Nancy O'Sullivan, Ph.D.

Education:
1979, A.S., Medical Laboratory Technology, Schoolcraft College, Livonia, MI
1984, B.S., Biology, Wayne State University, Detroit, MI.
1991, Ph.D., Immunology and Microbiology, Wayne State University, Detroit, MI.

Training
1991-1996, Postdoctoral Fellowship. Department of Immunology and Microbiology, Wayne State University School of Medicine.

Professional and Faculty Appointments:
1996, Research Assistant Professor, Department of Anatomy and Cell Biology, Wayne State University School of Medicine.
1997, Associate. Department of Immunology and Microbiology, Wayne State University School of Medicine.
1997, Graduate Faculty, Wayne State University

Research Interests
Mucosal immunobiology of the ocular and oral compartments.

Current Research
I am investigating the role of dendritic cells (DC) in salivary secretory IgA immune responses. An understanding of the function of DC at the inductive and effector sites and the effect of immunomodulators in regulating the outcome of the DC response will provide important information for the development of vaccine strategies to optimize the induction of salivary IgA for the protection of the oral cavity. In addition, I am collaborating with Dr. Montgomery (Immunology/Microbiology, WSU) in similar studies investigating the role of DC in ocular secretory IgA immune responses.

References "

1. O'Sullivan, N.L., Skandera, C. A., Chin, Y-H and P. C. Montgomery. 1994. In vitro adhesive interactions between rat lymphocytes and lacrimal gland acinar epithelium: Phenotype of adherent lymphocytes and involvement of adhesion molecules. J. Immunol. 152:1684-1692. Medline

2. Elfaki, M. G., O'Sullivan, N.L., Skandera, C. A., and P. C. Montgomery. 1994. Inhibition of lymphocyte adhesion to rat lacrimal acinar epithelial cells by interleukin-4 and transforming growth factor-b. Cellular Immunol. 153:154-162. Medline

3. Elfaki, M. G., O'Sullivan, N.L., Skandera, C. A., and P. C. Montgomery. 1995. Modulation of lymphocyte adhesion to rat salivary glands by interleukin-4 and transforming growth factor-b. Regional Immunol. 6:255-231. Medline

4. O'Sullivan, N.L. Skandera, C.A. and P. C. Montgomery. 1996. The specificity of adhesive interactions between rat lymphocytes and salivary gland epilthelia. Cell. Immunol. 169:142-151. Medline

5. P. C. Montgomery O'Sullivan, N.L. and C.A. Skandera 1996. Phenotypic profiles of lymphocyte populations isolated from rat major salivary glands. Oral Microbiol. Immunol. 11:248-253. Medline

6. Carr, R.M., Lolachi, C.M., Albaran, R.G., Ridley, D.M., Montgomery, P.C. and O'Sullivan. 1996. Nasal associated lymphoid tissue is an inductive site for rat tear antibody responses. Immunol. Invest. 25:387-396. Medline

7. O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 1998. Rat lacrimal glands contain activated and resting mature T cells, recent thymic emigrants and possibly extrathymic populations. Adv. Exp. Med. Biol. 438:591-598. Medline

8. O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 2001. Lymphocyte lineages at mucosal effector sites: Rat salivary glands. J. Immunol. 166:5522-5529. Medline

9. O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 2001 Development of T cell lineages in rat lacrimal Galands. Curr. Eye Res 22:375-83. Medline

10. O’Sullivan, N.L., Baylor A.E. 3rd, and Montgomery, P.C. 2007. Development of immortalized rat conjunctival cell lines: an in vitro model to examine transepithelial antigen delivery. Exp. Eye. Res. 84(2):323-31. Medline

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1.	O'Sullivan, N.L., Skandera, C. A., Chin, Y-H and P. C. Montgomery. 1994. In vitro adhesive interactions between rat lymphocytes and lacrimal gland acinar epithelium: Phenotype of adherent lymphocytes and involvement of adhesion molecules. J. Immunol. 152:1684-1692. Medline
2.	Elfaki, M. G., O'Sullivan, N.L., Skandera, C. A., and P. C. Montgomery. 1994. Inhibition of lymphocyte adhesion to rat lacrimal acinar epithelial cells by interleukin-4 and transforming growth factor-b. Cellular Immunol. 153:154-162. Medline
3.	Elfaki, M. G., O'Sullivan, N.L., Skandera, C. A., and P. C. Montgomery. 1995. Modulation of lymphocyte adhesion to rat salivary glands by interleukin-4 and transforming growth factor-b. Regional Immunol. 6:255-231. Medline
4.	O'Sullivan, N.L. Skandera, C.A. and P. C. Montgomery. 1996. The specificity of adhesive interactions between rat lymphocytes and salivary gland epilthelia. Cell. Immunol. 169:142-151. Medline
5.	P. C. Montgomery O'Sullivan, N.L. and C.A. Skandera 1996. Phenotypic profiles of lymphocyte populations isolated from rat major salivary glands. Oral Microbiol. Immunol. 11:248-253. Medline
6.	Carr, R.M., Lolachi, C.M., Albaran, R.G., Ridley, D.M., Montgomery, P.C. and O'Sullivan. 1996. Nasal associated lymphoid tissue is an inductive site for rat tear antibody responses. Immunol. Invest. 25:387-396. Medline
7.	O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 1998. Rat lacrimal glands contain activated and resting mature T cells, recent thymic emigrants and possibly extrathymic populations. Adv. Exp. Med. Biol. 438:591-598. Medline
8.	O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 2001. Lymphocyte lineages at mucosal effector sites: Rat salivary glands. J. Immunol. 166:5522-5529. Medline
9.	O'Sullivan, N. L. , Skandera, C. A., and Montgomery, P. C. 2001 Development of T cell lineages in rat lacrimal Galands. Curr. Eye Res 22:375-83. Medline
10.	O’Sullivan, N.L., Baylor A.E. 3rd, and Montgomery, P.C. 2007. Development of immortalized rat conjunctival cell lines: an in vitro model to examine transepithelial antigen delivery. Exp. Eye. Res. 84(2):323-31. Medline