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Dr. Walker's Curriculum Vitae
e-mail- pdwalker@med.wayne.edu
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Education/Training:
B.S. (Biology), 1983, Albright College, Reading, PA
Ph.D. (Anatomy), 1987, Temple University School of Medicine, Philadelphia, PA
Postdoc (Neuroscience), 1987-1990, Rutgers University, Newark, NJ
Professional Appointments:
Assistant Professor, 1990-1996, Department of Anatomy & Cell Biology,
WSU SOM
Associate Professor (tenured), 1996-2002, Department of Anatomy & Cell
Biology, WSU SOM
Professor, 2002-present, Department of Anatomy & Cell Biology, WSU SOM
Major Research Interests:
Neuroscience- regulation of basal ganglia as related to movement disorders (e.g. Parkinson's Disease)
Current Research:
Our research focuses on serotonin and dopamine receptor-mediated signal transduction mechanisms
that influence movement following the degeneration of dopamine neurons in animal models of Parkinson's
disease. Research methods involve whole animal research and include stereotaxic surgery, guide cannulation,
systemic and intracerebral pharmacological manipulation, computerized animal activity monitoring, in situ
hybridization, immunohistochemistry, high performance liquid chromatography, as well as various biochemical
methods to study signal transduction mechanisms.
Selected Publications:
| 1. | Taylor JL, Bishop C, Walker PD. 2006. Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat. Neuropharmacol 50: 761-768. Full Text |
| 2. | Bishop C, Daut GS, Walker PD. 2005. Serotonin 5-HT2A receptor but not 5-HT2C antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958. Neuropharmacol 49: 350-358. Full Text |
| 3. | Bishop C, Tessmer J, Ullrich T, Rice KC, Walker PD. 2004. Serotonin 5-HT2A receptors underlie abnormal movements induced in dopamine-depleted rats by intrastriatal 5-HT2A/2C agonism. J Pharmacol Exp Therap 310: 687-694. Full Text |
| 4. | Bishop C, Walker PD. 2003. Combined intrastriatal dopamine D1 and serotonin 5-HT2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats. Neurosci 121: 649-657. Full Text |
| 5. | Campbell BM, Gresch PJ, Walker PD. 2001. Neonatal dopamine depletion reveals a synergistic mechanism of mRNA regulation that is mediated by dopamine D1 and serotonin 2 receptors and is targeted to tachykinin neurons of the dorsomedial striatum. Neurosci 105: 671-680. Full Text |
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