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Biochemistry and Molecular Biology

Chair: Barry Rosen, PhD
4374 Scott Hall
(313) 577-1511

Articles
Amro, NA., Kotra, LP., Wadu-Mesthrige, K., Bulychev, A., Mobashery, S., Liu, GY. High-resolution atomic force microscopy studies of the Escherichia coli outer membrane: structural basis for permeability. Langmuir, 16, 2789-2796, 2000.

Bednar, J., Studitsky, VM., Grigoryev, SA., Felsenfeld, G., Woodcock, CL. Nature of the nucleosomal barrier to transcription: direct observation of paused intermediates by electron cryo-microscopy. Mol Cell 4, 377-386, 1999.

Brown, S., Bernardo, M., Li, ZH., Kotra, LP., Tanaka, Y., Fridman, R., Mobashery, S. Potent and selective mechanism-based inhibition of gelatinases, J Am Chem Soc, 122, 6799-6800, 2000.

Brown, LS., Needleman, R. and Lanyi, JK. Origins of deuterium kinetic isotope effects on the proton transfers of the bacteriorhodopsin photocycle. Biochemistry 39(5), 938-45, 2000.

Bulychev, A., Bellettini, JR., O’Brien, M., Crocker, PJ., Samama, JP., Miller, MJ., Mobashery, S. N-Sulfonyloxy-ß-Lactam Inhibitors for ß-Lactamases, Tetrahedron, 56, 5719-5728, 2000.

Chen, Z, Oberley, TD, Ho, Y-S, Chua, CC, Siu, B, Hamdy, RC, Epstein, CJ and Chua BHL. Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury. Free Radic Biol Med 29:589-596, 2000.

Darville, MI, Ho, Y-S and Eizirik, D. NF- B is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells. Endocrinology 141:153-162, 2000.

Felsenfeld, G., Clark, DJ., Studitsky, VM. Transcription through nucleosomes. Biophys Chem 86, 231-237, 2000.

Fisher, JH, Sheftelyevich, V, Ho, Y-S, Fligel, S, McCormack, FX, Korfhagen, TR Whitsett, JA and Ikegami, M. Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol 278:L365-L373, 2000.

Ghosh, M., Shen, J. and Rosen, BP. Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96, 5001-5006, 1999.

Golemi, D., Maveyraud, L., Vakulenko, S., Tranier, S., Ishiwata, A., Kotra, LP., Samama, JP., Mobashery, S. The first structural and mechanistic insights for class D ß-Lactamases: Evidence for a novel catalytic process for turnover of ß-Lactam Antibiotics, J Am Chem Soc, 122, 6132-6133, 2000.

Golemi, D., Maveyraud, L., Ishiwata, A., Tranier, S., Miyashita, K., Nagase, T., Massova, I., Mourey, L., Samama, Jean-Pierre, Mobashery, S. 6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of ß-Lactamases, J Antibiot., 53, 1022-1027, 2000.

Haimeur, A., Guimond, C, Pilote, S., Mukhopadhyay, R., Rosen, BP., Poulin, R. and Ouellette, M. Elevated levels of polyamines and trypanothione resulting from overexpression of ornithine decarboxylase in arsenite resistant Leishmania. Mol. Microbiol. 34, 726-735, 1999.

Hanin, G. and Vinogradov, SN. Combinatorics of giant hexagonal bilayer hemoglobins. Math Biosci 163, 59-73, 2000.

Ishiwata, A., Kotra, LP., Miyashita, K., Nagase, T., Mobashery, S. Stereoselective redution of ß-bromopenicillanates by tributylphosphine. Org Lett, 2, 2889-2892, 2000.

Jiang, D, Akopian, G, Ho, Y-S, Walsh, JP and Andersen, JK. Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp Neurol 164:257-268, 2000.

Johnson, RM, Goyette, G. Ravindranath, Y., and Ho, Y-S. Red cells from glutathione peroxidase-1 deficient mice have nearly normal defenses against exogenous peroxides. Blood 96:1985-1988, 2000.

Johnson, RM., Buck, S., Chiu, C-H., Gage, DA., Shen, T-L., Hendrickx, AG., Gumucio, DL., and Goodman, M. Humans and old world monkeys have similar patterns of fetal globin expression. J Exp Zool (Mol Dev Evol) 288:318-326, 2000.

Johnson, RM, Goyette, Jr, G Ravindranath, Y and Ho, Y-S. Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides. Blood 96:1985-1988, 2000.

Kandori, H., Kinoshita, N., Yamazaki, Y., Maeda, A., Shichida, Y., Needleman, R., Lanyi, JK., Bizounok, M., Herzfeld, J., Raap, J. and Lugtenburg, J. Local and distant protein structural changes on photoisomerization of the retinal in bacteriorhodopsin. Proc Natl Acad Sci USA 97(9), 4643-8, 2000.

Kawase, Y., Tanio, M., Kira, A., Yamaguchi, S., Tuzi, S., Naito, A., Kataoka, M., Lanyi, JK., Needleman, R., and Saito, H. Alteration of Conformation and Dynamics of Bacteriorhodopsin Induced by Protonation of Asp 85 and Deprotonation of Schiff Base as Studied by (13)C NMR. Biochemistry, 39(47):14472-14480, Nov 28, 2000.

Keller, TN, Huang, FF, Zhu, T, Yu, T, Ho, Y-S and Kindy, MS. Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. J Cereb Blood Flow Metab 20:1463-1473, 2000.

Kolonin, MG., and Finley Jr., RL. A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. Developmental Biology, 227, 661-672, 2000.

Kotra, LP., Amro, NA., Liu, G., Mobashery, S. Visualizing bacteria at high resolution, ASM News, 66, 675-681, 2000.

Kotra, LP., Golemi, D., Vakulenko, S., Mobashery, S. Bacteria fight back, Chemistry and Industry, 341-344, 2000.

Kotra, LP., Haddad, J., Mobashery, S. Aminoglycoside Antibiotics: Perspectives on mechanisms of action and resistance and strategies to counter resistance, Antimicrob. Agents Chemother., 44, 3249-3256, 2000.

Kotra, LP., Vakulenko, S., Mobashery, S. From genes to sequences to antibiotics: prospects for future developments from microbial genomics, Microbes Infect, 2, 651-658, 2000.

Kuchumov, AR., Loo, JA and Vinogradov, SN. Subunit distribution of calcium binding sites in the 3.6 MDa hexagonal bilayer hemoglobin from Lumbricus terrestris. J Protein Chem 19, 139-149, 2000.

Lamy, J., Kuchumov, AR., Taveau J-C., Boisset, N., Vinogradov, SN and Lamy, JN. Reassembly of Lumbricus terrestris hemoglobin: a study by matrix-assisted laser desorption/ionization mass spectrometry and 3D reconstruction from frozen-hydrated specimens. J Mol Biol 298, 633-647, 2000.

Lee, WL., Li, ZH., Vakulenko, S., Mobashery, S. A light-inactivated antibiotic, J Med Chem., 43, 128-132, 2000.

Lehoux, IE. and Mitra, B. The Role of Arginine277 in (S)-Mandelate dehydrogenase from pseudomonas putida in substrate binding and transition state stabilization, Biochemistry 39:10055-10065, 2000.

Li., J. and Rosen, BP. The linker peptide of the ArsA ATPase. Mol Microbiol 35, 361-367, 2000.

Liang, L-P, Ho, Y-S and Patel, M. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 101:563-570, 2000.

Liu, G., Schwartz, JA. and Brooks, SC. Estrogen receptor protects p53 from being deactivated by hdm2. Cancer Research, 60:1810-1814, 2000.

Liu, M., Haddad, J., Azucena, E., Kotra, LP., Kirzhner, M., Mobashery, S. Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3’-Phosphotransferases. J Org Chem, 65, 7422-7431, 2000.

Luecke, H., Schobert, B., Cartailler, J. P., Richter, HT., Rosengarth, A., Needleman, R. and Lanyi, JK. Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin. J Mol Biol 300(5), 1237-55, 2000.

Mai, J., Finley Jr., RL., Waisman, DM., and Sloane, B. Procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J Biol Chem., 275 (17):12806-12812, 2000.

Maveyraud, L., Golemi, D., Kotra, L. P., Tranier, S., Vakulenko, S., Mobashery, S., Samama, JP. Insights into class D ß-lactamases are revealed by the crystal structure of the Oxa10 enzyme from pseudomonas aeruginosa Structure, 8, 1289-1298, 2000.

Mobashery, S., Azucena, E. Mechanisms of bacterial antibiotic resistance, In Encyclopedia Life Sci., London: Nature Publishing Group, UK.

Mobashery, S., Kotra, L. Transition State Stabilization, In Encyclopedia Life Sci, London: Nature Publishing Group, UK, 2000 www.els.net.

Mukhopadhyay, R., Shi, J. and Rosen BP. Text Box: Purification and characterization of Acr2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275,21149-21157, 2000.

Ohlemiller, KK, McFadden, SL, Ding, D-L, Lear, PM, and Ho, Y-S. Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. JARO 01:243-254, 2000.

Olson, MW., Bernardo, MM., Pietila, M., Gervasi, DC., Toth, M., Kotra, LP., Massova, I., Mobashery, S., Fridman, R. Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. J Biol Chem, 275, 2661-2668, 2000.

Raj, L., Hanes, SD., Appel, LF., Badam, E., Finley Jr., RL., Brent, R., and Weir, M. Partner of paired, a localized repressor of paired protein function. Current Biology, 10(20), 1265-1272, 2000.

Rensing, C., Fan, B., Sharma, R., Mitra, B. and Rosen, BP. CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. Proc. Natl. Acad. Sci. USA 97:652-656, 2000.

Rensing, C., Mitra, B. and Rosen, BP. A Zn(II)-translocating P-type ATPase from Proteus mirabilis. Biochemistry and Cell Biology, 76,787-790, 1999.

Sharma, R., Rensing, C., Rosen, BP. and Mitra, B. The ATP hydrolytic activity of purified ZntA, a Pb(II)/Cd(II)/Zn(II)-translocating ATPase from Escherichia coli. J Biol Chem 275:3873-3878, 2000.

Sharma, R., Rensing, C., Rosen, B.P. and Mitra, B. The ATP hydrolytic activity of purified ZntA, a Pb(II)/Cd(II)/Zn(II)-translocating ATPase from Escherichia coli. J Biol Chem, 275, 3873-3878, 2000.

Shi, J. Vlamis-Gardikas, A., Aslund, F., Holmgren, A. and Rosen, BP. Reactivity of glutaredoxins 1, 2 and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. J Biol Chem 274, 36039-36042, 1999.

Stevens, SY., Hu, W., Gladysheva, T., Rosen, BP., Zuiderweg, ER. and Lee, L. Secondary structure and fold homology of the ArsC protein from the Escherichia coli arsenic resistance plasmid R773. Biochemistry 38, 10178-10186, 1999.

Studitsky, VM. Preparation and analysis of positioned nucleosomes in Chromatin protocols. Humana Press, 17-27, 2000.

Tang, K., Finley Jr., RL., Nie, D., and Honn, KV. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry, 9(12):3185-3191, 2000.

Therrien, C., Kotra, LP., Sanschagrin, F., Mobashery, S., Levesque, RC. Evaluation of inhibition of carbenicillin-hydrolyzing ß-Lactamase PSE-4 by the clinically used mechanism-based inhibitors, FEBS Letters, 470, 285-292, 2000.

Toth, M., Bernardo, MM., Gervasi, DC., Soloway, PD., Wang, Z., Bigg, HF., Overall, C M., DeClerck, YA., Tschesche, D., Cher, ML., Brown, S., Mobashery, S., Fridman, R. TIMP-2 acts synergistically with synthetic MMP inhibitors but not with TIMP-4 to enhance the MT1-MMP-dependent activation of pro-MMP-2, J Biol Chem, 275, 41415-41423, 2000.

Verweij, BH., Muizelaar, JP., Vinas, FC., Xiong, Y and Lee, CP. Impaired Cerebral mitochondrial function after traumatic brain injury in humans. J Neurosurgery 93:815-820, 2000.

Verweij, BH., Muizelaar, JP., Vinas, FC, Peterson, PL., Xiong, Y and Lee, CP. Improvement in mitochondrial dysfunction as a new surrogate efficiency measure for preclinical trials: dose-response and time-window profiles for administration of the calcium channel blocker Ziconotide in experimental brain injury. J Neurosurgery 93: 829-834, 2000.

Walmsley, AR., Zhou, TQ., Borges-Walmsley, I. and Rosen, BP. The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. J Biol Chem 274, 16153-16161, 1999.

Wang, Z-G and Ackerman, SH. The assembly factor Atp11p binds to the {beta} subunit of the mitochondrial F1 ATPase. J Biol Chem, 275:5767-5772, 2000.

Wang, Z-G, Sheluho, D, Gatti, DL, and Ackerman, SH. The {alpha}subunit of the mitochondrial F1 ATPase interacts directly with the assembly factor Atp12p, EMBO J, 19:1486-1493, 2000.

Winters, MA., Coolley, KL., Cheng, P., Girard, YA., Hamdan, H., Kovari, LC. and Merigan, TC. Genotypic, phenotypic, and modeling studies of a deletion in the b3 - b4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors. J Virol 74:10707-10713, 2000.

Xiao, W., Brown, LS., Needleman, R., Lanyi, JK. and Shin, YK. Light-induced rotation of a transmembrane alpha-helix in bacteriorhodopsin. J Mol Biol. 304(5):715-21, Dec 15, 2000.

Yamaguchi, S., Tuzi, S., Tanio, M., Naito, A., Lanyi, JK., Needleman, R. and Saito, H. Irreversible conformational change of bacterio-opsin induced by binding of retinal during its reconstitution to bacteriorhodopsin, as studied by (13)C NMR. J. Biochem (Tokyo) 127(5), 861-9, 2000.

Yoshida, T, Maulik, N, Engelman, RM, Ho, Y-S and Das, DK. Targeted disruption of the mouse Sod1 gene makes the hearts vulnerable to ischemic reperfusion injury. Circ Res 86:264-269, 2000.

Zal, F., Green, BN., Martineu, FH., Lallier, A., Toulmond, A., Vinogradov SN. and Childress, JJ. Hemoglobin structure diversity among deep-sea hydrothermal vent alvinellid worms. Eur J Biochemistry, 267, 1-11, 2000.

Zhang, J, Graham, DG, Montine, TJ and Ho, Y-S. Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in copper-zinc superoxide dismutase or glutathione peroxidase. J Neuropathol Exp Neurol 59:53-61, 2000

Zhou, TQ., Radaev, S. Rosen, BP. and Gatti, DL. Structure of the ArsA ATPase: The catalytic subunit of a heavy metal pump. EMBO J, 19,4838-4845, 2000.

Zhou, TQ. and Rosen, BP. Asp45 is a Mg²⁺ ligand in the ArsA ATPase. J Biol Chem 274,13854-13858, 1999.

Zhou, TQ., Rosen, BP. and Gatti, DL. Crystallization and preliminary X-ray analysis of the catalytic subunit of the ATP-dependent arsenite pump encoded by the Escherichia coli plasmid R773. Acta Crystallogr D Biol Crystallogr. 55, 921-924, 1999.

Bhattacharjee, H., and Rosen, BP. Structure-function analysis of the ArsA ATPase: contribution of histidine residues. J Bioenergetic Biomemb, (in press), 2001.

Bhattacharjee, H., and Rosen, BP. Role of conserved histidine residues in metalloactivation of the ArsA ATPase. Biometals, (in press), 2001.

Cao, NJ, Brusilow, WSA, Tomashek, JJ, Woodbury, DJ. Characterization of reconstituted FO from wildtype Escherichia coli and identification of two other fluxes co-purifying with FO. Cell Biochem Biophys (in press) 2000.

Stemmler, TL., Alam, S., Huang, H., Davis, DR., Sundquist, WI. A beta-hairpin switch in the proteolytic maturation of HIV-1 Gag. Cell, 2000, submitted.

Studitsky, VM. Transcription through chromatin by prokaryotic and eukaryotic RNA polymerases, Mol Biol, (in press).

Studitsky, VM., Brodolin, KL., Liu, Y., Mirzabekov, AD. Topography of lacUV5 initiation complexes. Nucl Acids Res., (in press).

Tomashek, JJ, Poposki, JA, Brusilow, WSA. A functional his-tagged c subunit of the Escherichia coli F-type ATPase/synthase. Arch Biochem Biophys (in press) 2000.

Tomashek, JJ, Brusilow, WSA. Stoichiometry of energy coupling by proton-translocating ATPases: a history of variability. J Biomemb Bioenerg (in press) 2000.

Walmsley, AR., Zhou, TQ., Borges-Walmsley, I. and Rosen, BP. Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump. Biochemistry, (in press), 2000.

Walmsley AR, Zhou, TQ, Borges-Walmsley MI, Rosen, BP. A kinetic model for the action of a resistance efflux pump. J Biol Chem, (in press), 2001.

Weber, RE. and Vinogradov, SN. Nonvertebrate hemoglobins: functions and molecular adaptations. Physiol. Rev., (in press).

Xiong, Y., Peterson, PL and Lee, CP. Alterations in cerebral energy metabolism induced by traumatic brain injury. J. Neurological Research, (in press).

Books, Chapters and Reviews
Bhattacharjee, H., Zhou, T., Li, J., Gatti, DL., Walmsley, AR. Rosen, BP. Structure–function relationships in an anion-translocating ATPase. Biochem Soc Trans 28, 520–526, 2000.

Bhattacharjee, H., Ghosh, M., Mukhopadhyay, R. and Rosen, BP. Arsenic pumps from E. coli to humans. In Transport of Molecules Across Membranes, JK. Broome-Smith, S. Baumber, CJ. Stirling, and BF. Ward, eds, Society for General Microbiology 58, 58-79 1999.

Driessen, AJM., Rosen, BP. and Konings, WN. Diversity of transport mechanisms: common structural principals. Trends in Biochem Sci 25:397-40, 2000.

Gatti, D., Mitra, B. and Rosen, BP. Escherichia coli Soft metal ion-translocating ATPases, J Biol Chem, 275:34009-34012, 2000.

Ghosh, M. and Rosen, BP. Microbial resistance mechanisms for heavy metals and metalloids. For Handbook of Heavy Metals in the Environment, ed., B. Sarkar, 2000.

Golemis, EA., Serebriiskii, I, Finley Jr., RL., Kolonin, MG., Gyuris, J, and Brent, R. Interaction trap/two-hybrid system to identify interacting proteins, in Current Protocols in Molecular Biology, Unit 20.1., and Current Protocols in Protein Science, Unit 19.1, John Wiley and Sons, Inc., New York, NY, 1998-2001.

Kolonin, MG., Zhong, J., and Finley, Jr., RL. Interaction mating methods in two-hybrid systems, in Methods in Enzymology vol. 328, Chimeric Proteins (eds. Thorner, J., Emr, S.D., and Abelson, J.N.) Academic Press, San Diego, CA., pp. 26-46, 2000.

Mitra, B., Gatti, DL. and Rosen, BP. Bacterial soft metal ATPases. J Biol Chem, 275, 34009-34012, 2000.

Thorner, J., Emr, S.D., and Abelson, J.N. Academic Press, San Diego, CA., pp. 26-46, 2000.

Rensing, C., Ghosh, M. and Rosen, BP. Families of soft metal ATPases. J Bacteriol. 181, 5891-5897, 1999.

Rensing, C. and Rosen, BP. Transport of Soft Metals in Prokaryotes. In Molecular Biology and Toxicology of Metals, RK. Zalpus and DJ. Koropatnick, eds. Taylor and Francis, London, pp 129-149, 1999.

Rosen, BP. Families of arsenic transporters. Trends in Microbiology, 7, 207-212 1999.

Rosen, BP. The role of efflux in bacterial resistance to soft metals and metalloids. In Essays in Biochemistry, Vol. 34: Metalloproteins; S.J. Higgins and D.P. Ballou, eds., pp 1-15, 1999.

Rosen, BP., Bhattacharjee, H., Zhou, TQ. and Walmsely, AR. Mechanism of the ArsA ATPase, Biochem. Biophys. Acta. 1461, 207-215, 1999.

Stanyon, C., and Finley Jr., RL. Functional Genomics - Progress and potential of Drosophila PIMS. Pharmacogenomics 1(4), 417-432, 2000.

Xu, C. and Rosen, BP. Metalloregulation of soft metal resistance pumps. In Metals and Genetics, B. Sarkar, ed., Plenum Press, p 406, 1999.

Finley Jr., R.L., Soans, A.H., and Stanyon, C.A. Peptide aptamers to study proteins and protein networks, in Protein Interactions, a Laboratory Manual, (eds. Golemis, E., and Serebriiskii, I.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. (in press).

Serebriiskii, I., Toby, GG., Finley Jr., RL., and Golemis, EA. Genomic analysis utilizing the yeast two-hybrid system, in Methods in Molecular Biology: Genomics Protocols, The Humana Press, Inc., Totowa, NJ, (in press). 2001

Xiong, Y., Peterson, PL and. Lee, CP. Mitochondrial dysfunction following traumatic brain injury. In: Head Trauma: Basic, Preclinical and Clinical Aspects. [eds L. P. Miller, R.L. Hayes and J. Newcomb], John Wiley & Sons, New York, 2000, (in press).

Xiong, Y., Peterson PL and. Lee, CP. Mitochondrial dysfunction following experimental traumatic brain injury: efficacy of blood brain barrier-penetrating antioxidant. In Mitochondrial Ubiquinone [Coenzyme Q 10]: Biochemical, Functional, Medical, and Therapeutic Aspects in Human Health and Diseases [eds. M. Ebadi, J. Marwah and RK. Chopra] Peominent Press, AZ, 2000, (in press).

Abstracts
Kovari, L. C., Cheng, P., Lu, T., Hinton, A., Wang, J., MacArthur, R. D., Draghici, S., Winters, M. A. and Merigan, T. C. HIV protease multidrug resistance is associated with the loss of key contacts between the protease and the inhibitor. 4^th International Workshop on HIV Drug Resistance and Treatment Strategies, June 12-16, 2000, Sitges, Spain. Antiviral Therapy 5 (Suppl. 3): 36.

Martin, PM., DeMel, S., Howard, A., Shi, J., Gladysheva, T., Gatti, D., Rosen, BR., and Edwards, BF. Arsenate Reductase: A Unique Heavy Atom, An Unexpected Product, And An Unprecedented Hydration Sphere, at 1.65 Å. American Crystallographic Association, vol. 27: 101-102, 2000.

Wang, Z-G and Ackerman, SH. Characterization of human homologs of the yeast Atp11p and Atp12p assembly factor proteins, FASEB J., (in press) 2000.

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Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology