis Rheum 43:S214, 2000.

Ren W, Yang SY, Park YS, Hsu S, Nasser S, Wooley PH. Variations in the shape of orthopaedic wear debris particles results in different apoptotic responses in a murine air pouch model. Arthritis Rheum 43:S214, 2000.

Wooley PH, Emmell E, Mayton ML, Shealy DJ, Treacy G, Wagner CL. Treatment with anti-TNFalpha antibody allows joint damage to heal in polyarthritic Tg197 transgenic mice. Arthritis Rheum 43:S233, 2000.

Baxa D, Yoshimura FK. Genistein induces apoptosis in T cell lymphomas generated by an oncogenic murine retrovirus. Am Soc Microbiol (in press).

Klein R, Arnstein J, Sobel JD. Oropharyngeal Candida colonization and human immunodeficiency virus type-1 inffection. J Infect Dis 181:812, 2000.

Graybill JR, Sobel JD. The role of lumbar puncture in the management of elevated intracranial pressure in patients with AIDS-associated cryptococcal meningitis. Clin Infec Dis 33:1310-11, 2000.

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research